{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:50:02Z","timestamp":1793505002855,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960677"],"award-info":[{"award-number":["81960677"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074095"],"award-info":[{"award-number":["82074095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.phymed.2022.154599","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:39:20Z","timestamp":1670985560000},"page":"154599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Carnosic acid suppressed the formation of NETs in alcoholic hepatosteatosis based on P2X7R-NLRP3 axis"],"prefix":"10.1016","volume":"110","author":[{"given":"Rong-Mei","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ya","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Xing","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hua","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2022.154599_bib0001","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1002\/jbmr.4384","article-title":"Nitrogen-containing bisphosphonates and lipopolysaccharide mutually augment inflammation via adenosine triphosphate (ATP)-mediated and interleukin 1\u03b2 (IL-1\u03b2)-mediated production of neutrophil extracellular traps (NETs)","volume":"36","author":"Bando","year":"2021","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phymed.2022.154599_bib0002","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2022.154599_bib0003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phytochem.2014.12.026","article-title":"Carnosic acid","volume":"115","author":"Birtic","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2022.154599_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010231","article-title":"Neutrophil extracellular traps and cardiovascular diseases: an update","volume":"9","author":"Bonaventura","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2022.154599_bib0005","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.plefa.2010.02.012","article-title":"Fatty liver: role of inflammation and fatty acid nutrition","volume":"82","author":"Byrne","year":"2010","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.phymed.2022.154599_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118905","article-title":"Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway","volume":"266","author":"Cheng","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2022.154599_bib0007","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1007\/s12035-017-0842-6","article-title":"Carnosic acid as a promising agent in protecting mitochondria of brain cells","volume":"55","author":"de Oliveira","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2022.154599_bib0008","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/j.2040-4603.2013.tb00510.x","article-title":"Kupffer cells in the liver","volume":"3","author":"Dixon","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.phymed.2022.154599_bib0009","doi-asserted-by":"crossref","first-page":"9641","DOI":"10.1074\/jbc.RA120.013037","article-title":"A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds","volume":"295","author":"Du","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2022.154599_bib0010","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01044.x","article-title":"Caspase 1 induced pyroptotic cell death","volume":"243","author":"Edward A. Miao","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2022.154599_bib0011","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3927134","article-title":"Inflammation in liver diseases","volume":"2018","author":"Feng","year":"2018","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phymed.2022.154599_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040915","article-title":"Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses","volume":"9","author":"Fousert","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2022.154599_bib0013","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jhep.2018.10.023","article-title":"Inflammatory pathways in alcoholic steatohepatitis","volume":"70","author":"Gao","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2022.154599_bib0014","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1002\/mnfr.201500878","article-title":"Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1\/ChREBP and SIRT1\/p66shc pathways in rats","volume":"60","author":"Gao","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2022.154599_bib0015","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.3389\/fimmu.2019.02670","article-title":"Contribution of macrophage efferocytosis to liver homeostasis and disease","volume":"10","author":"Horst","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2022.154599_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2022.126953","article-title":"Effects of carnosic acid on arsenic-induced liver injury in mice: a comparative transcriptomics analysis","volume":"71","author":"Jin","year":"2022","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.phymed.2022.154599_bib0017","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13046-020-01782-w","article-title":"Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARalpha to activate the NF-kappaB signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance","volume":"40","author":"Kong","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2022.154599_bib0018","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.phymed.2022.154599_bib0019","doi-asserted-by":"crossref","first-page":"237","DOI":"10.35946\/arcr.v37.2.08","article-title":"The role of innate immunity in alcoholic liver disease","volume":"37","author":"Nagy","year":"2015","journal-title":"Alcoholic Res. Curr. Rev."},{"key":"10.1016\/j.phymed.2022.154599_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22042139","article-title":"The purinergic P2X7 receptor-NLRP3 inflammasome pathway: a new target in alcoholic liver disease?","volume":"22","author":"Le Dare","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.154599_bib0021","article-title":"Carnosic acid attenuates an early increase in ROS levels during adipocyte differentiation by suppressing translation of Nox4 and inducing translation of antioxidant enzymes","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2022.154599_bib0022","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/gutjnl-2016-311861","article-title":"MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47(phox)-oxidative stress pathway in neutrophils","volume":"66","author":"Li","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2022.154599_bib0023","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3389\/fimmu.2019.01328","article-title":"Recent insights into the role of immune cells in alcoholic liver disease","volume":"10","author":"Li","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2022.154599_bib0024","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/bph.14145","article-title":"Liver kinase B1\/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis","volume":"175","author":"Li","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154599_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/949157","article-title":"Innate immune cells in liver inflammation","volume":"2012","author":"Liaskou","year":"2012","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.phymed.2022.154599_bib0026","doi-asserted-by":"crossref","first-page":"14672","DOI":"10.3748\/wjg.v20.i40.14672","article-title":"Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver","volume":"20","author":"Liu","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2022.154599_bib0027","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2022.154599_bib0028","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1530-0277.2008.00827.x","article-title":"Molecular mechanisms of alcoholic fatty liver","volume":"33","author":"Purohit","year":"2009","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.phymed.2022.154599_bib0029","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1038\/cddis.2012.144","article-title":"ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation","volume":"3","author":"Riteau","year":"2012","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2022.154599_bib0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.phymed.2022.154599_bib0031","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ajg.2017.469","article-title":"ACG clinical guideline: alcoholic liver disease","volume":"113","author":"Singal","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.phymed.2022.154599_bib0032","first-page":"193","article-title":"Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS","volume":"42","author":"Song","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2022.154599_bib0033","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/hep.23337","article-title":"Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity","volume":"51","author":"Stienstra","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2022.154599_bib0034","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2022.154599_bib0035","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1189\/jlb.6A0114-004RR","article-title":"Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice","volume":"96","author":"Wang","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.phymed.2022.154599_bib0036","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.29129","article-title":"Inflammation is independent of steatosis in a murine model of steatohepatitis","volume":"66","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2022.154599_bib0037","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1007\/s10753-021-01442-x","article-title":"Neutrophil-induced liver injury and interactions between neutrophils and liver sinusoidal endothelial cells","volume":"44","author":"Wang","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2022.154599_bib0038","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","author":"Wu","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.phymed.2022.154599_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.708978","article-title":"Hepatic macrophage as a key player in fatty liver disease","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2022.154599_bib0040","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11011-016-9941-8","article-title":"Carnosic acid protects non-alcoholic fatty liver-induced dopaminergic neuron injury in rats","volume":"32","author":"Xu","year":"2016","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.phymed.2022.154599_bib0041","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1111\/bph.14766","article-title":"Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers","volume":"176","author":"Yin","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154599_bib0042","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3389\/fphar.2017.00976","article-title":"Carnosic acid alleviates BDL-induced liver fibrosis through miR-29b-3p-mediated inhibition of the high-mobility group box 1\/Toll-like receptor 4 signaling pathway in rats","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154599_bib0043","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1111\/bph.15007","article-title":"P2X7 receptor-targeted regulation by tetrahydroxystilbene glucoside in alcoholic hepatosteatosis: a new strategy towards macrophage-hepatocyte crosstalk","volume":"177","author":"Zhang","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2022.154599_bib0044","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.ajpath.2011.11.017","article-title":"Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis","volume":"180","author":"Zhong","year":"2012","journal-title":"Am. J. Pathol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322006870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322006870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:39:15Z","timestamp":1760553555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322006870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":44,"alternative-id":["S0944711322006870"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154599","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carnosic acid suppressed the formation of NETs in alcoholic hepatosteatosis based on P2X7R-NLRP3 axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154599","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"154599"}}