{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:05:51Z","timestamp":1790111151912,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801064"],"award-info":[{"award-number":["81801064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2019xkj138"],"award-info":[{"award-number":["2019xkj138"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2021xkjT003"],"award-info":[{"award-number":["2021xkjT003"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2022YPJH201"],"award-info":[{"award-number":["2022YPJH201"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["XJ201722"],"award-info":[{"award-number":["XJ201722"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.phymed.2022.154426","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T02:29:49Z","timestamp":1662085789000},"page":"154426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Shufeng Jiedu capsule ameliorates olfactory dysfunction via the AMPK\/mTOR autophagy pathway in a mouse model of allergic rhinitis"],"prefix":"10.1016","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5142-3984","authenticated-orcid":false,"given":"Hongjun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Friedemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-9602","authenticated-orcid":false,"given":"Sven","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154426_bib0001","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1183\/09031936.03.00098803","article-title":"Innate immunity in the lung: how epithelial cells fight against respiratory pathogens","volume":"23","author":"Bals","year":"2004","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.phymed.2022.154426_bib0002","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5582\/bst.2015.01172","article-title":"Effect of Shufeng Jiedu capsules as a broad-spectrum antibacterial","volume":"10","author":"Bao","year":"2016","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.phymed.2022.154426_bib0003","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.iac.2015.12.004","article-title":"Allergic rhinitis: mechanisms and treatment","volume":"36","author":"Bernstein","year":"2016","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.phymed.2022.154426_bib0004","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13024-021-00434-7","article-title":"Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models","volume":"16","author":"Chen","year":"2021","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.phymed.2022.154426_bib0006","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mcna.2019.09.001","article-title":"Approach to patients with allergic rhinitis","volume":"104","author":"Cox","year":"2020","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.phymed.2022.154426_bib0007","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chom.2009.05.016","article-title":"Autophagy, immunity, and microbial adaptations","volume":"5","author":"Deretic","year":"2009","journal-title":"Cell Host. Microbe."},{"key":"10.1016\/j.phymed.2022.154426_bib0008","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1038\/s41598-017-05970-1","article-title":"Olfactory bulb plasticity ensures proper olfaction after severe impairment in postnatal neurogenesis","volume":"7","author":"Diaz","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154426_bib0009","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/jcmm.13976","article-title":"MicroRNAs as regulators of cell death mechanisms in amyotrophic lateral sclerosis","volume":"23","author":"Gagliardi","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.phymed.2022.154426_bib0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3892\/or.2020.7838","article-title":"Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma","volume":"45","author":"Gan","year":"2021","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.phymed.2022.154426_bib0011","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12261-2","article-title":"Dermatophagoides pteronyssinus immunotherapy changes the T-regulatory cell activity","volume":"7","author":"Gonzalez","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154426_bib0012","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1083\/jcb.201701049","article-title":"p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1","volume":"217","author":"He","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2022.154426_bib0013","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.iac.2011.05.003","article-title":"Antihistamine therapy in allergic rhinitis","volume":"31","author":"Hoyte","year":"2011","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.phymed.2022.154426_bib0014","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/15548627.2018.1505155","article-title":"Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy","volume":"15","author":"Jia","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2022.154426_bib0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2022.154426_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104896","article-title":"Efficacy and safety of integrated traditional chinese and western medicine for corona virus disease 2019 (COVID-19): a systematic review and meta-analysis","volume":"158","author":"Liu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2022.154426_bib0017","doi-asserted-by":"crossref","first-page":"530","DOI":"10.5582\/bst.2019.01332","article-title":"Shufengjiedu capsules protect against neuronal loss in olfactory epithelium and lung injury by enhancing autophagy in rats with allergic rhinitis","volume":"13","author":"Mei","year":"2019","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.phymed.2022.154426_bib0018","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/imr.12634","article-title":"Mast cells as sources of cytokines, chemokines, and growth factors","volume":"282","author":"Mukai","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2022.154426_bib0019","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/s11682-016-9567-9","article-title":"Changes in olfactory bulb volume following lateralized olfactory training","volume":"11","author":"Negoias","year":"2017","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.phymed.2022.154426_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18092016","article-title":"Autophagy and inflammatory response in the tumor microenvironment","volume":"18","author":"Ngabire","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.154426_bib0021","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1080\/15548627.2016.1215382","article-title":"Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression","volume":"12","author":"Oh","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2022.154426_bib0022","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jep.2018.11.037","article-title":"Ethanol extract of Dryopteris crassirhizoma alleviates allergic inflammation via inhibition of Th2 response and mast cell activation in a murine model of allergic rhinitis","volume":"232","author":"Piao","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2022.154426_bib0023","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/15548627.2017.1389823","article-title":"Autophagy and inflammation in chronic respiratory disease","volume":"14","author":"Racanelli","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2022.154426_bib0024","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5582\/bst.8.45","article-title":"Shufeng jiedu capsule protect against acute lung injury by suppressing the MAPK\/NF-\u03baB pathway","volume":"8","author":"Tao","year":"2014","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.phymed.2022.154426_bib0025","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1021\/acs.jproteome.7b00409","article-title":"Therapeutic mechanistic studies of ShuFengJieDu capsule in an acute lung injury animal model using quantitative proteomics technology","volume":"16","author":"Tao","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.phymed.2022.154426_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104243","article-title":"Systematic analyses on the potential immune and anti-inflammatory mechanisms of Shufeng Jiedu capsule against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused pneumonia","volume":"75","author":"Tao","year":"2020","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2022.154426_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2021.100017","article-title":"A synthesis of the evidence regarding safety of a Chinese herbal formula Shufeng Jiedu: A pharmacological review","volume":"2","author":"Trill","year":"2022","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"10.1016\/j.phymed.2022.154426_bib0028","article-title":"Schizandrin protects against OGD\/R-induced neuronal injury by suppressing autophagy: involvement of the AMPK\/mTOR pathway","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2022.154426_bib0029","first-page":"3971","article-title":"Intranasal application of glucocorticoid alleviates olfactory dysfunction in mice with allergic rhinitis","volume":"14","author":"Wang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2022.154426_bib0030","doi-asserted-by":"crossref","first-page":"64","DOI":"10.5582\/bst.2020.01030","article-title":"Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment","volume":"14","author":"Wang","year":"2020","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.phymed.2022.154426_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153390","article-title":"Shufeng Jiedu, a promising herbal therapy for moderate COVID-19:Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study","volume":"85","author":"Xia","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2022.154426_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2020.112298","article-title":"Labdane diterpenoids from Forsythia suspensa with anti-inflammatory and anti-viral activities","volume":"173","author":"Xiang","year":"2020","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2022.154426_bib0033","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1159\/000478754","article-title":"Emodin: one main ingredient of shufeng jiedu capsule reverses chemoresistance of lung cancer cells through inhibition of EMT","volume":"42","author":"Ying","year":"2017","journal-title":"Cell. Physiol. Biochem."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322005153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322005153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:38:22Z","timestamp":1760553502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322005153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":32,"alternative-id":["S0944711322005153"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154426","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shufeng Jiedu capsule ameliorates olfactory dysfunction via the AMPK\/mTOR autophagy pathway in a mouse model of allergic rhinitis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154426","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154426"}}