{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:38:18Z","timestamp":1792813098947,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.phymed.2022.154097","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T11:45:59Z","timestamp":1649245559000},"page":"154097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90\u03b1, and RXR\u03b1"],"prefix":"10.1016","volume":"101","author":[{"given":"Lingming","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanglan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154097_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2016.08.001","article-title":"Drug metabolism in the liver","volume":"21","author":"Almazroo","year":"2017","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.phymed.2022.154097_bib0002","doi-asserted-by":"crossref","first-page":"a034017","DOI":"10.1101\/cshperspect.a034017","article-title":"Structure, function, and regulation of the Hsp90 machinery","volume":"11","author":"Biebl","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.phymed.2022.154097_bib0003","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.phymed.2017.09.016","article-title":"Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity","volume":"36","author":"Chang","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2022.154097_bib0004","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.3390\/cells9112395","article-title":"Regulation of CAR and PXR expression in health and disease","volume":"9","author":"Daujat-Chavanieu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2022.154097_bib0005","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1523\/JNEUROSCI.0367-19.2019","article-title":"CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons","volume":"40","author":"Esvald","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2022.154097_bib0006","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cell.2014.03.012","article-title":"Nuclear receptors, RXR, and the big bang","volume":"157","author":"Evans","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2022.154097_bib0007","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1124\/mol.62.2.359","article-title":"Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor","volume":"62","author":"Goodwin","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154097_bib0008","first-page":"1329","article-title":"The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module","volume":"56","author":"Goodwin","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154097_bib0009","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bcp.2018.11.009","article-title":"Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor","volume":"159","author":"Hu","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154097_bib0010","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/bph.13472","article-title":"The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (\"squelching\") SRC-1 coactivator","volume":"173","author":"Hyrsova","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154097_bib0011","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mce.2010.06.012","article-title":"The challenge of modeling nuclear receptor regulatory networks in mammalian cells","volume":"334","author":"Jagannathan","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.phymed.2022.154097_bib0012","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00384-006-0112-y","article-title":"NF-kappaB\/PPAR gamma and\/or AP-1\/PPAR gamma 'on\/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression","volume":"22","author":"Konstantinopoulos","year":"2007","journal-title":"Int. J. Colorectal Dis."},{"key":"10.1016\/j.phymed.2022.154097_bib0013","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.bcp.2011.08.023","article-title":"Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene","volume":"82","author":"Krausova","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154097_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.04.016","article-title":"Alternative retinoid X receptor (RXR) ligands","volume":"491","author":"Krezel","year":"2019","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.phymed.2022.154097_bib0015","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-2265.2011.04214.x","article-title":"Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma","volume":"75","author":"Kroiss","year":"2011","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.phymed.2022.154097_bib0016","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1124\/dmd.118.081042","article-title":"The roles of xenobiotic receptors: beyond chemical disposition","volume":"46","author":"Mackowiak","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phymed.2022.154097_bib0017","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s40262-019-00783-z","article-title":"Phenotyping of human CYP450 enzymes by endobiotics: current knowledge and methodological approaches","volume":"58","author":"Magliocco","year":"2019","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.phymed.2022.154097_bib0018","doi-asserted-by":"crossref","first-page":"567","DOI":"10.5483\/BMBRep.2013.46.12.248","article-title":"CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis","volume":"46","author":"Oh","year":"2013","journal-title":"BMB Rep."},{"key":"10.1016\/j.phymed.2022.154097_bib0019","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/mol.117.110155","article-title":"PXR: more than just a master xenobiotic receptor","volume":"93","author":"Oladimeji","year":"2018","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154097_bib0020","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fphar.2016.00456","article-title":"Pregnane X receptor (PXR)-mediated gene repression and cross-talk of PXR with other nuclear receptors via coactivator interactions","volume":"7","author":"Pavek","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154097_bib0021","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bcp.2009.08.017","article-title":"Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene","volume":"79","author":"Pavek","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2022.154097_bib0022","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/toxsci\/kfab023","article-title":"Targeting xenobiotic nuclear receptors PXR and CAR to prevent cobicistat hepatotoxicity","volume":"181","author":"Shehu","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.phymed.2022.154097_bib0023","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1124\/molpharm.120.000103","article-title":"Antiepileptic drug-activated constitutive androstane receptor inhibits peroxisome proliferator-activated receptor alpha and peroxisome proliferator-activated receptor gamma coactivator 1alpha-dependent gene expression to increase blood triglyceride levels","volume":"98","author":"Shizu","year":"2020","journal-title":"Mol. Pharmacol."},{"issue":"10","key":"10.1016\/j.phymed.2022.154097_bib0024","doi-asserted-by":"crossref","first-page":"e00649","DOI":"10.1128\/MCB.00649-16","article-title":"Phosphorylated nuclear receptor CAR forms a homodimer to repress its constitutive activity for ligand activation","volume":"37","author":"Shizu","year":"2017","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2022.154097_bib0025","doi-asserted-by":"crossref","first-page":"49307","DOI":"10.1074\/jbc.M407281200","article-title":"Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver","volume":"279","author":"Squires","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2022.154097_bib0026","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3109\/03602532.2012.748793","article-title":"Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver","volume":"45","author":"Staudinger","year":"2013","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.phymed.2022.154097_bib0027","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.3390\/ijms19061785","article-title":"Mathematical models in the description of pregnane X receptor (PXR)-regulated cytochrome P450 enzyme induction","volume":"19","author":"Tebbens","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.154097_bib0028","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.addr.2010.08.006","article-title":"Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR","volume":"62","author":"Tolson","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2022.154097_bib0029","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1124\/mol.108.050575","article-title":"Unveiling a new essential cis element for the transactivation of the CYP3A4 gene by xenobiotics","volume":"75","author":"Toriyabe","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154097_bib0030","doi-asserted-by":"crossref","first-page":"18180","DOI":"10.1074\/jbc.RA118.004652","article-title":"Ligand binding and heterodimerization with retinoid X receptor alpha (RXRalpha) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding","volume":"293","author":"Wang","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2022.154097_bib0031","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/ptr.6290","article-title":"Effect of panaxytriol on cytochrome P450 3A4 via the pregnane X receptor regulatory pathway","volume":"33","author":"Wu","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2022.154097_bib0032","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.molcel.2017.03.019","article-title":"Glucocorticoid receptor: MegaTrans switching mediates the repression of an ERalpha-regulated transcriptional program","volume":"66","author":"Yang","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2022.154097_bib0033","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.molcel.2020.06.031","article-title":"Structural insights of transcriptionally active, full-length androgen receptor coactivator complexes","volume":"79","author":"Yu","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2022.154097_bib0034","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1124\/dmd.112.048025","article-title":"Identification of the active components in Shenmai injection that differentially affect CYP3A4-mediated 1\u2032-hydroxylation and 4-hydroxylation of midazolam","volume":"41","author":"Zeng","year":"2013","journal-title":"Drug Metab. Dispos."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322001751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322001751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:33:41Z","timestamp":1760553221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322001751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":34,"alternative-id":["S0944711322001751"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154097","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90\u03b1, and RXR\u03b1","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154097"}}