{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:04:32Z","timestamp":1793189072209,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017170","name":"Thailand Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.phymed.2022.154238","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T20:50:05Z","timestamp":1654289405000},"page":"154238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Tabersonine attenuates Angiotensin II-induced cardiac remodeling and dysfunction through targeting TAK1 and inhibiting TAK1-mediated cardiac inflammation"],"prefix":"10.1016","volume":"103","author":[{"given":"Chengyi","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-718X","authenticated-orcid":false,"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154238_bib0001","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jacc.2013.11.053","article-title":"The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries","volume":"63","author":"Ambrosy","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2022.154238_bib0002","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1124\/pr.118.017129","article-title":"Novel therapeutic approaches targeting the renin-angiotensin system and associated peptides in hypertension and heart failure","volume":"71","author":"Arendse","year":"2019","journal-title":"Pharmacol.\u00a0 Rev."},{"key":"10.1016\/j.phymed.2022.154238_bib0003","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1161\/CIRCRESAHA.116.307509","article-title":"The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease","volume":"118","author":"Blenck","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2022.154238_bib0004","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/cdd.2017.17","article-title":"The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways","volume":"24","author":"Cohen","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2022.154238_bib0005","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/1753944716642677","article-title":"Cardiac remodelling and RAS inhibition","volume":"10","author":"Ferrario","year":"2016","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"10.1016\/j.phymed.2022.154238_bib0006","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00395-016-0599-5","article-title":"MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4\/NF-\u03baB signaling pathway","volume":"112","author":"Han","year":"2017","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.phymed.2022.154238_bib0007","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/HYPERTENSIONAHA.110.149963","article-title":"Tumor suppressor A20 protects against cardiac hypertrophy and fibrosis by blocking transforming growth factor-beta-activated kinase 1-dependent signaling","volume":"56","author":"Huang","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2022.154238_bib0008","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yjmcc.2020.09.008","article-title":"FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway","volume":"151","author":"Hui","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.phymed.2022.154238_bib0009","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pharmthera.2014.05.013","article-title":"Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives","volume":"144","author":"Javadov","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2022.154238_bib0010","doi-asserted-by":"crossref","first-page":"11267","DOI":"10.1038\/ncomms11267","article-title":"The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling","volume":"7","author":"Ji","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2022.154238_bib0011","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1172\/JCI44824","article-title":"Pivotal role of cardiomyocyte TGF-\u03b2 signaling in the murine pathological response to sustained pressure overload","volume":"121","author":"Koitabashi","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2022.154238_bib0012","doi-asserted-by":"crossref","unstructured":"Li, C., Zhou, Q., Yang, L., Chen, Y., Hou, J., Guo, K., Wang, Y., Li, Y.J.B.r.i.c., 2016a. Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK\/-JNK1\/2 signaling pathway. 111, 19.","DOI":"10.1007\/s00395-016-0536-7"},{"key":"10.1016\/j.phymed.2022.154238_bib0014","doi-asserted-by":"crossref","first-page":"16626","DOI":"10.1038\/srep16626","article-title":"TAK1 regulates myocardial response to pathological stress via NFAT, NFkappaB, and Bnip3 pathways","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154238_bib0015","doi-asserted-by":"crossref","unstructured":"Liao, H.H., Zhang, N., Meng, Y.Y., Feng, H., Yang, J.J., Li, W.J., Chen, S., Wu, H.M., Deng, W., Tang, Q.Z., 2019. Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6\/TAK1\/MAPK and Nrf2 Signaling Pathway. Oxid. Med. Cell Longev. 2019, 6304058.","DOI":"10.1155\/2019\/6304058"},{"key":"10.1016\/j.phymed.2022.154238_bib0016","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.tips.2008.05.003","article-title":"Role of the renin-angiotensin system in vascular inflammation","volume":"29","author":"Marchesi","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2022.154238_bib0017","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phymed.2022.154238_bib0018","doi-asserted-by":"crossref","first-page":"107799","DOI":"10.1016\/j.pharmthera.2020.107799","article-title":"Role of inflammatory chemokines in hypertension","volume":"223","author":"Mikolajczyk","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2022.154238_bib0019","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.1093\/nar\/gkq439","article-title":"Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon","volume":"38","author":"Moreno","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phymed.2022.154238_bib0020","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/982412","article-title":"Ornamental exterior versus therapeutic interior of Madagascar periwinkle (Catharanthus roseus): the two faces of a versatile herb","author":"Nejat","year":"2015","journal-title":"Sci. World J."},{"key":"10.1016\/j.phymed.2022.154238_bib0021","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jacc.2021.01.052","article-title":"Myocardial angiotensin metabolism in end-stage heart failure","volume":"77","author":"Pavo","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2022.154238_bib0022","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pharmthera.2009.05.002","article-title":"Cardiac fibroblasts: at the heart of myocardial remodeling","volume":"123","author":"Porter","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2022.154238_bib0023","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tips.2012.06.007","article-title":"Targeting of TAK1 in inflammatory disorders and cancer","volume":"33","author":"Sakurai","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2022.154238_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119919","article-title":"Crosstalk between the renin-angiotensin system and the endoplasmic reticulum stress in the cardiovascular system: Lessons learned so far","volume":"284","author":"Sep\u00falveda-Fragoso","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.154238_bib0025","doi-asserted-by":"crossref","DOI":"10.1177\/1559325820912067","article-title":"Activation of CREB protein with tabersonine attenuates STAT3 during atherosclerosis in apolipoprotein E-deficient mice","volume":"18","author":"Shi","year":"2020","journal-title":"Dose Response"},{"key":"10.1016\/j.phymed.2022.154238_bib0026","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35085597","article-title":"TAK1 is a ubiquitin-dependent kinase of MKK and IKK","volume":"412","author":"Wang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2022.154238_bib0027","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13578-019-0348-1","article-title":"Angiotensin II receptor blocker LCZ696 attenuates cardiac remodeling through the inhibition of the ERK signaling pathway in mice with pregnancy-associated cardiomyopathy","volume":"9","author":"Wang","year":"2019","journal-title":"Cell Biosci."},{"key":"10.1016\/j.phymed.2022.154238_bib0028","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1038\/s41467-020-15978-3","article-title":"MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2022.154238_bib0029","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cardiores.2005.11.007","article-title":"A direct interaction between TGFbeta activated kinase 1 and the TGFbeta type II receptor: implications for TGFbeta signalling and cardiac hypertrophy","volume":"69","author":"Watkins","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2022.154238_bib0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.lfs.2015.12.034","article-title":"Olmesartan ameliorates pressure overload-induced cardiac remodeling through inhibition of TAK1\/p38 signaling in mice","volume":"145","author":"Wu","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.154238_bib0031","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature08247","article-title":"Direct activation of protein kinases by unanchored polyubiquitin chains","volume":"461","author":"Xia","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2022.154238_bib0032","doi-asserted-by":"crossref","first-page":"eaau0495","DOI":"10.1126\/sciadv.aau0495","article-title":"The immunoproteasome catalytic \u03b25i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation","volume":"5","author":"Xie","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2022.154238_bib0033","doi-asserted-by":"crossref","first-page":"112121","DOI":"10.1016\/j.biopha.2021.112121","article-title":"Curcumin analogue C66 attenuates obesity-induced myocardial injury by inhibiting JNK-mediated inflammation","volume":"143","author":"Ye","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2022.154238_bib0034","doi-asserted-by":"crossref","unstructured":"Ye, S., Luo, W., Khan, Z., Wu, G., Xuan, L., Shan, P., Lin, K., Chen, T., Wang, J., Hu, X., Wang, S., Huang, W., Liang, G.J.C.r., 2020. Celastrol attenuates angiotensin II-induced cardiac remodeling by targeting STAT3. 126, 1007\u20131023.","DOI":"10.1161\/CIRCRESAHA.119.315861"},{"key":"10.1016\/j.phymed.2022.154238_bib0036","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1161\/HYPERTENSIONAHA.116.07906","article-title":"Mnk1 (Mitogen-Activated Protein Kinase-Interacting Kinase 1) Deficiency Aggravates Cardiac Remodeling in Mice","volume":"68","author":"Yuan","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2022.154238_bib0037","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/75037","article-title":"TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice","volume":"6","author":"Zhang","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2022.154238_bib0038","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bcp.2018.05.004","article-title":"Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination","volume":"154","author":"Zhang","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154238_bib0040","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014311","article-title":"Dual-Specificity Phosphatase 26 Protects Against Cardiac Hypertrophy Through TAK1","volume":"10","author":"Zhao","year":"2021","journal-title":"J. Am. Heart Assoc."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322003178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322003178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:37:04Z","timestamp":1760553424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322003178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":37,"alternative-id":["S0944711322003178"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154238","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tabersonine attenuates Angiotensin II-induced cardiac remodeling and dysfunction through targeting TAK1 and inhibiting TAK1-mediated cardiac inflammation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154238"}}