{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:09:06Z","timestamp":1788635346726,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.phymed.2022.154208","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T11:49:10Z","timestamp":1653997750000},"page":"154208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-\u03baB\/CCL3\/CCR1 axis"],"prefix":"10.1016","volume":"103","author":[{"given":"Yi-yun","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-ran","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2303-0494","authenticated-orcid":false,"given":"Ai-ping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8680-8400","authenticated-orcid":false,"given":"Bao-cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154208_bib0001","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1042\/CS20190068","article-title":"Processes exacerbating apoptosis in non-alcoholic steatohepatitis","volume":"133","author":"Afonso","year":"2019","journal-title":"Clin. Sci. (Lond)."},{"key":"10.1016\/j.phymed.2022.154208_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.725390","article-title":"Molecular and cellular mediators of the gut-liver axis in the progression of liver diseases","volume":"8","author":"Bruneau","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.phymed.2022.154208_bib0003","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American association for the study of liver diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2022.154208_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105849","article-title":"Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis","volume":"172","author":"Chen","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2022.154208_bib0005","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phymed.2022.154208_bib0006","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.spinee.2020.07.001","article-title":"Small molecule antagonist of C-C chemokine receptor 1 (CCR1) reduces disc inflammation in the rabbit model","volume":"20","author":"Chou","year":"2020","journal-title":"Spine J."},{"key":"10.1016\/j.phymed.2022.154208_bib0007","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.jhep.2020.06.025","article-title":"Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials","volume":"73","author":"Davison","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2022.154208_bib0008","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phymed.2022.154208_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1826746","article-title":"B. adolescentis ameliorates chronic colitis by regulating Treg\/Th2 response and gut microbiota remodeling","volume":"13","author":"Fan","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phymed.2022.154208_bib0010","doi-asserted-by":"crossref","first-page":"8670","DOI":"10.4049\/jimmunol.181.12.8670","article-title":"Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury","volume":"181","author":"Furuichi","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2022.154208_bib0011","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0303-7207(01)00394-X","article-title":"Chemokines control fat accumulation and leptin secretion by cultured human adipocytes","volume":"175","author":"Gerhardt","year":"2001","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.phymed.2022.154208_bib0012","article-title":"Effect of electroacupuncture at Zusanli (ST36) on intestinal microbiota in rats with chronic atrophic gastritis","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.phymed.2022.154208_bib0013","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2022.154208_bib0014","first-page":"8","article-title":"Stearic acid and TNF-\u03b1 co-operatively potentiate MIP-1\u03b1 production in monocytic cells via MyD88 independent TLR4\/TBK\/IRF3 signaling pathway","author":"Kochumon","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.phymed.2022.154208_bib0015","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000500478","article-title":"Systemic succinate, hypoxia-inducible factor-1 alpha, and IL-1\u03b2 gene expression in autosomal dominant polycystic kidney disease with and without hypertension","volume":"9","author":"Kocyigit","year":"2019","journal-title":"Cardiorenal. Med."},{"key":"10.1016\/j.phymed.2022.154208_bib0016","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1053\/j.gastro.2009.01.063","article-title":"Hepatocyte transplantation-induced liver inflammation is driven by cytokines-chemokines associated with neutrophils and Kupffer cells","volume":"136","author":"Krohn","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2022.154208_bib0017","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mib.2020.02.005","article-title":"Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms","volume":"53","author":"Kwiecinski","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.phymed.2022.154208_bib0018","article-title":"High red meat intake exacerbates dextran sulfate-induced colitis by altering gut microbiota in mice","volume":"8","author":"Li","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2022.154208_bib0019","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcmm.13564","article-title":"Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China","volume":"23","author":"Li","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phymed.2022.154208_bib0020","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1038\/ncomms4039","article-title":"Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages","volume":"5","author":"Ling","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2022.154208_bib0021","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijbiomac.2021.08.139","article-title":"Poria cocos polysaccharides attenuate chronic nonbacterial prostatitis by targeting the gut microbiota: comparative study of Poria cocos polysaccharides and finasteride in treating chronic prostatitis","volume":"189","author":"Liu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2022.154208_bib0022","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ijbiomac.2021.10.017","article-title":"Effect of carbohydrate-feeding strategy on the production, physiochemical changes, anti-inflammation activities of polysaccharides of Poria cocos","volume":"192","author":"Lu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2022.154208_bib0023","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phymed.2022.154208_bib0024","first-page":"e01462","article-title":"Ampicillin plus ceftriaxone therapy against Enterococcus faecalis endocarditis: a case report, guidelines considerations, and literature review","volume":"28","author":"Marino","year":"2022","journal-title":"ID Cases"},{"key":"10.1016\/j.phymed.2022.154208_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9547613","article-title":"Role of oxidative stress in pathophysiology of nonalcoholic fatty liver disease","volume":"2018","author":"Masarone","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2022.154208_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00379","article-title":"Chemokines and chemokine receptors: new targets for cancer immunotherapy","volume":"10","author":"Mollica Poeta","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2022.154208_bib0027","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1074\/jbc.271.10.5878","article-title":"Regulation of macrophage inflammatory protein-1alpha mRNA by oxidative stress","volume":"271","author":"Shi","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2022.154208_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/cells9081799","article-title":"MIP-1\u03b1 expression induced by co-stimulation of human monocytic cells with palmitate and TNF-\u03b1 involves the TLR4-IRF3 pathway and is amplified by oxidative Stress","volume":"9","author":"Sindhu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2022.154208_bib0029","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/MOG.0b013e328324f857","article-title":"Nuclear factor-kappa B in intestinal protection and destruction","volume":"25","author":"Spehlmann","year":"2009","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.phymed.2022.154208_bib0030","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1830693","article-title":"Therapeutic manipulation of gut microbiota by polysaccharides of Wolfiporia cocos reveals the contribution of the gut fungi-induced PGE(2) to alcoholic hepatic steatosis","volume":"12","author":"Sun","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phymed.2022.154208_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102913","article-title":"Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells","volume":"58","author":"Takahashi","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phymed.2022.154208_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/nu12030820","article-title":"Gut microbiota dysbiosis in patients with biopsy-proven nonalcoholic fatty liver disease: a cross-sectional study in Taiwan","volume":"12","author":"Tsai","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2022.154208_bib0033","doi-asserted-by":"crossref","DOI":"10.3390\/nu12103197","article-title":"A high-fat diet increases gut microbiota biodiversity and energy expenditure due to nutrient difference","volume":"12","author":"Wang","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2022.154208_bib0034","article-title":"Lactobacillus plantarum SHY130 isolated from yak yogurt attenuates hyperglycemia in C57BL\/6J mice by regulating the enteroinsular axis","author":"Wang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2022.154208_bib0035","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/bioinformatics\/btp612","article-title":"DEGseq: an R package for identifying differentially expressed genes from RNA-seq data","volume":"26","author":"Wang","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phymed.2022.154208_bib0036","article-title":"Soyasaponin A(2) alleviates steatohepatitis possibly through regulating bile acids and gut microbiota in the methionine and choline-deficient (MCD) diet-induced nonalcoholic steatohepatitis (NASH) mice","volume":"65","author":"Xiong","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2022.154208_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154914","article-title":"CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1\/M2 status in mice","volume":"125","author":"Xu","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2022.154208_bib0038","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1007\/s13311-019-00821-5","article-title":"CCR1 activation promotes neuroinflammation through CCR1\/TPR1\/ERK1\/2 signaling pathway after intracerebral hemorrhage in mice","volume":"17","author":"Yan","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.phymed.2022.154208_bib0039","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2022.154208_bib0040","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1080\/13880209.2021.1979594","article-title":"Jiang Zhi Granule protects immunological barrier of intestinal mucosa in rats with non-alcoholic steatohepatitis","volume":"59","author":"Yu","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2022.154208_bib0041","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3389\/fonc.2019.01149","article-title":"Canmei formula reduces colitis-associated colorectal carcinogenesis in mice by modulating the composition of gut microbiota","volume":"9","author":"Zhang","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phymed.2022.154208_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.535940","article-title":"E. coli NF73-1 isolated from NASH patients aggravates NAFLD in mice by translocating into the liver and stimulating M1 polarization","volume":"10","author":"Zhang","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322002860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322002860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:36:45Z","timestamp":1760553405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322002860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":42,"alternative-id":["S0944711322002860"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154208","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-\u03baB\/CCL3\/CCR1 axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"154208"}}