{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:50:04Z","timestamp":1793505004609,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.phymed.2022.154585","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T11:22:47Z","timestamp":1670412167000},"page":"154585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Hastatoside attenuatescarbon tetrachloride-induced liver fibrosis by targeting glycogen synthase kinase-3\u03b2"],"prefix":"10.1016","volume":"109","author":[{"given":"Changlin","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongwen","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2208-2505","authenticated-orcid":false,"given":"Taotao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154585_bib0001","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1136\/ard.2010.147140","article-title":"Inhibition of glycogen synthase kinase 3\u03b2 induces dermal fibrosis by activation of the canonical Wnt pathway","volume":"70","author":"Bergmann","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phymed.2022.154585_bib35","doi-asserted-by":"crossref","unstructured":"Chen, X., Li, X.F., Chen, Y., Zhu, S., Li, H.D., Chen, S.Y., Wang, J.N., Pan, X.Y., Bu, F.T., Huang, C., Li, J.,2019.Hesperetin derivative attenuates CCl4-induced hepatic fibrosis and inflammation by Gli-1-dependent mechanisms.Int Immunopharmacol. 76,105838.","DOI":"10.1016\/j.intimp.2019.105838"},{"key":"10.1016\/j.phymed.2022.154585_bib0002","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41419-021-03709-5","article-title":"Permissive effect of GSK3\u03b2 on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease","volume":"12","author":"Chen","year":"2021","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2022.154585_bib0003","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/hep.30193","article-title":"Retinoic acid receptor-\u03b2 is downregulated in hepatocellular carcinoma and cirrhosis and its expression inhibits myosin-driven activation and durotaxis in hepatic stellate cells","volume":"69","author":"Cortes","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2022.154585_bib0004","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1535370219898141","article-title":"Mechanisms of liver fibrosis and its role in liver cancer","volume":"245","author":"Dhar","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.phymed.2022.154585_bib0005","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1053\/he.2000.6126","article-title":"Modulation of transforming growth factor \u03b2 response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts","volume":"31","author":"Dooley","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2022.154585_bib0006","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jhep.2011.09.024","article-title":"Clinical evidence for the regression of liver fibrosis","volume":"56","author":"Ellis","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2022.154585_bib0007","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2022.154585_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111130","article-title":"Dimethyl fumarate protects against intestinal ischemia\/reperfusion lesion: participation of Nrf2\/HO-1, GSK-3\u03b2 and Wnt\/\u03b2-catenin pathway","volume":"134","author":"Gendy","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2022.154585_bib0009","first-page":"491","article-title":"Short-term effects of Verbena officinalis Linn decoction on patients suffering from chronic generalized gingivitis: double-blind randomized controlled multicenter clinical trial","volume":"47","author":"Grawish","year":"2016","journal-title":"Quintessence Int."},{"key":"10.1016\/j.phymed.2022.154585_bib0010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yjmcc.2017.07.011","article-title":"Entanglement of GSK-3\u03b2, \u03b2-catenin and TGF-\u03b21 signaling network to regulate myocardial fibrosis","volume":"110","author":"Guo","year":"2017","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.phymed.2022.154585_bib0011","first-page":"234","article-title":"Herbs of special interest to women","volume":"40","author":"Hardy","year":"2000","journal-title":"J. Am. Pharm. Assoc."},{"key":"10.1016\/j.phymed.2022.154585_bib0012","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2022.154585_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctcp.2020.101300","article-title":"TCM use in pregnant women and nursing mothers: a study from Turkey","volume":"42","author":"Kaygusuz","year":"2021","journal-title":"Complement. Ther. Clin. Pract."},{"key":"10.1016\/j.phymed.2022.154585_bib0014","first-page":"512","article-title":"Study on in-vivo anti-tumor activity of Verbena officinalis extract","volume":"10","author":"Kou","year":"2013","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2022.154585_bib0015","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1055\/a-1232-5758","article-title":"Verbena officinalis (Common Vervain) \u2013 a review on the investigations of this medicinally important plant species","volume":"86","author":"Kubica","year":"2020","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2022.154585_bib0016","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/md16010019","article-title":"The bioactive extract of pinnigorgia sp. induces apoptosis of hepatic stellate cells via ROS-ERK\/JNK-caspase-3 signaling","volume":"16","author":"Kuo","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phymed.2022.154585_bib0017","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCRESAHA.116.303613","article-title":"The GSK-3 family as therapeutic target for myocardial diseases","volume":"116","author":"Lal","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2022.154585_bib0019","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.7150\/thno.27372","article-title":"Alkaline phosphatase controls lineage switching of mesenchymal stem cells by regulating the LRP6\/GSK3\u03b2 complex in hypophosphatasia","volume":"8","author":"Liu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2022.154585_bib0020","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41419-020-2597-7","article-title":"Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2022.154585_bib0018","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1016\/j.apsb.2021.06.017","article-title":"TRIB3-GSK-3\u03b2 interaction promotes lung fibrosis and serves as a potential therapeutic target","volume":"11","author":"Liu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2022.154585_bib0021","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/hep.30965","article-title":"A deactivation factor of fibrogenic hepatic stellate cells induces regression of liver fibrosis in mice","volume":"71","author":"Nakano","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2022.154585_bib0022","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/hep.30083","article-title":"Diabetes, plasma glucose, and incidence of fatty liver, cirrhosis, and liver cancer: a prospective study of 0.5 million people","volume":"68","author":"Pang","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2022.154585_bib0023","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ccr.2008.10.013","article-title":"Glycogen synthase kinase-3 and cancer: good cop, bad cop?","volume":"14","author":"Patel","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2022.154585_bib0024","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/j.2040-4603.2013.tb00529.x","article-title":"Hepatic stellate cells and liver fibrosis","volume":"3","author":"Puche","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.phymed.2022.154585_bib0025","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.lwt.2010.11.035","article-title":"Chemical composition, mineral content and antioxidant activity of Verbena officinalis L","volume":"44","author":"Rehecho","year":"2011","journal-title":"LWT - Food Sci. Technol."},{"key":"10.1016\/j.phymed.2022.154585_bib0026","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0014-5793(97)01235-0","article-title":"Further evidence that the inhibition of glycogen synthase kinase-3\u03b2 by IGF-1 is mediated by PDK1\/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216","volume":"416","author":"Shaw","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2022.154585_bib0027","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jhep.2019.09.033","article-title":"PSMP\/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target","volume":"72","author":"She","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2022.154585_bib0028","doi-asserted-by":"crossref","first-page":"10473","DOI":"10.3390\/molecules190710473","article-title":"Two new iridoids from Verbena officinalis L","volume":"19","author":"Shu","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2022.154585_bib0029","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2022.154585_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153856","article-title":"Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3\u03b2 activity and activating the Nrf2\/HO-1 pathway","volume":"95","author":"Wen","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2022.154585_bib0031","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.omtn.2019.10.025","article-title":"NPAS2 contributes to liver fibrosis by direct transcriptional activation of hes1 in hepatic stellate cells","volume":"18","author":"Yang","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.phymed.2022.154585_bib0032","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41401-020-0498-z","article-title":"MicroRNA-99b-3p promotes angiotensin II-induced cardiac fibrosis in mice by targeting GSK-3\u03b2","volume":"42","author":"Yu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2022.154585_bib0033","doi-asserted-by":"crossref","first-page":"11737","DOI":"10.7150\/thno.47717","article-title":"Glycogen synthase kinase-3\u03b2: a promising candidate in the fight against fibrosis","volume":"10","author":"Zheng","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2022.154585_bib0034","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1096\/fj.201701137R","article-title":"Inhibition of GSK-3\u03b2 induces AP-1-mediated osteopontin expression to promote cholestatic liver fibrosis","volume":"32","author":"Zhuang","year":"2018","journal-title":"FASEB J."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322006730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322006730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:44:14Z","timestamp":1760553854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322006730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":35,"alternative-id":["S0944711322006730"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154585","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hastatoside attenuatescarbon tetrachloride-induced liver fibrosis by targeting glycogen synthase kinase-3\u03b2","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154585","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154585"}}