{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:49:53Z","timestamp":1792547393322,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873185"],"award-info":[{"award-number":["81873185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860773"],"award-info":[{"award-number":["81860773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.phymed.2022.154640","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T09:16:03Z","timestamp":1672564563000},"page":"154640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis"],"prefix":"10.1016","volume":"110","author":[{"given":"Xiaoli","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-5377","authenticated-orcid":false,"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phymed.2022.154640_bib0001","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00296-020-04731-0","article-title":"The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review","volume":"41","author":"Almutairi","year":"2021","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.phymed.2022.154640_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112847","article-title":"The enhanced mitochondrial dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK\/Sirt 1\/NF-\u03baB pathway activation","volume":"149","author":"Bai","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.phymed.2022.154640_bib0003","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrrheum.2012.190","article-title":"Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors","volume":"9","author":"Bottini","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7","key":"10.1016\/j.phymed.2022.154640_bib0004","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrrheum.2017.95","article-title":"Managing rheumatic and musculoskeletal diseases-past, present and future","volume":"13","author":"Burmester","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7","key":"10.1016\/j.phymed.2022.154640_bib0005","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2006.06.010","article-title":"Mitochondria: dynamic organelles in disease, aging, and development","volume":"125","author":"Chan","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2022.154640_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172799","article-title":"Osthole ameliorates cartilage degradation by downregulation of NF-\u03baB and HIF-2\u03b1 pathways in an osteoarthritis murine model","volume":"867","author":"Chern","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2022.154640_bib0007","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.mcna.2020.10.006","article-title":"Rheumatoid arthritis: early diagnosis and treatment","volume":"105","author":"Cush","year":"2021","journal-title":"Med. Clin. North Am."},{"issue":"9","key":"10.1016\/j.phymed.2022.154640_bib0008","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/art.39269","article-title":"Perspectives from masters in rheumatology and autoimmunity: can we get closer to a cure for rheumatoid arthritis?","volume":"67","author":"Feldmann","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"10.1016\/j.phymed.2022.154640_bib0009","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/art.20221","article-title":"Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate","volume":"50","author":"Genovese","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.phymed.2022.154640_bib0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.phymed.2022.154640_bib0011","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1080\/15548627.2016.1166318","article-title":"Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways","volume":"12","author":"Huang","year":"2016","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.phymed.2022.154640_bib0012","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.bbrc.2006.10.138","article-title":"Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells","volume":"351","author":"Jhun","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.phymed.2022.154640_bib0013","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.smim.2013.10.018","article-title":"Interleukin-1\u03b2 in innate inflammation, autophagy and immunity","volume":"25","author":"Joosten","year":"2013","journal-title":"Semin. Immunol."},{"issue":"12","key":"10.1016\/j.phymed.2022.154640_bib0014","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/nm.2050","article-title":"Synovial fibroblasts spread rheumatoid arthritis to unaffected joints","volume":"15","author":"Lef\u00e8vre","year":"2009","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.phymed.2022.154640_bib0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/08830185.2017.1363198","article-title":"Redox-sensitive transcription factors play a significant role in the development of rheumatoid arthritis","volume":"37","author":"Le","year":"2018","journal-title":"Int. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.phymed.2022.154640_bib0016","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/BOR.0b013e32832a2e16","article-title":"Environmental influences on risk for rheumatoid arthritis","volume":"21","author":"Liao","year":"2009","journal-title":"Curr. Opin. Rheumatol."},{"issue":"2","key":"10.1016\/j.phymed.2022.154640_bib0017","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10067-020-05263-5","article-title":"Potential role of mitochondria in synoviocytes","volume":"40","author":"Li","year":"2021","journal-title":"Clin. Rheumatol."},{"issue":"7","key":"10.1016\/j.phymed.2022.154640_bib0018","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00011-019-01244-w","article-title":"TNF\u03b1\/calreticulin dual signaling induced NLRP3 inflammasome activation associated with HuR nucleocytoplasmic shuttling in rheumatoid arthritis","volume":"68","author":"Liu","year":"2019","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.phymed.2022.154640_bib0019","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fphar.2020.00335","article-title":"Traditional Chinese medicine of angelicae pubescentis radix: a review of phytochemistry, pharmacology and pharmacokinetics","volume":"11","author":"Lu","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2022.154640_bib0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1113\/jphysiol.2006.108324","article-title":"AMPK and cell proliferation\u2013AMPK as a therapeutic target for atherosclerosis and cancer","volume":"574","author":"Motoshima","year":"2006","journal-title":"J. Physiol."},{"issue":"10","key":"10.1016\/j.phymed.2022.154640_bib0021","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.molmed.2010.07.004","article-title":"Rheumatoid arthritis progression mediated by activated synovial fibroblasts","volume":"16","author":"Neumann","year":"2010","journal-title":"Trends Mol. Med."},{"issue":"6","key":"10.1016\/j.phymed.2022.154640_bib0022","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41584-020-0413-5","article-title":"Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes","volume":"16","author":"Nygaard","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1\u20132","key":"10.1016\/j.phymed.2022.154640_bib0024","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10354-015-0344-y","article-title":"Anti-TNF in rheumatoid arthritis: an overview","volume":"165","author":"Radner","year":"2015","journal-title":"Wien. Med. Wochenschr."},{"issue":"11","key":"10.1016\/j.phymed.2022.154640_bib0025","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.3390\/cells10112857","article-title":"Management of rheumatoid arthritis: an overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.phymed.2022.154640_bib0026","first-page":"2628","article-title":"Stochastic processes in the causation of rheumatic disease","volume":"29","author":"Roberts-Thomson","year":"2002","journal-title":"J. Rheumatol."},{"issue":"7","key":"10.1016\/j.phymed.2022.154640_bib0027","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.autrev.2018.01.020","article-title":"NLRP3: a promising therapeutic target for autoimmune diseases","volume":"17","author":"Shen","year":"2018","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.phymed.2022.154640_bib0028","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.trsl.2015.05.006","article-title":"Targeting inflammation in the prevention of cardiovascular disease in patients with inflammatory arthritis","volume":"167","author":"Shen","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.phymed.2022.154640_bib0029","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"10055","key":"10.1016\/j.phymed.2022.154640_bib0030","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.phymed.2022.154640_bib0031","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00044-021-02775-w","article-title":"Osthole: an overview of its sources, biological activities, and modification development","volume":"30","author":"Sun","year":"2021","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.phymed.2022.154640_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104604","article-title":"Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica Pubescens","volume":"107","author":"Tian","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"7","key":"10.1016\/j.phymed.2022.154640_bib0033","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/rheumatology\/keu016","article-title":"Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes","volume":"53","author":"Valc\u00e1rcel-Ares","year":"2014","journal-title":"Rheumatology (Oxford)"},{"issue":"7512","key":"10.1016\/j.phymed.2022.154640_bib0034","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature13322","article-title":"Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis","volume":"512","author":"Vande","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2022.154640_bib0035","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.2147\/DDDT.S256850","article-title":"Dexamethasone-loaded thermosensitive hydrogel suppresses inflammation and pain in collagen-induced arthritis rats","volume":"14","author":"Wang","year":"2020","journal-title":"Drug. Des. Dev. Ther."},{"issue":"8","key":"10.1016\/j.phymed.2022.154640_bib0036","doi-asserted-by":"crossref","first-page":"e5389","DOI":"10.1002\/bmc.5389","article-title":"A novel method for investigating the mechanism of the anti-rheumatoid arthritis activity of Angelicae pubescentis radix by integrating UHPLC-QTOF\/MS and network pharmacology","volume":"36","author":"Wang","year":"2022","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.phymed.2022.154640_bib0037","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s11658-018-0086-0","article-title":"Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress","volume":"23","author":"Xu","year":"2018","journal-title":"Cell Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.phymed.2022.154640_bib0038","doi-asserted-by":"crossref","first-page":"5","DOI":"10.23937\/2469-5726\/1510005","article-title":"Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation","volume":"1","author":"Yan","year":"2015","journal-title":"J. Rheum. Dis. Treat."},{"key":"10.1016\/j.phymed.2022.154640_bib0039","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3389\/fimmu.2019.01395","article-title":"Regulation of immune responses and chronic inflammation by fibroblast-like synoviocytes","volume":"10","author":"Yoshitomi","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2022.154640_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107819","article-title":"Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation","volume":"97","author":"Yue","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"18","key":"10.1016\/j.phymed.2022.154640_bib0041","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.2174\/1389557520666200709175948","article-title":"Osthole: a multifunctional natural compound with potential anticancer, antioxidant and anti-inflammatory activities","volume":"21","author":"Zafar","year":"2021","journal-title":"Mini. Rev. Med. Chem."},{"issue":"7329","key":"10.1016\/j.phymed.2022.154640_bib0042","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322007279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711322007279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:31:13Z","timestamp":1778776273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711322007279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":41,"alternative-id":["S0944711322007279"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154640","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2022.154640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154640"}}