{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:58Z","timestamp":1790744578947,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703840"],"award-info":[{"award-number":["81703840"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703951"],"award-info":[{"award-number":["81703951"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973711"],"award-info":[{"award-number":["81973711"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002888","name":"Beijing Municipal Commission of Education","doi-asserted-by":"publisher","award":["KM202010025024"],"award-info":[{"award-number":["KM202010025024"]}],"id":[{"id":"10.13039\/501100002888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1708900"],"award-info":[{"award-number":["2019YFC1708900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.phymed.2022.154185","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T11:52:54Z","timestamp":1654084374000},"page":"154185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Yi-Xin-Shu capsule ameliorates cardiac hypertrophy by regulating RB\/HDAC1\/GATA4 signaling pathway based on proteomic and mass spectrometry image analysis"],"prefix":"10.1016","volume":"103","author":[{"given":"Minyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-7595","authenticated-orcid":false,"given":"Minghua","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5231-2888","authenticated-orcid":false,"given":"Junying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangning","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muxin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.phymed.2022.154185_bib0001","article-title":"Yixinshu capsule combined with conventional treatment for chronic heart failure protocol for a systematic review and trial sequential analysis","volume":"98","author":"Cai","year":"2019","journal-title":"Medicine (Baltimore)."},{"key":"10.1016\/j.phymed.2022.154185_bib0002","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phymed.2022.154185_bib0003","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrcardio.2011.159","article-title":"Mechanisms of disease: hypertrophic cardiomyopathy","volume":"9","author":"Frey","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2022.154185_bib0004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/srep17927","article-title":"Direct evidence that myocardial insulin resistance following myocardial ischemia contributes to post-ischemic heart failure","volume":"5","author":"Fu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154185_bib0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.21037\/atm.2018.04.14","article-title":"Traditional Chinese medicine Qiliqiangxin attenuates phenylephrine-induced cardiac hypertrophy via upregulating PPAR\u03b3 and PGC-1\u03b1","volume":"6","author":"Gao","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phymed.2022.154185_bib0006","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1038\/sj.onc.1209615","article-title":"RB and cell cycle progression","volume":"25","author":"Giacinti","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2022.154185_bib0007","doi-asserted-by":"crossref","unstructured":"Giamouzis, G., Dimos, A., Xanthopoulos, A., Skoularigis, J., Triposkiadis, F., 2021. Left ventricular hypertrophy and sudden cardiac death. 10.1007\/s10741-021-10134-5.","DOI":"10.1007\/s10741-021-10134-5"},{"key":"10.1016\/j.phymed.2022.154185_bib0008","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nrcardio.2015.60","article-title":"Traditional Chinese medication for cardiovascular disease","volume":"12","author":"Hao","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2022.154185_bib0009","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/cvr\/cvw074","article-title":"Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb\/E2f-signalling","volume":"110","author":"Hille","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2022.154185_bib0010","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/cvr\/cvw074","article-title":"Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb\/E2f-signalling","volume":"110","author":"Hille","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2022.154185_bib0011","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2022.154185_bib0012","first-page":"H1378","volume":"316","author":"Huang","year":"2019","journal-title":"A novel traditional Chinese medicine ameliorates fatigue-induced cardiac hypertrophy and dysfunction via regulation of energy metabolism"},{"key":"10.1016\/j.phymed.2022.154185_bib0013","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1536\/ihj.16-404","article-title":"Regulation of cardiac transcription factor GATA4 by post-translational modification in cardiomyocyte hypertrophy and heart failure","volume":"57","author":"Katanasaka","year":"2016","journal-title":"Int. Heart J."},{"key":"10.1016\/j.phymed.2022.154185_bib0014","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-1-4899-8032-8_6","article-title":"RB and lamins in cell cycle regulation and aging","volume":"773","author":"Kennedy","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2022.154185_bib0015","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/01913123.2016.1260080","article-title":"Therapeutic effect of mesenchymal stem cells on experimentally induced hypertensive cardiomyopathy in adult albino rats","volume":"41","author":"Khater","year":"2017","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.phymed.2022.154185_bib0016","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1023\/A:1009813621103","article-title":"The cytoskeleton and related proteins in the human failing heart","volume":"5","author":"Kostin","year":"2000","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.phymed.2022.154185_bib0017","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tig.2015.10.007","article-title":"Lateral thinking: how histone modifications regulate gene expression","volume":"32","author":"Lawrence","year":"2016","journal-title":"Trends Genet."},{"key":"10.1016\/j.phymed.2022.154185_bib0018","first-page":"639","volume":"472","author":"Lee","year":"2020","journal-title":"Chamber-specific regulation of atrial natriuretic peptide secretion in cardiac hypertrophy: atrial wall dynamics in the ANP secretion"},{"key":"10.1016\/j.phymed.2022.154185_bib0019","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejphar.2018.08.034","article-title":"Antioxidant N-acetylcysteine inhibits maladaptive myocyte autophagy in pressure overload induced cardiac remodeling in rats","volume":"839","author":"Li","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154185_bib0020","doi-asserted-by":"crossref","unstructured":"Li, E.C., Heran, B.S., Wright, J.M., 2014a. Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension. The Cochrane database of systematic reviews 2014, Cd009096. https:\/\/doi.org\/10.1002\/14651858.CD009096.pub2.","DOI":"10.1002\/14651858.CD009096.pub2"},{"key":"10.1016\/j.phymed.2022.154185_bib0021","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010926","article-title":"Metabolic changes in spontaneously hypertensive rat hearts precede cardiac dysfunction and left ventricular hypertrophy","volume":"8","author":"Li","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.phymed.2022.154185_bib0022","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41569-019-0235-9","article-title":"Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2022.154185_bib0023","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.3892\/mmr.2017.6318","article-title":"Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT\/ANP\/BNP signaling pathway","volume":"15","author":"Li","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2022.154185_bib0024","article-title":"Cardiac troponin T (TNNT2) mutations in Chinese dilated cardiomyopathy patients","volume":"2014","author":"Li","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phymed.2022.154185_bib0025","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/cea.13326","article-title":"Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema","volume":"49","author":"Liau","year":"2019","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.phymed.2022.154185_bib0026","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000371454","article-title":"Hyperphosphate-induced myocardial hypertrophy through the GATA-4\/NFAT-3 signaling pathway is attenuated by ERK inhibitor treatment","volume":"5","author":"Liu","year":"2015","journal-title":"CardioRenal Med."},{"key":"10.1016\/j.phymed.2022.154185_bib0027","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.hfc.2017.08.002","article-title":"Natriuretic peptides in heart failure: atrial and B-type natriuretic peptides","volume":"14","author":"Maisel","year":"2018","journal-title":"Heart Fail. Clin."},{"key":"10.1016\/j.phymed.2022.154185_bib0028","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.peptides.2018.08.006","article-title":"Natriuretic peptides in human heart: novel insight into their molecular forms, functions, and diagnostic use","volume":"111","author":"Matsuo","year":"2019","journal-title":"Peptides"},{"key":"10.1016\/j.phymed.2022.154185_bib0029","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10741-016-9569-0","article-title":"Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease","volume":"21","author":"Mikhailov","year":"2016","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.phymed.2022.154185_bib0030","doi-asserted-by":"crossref","first-page":"ra34","DOI":"10.1126\/scisignal.aad5736","article-title":"Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression","volume":"9","author":"Morales","year":"2016","journal-title":"Sci. Signal"},{"key":"10.1016\/j.phymed.2022.154185_bib0031","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1001\/jama.2021.18463","article-title":"Effect of sacubitril\/valsartan vs standard medical therapies on plasma NT-proBNP concentration and submaximal exercise capacity in patients with heart failure and preserved ejection fraction: the PARALLAX randomized clinical trial","volume":"326","author":"Pieske","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.phymed.2022.154185_bib0032","first-page":"D845","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.phymed.2022.154185_bib0033","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCHEARTFAILURE.114.001781","article-title":"HDACs regulate miR-133a expression in pressure overload-induced cardiac fibrosis","volume":"8","author":"Renaud","year":"2015","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.phymed.2022.154185_bib0034","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.molcel.2018.08.010","article-title":"Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication","volume":"72","author":"Reveron-Gomez","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2022.154185_bib0035","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.cell.2014.10.056","article-title":"The structure and regulation of human muscle alpha-actinin","volume":"159","author":"Ribeiro","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2022.154185_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21134709","article-title":"Pharmacogenomics of hypertension treatment","volume":"21","author":"Rysz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.154185_bib0037","doi-asserted-by":"crossref","first-page":"75","DOI":"10.12659\/MSMBR.900437","article-title":"Cardiac hypertrophy: an introduction to molecular and cellular basis","volume":"22","author":"Samak","year":"2016","journal-title":"Med. Sci. Monit. Basic Res."},{"key":"10.1016\/j.phymed.2022.154185_bib0038","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.201012049","article-title":"Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes","volume":"194","author":"Sdek","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2022.154185_bib0039","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.phymed.2022.154185_bib0040","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1038\/ncomms4680","article-title":"GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development","volume":"5","author":"Stefanovic","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2022.154185_bib0041","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cell.2018.08.032","article-title":"Histone modifications: insights into their influence on gene expression","volume":"175","author":"Stillman","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2022.154185_bib0042","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1248\/yakushi.15-00226-2","article-title":"Functional analysis of GATA4 complex, a cardiac hypertrophy-response transcriptional factor, using a proteomics approach","volume":"136","author":"Sunagawa","year":"2016","journal-title":"Yakugaku zasshi: J. Pharmaceut. Soc. Jpn."},{"key":"10.1016\/j.phymed.2022.154185_bib0043","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1002\/jssc.201500698","article-title":"Identification of the chemical constituents of Chinese medicine Yi-Xin-Shu capsule by molecular feature orientated precursor ion selection and tandem mass spectrometry structure elucidation","volume":"38","author":"Wang","year":"2015","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.phymed.2022.154185_bib0044","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s11596-009-0611-5","article-title":"Interaction among Rb\/p16, Rb\/E2F1 and HDAC1 proteins in gallbladder carcinoma","volume":"29","author":"Wang","year":"2009","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"10.1016\/j.phymed.2022.154185_bib0045","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1096\/fj.201800673RR","article-title":"Signature-oriented investigation of the efficacy of multicomponent drugs against heart failure","volume":"33","author":"Wei","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2022.154185_bib0046","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1038\/s41598-020-58387-8","article-title":"Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes","volume":"10","author":"Xu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154185_bib0047","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.1038\/s41598-018-25817-7","article-title":"Region of Interest analysis using mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue","volume":"8","author":"Yajima","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154185_bib0048","doi-asserted-by":"crossref","first-page":"11886","DOI":"10.1021\/acs.analchem.6b03701","article-title":"Fluorescent nanocomposite for visualizing cross-talk between MicroRNA-21 and hydrogen peroxide in ischemia-reperfusion injury in live cells and in vivo","volume":"88","author":"Yang","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.phymed.2022.154185_bib0049","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1039\/C6MB00813E","article-title":"Identification of active components in Yixinshu Capsule with protective effects against myocardial dysfunction on human induced pluripotent stem cell-derived cardiomyocytes by an integrative approach","volume":"13","author":"Zhang","year":"2017","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.phymed.2022.154185_bib0050","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41569-018-0119-4","article-title":"Epidemiology of cardiovascular disease in China: current features and implications","volume":"16","author":"Zhao","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2022.154185_bib0051","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/B978-0-12-387786-4.00005-1","article-title":"Regulation of GATA4 transcriptional activity in cardiovascular development and disease","volume":"100","author":"Zhou","year":"2012","journal-title":"Curr. Top. Dev. Biol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132200263X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132200263X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:35:10Z","timestamp":1760553310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132200263X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":51,"alternative-id":["S094471132200263X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154185","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Yi-Xin-Shu capsule ameliorates cardiac hypertrophy by regulating RB\/HDAC1\/GATA4 signaling pathway based on proteomic and mass spectrometry image analysis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154185"}}