{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:04:44Z","timestamp":1789769084714,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603250"],"award-info":[{"award-number":["81603250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973624"],"award-info":[{"award-number":["81973624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1708803"],"award-info":[{"award-number":["2019YFC1708803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["21ZYJDJC00070"],"award-info":[{"award-number":["21ZYJDJC00070"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.phymed.2022.154257","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T15:56:16Z","timestamp":1654790176000},"page":"154257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Aristolone in Nardostachys jatamansi DC. induces mesenteric vasodilation and ameliorates hypertension via activation of the KATP channel and PDK1-Akt-eNOS pathway"],"prefix":"10.1016","volume":"104","author":[{"given":"Jingmei","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-7175","authenticated-orcid":false,"given":"Patrick Kwabena","family":"Oduro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-4282","authenticated-orcid":false,"given":"Hong-Hua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-991X","authenticated-orcid":false,"given":"Qilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154257_bib0001","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.vph.2015.05.008","article-title":"The critical role of Akt in cardiovascular function","volume":"74","author":"Abeyrathna","year":"2015","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154257_bib0002","doi-asserted-by":"crossref","first-page":"W530","DOI":"10.1093\/nar\/gkab294","article-title":"PLIP 2021: expanding the scope of the protein-ligand interaction profiler to DNA and RNA","volume":"49","author":"Adasme","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phymed.2022.154257_bib0003","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phytochem.2012.11.018","article-title":"Sesquiterpene lactones from the leaves of Hedyosmum brasiliense (Chloranthaceae)","volume":"87","author":"Amoah","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2022.154257_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2020.102532","article-title":"Efficacy of Nardostachys jatamansi (D.Don) DC in essential hypertension: a randomized controlled study","author":"Bhat","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.phymed.2022.154257_bib0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.phymed.2018.08.010","article-title":"Secondary metabolite profiling, cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and cognitive disorders","volume":"55","author":"Bose","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2022.154257_bib0006","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.chembiol.2012.07.017","article-title":"Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site","volume":"19","author":"Busschots","year":"2012","journal-title":"Chem. Biol."},{"key":"10.1016\/j.phymed.2022.154257_bib0007","doi-asserted-by":"crossref","first-page":"15114","DOI":"10.1038\/s41598-017-15483-6","article-title":"Novel serotonin transporter regulators: Natural aristolane- and nardosinane- types of sesquiterpenoids from Nardostachys chinensis Batal","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154257_bib0008","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jacc.2019.07.012","article-title":"Large-artery stiffness in health and disease: JACC state-of-the-art review","volume":"74","author":"Chirinos","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2022.154257_bib0009","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/ptr.2696","article-title":"Coronary vasodilator activity of vulgarenol, a sesquiterpene isolated from Magnolia grandiflora, and its possible mechanism","volume":"23","author":"Del Valle-Mondragon","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2022.154257_bib0010","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.bmcl.2017.01.008","article-title":"Nardonaphthalenones A and B from the roots and rhizomes of Nardostachys chinensis Batal","volume":"27","author":"Deng","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2022.154257_bib0011","first-page":"167","article-title":"Vasodilatation effect of baicalein on rat thoracic artery and its related mechanism","volume":"19","author":"Gang-gang","year":"2013","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"10.1016\/j.phymed.2022.154257_bib0012","first-page":"5017","article-title":"A review: pharmacognostics and pharmacological profiles of nardastachys jatamansi dc Elixir","volume":"39","author":"Habibur Rahman","year":"2011","journal-title":"Pharmacy"},{"key":"10.1016\/j.phymed.2022.154257_bib0013","first-page":"131","article-title":"Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation","author":"Jin","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2022.154257_bib0014","article-title":"Endothelium-dependent vasorelaxant effect of Prunus persica branch on isolated rat thoracic aorta","volume":"11","author":"Kim","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2022.154257_bib0015","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1038\/sj.emboj.7600379","article-title":"Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates","volume":"23","author":"Komander","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.phymed.2022.154257_bib0016","doi-asserted-by":"crossref","first-page":"18797","DOI":"10.1074\/jbc.M500977200","article-title":"Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding","volume":"280","author":"Komander","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2022.154257_bib0017","doi-asserted-by":"crossref","unstructured":"Koon, C.M., Fong, S., Wat, E., Wang, Y.P., Cheung, W.S., Lau, B.S., Leung, P.C., Sun, H.D., Zhao, Q.S., Fung, K.P.J.J.o.E., 2014. Mechanisms of the dilator action of the Erigerontis Herba on rat aorta. 155, 1561-1567.","DOI":"10.1016\/j.jep.2014.07.053"},{"key":"10.1016\/j.phymed.2022.154257_bib0018","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2016.12.022","article-title":"5,6-\u03b4-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation","volume":"103","author":"Levi-Rosenzvig","year":"2016","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.phymed.2022.154257_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113601","article-title":"Antidepressant activities and regulative effects on serotonin transporter of Nardostachys jatamansi DC","volume":"268","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2022.154257_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23061474","article-title":"Vasodilator activity of compounds isolated from plants used in Mexican traditional medicine","volume":"23","author":"Luna-Vazquez","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2022.154257_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116761","article-title":"The volatile oil of Nardostachyos Radix et Rhizoma induces endothelial nitric oxide synthase activity in HUVEC cells","volume":"10","author":"Maiwulanjiang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2022.154257_bib0022","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jep.2014.03.010","article-title":"The volatile oil of Nardostachyos Radix et Rhizoma inhibits the oxidative stress-induced cell injury via reactive oxygen species scavenging and Akt activation in H9c2 cardiomyocyte","volume":"153","author":"Maiwulanjiang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2022.154257_bib0023","doi-asserted-by":"crossref","unstructured":"Qu, Z., Zhang, J., Gao, W., Chen, H., Guo, H., Wang, T., Li, H., Liu, C.J.J.o.E., 2014. Vasorelaxant effects of Cerebralcare Granule are mediated by NO\/cGMP pathway, potassium channel opening and calcium channel blockade in isolated rat thoracic aorta. 155, 572-579.","DOI":"10.1016\/j.jep.2014.05.062"},{"key":"10.1016\/j.phymed.2022.154257_bib0024","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.chembiol.2016.06.017","article-title":"Bidirectional allosteric communication between the ATP-binding site and the regulatory PIF pocket in PDK1 protein kinase","volume":"23","author":"Schulze","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.phymed.2022.154257_bib0025","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1211\/jpp.58.2.0014","article-title":"Protective effect of Nardostachys jatamansi on oxidative injury and cellular abnormalities during doxorubicin-induced cardiac damage in rats","volume":"58","author":"Subashini","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154257_bib0026","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.phrs.2018.12.021","article-title":"Gender-specific therapeutic approach in arterial hypertension - challenges ahead","volume":"141","author":"Tadic","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2022.154257_bib0027","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jep.2017.02.001","article-title":"Vasorelaxation effect of Glycyrrhizae uralensis through the endothelium-dependent Pathway","volume":"199","author":"Tan","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2022.154257_bib0028","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/00005344-200211000-00008","article-title":"Nitric oxide formation and corresponding relaxation of porcine coronary arteries induced by plant phenols: essential structural features","volume":"40","author":"Taubert","year":"2002","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154257_bib0029","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/0974-8520.169008","article-title":"A comparative clinical study on the effect of Tagara (Valeriana wallichii DC.) and Jatamansi (Nardostachys jatamansi DC.) in the management of Anidra (primary insomnia)","volume":"36","author":"Toolika","year":"2015","journal-title":"Ayu"},{"key":"10.1016\/j.phymed.2022.154257_bib0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2022.154257_bib0031","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2337\/db16-0915","article-title":"Metformin suppresses diabetes-accelerated atherosclerosis via the inhibition of Drp1-mediated mitochondrial fission","volume":"66","author":"Wang","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2022.154257_bib0032","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.phytochem.2018.03.002","article-title":"Dinardokanshones C-E, isonardoeudesmols A-D and nardoeudesmol D from Nardostachys jatamansi DC","volume":"150","author":"Wu","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2022.154257_bib0033","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1055\/s-0043-123655","article-title":"A simple and rapid UPLC-PDA method for quality control of Nardostachys jatamansi","volume":"84","author":"Zhang","year":"2018","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2022.154257_bib0034","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1021\/acs.jnatprod.7b00690","article-title":"Absolute configurations and bioactivities of Guaiane-type sesquiterpenoids isolated from pogostemon cablin","volume":"81","author":"Zhou","year":"2018","journal-title":"J. Nat. Prod."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322003361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322003361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:54:50Z","timestamp":1789768490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322003361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":34,"alternative-id":["S0944711322003361"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154257","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aristolone in Nardostachys jatamansi DC. induces mesenteric vasodilation and ameliorates hypertension via activation of the KATP channel and PDK1-Akt-eNOS pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154257","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154257"}}