{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:29:31Z","timestamp":1789907371917,"version":"4.0.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"am","delay-in-days":304,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.phymed.2022.154474","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T12:12:15Z","timestamp":1664280735000},"page":"154474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Chlorogenic acid enhances alveolar macrophages phagocytosis in acute respiratory distress syndrome by activating G protein-coupled receptor 37 (GPR 37)"],"prefix":"10.1016","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3721-198X","authenticated-orcid":false,"given":"Fei","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154474_bib0001","doi-asserted-by":"crossref","first-page":"L709","DOI":"10.1152\/ajplung.00341.2013","article-title":"Diverse macrophage populations mediate acute lung inflammation and resolution","volume":"306","author":"Aggarwal","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.phymed.2022.154474_bib0002","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1172\/JCI99888","article-title":"GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain","volume":"128","author":"Bang","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2022.154474_bib0003","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1038\/s41467-021-21940-8","article-title":"Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice","volume":"12","author":"Bang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2022.154474_bib0004","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ccr.2009.10.015","article-title":"The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors","volume":"16","author":"Hedvat","year":"2009","journal-title":"Cancer Cell."},{"key":"10.1016\/j.phymed.2022.154474_bib0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: plasticity in a tissue-specific context","volume":"14","author":"Hussell","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2022.154474_bib0006","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1179\/1476830514Y.0000000146","article-title":"Cognitive and neuroprotective effects of chlorogenic acid","volume":"20","author":"Heitman","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.phymed.2022.154474_bib0007","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.ejmech.2018.08.037","article-title":"Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis","volume":"157","author":"Huang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2022.154474_bib0008","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.biopha.2018.07.111","article-title":"Xuebijing injection induces anti-inflammatory-like effects and downregulates the expression of TLR4 and NF-\u03baB in lung injury caused by dichlorvos poisoning","volume":"106","author":"He","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2022.154474_bib0009","doi-asserted-by":"crossref","first-page":"41363","DOI":"10.1038\/srep41363","article-title":"Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress","volume":"7","author":"Khan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154474_bib0010","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1111\/1541-4337.12620","article-title":"Chlorogenic acid: a comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions","volume":"19","author":"Lu","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.phymed.2022.154474_bib0011","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3892\/mmr.2021.12508","article-title":"All-trans retinoic acid promotes macrophage phagocytosis and decreases inflammation via inhibiting CD14\/TLR4 in acute lung injury","volume":"24","author":"Li","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2022.154474_bib0012","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.1038\/s41598-017-10147-x","article-title":"The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A(2A) receptor controlling its cell surface expression and function in vivo","volume":"7","author":"Morat\u00f3","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154474_bib0013","doi-asserted-by":"crossref","first-page":"10680","DOI":"10.1096\/fj.201900070R","article-title":"Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice","volume":"33","author":"McCrary","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2022.154474_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112037","article-title":"Nuclear HMGB1 promotes the phagocytic ability of macrophages","volume":"393","author":"Miao","year":"2020","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.phymed.2022.154474_bib0015","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(21)00439-6","article-title":"Acute respiratory distress syndrome","volume":"398","author":"Meyer","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2022.154474_bib0016","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.lfs.2017.09.015","article-title":"Protective effect of chlorogenic acid on the inflammatory damage of pancreas and lung in mice with l-arginine-induced pancreatitis","volume":"190","author":"Ohkawara","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.154474_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113719","article-title":"GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke","volume":"342","author":"Owino","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2022.154474_bib0018","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3390\/pathogens10070905","article-title":"The role of macrophages in the Host's defense against sporothrix schenckii","volume":"10","author":"Ruiz-Baca","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.phymed.2022.154474_bib0019","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00210-012-0807-2","article-title":"Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer","volume":"386","author":"Shimoyama","year":"2013","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154474_bib0020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00011-013-0610-7","article-title":"Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells","volume":"62","author":"Shi","year":"2013","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.phymed.2022.154474_bib0021","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1473-3099(13)70286-X","article-title":"Pathogenesis of influenza-induced acute respiratory distress syndrome","volume":"14","author":"Short","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.phymed.2022.154474_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700928","article-title":"Chlorogenic acid protects against oxLDL-induced oxidative damage and mitochondrial dysfunction by modulating SIRT1 in endothelial cells","volume":"62","author":"Tsai","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2022.154474_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107600","article-title":"Anti-inflammatory effects of curcumin in acute lung injury: In vivo and in vitro experimental model studies","volume":"96","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2022.154474_bib0024","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.injury.2010.02.029","article-title":"Chlorogenic acid protects mice against lipopolysaccharide-induced acute lung injury","volume":"41","author":"Zhang","year":"2010","journal-title":"Injury"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322005633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322005633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:43:13Z","timestamp":1760553793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322005633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":24,"alternative-id":["S0944711322005633"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154474","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chlorogenic acid enhances alveolar macrophages phagocytosis in acute respiratory distress syndrome by activating G protein-coupled receptor 37 (GPR 37)","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154474","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154474"}}