{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:48:59Z","timestamp":1775267339524,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.phymed.2022.154413","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T01:46:18Z","timestamp":1661132778000},"page":"154413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Investigation of the mechanism of action of Shengxuexiaoban Capsules against primary immune thrombocytopenia using network pharmacology and experimental validation"],"prefix":"10.1016","volume":"106","author":[{"given":"Liping","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinwei","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoding","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154413_bib0001","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1172\/JCI71861","article-title":"Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation","volume":"124","author":"Bluteau","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.phymed.2022.154413_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109234","article-title":"Study of the mechanism underlying therapeutic effect of compound longmaining on myocardial infarction using a network pharmacology-based approach","volume":"118","author":"Bu","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.phymed.2022.154413_bib0003","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.clinthera.2009.09.013","article-title":"Romiplostim in chronic immune thrombocytopenic purpura","volume":"31","author":"Cersosimo","year":"2009","journal-title":"Clin Ther"},{"key":"10.1016\/j.phymed.2022.154413_bib0004","first-page":"701","article-title":"Treatment of 34 cases of Sjogren's syndrome with neutropenia by Yiqi Disinfecting Formula combined with leucine and leucogen","volume":"53","author":"Chen","year":"2012","journal-title":"J Tradit Chin Med"},{"key":"10.1016\/j.phymed.2022.154413_bib0005","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.biochi.2015.06.001","article-title":"Kaempferol inhibits thrombosis and platelet activation","volume":"115","author":"Choi","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.phymed.2022.154413_bib0006","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1517\/13543776.2015.1019865","article-title":"Indirubin derivatives: a patent review (2010 - present)","volume":"25","author":"Gaboriaud-Kolar","year":"2015","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.phymed.2022.154413_bib0007","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s11655-012-1292-4","article-title":"Research and development of the effective components of panaxdiol saponin as new Chinese patent medicine for treating hemocytopenia","volume":"18","author":"Gao","year":"2012","journal-title":"Chin J Integr Med"},{"key":"10.1016\/j.phymed.2022.154413_bib0008","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.acthis.2016.06.004","article-title":"Indirubin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice through the inhibition of inflammation and the induction of Foxp3-expressing regulatory T cells","volume":"118","author":"Gao","year":"2016","journal-title":"Acta Histochem"},{"key":"10.1016\/j.phymed.2022.154413_bib0009","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.3390\/molecules19045448","article-title":"Two ellagic acids isolated from roots of Sanguisorba officinalis L. promote hematopoietic progenitor cell proliferation and megakaryocyte differentiation","volume":"19","author":"Gao","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2022.154413_bib0010","first-page":"422","article-title":"The effect of Shengxuefang capsule on CD_4\u223c+CD_(25)\u223c+Treg cells of immune thrombocytopenic purpura","volume":"33","author":"He","year":"2015","journal-title":"Chinese J Traditional Chinese Med"},{"key":"10.1016\/j.phymed.2022.154413_bib0011","first-page":"6986","article-title":"Qian Five Rhinoceros Gindeng (QFRG) protects against development of immune thrombocytopenia via miR-181a inhibition of TLR-4 expression","volume":"8","author":"He","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.phymed.2022.154413_bib0012","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.humimm.2012.04.015","article-title":"Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia","volume":"73","author":"Hu","year":"2012","journal-title":"Hum ImmunoL"},{"key":"10.1016\/j.phymed.2022.154413_bib0013","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.phymed.2022.154413_bib0014","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ctim.2013.08.005","article-title":"Alternative therapy for persistent childhood immune thrombocytopenic purpura unresponsive to intravenous immunoglobulin","volume":"21","author":"Huang","year":"2013","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.phymed.2022.154413_bib0015","first-page":"99","article-title":"Heat cool blood Yiqi Yin Fang combined western medicine treatment of children with idiopathic thrombocytopenic purpura random parallel controlled study","author":"HY","year":"2014","journal-title":"J Practical Traditional Chinese Inter Med"},{"key":"10.1016\/j.phymed.2022.154413_bib0016","article-title":"Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K\/AKT\/GSK3\u03b2 Signaling Pathways in HT22 Hippocampal Neurons","volume":"11","author":"Jiang","year":"2016","journal-title":"Plos One"},{"key":"10.1016\/j.phymed.2022.154413_bib0017","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1182\/asheducation.V2012.1.444.3806864","article-title":"Childhood immune thrombocytopenia: role of rituximab, recombinant thrombopoietin, and other new therapeutics","volume":"2012","author":"Journeycake","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.phymed.2022.154413_bib0018","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00277-010-1087-x","article-title":"Costs of managing severe immune thrombocytopenia in adults: a retrospective analysis","volume":"90","author":"Khellaf","year":"2011","journal-title":"Ann Hematol"},{"key":"10.1016\/j.phymed.2022.154413_bib0019","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3746\/pnf.2017.22.4.320","article-title":"Kaempferol Inhibits Angiogenesis by Suppressing HIF-1\u03b1 and VEGFR2 Activation via ERK\/P38 MAPK and PI3K\/AKT\/mTOR Signaling Pathways in Endothelial Cells","volume":"22","author":"Kim","year":"2017","journal-title":"Prev Nutr Food Sci"},{"key":"10.1016\/j.phymed.2022.154413_bib0020","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1016\/j.fct.2011.07.012","article-title":"Luteolin attenuates the pulmonary inflammatory response involves abilities of antioxidation and inhibition of MAPK and NF\u03baB pathways in mice with endotoxin-induced acute lung injury","volume":"49","author":"Kuo","year":"2011","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.phymed.2022.154413_bib0021","doi-asserted-by":"crossref","first-page":"7572","DOI":"10.1074\/jbc.273.13.7572","article-title":"Characterization of the hematopoietic transcription factor NF-E2 in primary murine megakaryocytes","volume":"273","author":"Lecine","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.phymed.2022.154413_bib0022","first-page":"461","article-title":"Clinical observation on modified yiqi tongyang decoction in treating chronic immune thrombocytopenia","volume":"1","author":"Li","year":"2020","journal-title":"China J Traditional Chinese Med Pharmacy"},{"key":"10.1016\/j.phymed.2022.154413_bib0023","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/leu.2015.297","article-title":"Thrombocytopenia in MDS: epidemiology, mechanisms, clinical consequences and novel therapeutic strategies","volume":"30","author":"Li","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.phymed.2022.154413_bib0024","doi-asserted-by":"crossref","first-page":"D1121","DOI":"10.1093\/nar\/gkx1076","article-title":"Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics","volume":"46","author":"Li","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.phymed.2022.154413_bib0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.clinthera.2017.01.023","article-title":"Cost of bleeding-related episodes in adult patients with primary immune thrombocytopenia: A population-based retrospective cohort study of administrative claims data for commercial payers in the united states","volume":"39","author":"Lin","year":"2017","journal-title":"Clin Ther"},{"key":"10.1016\/j.phymed.2022.154413_bib0026","first-page":"978","article-title":"Effect of yiqi xiaodu decoction on ultrasound lesions of parotid gland in patients with sjogren's syndrome","volume":"43","author":"Liping","year":"2019","journal-title":"J Zhejiang Chinese Medical University"},{"key":"10.1016\/j.phymed.2022.154413_bib0027","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41401-019-0228-6","article-title":"CB-Dock: a web server for cavity detection-guided protein-ligand blind docking","volume":"41","author":"Liu","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.phymed.2022.154413_bib0028","first-page":"389","article-title":"[Cost-per-responder analysis comparing romiplostim to rituximab in the treatment of adult primary immune thrombocytopenia in Spain]","volume":"144","author":"Lopez","year":"2015","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.phymed.2022.154413_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106070","article-title":"Effects of luteolin on treatment of psoriasis by repressing HSP90","volume":"79","author":"Lv","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.phymed.2022.154413_bib0030","doi-asserted-by":"crossref","first-page":"5855","DOI":"10.1007\/s00216-019-01967-z","article-title":"Evaluation of an ionic liquid chiral selector based on clindamycin phosphate in capillary electrophoresis","volume":"411","author":"Ma","year":"2019","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.phymed.2022.154413_bib0031","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.201304054","article-title":"The incredible journey: From megakaryocyte development to platelet formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J Cell Biol"},{"key":"10.1016\/j.phymed.2022.154413_bib0032","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jpba.2018.09.002","article-title":"Chemical, biological and molecular modelling analyses to probe into the pharmacological potential of Antidesma madagascariense Lam.: A multifunctional agent for developing novel therapeutic formulations","volume":"161","author":"Mahomoodally","year":"2018","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.phymed.2022.154413_bib0033","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2105-11-91","article-title":"BisoGenet: a new tool for gene network building, visualization and analysis","volume":"11","author":"Martin","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.phymed.2022.154413_bib0034","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00002480-200007000-00005","article-title":"Long-term culture of fetal liver cells using a three-dimensional porous polymer substrate","volume":"46","author":"Miyoshi","year":"2000","journal-title":"Asaio J"},{"key":"10.1016\/j.phymed.2022.154413_bib0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4161\/cc.7.2.5148","article-title":"PI3K\/AKT\/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1)","volume":"7","author":"Nakao","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.phymed.2022.154413_bib0036","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cbi.2017.07.010","article-title":"Kaempferol impedes IL-32-induced monocyte-macrophage differentiation","volume":"274","author":"Nam","year":"2017","journal-title":"Chem-Biol Interact"},{"key":"10.1016\/j.phymed.2022.154413_bib0037","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J Cheminform"},{"key":"10.1016\/j.phymed.2022.154413_bib0038","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.phymed.2022.154413_bib0039","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.exphem.2019.04.002","article-title":"Indirubin regulates MPL and TNF expression in peripheral blood mononuclear cells from patients with primary immune thrombocytopenia","volume":"73","author":"Shao","year":"2019","journal-title":"Exp Hematol"},{"key":"10.1016\/j.phymed.2022.154413_bib0040","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/cdd.2017.19","article-title":"Non-apoptotic functions of caspases in myeloid cell differentiation","volume":"24","author":"Solier","year":"2017","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.phymed.2022.154413_bib0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1016\/j.phymed.2022.154413_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109656","article-title":"Material basis and molecular mechanisms of Dachengqi decoction in the treatment of acute pancreatitis based on network pharmacology","volume":"121","author":"Sun","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.phymed.2022.154413_bib0043","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1050285","article-title":"transcription factor IRF4 dysfunction affects the immunosuppressive function of treg cells in patients with primary immune thrombocytopenia","volume":"2019","author":"Tang","year":"2019","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.phymed.2022.154413_bib0044","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.toxlet.2018.03.024","article-title":"Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice","volume":"290","author":"Tsai","year":"2018","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.phymed.2022.154413_bib0045","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.etap.2018.04.014","article-title":"Kaempferol protects against gamma radiation-induced mortality and damage via inhibiting oxidative stress and modulating apoptotic molecules in vivo and vitro","volume":"60","author":"Wang","year":"2018","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.phymed.2022.154413_bib0046","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1182\/bloodadvances.2018026690","article-title":"Dysregulated megakaryocyte distribution associated with nestin (+) mesenchymal stem cells in immune thrombocytopenia","volume":"3","author":"Wang","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.phymed.2022.154413_bib0047","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3389\/fimmu.2019.00451","article-title":"High-dose dexamethasone alters the increase in interleukin-16 level in adult immune thrombocytopenia","volume":"10","author":"Wang","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.phymed.2022.154413_bib0048","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.intimp.2017.09.026","article-title":"Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17\/Treg balance through Tim-3 and TLR4-MyD88-NF-\u03baB pathway","volume":"53","author":"Wei","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.phymed.2022.154413_bib0049","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/jcmm.12964","article-title":"High-dose wogonin exacerbates DSS-induced colitis by up-regulating effector T cell function and inhibiting Treg cell","volume":"21","author":"Xiao","year":"2017","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.phymed.2022.154413_bib0050","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s11655-016-2278-7","article-title":"Effect of yiqi tongyang decoction on blood T cell subsets in patients with chronic immune thrombocytopenia","volume":"23","author":"Yang","year":"2017","journal-title":"Chin J Integr Med"},{"key":"10.1016\/j.phymed.2022.154413_bib0051","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10059-011-0041-7","article-title":"Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells","volume":"31","author":"Yu","year":"2011","journal-title":"Mol Cells"},{"key":"10.1016\/j.phymed.2022.154413_bib0052","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3390\/molecules22071135","article-title":"How cn synergism of traditional medicines benefit from network pharmacology","volume":"22","author":"Yuan","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2022.154413_bib0053","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3389\/fphar.2017.00694","article-title":"System pharmacology-based dissection of the synergistic mechanism of huangqi and huanglian for diabetes mellitus","volume":"8","author":"Yue","year":"2017","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.phymed.2022.154413_bib0054","article-title":"A combined molecular biology and network pharmacology approach to investigate the multi-target mechanisms of Chaihu Shugan San on Alzheimer's disease","volume":"120","author":"Zeng","year":"2019","journal-title":"Biomedecine & Pharmacotherapie"},{"key":"10.1016\/j.phymed.2022.154413_bib0055","article-title":"Indirubin increases CD4+CD25+Foxp3+ regulatory T cells to prevent immune thrombocytopenia in mice","volume":"10","author":"Zhang","year":"2015","journal-title":"Plos One"},{"key":"10.1016\/j.phymed.2022.154413_bib0056","first-page":"493","article-title":"Assessment of Th17\/Treg cells and Th cytokines in an improved immune thrombocytopenia mouse model","volume":"22","author":"Zhang","year":"2017","journal-title":"Hematology"},{"key":"10.1016\/j.phymed.2022.154413_bib0057","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/bjh.12934","article-title":"Reduced MIR130A is involved in primary immune thrombocytopenia via targeting TGFB1 and IL18","volume":"166","author":"Zhao","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.phymed.2022.154413_bib0058","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1111\/jcmm.14089","article-title":"Indirubin modulates CD4(+) T-cell homeostasis via PD1\/PTEN\/AKT signalling pathway in immune thrombocytopenia","volume":"23","author":"Zhao","year":"2019","journal-title":"J Cell Mol Med"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322005025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322005025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:39:34Z","timestamp":1760553574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322005025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":58,"alternative-id":["S0944711322005025"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154413","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of the mechanism of action of Shengxuexiaoban Capsules against primary immune thrombocytopenia using network pharmacology and experimental validation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154413"}}