{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:20:25Z","timestamp":1792794025883,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81622051"],"award-info":[{"award-number":["81622051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174047"],"award-info":[{"award-number":["82174047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.phymed.2023.154644","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T20:38:59Z","timestamp":1672778339000},"page":"154644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"special_numbering":"C","title":["Gomisin N attenuated cerebral ischemia-reperfusion injury through inhibition of autophagy by activating the PI3K\/AKT\/mTOR pathway"],"prefix":"10.1016","volume":"110","author":[{"given":"Ruoqi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-0378","authenticated-orcid":false,"given":"Xiang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.154644_bib0001","first-page":"3705","article-title":"Effect of autophagy on myocardial infarction and its mechanism","volume":"21","author":"Aisa","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2023.154644_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107848","article-title":"Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics","volume":"225","author":"Ajoolabady","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2023.154644_bib0003","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jphs.2016.09.004","article-title":"Gomisin N ameliorates lipopolysaccharide-induced depressive-like behaviors by attenuating inflammation in the hypothalamic paraventricular nucleus and central nucleus of the amygdala in mice","volume":"132","author":"Araki","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2023.154644_bib0004","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature09204","article-title":"Network organization of the human autophagy system","volume":"466","author":"Behrends","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2023.154644_bib0005","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3892\/ijmm.2017.3008","article-title":"The PI3K\/Akt\/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells","volume":"40","author":"Chang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2023.154644_bib0006","doi-asserted-by":"crossref","first-page":"e61590","DOI":"10.1371\/journal.pone.0061590","article-title":"Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2023.154644_bib0007","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"20","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2023.154644_bib0008","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.2353\/ajpath.2009.090463","article-title":"Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms","volume":"175","author":"Ginet","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2023.154644_bib0009","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.phymed.2023.154644_bib0010","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s10753-016-0482-4","article-title":"Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells","volume":"40","author":"Hosokawa","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2023.154644_bib0011","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1089\/dna.2019.4767","article-title":"Advances on Cell Autophagy and Its Potential Regulatory Factors in Renal Ischemia-Reperfusion Injury","volume":"38","author":"Hou","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.phymed.2023.154644_bib0012","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jns.2019.03.015","article-title":"The progress of neuronal autophagy in cerebral ischemia stroke: mechanisms, roles and research methods","volume":"400","author":"Hou","year":"2019","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.phymed.2023.154644_bib0013","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1248\/cpb.27.1383","article-title":"The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin","volume":"27","author":"Ikeya","year":"1979","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phymed.2023.154644_bib0014","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1248\/bpb.b15-01020","article-title":"Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis","volume":"39","author":"Jang","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2023.154644_bib0015","doi-asserted-by":"crossref","first-page":"160","DOI":"10.5853\/jos.2019.00584","article-title":"tPA Helpers in the Treatment of Acute Ischemic Stroke: are They Ready for Clinical Use?","volume":"21","author":"Kim","year":"2019","journal-title":"J. Stroke"},{"key":"10.1016\/j.phymed.2023.154644_bib0016","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.3892\/mmr.2015.3618","article-title":"Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice","volume":"12","author":"Lee","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2023.154644_bib0017","doi-asserted-by":"crossref","first-page":"e11002","DOI":"10.15252\/emmm.201911002","article-title":"Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke","volume":"12","author":"Li","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.phymed.2023.154644_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107216","article-title":"Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: potential mechanisms, targets, therapeutic drugs and biomarkers","volume":"90","author":"Ma","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2023.154644_bib0019","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4103\/1673-5374.274331","article-title":"Autophagy and inflammation in ischemic stroke","volume":"15","author":"Mo","year":"2020","journal-title":"Neural. Regen. Res."},{"key":"10.1016\/j.phymed.2023.154644_bib0020","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.3390\/ijms19092601","article-title":"Gomisin N Alleviates Ethanol-Induced Liver Injury through Ameliorating Lipid Metabolism and Oxidative Stress","volume":"19","author":"Nagappan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.154644_bib0021","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4161\/auto.6.8.13426","article-title":"p62\/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both","volume":"6","author":"Narendra","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2023.154644_bib0022","doi-asserted-by":"crossref","first-page":"e51469","DOI":"10.1371\/journal.pone.0051469","article-title":"Autophagy and apoptosis are differentially induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra","volume":"7","author":"Pamenter","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2023.154644_bib0023","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.154644_bib0024","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jep.2008.04.020","article-title":"Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine","volume":"118","author":"Panossian","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.phymed.2023.154644_bib0025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.semcancer.2019.06.002","article-title":"Akt in cancer: mediator and more","volume":"59","author":"Revathidevi","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phymed.2023.154644_bib0026","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.2174\/0929867327666200812221022","article-title":"Drug repurposing: promises of edaravone target drug in traumatic brain injury","volume":"28","author":"Shakkour","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phymed.2023.154644_bib0027","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2174\/1570159X18666200729101913","article-title":"The Role of Autophagy in the Pathogenesis of Ischemic Stroke","volume":"19","author":"Shi","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.phymed.2023.154644_bib0028","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pneurobio.2018.01.001","article-title":"Autophagy in ischemic stroke","volume":"163-164","author":"Wang","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2023.154644_bib0029","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1161\/STROKEAHA.113.003823","article-title":"Effects of tissue plasminogen activator and annexin A2 combination therapy on long-term neurological outcomes of rat focal embolic stroke","volume":"45","author":"Wang","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2023.154644_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113684","article-title":"An updated review of autophagy in ischemic stroke: from mechanisms to therapies","volume":"340","author":"Wang","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2023.154644_bib0031","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/cns.12005","article-title":"A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injury","volume":"18","author":"Wei","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2023.154644_bib0032","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3390\/cells8091075","article-title":"Roles of mTOR Signaling in Tissue Regeneration","volume":"8","author":"Wei","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2023.154644_bib0033","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4161\/auto.8.1.18217","article-title":"Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction","volume":"8","author":"Xing","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2023.154644_bib0034","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.wneu.2017.01.091","article-title":"Risk factors for hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: a retrospective single-center study","volume":"101","author":"Xu","year":"2017","journal-title":"World Neurosurg."},{"key":"10.1016\/j.phymed.2023.154644_bib0035","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.semcancer.2019.04.001","article-title":"Emerging role of PI3K\/AKT in tumor-related epigenetic regulation","volume":"59","author":"Yang","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phymed.2023.154644_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153526","article-title":"Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK\/mTOR-mediated autophagy","volume":"85","author":"Yang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.154644_bib0037","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.fitote.2014.04.017","article-title":"Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system","volume":"96","author":"Zhang","year":"2014","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2023.154644_bib0038","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.4161\/auto.25132","article-title":"Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance","volume":"9","author":"Zhang","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2023.154644_bib0039","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2147\/DDDT.S204958","article-title":"Emodin-induced autophagy against cell apoptosis through the PI3K\/AKT\/mTOR pathway in human hepatocytes","volume":"13","author":"Zheng","year":"2019","journal-title":"Drug Des., Devel. Therapy"},{"key":"10.1016\/j.phymed.2023.154644_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105975","article-title":"Investigation on the potential targets of Astragaloside IV against intracerebral hemorrhage based on network pharmacology and experimental validation","volume":"127","author":"Zheng","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2023.154644_bib0041","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1248\/bpb.b20-00030","article-title":"Gomisin N Exerts Anti-liver Cancer Effects and Regulates PI3K-Akt and mTOR-ULK1 Pathways in Vitro","volume":"43","author":"Zhu","year":"2020","journal-title":"Biol. Pharm. Bull."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323000041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323000041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:42:55Z","timestamp":1760553775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323000041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":41,"alternative-id":["S0944711323000041"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154644","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gomisin N attenuated cerebral ischemia-reperfusion injury through inhibition of autophagy by activating the PI3K\/AKT\/mTOR pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154644"}}