{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:04:05Z","timestamp":1775671445093,"version":"3.50.1"},"reference-count":219,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.phymed.2022.154581","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T20:32:09Z","timestamp":1669840329000},"page":"154581","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Protective effects of pomegranate (Punica granatum) and its main components against natural and chemical toxic agents: A comprehensive review"],"prefix":"10.1016","volume":"109","author":[{"given":"Azar","family":"Hosseini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibi Marjan","family":"Razavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-851X","authenticated-orcid":false,"given":"Hossein","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154581_bib0001","series-title":"IOSR Journal of Environmental Science, Toxicol Food Techno (IOSR-JESTFT)","first-page":"2319","article-title":"Assessment the effect of pomegranate molasses against diazinon toxicity in male Rats","author":"Abd Elmonem","year":"2014"},{"key":"10.1016\/j.phymed.2022.154581_bib0002","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jphs.2020.01.007","article-title":"Ellagic acid attenuates liver toxicity induced by valproic acid in rats","volume":"143","author":"Abdelkader","year":"2020","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0003","first-page":"1011","article-title":"Ameliorative effects of Punica Granatum juice and extracts against 7, 12-Dimethylbenz (a) Anthracene and carbon tetrachloride-induced Cardiorenal toxicity in albino rats","volume":"2","author":"Ahmed","year":"2016","journal-title":"SM J Biol"},{"key":"10.1016\/j.phymed.2022.154581_bib0004","first-page":"6493","article-title":"Punica granatum mitigates 7, 12-dimethylbenz [a] anthracene and CCL4-induced oxidative stress and hepatic precancerous lesions in wistar rats","volume":"6","author":"Ahmed","year":"2016","journal-title":"Indo Am J Pharm Res"},{"key":"10.1016\/j.phymed.2022.154581_bib0005","first-page":"3148","article-title":"Protective Effect Of Ellagic Acid Against Carbon Tetrachloride (CCl4) Induced Oxidative Brain Injury In Rats","volume":"27","author":"Akkoyun","year":"2018","journal-title":"Fresenius Environ. Bull."},{"key":"10.1016\/j.phymed.2022.154581_bib0006","doi-asserted-by":"crossref","first-page":"e22384","DOI":"10.1002\/jbt.22384","article-title":"Palliative effect of curcumin on doxorubicin-induced testicular damage in male rats","volume":"33","author":"Aksu","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0007","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/2008-7802.184314","article-title":"Potential effects of pomegranate on lipid peroxidation and pro-inflammatory changes in daunorubicin-induced cardiotoxicity in rats","volume":"7","author":"Al-Kuraishy","year":"2016","journal-title":"Int. J. Prev. Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0008","first-page":"102","article-title":"Effect of Pomegranate Seed Oil against Hepatotoxicity-Induced by Sodium Fluoride in Adult Female Rats (Part II). raqi","volume":"43","author":"Al-Okaily","year":"2019","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-14-164","article-title":"Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats","volume":"14","author":"Al-Olayan","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3746\/pnf.2016.21.1.14","article-title":"Ameliorative effects of pomegranate peel extract against dietary-induced nonalcoholic fatty liver in rats","volume":"21","author":"Al-Shaaibi","year":"2016","journal-title":"Prev. Nut. Food Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120071","article-title":"Punicalagin prevents cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammatory response, and apoptosis in rats","volume":"286","author":"Aladaileh","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/JPRI\/2018\/41611","article-title":"Interaction of Cyclosporine A with Pomegranate Juice and Its Potential Nephroprotective Effect in Rats","volume":"25","author":"Ali","year":"2018","journal-title":"J. Pharm. Res. Internatl."},{"key":"10.1016\/j.phymed.2022.154581_bib0013","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1742-7843.2011.00728.x","article-title":"Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research","volume":"109","author":"Ali","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0147","first-page":"103","article-title":"Survey of pesticides used in Qat cultivation in Dhale\u2019 and Yafe\u2019 and their adverse effects","volume":"9","author":"Al-Haj","year":"2005","journal-title":"J. Nat. Appl. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0015","first-page":"422","article-title":"Protective effects of pomegranate juice on nephrotoxicity induced by captopril and gentamicin in rats","volume":"11","author":"Alimoradian","year":"2017","journal-title":"Iran J. Kidney Dis."},{"key":"10.1016\/j.phymed.2022.154581_bib0016","doi-asserted-by":"crossref","first-page":"35","DOI":"10.22317\/jcms.v5i1.522","article-title":"Pomegranate protects renal proximal tubules during gentamicin induced-nephrotoxicity in rats","volume":"5","author":"Alkuraishy","year":"2019","journal-title":"J. Contemp. Med. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0017","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/03601230009373255","article-title":"Effect of dimethoate on the immune system of female mice","volume":"35","author":"Aly","year":"2000","journal-title":"J. Environ. Sci. Health Part B"},{"key":"10.1016\/j.phymed.2022.154581_bib0018","doi-asserted-by":"crossref","first-page":"168","DOI":"10.22159\/ijpps.2017v9i8.18449","article-title":"Hepatoprotective effects of Punica granatum fruit against d-galactosamine induced hepatotoxicity in rats: in vitro and in vivo studies","volume":"9","author":"Amir","year":"2017","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0019","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3390\/nu12051516","article-title":"Punicalagin protects diabetic nephropathy by inhibiting pyroptosis based on TXNIP\/NLRP3 pathway","volume":"12","author":"An","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2022.154581_bib0020","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0270-9295(03)00089-5","article-title":"Cisplatin nephrotoxicity","volume":"23","author":"Arany","year":"2003","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.phymed.2022.154581_bib0021","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.1007\/s11033-020-05873-x","article-title":"Ellagic acid prevents kidney injury and oxidative damage via regulation of Nrf-2\/NF-\u03baB signaling in carbon tetrachloride induced rats","volume":"47","author":"Aslan","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.phymed.2022.154581_bib0022","doi-asserted-by":"crossref","first-page":"13217","DOI":"10.1111\/jfbc.13217","article-title":"The preventive effect of ellagic acid on brain damage in rats via regulating of Nrf-2, NF-kB and apoptotic pathway","volume":"44","author":"Aslan","year":"2020","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.phymed.2022.154581_bib0023","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tox.2005.04.016","article-title":"Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats","volume":"212","author":"Atessahin","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2022.154581_bib0024","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s10616-015-9928-z","article-title":"Protective effects of ellagic acid in D-galactosamine-induced kidney damage in rats","volume":"68","author":"Ayhanci","year":"2016","journal-title":"Cytotechnology"},{"key":"10.1016\/j.phymed.2022.154581_bib0025","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.fct.2011.02.024","article-title":"An aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice","volume":"49","author":"Bachoual","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0026","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3390\/toxins12120748","article-title":"Bioactive components of pomegranate oil and their influence on mycotoxin secretion","volume":"12","author":"Badr","year":"2020","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.phymed.2022.154581_bib0027","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s11011-018-0194-6","article-title":"The effects of tramadol administration on hippocampal cell apoptosis, learning and memory in adult rats and neuroprotective effects of crocin","volume":"33","author":"Baghishani","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.phymed.2022.154581_bib0028","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3109\/13813455.2015.1068336","article-title":"The protective effect of pomegranate extract against cisplatin toxicity in rat liver and kidney tissue","volume":"121","author":"Bak\u0131r","year":"2015","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.phymed.2022.154581_bib0029","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.nutres.2013.03.003","article-title":"Pomegranate and type 2 diabetes","volume":"33","author":"Banihani","year":"2013","journal-title":"Nut. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0030","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0891-5849(89)90144-5","article-title":"Carcinogenic nitrosamines: free radical aspects of their action","volume":"7","author":"Bartsch","year":"1989","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0031","first-page":"44","article-title":"Effect of Punica granatum seeds on doxorubicin and gamma radiation-induced hepatotoxicity in Wistar rats","volume":"4","author":"Bashandy","year":"2019","journal-title":"Int. J. Biol. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0032","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/10715762.2014.899694","article-title":"New insights into antioxidant strategies against paraquat toxicity","volume":"48","author":"Blanco-Ayala","year":"2014","journal-title":"Free Radical Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0033","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.vetimm.2008.04.020","article-title":"Immune response to fungal infections","volume":"125","author":"Blanco","year":"2008","journal-title":"et. Immunol. Immunopathol."},{"key":"10.1016\/j.phymed.2022.154581_bib0034","first-page":"821","article-title":"Protective effect of pomegranate seed oil against acute toxicity of diazinon in rat kidney","volume":"12","author":"Boroushaki","year":"2013","journal-title":"Iran J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0035","first-page":"991","article-title":"Protective effect of pomegranate seed oil against mercuric chloride-induced hepatotoxicity in rat","volume":"73","author":"Boroushaki","year":"2016","journal-title":"Acta Poloniae Pharmaceutica Drug Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0036","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.3109\/0886022X.2014.949770","article-title":"Protective effect of pomegranate seed oil against mercuric chloride-induced nephrotoxicity in rat","volume":"36","author":"Boroushaki","year":"2014","journal-title":"Ren. Fail."},{"key":"10.1016\/j.phymed.2022.154581_bib0037","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3109\/0886022X.2015.1073496","article-title":"Protective effect of pomegranate seed oil against cisplatin-induced nephrotoxicity in rat","volume":"37","author":"Boroushaki","year":"2015","journal-title":"Ren. Fail."},{"key":"10.1016\/j.phymed.2022.154581_bib0038","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1139\/cjpp-2015-0226","article-title":"Prophylactic effects of pomegranate (Punica granatum) juice on sodium fluoride induced oxidative damage in liver and erythrocytes of rats","volume":"94","author":"Bouasla","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0039","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3109\/08860221003778056","article-title":"Protective effect of pomegranate seed oil on hexachlorobutadiene-induced nephrotoxicity in rat kidneys","volume":"32","author":"Bouroshaki","year":"2010","journal-title":"Ren. Fail."},{"key":"10.1016\/j.phymed.2022.154581_bib0040","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1200\/JCO.2004.09.114","volume":"22","author":"Bredenfeld","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phymed.2022.154581_bib0041","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1590\/0001-3765201420140204","article-title":"Endothelial, renal and hepatic variables in wistar rats treated with Vancomycin","volume":"86","author":"Bruniera","year":"2014","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.phymed.2022.154581_bib0042","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jtemb.2019.07.011","article-title":"Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis","volume":"56","author":"Caglayan","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.phymed.2022.154581_bib0043","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1093\/jn\/133.7.2137","article-title":"Berry intake increases the activity of the \u03b3-glutamylcysteine synthetase promoter in transgenic reporter mice","volume":"133","author":"Carlsen","year":"2003","journal-title":"J. Nut. Nutrition"},{"key":"10.1016\/j.phymed.2022.154581_bib0044","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1089\/jmf.2010.0286","article-title":"Pomegranate seed extract attenuates chemotherapy-induced acute nephrotoxicity and hepatotoxicity in rats","volume":"14","author":"\u00c7ay\u0131r","year":"2011","journal-title":"J. Med. Food"},{"key":"10.1016\/j.phymed.2022.154581_bib0014","series-title":"Pakistan J. Zool.","first-page":"1251","article-title":"Potential recruiting and hepatoprotective effects of ellagic acid in D-galactosamine-induced liver damage in rats","volume":"49","author":"Cengiz","year":"2017"},{"key":"10.1016\/j.phymed.2022.154581_bib0045","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.17582\/journal.pjz\/2017.49.4.1251.1259","article-title":"Potential recruiting and hepatoprotective effects of ellagic acid in d-galactosamine-induced liver damage in rats","volume":"49","author":"Cengiz","year":"2017","journal-title":"Pak. J. Zool."},{"key":"10.1016\/j.phymed.2022.154581_bib0046","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1742-7843.2010.00571.x","article-title":"Toxic effect of cyclophosphamide on sperm morphology, testicular histology and blood oxidant-antioxidant balance, and protective roles of lycopene and ellagic acid","volume":"107","author":"\u00c7eriba\u015fi","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0047","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cbi.2019.05.040","article-title":"Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis","volume":"308","author":"Chen","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2022.154581_bib0048","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.mrgentox.2004.08.010","article-title":"Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation","volume":"564","author":"Cherry","year":"2004","journal-title":"Mutat. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0049","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.redox.2018.07.012","article-title":"Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress","volume":"18","author":"Cho","year":"2018","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2022.154581_bib0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jnutbio.2016.09.001","article-title":"Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells","volume":"38","author":"Choudhury","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2022.154581_bib0051","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1095\/biolreprod.107.060244","article-title":"Chronic cyclophosphamide exposure alters the profile of rat sperm nuclear matrix proteins","volume":"77","author":"Codrington","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.phymed.2022.154581_bib0052","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jopan.2010.05.011","article-title":"Evaluation of the anti-inflammatory effects of ellagic acid","volume":"25","author":"Corbett","year":"2010","journal-title":"J. Perianesth. Nurs."},{"key":"10.1016\/j.phymed.2022.154581_bib0053","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0054","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00011-013-0659-3","article-title":"Therapeutic potential of biodegradable microparticles containing Punica granatum L.(pomegranate) in murine model of asthma","volume":"62","author":"de Oliveira","year":"2013","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0055","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s11064-016-1853-9","article-title":"The effects of ellagic acid upon brain cells: a mechanistic view and future directions","volume":"41","author":"de Oliveira","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0056","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.3892\/etm.2017.4966","article-title":"Protective effects of ellagic acid against tetrachloride-induced cirrhosis in mice through the inhibition of reactive oxygen species formation and angiogenesis","volume":"14","author":"Ding","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0057","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cofs.2021.01.004","article-title":"Pathways of human exposure to microplastics, and estimation of the total burden","volume":"39","author":"Domenech","year":"2021","journal-title":"Current Opinion Food Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0058","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/15538362.2019.1653809","article-title":"Punica granatum with multiple effects in chronic diseases","volume":"20","author":"Doostkam","year":"2020","journal-title":"Int. J. Fruit Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0059","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/01480545.2017.1417995","article-title":"Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review","volume":"41","author":"Dorri","year":"2018","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0060","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/ptr.6645","article-title":"Garlic (Allium sativum) as an antidote or a protective agent against natural or chemical toxicities: a comprehensive update review","volume":"34","author":"Dorrigiv","year":"2020","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0061","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1099\/00222615-47-3-189","article-title":"The rapid diagnosis of isoniazid and rifampicin resistance in Mycobacterium tuberculosis\u2014a molecular story","volume":"47","author":"Drobniewski","year":"1998","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.phymed.2022.154581_bib0062","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jff.2018.01.028","article-title":"Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264. 7 macrophages via the suppression of MAPKs activation","volume":"43","author":"Du","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2022.154581_bib0063","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1039\/C4AN00650J","article-title":"Native fluorescence spectroscopic characterization of DMBA induced carcinogenesis in mice skin for the early detection of tissue transformation","volume":"140","author":"Ebenezar","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.phymed.2022.154581_bib0064","first-page":"247","article-title":"Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation","volume":"2","author":"El-Missiry","year":"2015","journal-title":"Egypt J. Basic Appl. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pestbp.2009.09.008","article-title":"Amelioratory effect of vitamin E on organophosphorus insecticide diazinon-induced oxidative stress in mice liver","volume":"96","author":"El-Shenawy","year":"2010","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.phymed.2022.154581_bib0066","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1007\/s11356-020-10999-3","article-title":"The efficiency of pomegranate (Punica granatum) peel ethanolic extract in attenuating the vancomycin-triggered liver and kidney tissues injury in rats","volume":"28","author":"El Bohi","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0067","first-page":"1","article-title":"Pomegranate peel extract protects against carbon tetrachloride-induced nephrotoxicity in mice through increasing antioxidants status","volume":"13","author":"Emam","year":"2020","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.phymed.2022.154581_bib0068","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.fct.2008.03.005","article-title":"Corn oil enhancing hepatic lipid peroxidation induced by CCl4 does not aggravate liver fibrosis in rats","volume":"46","author":"Fang","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0069","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00394-007-0661-z","article-title":"Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress","volume":"46","author":"Faria","year":"2007","journal-title":"Eur. J. Nut."},{"key":"10.1016\/j.phymed.2022.154581_bib0070","first-page":"100","article-title":"Recovery effects of pomegranate seed powder on the testes following cadmium poisoning in Japanese quail (Coturnix japonica); A stereological and lipid peroxidation study","volume":"13","author":"Fatahian Dehkordi","year":"2021","journal-title":"Iran. J. Vet. Sci. Technol."},{"key":"10.1016\/j.phymed.2022.154581_bib0071","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-021-03298-y","article-title":"Neuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson's disease","volume":"21","author":"Fathy","year":"2021","journal-title":"BMC complement Med. Ther."},{"key":"10.1016\/j.phymed.2022.154581_bib0072","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.toxrep.2018.02.017","article-title":"Ellagic acid attenuates arsenic induced neuro-inflammation and mitochondrial dysfunction associated apoptosis","volume":"5","author":"Firdaus","year":"2018","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.phymed.2022.154581_bib0073","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/15376516.2016.1211207","article-title":"Nephroprotection of punicalagin in rat model of endotoxemic acute kidney injury","volume":"26","author":"Fouad","year":"2016","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.phymed.2022.154581_bib0074","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11130-020-00863-7","article-title":"Bioactive compounds and pharmacological potential of pomegranate (Punica granatum) seeds-a review","volume":"75","author":"Fourati","year":"2020","journal-title":"Plant Foods Human Nut."},{"key":"10.1016\/j.phymed.2022.154581_bib0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-483X(00)00352-8","article-title":"Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen","volume":"156","author":"George","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2022.154581_bib0076","doi-asserted-by":"crossref","first-page":"e21937","DOI":"10.1002\/jbt.21937","article-title":"Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats","volume":"31","author":"Georgy","year":"2017","journal-title":"J. BiochemMol. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0077","doi-asserted-by":"crossref","first-page":"e57499","DOI":"10.5812\/jjnpp.57499","article-title":"The effects of pomegranate (Punica granatum L.) peel methanolic extract on methotrexate induced changes in hepatic antioxidant enzymes of rats","volume":"12","author":"Ghamarzad Shishavan","year":"2017","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"10.1016\/j.phymed.2022.154581_bib0078","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ajog.2018.04.040","article-title":"Maternal pomegranate juice attenuates maternal inflammation\u2013induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-\u03baB in a rat model","volume":"219","author":"Ginsberg","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.phymed.2022.154581_bib0079","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1472-8206.2009.00722.x","article-title":"Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice","volume":"23","author":"Girish","year":"2009","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0080","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.lfs.2018.02.022","article-title":"The possible neuroprotective effect of ellagic acid on sodium arsenate-induced neurotoxicity in rats","volume":"198","author":"Goudarzi","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0081","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12012-018-9446-2","article-title":"Protective effect of ellagic acid against sodium arsenite-induced cardio-and hematotoxicity in rats","volume":"18","author":"Goudarzi","year":"2018","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0082","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2165\/00003088-200443130-00004","article-title":"Clinical pharmacology of tramadol","volume":"43","author":"Grond","year":"2004","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.phymed.2022.154581_bib0083","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.intimp.2014.07.005","article-title":"Ellagic acid protects Lipopolysaccharide\/D-galactosamine-induced acute hepatic injury in mice","volume":"22","author":"Gu","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0084","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1124\/jpet.117.242420","article-title":"Urolithin A mitigates cisplatin-induced nephrotoxicity by inhibiting renal inflammation and apoptosis in an experimental rat model","volume":"363","author":"Guada","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phymed.2022.154581_bib0086","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00217-014-2280-2","article-title":"Punicalagin exhibits negative regulatory effects on LPS-induced acute lung injury","volume":"239","author":"Guan","year":"2014","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.phymed.2022.154581_bib0085","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1080\/09540105.2017.1339670","article-title":"Ellagic acid protects against LPS-induced acute lung injury through inhibition of nuclear factor kappa B, proinflammatory cytokines and enhancement of interleukin-10","volume":"28","author":"Guan","year":"2017","journal-title":"Food Agric. Immunol."},{"key":"10.1016\/j.phymed.2022.154581_bib0087","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/00015458.2013.11680929","article-title":"The protective effect of ellagic acid on lung damage caused by experimental obstructive jaundice model","volume":"113","author":"Gul\u2019","year":"2013","journal-title":"Acta Chir. Belg."},{"key":"10.1016\/j.phymed.2022.154581_bib0088","doi-asserted-by":"crossref","first-page":"167","DOI":"10.22376\/ijpbs\/lpr.2021.11.2.L167-173","article-title":"Punicalagin Reverses Methotrexate-Induced Nephrotoxicity by Attenuating Oxidative Stress, Inflammation and Apoptosis","volume":"11","author":"H","year":"2021","journal-title":"Int. J. Life Sci. Pharma. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0089","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-4274(02)00128-5","article-title":"A biochemical, histochemical, and ultrastructural evaluation of the effect of dimethoate intoxication on rat pancreas","volume":"133","author":"Hagar","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phymed.2022.154581_bib0090","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/01913123.2019.1671569","article-title":"Testicular protective effects of ellagic acid on monosodium glutamate-induced testicular structural alterations in male rats","volume":"43","author":"Hamza","year":"2019","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.phymed.2022.154581_bib0091","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.pbi.2009.05.006","article-title":"Physiological functions of mineral micronutrients (cu, Zn, Mn, Fe, Ni, Mo, B, cl)","volume":"12","author":"H\u00e4nsch","year":"2009","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.phymed.2022.154581_bib0092","series-title":"Cataract: biochemistry, Epidemiology and Pharmacology","author":"Harding","year":"2003"},{"key":"10.1016\/j.phymed.2022.154581_bib0093","doi-asserted-by":"crossref","first-page":"8905","DOI":"10.2147\/IJN.S229461","article-title":"Pomegranate juice diminishes the mitochondria-dependent cell death and Nf-kB signaling pathway induced by copper oxide nanoparticles on liver and kidneys of rats","volume":"14","author":"Hassanen","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.phymed.2022.154581_bib0094","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/13880209.2010.517758","article-title":"Cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat","volume":"49","author":"Hassanpour Fard","year":"2011","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2022.154581_bib0095","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/15287390500246431","article-title":"The effects of ellagic acid and vitamin E succinate on antioxidant enzymes activities and glutathione levels in different brain regions of rats after subchronic exposure to TCDD","volume":"69","author":"Hassoun","year":"2006","journal-title":"Journal of Toxicol. Environ. Heal., Part A"},{"key":"10.1016\/j.phymed.2022.154581_bib0096","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0169-409X(97)00043-4","article-title":"Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery","volume":"27","author":"Hebert","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2022.154581_bib0097","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/0960327117701986","article-title":"Ellagic acid protects against arsenic trioxide\u2013induced cardiotoxicity in rat","volume":"37","author":"Hemmati","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0098","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jnutbio.2007.11.006","article-title":"Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor","volume":"19","author":"Hong","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2022.154581_bib0099","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/toxsci\/kfr111","article-title":"Mechanism of pyrethroid pesticide\u2013induced apoptosis: role of Calpain and the ER stress pathway","volume":"122","author":"Hossain","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0100","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.biopha.2018.01.072","article-title":"Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: a review","volume":"99","author":"Hosseini","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2022.154581_bib0101","first-page":"243","article-title":"Reversal of doxorubicin-induced cardiotoxicity by using phytotherapy: a review","volume":"20","author":"Hosseini","year":"2017","journal-title":"J. Pharmacopunct."},{"key":"10.1016\/j.phymed.2022.154581_bib0102","unstructured":"Hosseini, S., Mehrabani, D., REZAEI, E., 2014. Effects of pomegranate juice on liver enzymes (ALT, ALP, AST) in diabetic and non-diabetic rats."},{"key":"10.1016\/j.phymed.2022.154581_bib0103","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/jncimonographs\/lgi003","article-title":"Spermatogenesis after cancer treatment: damage and recovery","volume":"2005","author":"Howell","year":"2005","journal-title":"JNCi Monographs"},{"key":"10.1016\/j.phymed.2022.154581_bib0104","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.freeradbiomed.2014.04.026","article-title":"Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells","volume":"73","author":"Huerta-Garc\u00eda","year":"2014","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4274(02)00084-X","article-title":"Arsenic toxicity and potential mechanisms of action","volume":"133","author":"Hughes","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phymed.2022.154581_bib0106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-26611-1","article-title":"Pomegranate action in curbing the incidence of liver injury triggered by Diethylnitrosamine by declining oxidative stress via Nrf2 and NF\u03baB regulation","volume":"8","author":"Husain","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2022.154581_bib0107","first-page":"83","article-title":"Ameliorative effect of pomegranate molasses on deltamethrin induced neurotoxicity in adult albino rats: biochemical, histopathological & immunohistochemical study","volume":"18","author":"Hussein","year":"2018","journal-title":"Egypt. J. Forensic. Sci. Appl. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0108","doi-asserted-by":"crossref","first-page":"74","DOI":"10.30539\/iraqijvm.v38i1.258","article-title":"Protective Role of Pomegranate Peel Extract on Testis in Adult Male Rabbits Treated with Carbon Tetrachloride","volume":"38","author":"Hussen","year":"2014","journal-title":"Iraqi J. Veterin. Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0109","doi-asserted-by":"crossref","DOI":"10.5644\/ama2006-124.94","article-title":"The sensitivity of male rat reproductive organs to monosodium glutamate","volume":"43","author":"Iamsaard","year":"2014","journal-title":"Acta Med. Acad."},{"key":"10.1016\/j.phymed.2022.154581_bib0110","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.3892\/mmr.2016.4956","article-title":"Ameliorative effects of pomegranate on carbon tetrachloride hepatotoxicity in rats: a molecular and histopathological study","volume":"13","author":"Ibrahim","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2022.154581_bib0111","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jep.2012.07.004","article-title":"Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects","volume":"143","author":"Ismail","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0112","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s12012-010-9076-9","article-title":"Pomegranate (Punica granatum L.) juice supplementation attenuates isoproterenol-induced cardiac necrosis in rats","volume":"10","author":"Jadeja","year":"2010","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0113","series-title":"Mercury in the environment: sources, toxicities, and Prevention of Exposure","first-page":"437","author":"Johnson","year":"2004"},{"key":"10.1016\/j.phymed.2022.154581_bib0114","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0014-2964(80)90156-5","article-title":"Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model","volume":"16","author":"Jordan","year":"1980","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.phymed.2022.154581_bib0115","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.etap.2005.11.007","article-title":"Effects of diazinon on pseudocholinesterase activity and haematological indices in rats: the protective role of vitamin E","volume":"22","author":"Kalender","year":"2006","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0116","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.acthis.2010.09.008","article-title":"Calretinin immunoreactivity in normal and carbon tetrachloride-induced nephrotoxic rats","volume":"113","author":"Kang","year":"2011","journal-title":"Acta Histochem."},{"key":"10.1016\/j.phymed.2022.154581_bib0117","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2011.02.037","article-title":"Ellagic acid ameliorates isoproterenol induced oxidative stress: evidence from electrocardiological, biochemical and histological study","volume":"659","author":"Kannan","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0118","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1039\/C6FO00188B","article-title":"Antioxidant and anti-inflammatory potential of pomegranate rind extract to ameliorate cisplatin-induced acute kidney injury","volume":"7","author":"Karwasra","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2022.154581_bib0119","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.taap.2010.06.003","article-title":"Impact of developmental lead exposure on splenic factors","volume":"247","author":"Kasten-Jolly","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0120","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.2215\/CJN.01520209","article-title":"Risk factors for cyclosporin A nephrotoxicity in children with steroid-dependant nephrotic syndrome","volume":"4","author":"Kengne","year":"2009","journal-title":"Clinical J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2022.154581_bib0121","doi-asserted-by":"crossref","first-page":"112","DOI":"10.21608\/ejhm.2004.18179","article-title":"A hepatoprotective effect of an aqueous extract of pomegranate (Punica granatum L.) rind against acetaminop hen treated rats","volume":"16","author":"Khalil","year":"2004","journal-title":"Egypt. J. Hospital Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0122","doi-asserted-by":"crossref","first-page":"888","DOI":"10.31024\/ajpp.2018.4.6.26","article-title":"Hepatoprotective effect of aqueous extracts of root and peel of in Punica granatum wistar rats","volume":"4","author":"Khan","year":"2018","journal-title":"Asian J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-12-178","article-title":"CCl 4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat","volume":"12","author":"Khan","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0124","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fct.2013.03.046","article-title":"Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity in Wistar rats","volume":"58","author":"Khan","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0125","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3177\/jnsv.51.8","article-title":"Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats","volume":"51","author":"Kim","year":"2005","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.phymed.2022.154581_bib0126","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuropharm.2017.01.025","article-title":"Inhibitory effect of punicalagin on lipopolysaccharide-induced neuroinflammation, oxidative stress and memory impairment via inhibition of nuclear factor-kappaB","volume":"117","author":"Kim","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2022.154581_bib0127","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11010-005-6630-z","article-title":"Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats","volume":"278","author":"Koc","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.phymed.2022.154581_bib0128","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/art.20278","article-title":"Toward a better understanding of methotrexate","volume":"50","author":"Kremer","year":"2004","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.phymed.2022.154581_bib0129","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/clpt.1988.87","article-title":"Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs","volume":"43","author":"Kronbach","year":"1988","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2022.154581_bib0130","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s12010-014-1276-5","article-title":"Protective effect of Punica granatum peel and Vitis vinifera seeds on DEN-induced oxidative stress and hepatocellular damage in rats","volume":"175","author":"Kumar","year":"2015","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.phymed.2022.154581_bib0131","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.5958\/0974-360X.2019.00462.1","article-title":"Effect of Punica granatum peel and Vitis vinifera seeds on Biochemical Indices in DEN induced Hepatocellular Carcinoma in Rats","volume":"12","author":"Kumar","year":"2019","journal-title":"Res. J. Pharm. Technol."},{"key":"10.1016\/j.phymed.2022.154581_bib0132","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.3389\/fmicb.2016.02170","article-title":"Aflatoxins: a global concern for food safety, human health and their management","volume":"7","author":"Kumar","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2022.154581_bib0133","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2478\/v10102-010-0005-3","article-title":"Different experimental approaches in modelling cataractogenesis: an overview of selenite-induced nuclear cataract in rats","volume":"3","author":"Kyselova","year":"2010","journal-title":"Interdisc. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0134","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12989-016-0169-x","article-title":"Comparative toxicity and biodistribution assessments in rats following subchronic oral exposure to copper nanoparticles and microparticles","volume":"13","author":"Lee","year":"2016","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154328","article-title":"Physalis alkekengi L. var. franchetii (Mast.) Makino: a review of the pharmacognosy, chemical constituents, pharmacological effects, quality control, and applications","volume":"105","author":"Liang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2022.154581_bib0136","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12012-013-9197-z","article-title":"Preventive effects of ellagic acid against doxorubicin-induced cardio-toxicity in mice","volume":"13","author":"Lin","year":"2013","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0137","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.70902","article-title":"Free radicals, antioxidants and functional foods: impact on human health","volume":"4","author":"Lobo","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.phymed.2022.154581_bib0138","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00695873","article-title":"The acute toxic effects of hexachloro-1: 3-butadiene on the rat kidney","volume":"43","author":"Lock","year":"1979","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0139","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1289\/ehp.10216","article-title":"Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro","volume":"115","author":"Long","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.phymed.2022.154581_bib0140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1567-5769(02)00259-X","article-title":"Immunomodulatory activity of TNF-\u03b1 during acute liver injury induced by D-galactosamine and its protection by PGE1 in rats","volume":"3","author":"Lozano","year":"2003","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0141","article-title":"Protective effect of pomegranate (Punica granatum Linn.) juice against hepatotoxicity and testicular toxicity induced by ethanol in mice","volume":"5","author":"Luangpirom","year":"2013","journal-title":"Anim. Biol. Anim. Husb."},{"key":"10.1016\/j.phymed.2022.154581_bib0142","first-page":"924","article-title":"Nephrotoxicity of anticancer treatment","volume":"32","author":"Ma\u0142yszko","year":"2017","journal-title":"Nephrol. Dialy. Transplant."},{"key":"10.1016\/j.phymed.2022.154581_bib0143","unstructured":"Manjrekar, A., Jisha, V., Bag, P., Adhikary, B., Pai, M., Hegde, A., Nandini, M., 2008. Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl 4 induced hepatotoxic rats."},{"key":"10.1016\/j.phymed.2022.154581_bib0144","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0165-4608(98)00125-3","article-title":"Analysis of sperm chromosome complements before, during, and after chemotherapy","volume":"108","author":"Martin","year":"1999","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.phymed.2022.154581_bib0145","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00795-003-0213-4","article-title":"Ultrastructural study on cytotoxic effects of cyclosporine A in spermiogenesis in rats","volume":"36","author":"Masuda","year":"2003","journal-title":"Medic. Electron Microsc."},{"key":"10.1016\/j.phymed.2022.154581_bib0146","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/nbdi.2002.0507","article-title":"Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat","volume":"10","author":"McCormack","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2022.154581_bib0148","first-page":"1","article-title":"Effect of Pomegranate (Punica granatum L.) Seed Oil on Markers of Oxidative Stress Induced by Carbon Tetra-chloride in Wistar Rats","volume":"5","author":"Melo","year":"2015","journal-title":"Int. J. Food Sci. Nutr. Diet"},{"key":"10.1016\/j.phymed.2022.154581_bib0149","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2732958","article-title":"Pomegranate seeds extract possesses a protective effect against tramadol-induced Testicular toxicity in experimental rats","volume":"2020","author":"Minisy","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phymed.2022.154581_bib0150","first-page":"1","article-title":"Protective effect of pomegranate peel extract against titanium dioxide nanoparticles (TiO2-NPs)-induced neurotoxicity in rats","volume":"8","author":"Mohammed","year":"2018","journal-title":"Am. J. Physiol., Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0151","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4103\/0976-500X.64533","article-title":"Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats","volume":"1","author":"Mohan","year":"2010","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.phymed.2022.154581_bib0152","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s13105-012-0218-3","article-title":"The potential effects of pomegranate (Punica granatum) juice on carbon tetrachloride-induced nephrotoxicity in rats","volume":"69","author":"Moneim","year":"2013","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.phymed.2022.154581_bib0153","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154333","article-title":"A systematic review on potential anticancer activities of Ficus carica L. with focus on cellular and molecular mechanisms","volume":"105","author":"Morovati","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2022.154581_bib0154","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jnutbio.2013.07.005","article-title":"Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-\u03baB pathways","volume":"24","author":"Mukherjee","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2022.154581_bib0155","first-page":"617","article-title":"Developmental neurotoxicological effects of lead and dimethoate in animal experiments","volume":"19","author":"Nagymajtenyi","year":"1998","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.phymed.2022.154581_bib0156","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/bcpt.13179","article-title":"Impact of chronic lead exposure on liver and kidney function and haematologic parameters","volume":"124","author":"Nakhaee","year":"2019","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0157","first-page":"181","article-title":"Hepatoprotective effect of pomegranate (Punica granatum) fruit juice and seed extracts against CCL4-induced toxicity","volume":"8","author":"Niknahad","year":"2012","journal-title":"Iran. J. Pharmac. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0158","doi-asserted-by":"crossref","unstructured":"Oklla, K.A.B., 2017. Histopathological study of toxicity aflatoxin of treatment by Aqueous extract seed pomgranate (Punica granulatum) in male New Zealand white Rabbits (Oryctolacus cunnculus).","DOI":"10.37623\/SJMR.2017.1301"},{"key":"10.1016\/j.phymed.2022.154581_bib0159","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/mnfr.201400163","article-title":"Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia","volume":"58","author":"Olajide","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0160","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1021\/jf00077a042","article-title":"Inhibition of in vitro lipid peroxidation by ellagic acid","volume":"35","author":"Osawa","year":"1987","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2022.154581_bib0161","first-page":"261","article-title":"The role of oxidative stress and endothelial injury in diabetic neuropathy and neuropathic pain","volume":"31","author":"Ozkul","year":"2010","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.phymed.2022.154581_bib0162","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1007\/s11033-014-3292-5","article-title":"Protective effect of ellagic acid against TCDD-induced renal oxidative stress: modulation of CYP1A1 activity and antioxidant defense mechanisms","volume":"41","author":"Padma","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.phymed.2022.154581_bib0163","first-page":"233","article-title":"Drug-induced hepatotoxicity: a review","volume":"2","author":"Pandit","year":"2012","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0164","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1472-8206.2008.00609.x","article-title":"Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats","volume":"22","author":"Pari","year":"2008","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0165","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s10753-014-9955-5","article-title":"Punicalagin ameliorates lipopolysaccharide-induced acute respiratory distress syndrome in mice","volume":"38","author":"Peng","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2022.154581_bib0166","article-title":"Punica granatum L. leaf extract attenuates lung inflammation in mice with acute lung injury","author":"Pinheiro","year":"2018","journal-title":"J. Immunol. Res. 2018"},{"key":"10.1016\/j.phymed.2022.154581_bib0167","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0031-6997(25)06814-0","article-title":"Short-term toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models","volume":"46","author":"Pohjanvirta","year":"1994","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phymed.2022.154581_bib0168","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tiv.2012.01.020","article-title":"A new approach on valproic acid induced hepatotoxicity: involvement of lysosomal membrane leakiness and cellular proteolysis","volume":"26","author":"Pourahmad","year":"2012","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.phymed.2022.154581_bib0169","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117599","article-title":"New molecular and biochemical insights of doxorubicin-induced hepatotoxicity","volume":"250","author":"Prasanna","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.intimp.2010.10.016","article-title":"Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress","volume":"11","author":"Qiao","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0171","doi-asserted-by":"crossref","DOI":"10.5530\/pj.2017.5.109","article-title":"Active constituents of pomegranates (Punica granatum) as potential candidates in the management of health through modulation of biological activities","volume":"9","author":"Rahmani","year":"2017","journal-title":"Pharmacogn. J."},{"key":"10.1016\/j.phymed.2022.154581_bib0172","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.fct.2016.11.035","article-title":"Protective effects of green tea and its main constituents against natural and chemical toxins: a comprehensive review","volume":"100","author":"Rameshrad","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0173","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.prostaglandins.2006.02.003","article-title":"The differential effect of PGE1 on D-galactosamine-induced nitrosative stress and cell death in primary culture of human hepatocytes","volume":"79","author":"Ranchal","year":"2006","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.phymed.2022.154581_bib0174","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.rvsc.2010.04.011","article-title":"Aflatoxin B1 in poultry: toxicology, metabolism and prevention","volume":"89","author":"Rawal","year":"2010","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0175","first-page":"1","article-title":"Saffron as an antidote or a protective agent against natural or chemical toxicities","volume":"23","author":"Razavi","year":"2015","journal-title":"DARU J. Pharmac. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0176","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jaad.2009.05.017","article-title":"Cyclosporine and psoriasis: 2008 National Psoriasis Foundation Consensus Conference","volume":"62","author":"Rosmarin","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.phymed.2022.154581_bib0177","first-page":"45","article-title":"Protective effect of pomegranate flower extract against gentamicin-induced renal toxicity in male rats","volume":"4","author":"Sadeghi","year":"2015","journal-title":"J. Renal. Inj. Prev."},{"key":"10.1016\/j.phymed.2022.154581_bib0178","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.exer.2007.10.016","article-title":"Prevention of selenite-induced cataractogenesis in Wistar rats by the polyphenol, ellagic acid","volume":"86","author":"Sakthivel","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0179","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.lfs.2016.07.006","article-title":"Ellagic and ferulic acids alleviate gamma radiation and aluminium chloride-induced oxidative damage","volume":"160","author":"Salem","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0180","first-page":"925","article-title":"Influence of pomegranate (Punica granatum L.) on dimethoate induced hepatotoxicity in rats","volume":"8","author":"Salim","year":"2014","journal-title":"Int. J. Biotechnol. Bioeng."},{"key":"10.1016\/j.phymed.2022.154581_bib0181","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/0976-9668.149085","article-title":"Evaluation of antidiabetic, hypolipedimic and antioxidant activity of hydroalcoholic extract of leaves and fruit peel of Punica granatum in male Wistar albino rats","volume":"6","author":"Salwe","year":"2015","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0182","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/wnan.103","article-title":"Metal-based nanoparticles and their toxicity assessment","volume":"2","author":"Schrand","year":"2010","journal-title":"Wiley Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.phymed.2022.154581_bib0183","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.3390\/ijms21144975","article-title":"Punicalagin ameliorates lupus nephritis via inhibition of PAR2","volume":"21","author":"Seo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0184","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1089\/jmf.2012.0306","article-title":"Effect of Punica granatum (pomegranate) juice extract on healthy liver and hepatotoxicity induced by diethylnitrosamine and phenobarbital in male rats","volume":"17","author":"Shaban","year":"2014","journal-title":"J. Med. Food"},{"key":"10.1016\/j.phymed.2022.154581_bib0185","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12011-015-0397-1","article-title":"Protective effects of combined selenium and Punica granatum treatment on some inflammatory and oxidative stress markers in arsenic-induced hepatotoxicity in rats","volume":"169","author":"Shafik","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0186","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1016\/j.fct.2010.09.003","article-title":"Diazinon-induced oxidative stress and renal dysfunction in rats","volume":"48","author":"Shah","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0187","doi-asserted-by":"crossref","first-page":"827","DOI":"10.7326\/0003-4819-126-10-199705150-00020","article-title":"Anthracycline-induced cardiotoxicity","volume":"126","author":"Shan","year":"1997","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0188","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/ptr.6641","article-title":"Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: a review","volume":"34","author":"Shirani","year":"2020","journal-title":"Phytoth. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0189","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154359","article-title":"Xanthorrhizol, a potential anticancer agent, from Curcuma xanthorrhiza Roxb","volume":"105","author":"Simamora","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2022.154581_bib0190","unstructured":"Singh, K., Khanna, A., Chander, R., 1999a. Hepatoprotective activity of ellagic acid against carbon tetrachloride induced hepatotoxicity in rats."},{"key":"10.1016\/j.phymed.2022.154581_bib0191","unstructured":"Singh, K., Khanna, A., Visen, P., Chander, R., 1999b. Protective effect of ellagic acid on t-butyl hydroperoxide induced lipid peroxidation in isolated rat hepatocytes."},{"key":"10.1016\/j.phymed.2022.154581_bib0192","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12011-015-0265-z","article-title":"Effects of fluoride on DNA damage and caspase-mediated apoptosis in the liver of rats","volume":"166","author":"Song","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0193","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cardiores.2007.02.016","article-title":"Downregulation of CuZn-superoxide dismutase contributes to \u03b2-adrenergic receptor-mediated oxidative stress in the heart","volume":"74","author":"Srivastava","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2022.154581_bib0194","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4292\/wjgpt.v5.i3.113","article-title":"Use of methotrexate in inflammatory bowel disease in 2014: a User's Guide","volume":"5","author":"Swaminath","year":"2014","journal-title":"World J. Gastrointest Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2022.154581_bib0195","first-page":"2","article-title":"Black seed (Nigella sativa) and its constituent thymoquinone as an antidote or a protective agent against natural or chemical toxicities","volume":"16","author":"Tavakkoli","year":"2017","journal-title":"Iranian J. Pharmac. Res.: IJPR."},{"key":"10.1016\/j.phymed.2022.154581_bib0196","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810077","article-title":"Molecular Mechanism of Arsenic-Induced Neurotoxicity including Neuronal Dysfunctions","volume":"22","author":"Thakur","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0197","doi-asserted-by":"crossref","first-page":"641","DOI":"10.21608\/jappmu.2010.86279","article-title":"Modulation of aflatoxins toxicity in rats by ethanolic pomegranate peel (Punica granatum. L) extract","volume":"1","author":"Tohame","year":"2010","journal-title":"J. Anim. Poultry Prod."},{"key":"10.1016\/j.phymed.2022.154581_bib0198","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0278-6915(91)90180-F","article-title":"Mean daily intake of volatile N-nitrosamines from foods and beverages in West Germany in 1989\u20131990","volume":"29","author":"Tricker","year":"1991","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0199","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0006-2952(96)00421-2","article-title":"Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L","volume":"52","author":"Tsuda","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0200","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.fertnstert.2007.04.059","article-title":"Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid","volume":"89","author":"T\u00fcrk","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.phymed.2022.154581_bib0201","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.intimp.2009.10.013","article-title":"Attenuation of cyclosporine A-induced testicular and spermatozoal damages associated with oxidative stress by ellagic acid","volume":"10","author":"T\u00fcrk","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2022.154581_bib0202","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2164\/jandrol.108.005132","article-title":"Oxidative stress: a common factor in testicular dysfunction","volume":"29","author":"Turner","year":"2008","journal-title":"J. Androl."},{"key":"10.1016\/j.phymed.2022.154581_bib0203","doi-asserted-by":"crossref","first-page":"178","DOI":"10.5567\/pharmacologia.2015.178.185","article-title":"Cardioprotective effects of co-administration of Pomegranate extract and vitamin E on electrocardiographic, biochemical and apoptotic changes in isoproterenol induced myocardial infarction in rats","volume":"6","author":"Upaganlawar","year":"2015","journal-title":"Pharmacologia"},{"key":"10.1016\/j.phymed.2022.154581_bib0204","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10072-011-0775-1","article-title":"Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats","volume":"33","author":"Uzar","year":"2012","journal-title":"Neurolog. Sci."},{"key":"10.1016\/j.phymed.2022.154581_bib0205","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.2174\/1381612811319320005","article-title":"Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases","volume":"19","author":"Vanessa Fiorentino","year":"2013","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.phymed.2022.154581_bib0206","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/009841098159006","article-title":"Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2, 4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes","volume":"54","author":"Waldbillig","year":"1998","journal-title":"J.Toxicol. Environm. Heal. Part A"},{"key":"10.1016\/j.phymed.2022.154581_bib0207","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacme.2015.02.003","article-title":"Cardioprotective effect of ellagic acid on doxorubicin induced cardiotoxicity in wistar rats","volume":"5","author":"Warpe","year":"2015","journal-title":"J. Acute Med."},{"key":"10.1016\/j.phymed.2022.154581_bib0208","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2019.103712","article-title":"Pomegranate peel extract ameliorates liver fibrosis induced by carbon tetrachloride in rats through suppressing p38MAPK\/Nrf2 pathway","volume":"65","author":"Wei","year":"2020","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2022.154581_bib0209","series-title":"Oxidative Stress and Alcoholic Liver disease, Seminars in Liver Disease","first-page":"141","author":"Wu","year":"2009"},{"key":"10.1016\/j.phymed.2022.154581_bib0210","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s10753-014-9816-2","article-title":"Punicalagin inhibits inflammation in LPS-induced RAW264. 7 macrophages via the suppression of TLR4-mediated MAPKs and NF-\u03baB activation","volume":"37","author":"Xu","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2022.154581_bib0211","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2022.154581_bib0212","first-page":"1842","article-title":"Pomegranate seed extract attenuates chemotherapy-induced liver damage in an experimental model of rabbits","volume":"59","author":"Yildirim","year":"2013","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.phymed.2022.154581_bib0213","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/13880200701538963","article-title":"Antihepatotoxic effect of Punica granatum. acetone extract against isoniazid-and rifampicin-induced hepatotoxicity","volume":"45","author":"Yogeeta","year":"2007","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2022.154581_bib0214","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1742-7843.2008.00284.x","article-title":"Amelioration of cyclosporine A-induced renal, hepatic and cardiac damages by ellagic acid in rats","volume":"103","author":"Y\u00fcce","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2022.154581_bib0215","doi-asserted-by":"crossref","first-page":"112","DOI":"10.21608\/zvjz.2017.7884","article-title":"Effect of Aqueous extract of punica granatum peel on the Oxidative Damage induced by Lead Intoxication in Rats","volume":"45","author":"Zaglool","year":"2017","journal-title":"Zagazig. Vet. J."},{"key":"10.1016\/j.phymed.2022.154581_bib0216","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/02772248.2014.918461","article-title":"Protective effect of Punica granatum L.(pomegranate) fruit extracts and ellagic acid against cytotoxicity induced by methyl tertiary butyl ether in isolated rat hepatocytes","volume":"96","author":"Zargar","year":"2014","journal-title":"Toxicol. Environ. Chem."},{"key":"10.1016\/j.phymed.2022.154581_bib0217","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20212196","article-title":"Lung-protective effect of Punicalagin on LPS-induced acute lung injury in mice","volume":"42","author":"Zeng","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.phymed.2022.154581_bib0218","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153736","article-title":"A review on pharmacological activities and synergistic effect of quercetin with small molecule agents","volume":"92","author":"Zou","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2022.154581_bib0219","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1089\/ars.2013.5538","article-title":"Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin","volume":"21","author":"Zou","year":"2014","journal-title":"Antioxid. Redox Signal."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322006699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322006699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:43:21Z","timestamp":1760553801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322006699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":219,"alternative-id":["S0944711322006699"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154581","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of pomegranate (Punica granatum) and its main components against natural and chemical toxic agents: A comprehensive review","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154581","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154581"}}