{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:42:34Z","timestamp":1775594554817,"version":"3.50.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.phymed.2022.154034","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T20:00:40Z","timestamp":1646424040000},"page":"154034","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke"],"prefix":"10.1016","volume":"99","author":[{"given":"Yule","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongda","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinran","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuecai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phymed.2022.154034_bib0001","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s12272-016-0835-4","article-title":"Guhong injection protects against focal cerebral ischemia-reperfusion injury via anti-inflammatory effects in rats","volume":"40","author":"Ai","year":"2017","journal-title":"Arch. Pharm. Res."},{"issue":"9","key":"10.1016\/j.phymed.2022.154034_bib0002","first-page":"e139","article-title":"Heart disease and stroke statistics-2020 update: a report from the","volume":"141","year":"2020","journal-title":"Am. Heart Assoc. Circ."},{"key":"10.1016\/j.phymed.2022.154034_bib0004","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.27","article-title":"Searching online mendelian inheritance in man (OMIM): a knowledgebase of human genes and genetic phenotypes","volume":"58","author":"Amberger","year":"2017","journal-title":"Curr. Protoc. Bioinform."},{"issue":"4","key":"10.1016\/j.phymed.2022.154034_bib0005","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s13311-016-0483-x","article-title":"Inflammation and stroke: an overview","volume":"13","author":"Anrather","year":"2016","journal-title":"Neurotherapeutics"},{"issue":"2","key":"10.1016\/j.phymed.2022.154034_bib0006","article-title":"An automated method for finding molecular complexes in large protein interaction networks","volume":"4","author":"Bader","year":"2003","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.phymed.2022.154034_bib0007","doi-asserted-by":"crossref","first-page":"01265","DOI":"10.3389\/fphar.2020.01265","article-title":"Therapeutic potential of hydroxysafflor yellow A on cardio-cerebrovascular diseases","volume":"11","author":"Bai","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2022.154034_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2018.09.012","article-title":"Current advances in ischemic stroke research and therapies","volume":"1866","author":"Barthels","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"8","key":"10.1016\/j.phymed.2022.154034_bib0009","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.phymed.2022.154034_bib0010","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1177\/1747493018761190","article-title":"Cut stroke in half: polypill for primary prevention in stroke","volume":"13","author":"Brainin","year":"2018","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.phymed.2022.154034_bib0011","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0812s15","article-title":"Motor coordination and balance in rodents","author":"Carter","year":"2001","journal-title":"Curr. Protoc. Neurosci."},{"issue":"14","key":"10.1016\/j.phymed.2022.154034_bib0012","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1073\/pnas.1820799116","article-title":"From single drug targets to synergistic network pharmacology in ischemic stroke","volume":"116","author":"Casas","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.phymed.2022.154034_bib0013","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"issue":"48","key":"10.1016\/j.phymed.2022.154034_bib0014","first-page":"2761","article-title":"Mouse model of middle cerebral artery occlusion","author":"Chiang","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"Suppl 4","key":"10.1016\/j.phymed.2022.154034_bib0015","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0016","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/0271678X19882788","article-title":"Post-stroke remodeling processes in animal models and humans","volume":"40","author":"Cirillo","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"2","key":"10.1016\/j.phymed.2022.154034_bib0017","first-page":"415","article-title":"Recovery after stroke","volume":"26","author":"Cramer","year":"2020","journal-title":"Contin. (Minneap. Minn.)"},{"issue":"7","key":"10.1016\/j.phymed.2022.154034_bib0018","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/cdd.2009.180","article-title":"Neuronal caspase-3 signaling: not only cell death","volume":"17","author":"D'Amelio","year":"2010","journal-title":"Cell. Death Differ."},{"issue":"D1","key":"10.1016\/j.phymed.2022.154034_bib0019","doi-asserted-by":"crossref","first-page":"D1138","DOI":"10.1093\/nar\/gkaa891","article-title":"Comparative toxicogenomics database (CTD): update 2021","volume":"49","author":"Davis","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phymed.2022.154034_bib0021","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejphar.2018.02.011","article-title":"Protective effect of hydroxysafflor yellow A alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat: a PET study using 18F-fuorodeoxyglucose","volume":"825","author":"Deng","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.phymed.2022.154034_bib0022","first-page":"1665","article-title":"Chinese expert consensus on the clinical application of Guhong injection","volume":"18","year":"2020","journal-title":"Chin. J. Integr. Med. Cardio Cerebrovasc. Dis."},{"key":"10.1016\/j.phymed.2022.154034_bib0023","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbr.2018.11.040","article-title":"Behavioral tests that reveal long-term deficits after permanent focal cerebral ischemia in mouse","volume":"360","author":"Frechou","year":"2019","journal-title":"Behav. Brain Res."},{"issue":"25","key":"10.1016\/j.phymed.2022.154034_bib0024","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1056\/NEJMoa1804492","article-title":"Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016","volume":"379","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2022.154034_bib0025","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.lfs.2016.09.021","article-title":"Disrupted mitochondrial genes and inflammation following stroke","volume":"166","author":"Gibbs","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.154034_bib0026","doi-asserted-by":"crossref","first-page":"W32","DOI":"10.1093\/nar\/gku293","article-title":"SwissTargetPrediction: a web server for target prediction of bioactive small molecules","volume":"42","author":"Gfeller","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.phymed.2022.154034_bib0027","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1023\/A:1020709814456","article-title":"Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury","volume":"14","author":"Hata","year":"1999","journal-title":"Metab. Brain Dis."},{"issue":"11","key":"10.1016\/j.phymed.2022.154034_bib0028","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0030","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","article-title":"Neuroinflammation: friend and foe for ischemic stroke","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J. Neuroinflamm."},{"issue":"5","key":"10.1016\/j.phymed.2022.154034_bib0031","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s12265-013-9508-6","article-title":"Role of inflammation and its mediators in acute ischemic stroke","volume":"6","author":"Jin","year":"2013","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.phymed.2022.154034_bib0032","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.brainresbull.2017.08.011","article-title":"Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K\/Akt and Nrf2\/ARE signaling pathways","volume":"134","author":"Jin","year":"2017","journal-title":"Brain Res. Bull."},{"issue":"5","key":"10.1016\/j.phymed.2022.154034_bib0033","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrn.2017.26","article-title":"Motor compensation and its effects on neural reorganization after stroke","volume":"18","author":"Jones","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0034","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/j.2040-4603.2017.tb00741.x","article-title":"Ischemia\/reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Compr. Physiol."},{"issue":"7","key":"10.1016\/j.phymed.2022.154034_bib0035","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s10072-017-2938-1","article-title":"Pathogenic mechanisms following ischemic stroke","volume":"38","author":"Khoshnam","year":"2017","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.phymed.2022.154034_bib0036","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-8994-2_9","article-title":"The open field test for measuring locomotor activity and anxiety-like behavior","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"10","key":"10.1016\/j.phymed.2022.154034_bib0037","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00210-019-01670-x","article-title":"Neuroprotective effect of chlorogenic acid in global cerebral ischemia-reperfusion rat model","volume":"392","author":"Kumar","year":"2019","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"20","key":"10.1016\/j.phymed.2022.154034_bib0038","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.3390\/ijms21207609","article-title":"Pathophysiology and treatment of stroke: present status and future perspectives","volume":"21","author":"Kuriakose","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0039","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12984-019-0570-4","article-title":"Bimanual coordination deficits in hands following stroke and their relationship with motor and functional performance","volume":"16","author":"Lai","year":"2019","journal-title":"J. Neuroeng. Rehabil."},{"issue":"5","key":"10.1016\/j.phymed.2022.154034_bib0040","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00401-018-1930-z","article-title":"Post-stroke inflammation-target or tool for therapy","volume":"137","author":"Lambertsen","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.phymed.2022.154034_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110213","article-title":"Shuxuening injection facilitates neurofunctional recovery via down-regulation of G-CSF-mediated granulocyte adhesion and diapedesis pathway in a subacute stroke mouse model","volume":"127","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2022.154034_bib0042","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-4939-7526-6_9","article-title":"Modeling transient focal ischemic stroke in rodents by intraluminal filament method of middle cerebral artery occlusion","volume":"1717","author":"Lopez","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.phymed.2022.154034_bib0043","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0278-5846(03)00022-8","article-title":"Apoptosis and brain ischaemia","volume":"27","author":"Love","year":"2003","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0044","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11655-019-3064-0","article-title":"Network pharmacology in research of Chinese medicine formula: methodology, application and prospective","volume":"26","author":"Luo","year":"2020","journal-title":"Chin. J. Integr. Med."},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0045","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12906-019-2703-5","article-title":"Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK\/NLRP3 Inflammasome Signalling pathway","volume":"19","author":"Ma","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2022.154034_bib0046","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fphar.2020.00519","article-title":"An integrative pharmacology-based analysis of refined Qingkailing injection against cerebral ischemic stroke: a novel combination of baicalin, geniposide, cholic acid, and hyodeoxycholic acid","volume":"11","author":"Ma","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2022.154034_bib0047","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2217\/bmm.09.30","article-title":"Molecular biomarkers in stroke diagnosis and prognosis","volume":"3","author":"Maas","year":"2009","journal-title":"Biomark. Med."},{"issue":"8","key":"10.1016\/j.phymed.2022.154034_bib0048","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00415-018-8935-3","article-title":"Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials","volume":"265","author":"Malhotra","year":"2018","journal-title":"J. Neurol."},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0049","first-page":"1","article-title":"Use of cardiovascular polypills for the secondary prevention of cerebrovascular disease","volume":"36","author":"Masjuan","year":"2021","journal-title":"Neurol. (Engl. Ed.)"},{"issue":"4","key":"10.1016\/j.phymed.2022.154034_bib0050","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.STR.0000120732.45951.26","article-title":"Nuclear factor-kappaB contributes to infarction after permanent focal ischemia","volume":"35","author":"Nurmi","year":"2004","journal-title":"Stroke"},{"issue":"10154","key":"10.1016\/j.phymed.2022.154034_bib0052","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(18)31269-8","article-title":"Prevention of stroke: a global perspective","volume":"392","author":"Pandian","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2022.154034_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113518","article-title":"Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies","volume":"335","author":"Paul","year":"2021","journal-title":"Exp. Neurol."},{"issue":"D1","key":"10.1016\/j.phymed.2022.154034_bib0054","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pinero","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.phymed.2022.154034_bib0055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","article-title":"Emerging roles of caspase-3 in apoptosis","volume":"6","author":"Porter","year":"1999","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.phymed.2022.154034_bib0056","first-page":"268","article-title":"Update on treatment of acute ischemic stroke","volume":"26","author":"Rabinstein","year":"2020","journal-title":"Contin. (Minneap. Minn.)"},{"issue":"2","key":"10.1016\/j.phymed.2022.154034_bib0057","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/1570161115666161104095522","article-title":"Apoptosis and acute brain ischemia in ischemic stroke","volume":"15","author":"Radak","year":"2017","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.phymed.2022.154034_bib0058","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000511064","article-title":"Use of the cardiovascular polypill in secondary prevention of cerebrovascular disease: a real-life tertiary hospital cohort study of 104 patients","volume":"10","author":"Ros-Castello","year":"2020","journal-title":"Cerebrovasc. Dis. Extra"},{"key":"10.1016\/j.phymed.2022.154034_bib0059","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform."},{"issue":"9","key":"10.1016\/j.phymed.2022.154034_bib0060","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2174\/1570159X16666180302115544","article-title":"Cell death mechanisms in stroke and novel molecular and cellular treatment options","volume":"16","author":"Sekerdag","year":"2018","journal-title":"Curr. Neuropharmacol."},{"issue":"24","key":"10.1016\/j.phymed.2022.154034_bib0061","first-page":"4829","article-title":"Effect and mechanism of Guhong injection against cerebral ischemia reperfusion injury","volume":"39","author":"Shu","year":"2014","journal-title":"China J. Chin. Mater. Med."},{"issue":"3","key":"10.1016\/j.phymed.2022.154034_bib0062","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00204-014-1448-7","article-title":"The mystery of BCL2 family: bcl-2 proteins and apoptosis: an update","volume":"89","author":"Siddiqui","year":"2015","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.phymed.2022.154034_bib0063","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/0271678X20970048","article-title":"Principles and requirements for stroke recovery science","volume":"41","author":"Sommer","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.phymed.2022.154034_bib0064","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinform."},{"key":"10.1016\/j.phymed.2022.154034_bib0065","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3804979","article-title":"Free radical damage in ischemia-reperfusion injury: an obstacle in acute ischemic stroke after revascularization therapy","volume":"2018","author":"Sun","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2022.154034_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107268","article-title":"Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a\/NF-\u03baB pathway","volume":"90","author":"Tan","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2022.154034_bib0067","article-title":"Galectin-3 mediated inflammatory response contributes to neurological recovery by QiShenYiQi in subacute stroke model","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154034_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109945","article-title":"Protection against acute cerebral ischemia\/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization","volume":"125","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2022.154034_bib0069","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2464269","article-title":"Disorder genes regulate the progression of ischemic stroke through the NF-\u03baB signaling pathway","volume":"2021","author":"Wei","year":"2021","journal-title":"Biomed. Res. Int."},{"issue":"2","key":"10.1016\/j.phymed.2022.154034_bib0070","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00415-018-8933-5","article-title":"Time window and \"tissue window\": two approaches to assist decision-making in strokes","volume":"266","author":"Xiang","year":"2019","journal-title":"J. Neurol."},{"issue":"3","key":"10.1016\/j.phymed.2022.154034_bib0071","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/1673-5374.128215","article-title":"Functional electrical stimulation-facilitated proliferation and regeneration of neural precursor cells in the brains of rats with cerebral infarction","volume":"9","author":"Xiang","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2022.154034_bib0072","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6687386","article-title":"Neuroprotective phytochemicals in experimental ischemic stroke: mechanisms and potential clinical applications","volume":"2021","author":"Xu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"D1","key":"10.1016\/j.phymed.2022.154034_bib0073","doi-asserted-by":"crossref","first-page":"D976","DOI":"10.1093\/nar\/gky987","article-title":"ETCM: an encyclopaedia of traditional Chinese medicine","volume":"47","author":"Xu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phymed.2022.154034_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109102","article-title":"Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage","volume":"117","author":"Yang","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.phymed.2022.154034_bib0075","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10822-016-9915-2","article-title":"TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models","volume":"30","author":"Yao","year":"2016","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0076","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12974-018-1379-y","article-title":"Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes","volume":"16","author":"Yew","year":"2019","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.phymed.2022.154034_bib0077","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12974-019-1693-z","article-title":"Dectin-1\/Syk signaling triggers neuroinflammation after ischemic stroke in mice","volume":"17","author":"Ye","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2022.154034_bib0078","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3389\/fphar.2018.00493","article-title":"Pharmacokinetics of active components from Guhong injection in normal and pathological rat models of cerebral ischemia: a comparative study","volume":"9","author":"Yu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154034_bib0079","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.716121","article-title":"Guhong injection alleviates cerebral ischemia-reperfusion injury via the PKC\/HIF-1\u03b1 pathway in rats","volume":"12","author":"Yu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.phymed.2022.154034_bib0080","first-page":"741","article-title":"Neuroprotective effects of aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion","volume":"33","author":"Zhang","year":"2015","journal-title":"Restor. Neurol. Neurosci."},{"issue":"3","key":"10.1016\/j.phymed.2022.154034_bib0081","first-page":"184","article-title":"Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation","volume":"16","author":"Zhang","year":"2018","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2022.154034_bib0082","article-title":"Guhong injection protects against apoptosis in cerebral ischemia by maintaining cerebral microvasculature and mitochondrial integrity through the PI3K\/AKT pathway","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132200112X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132200112X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:36:49Z","timestamp":1760553409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132200112X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":79,"alternative-id":["S094471132200112X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154034","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154034"}}