{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:30:31Z","timestamp":1793370631734,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.phymed.2023.154689","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T02:53:48Z","timestamp":1676429628000},"page":"154689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Kaempferol with Verapamil impeded panoramic chemoevasion pathways in breast cancer through ROS overproduction and disruption of lysosomal biogenesis"],"prefix":"10.1016","volume":"113","author":[{"given":"Sourav Kumar","family":"Nandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloy","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanaya","family":"Roychowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayan","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaiya","family":"Moiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnendu","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diptendra Kumar","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pubali","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitava","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6613-8481","authenticated-orcid":false,"given":"Rittwika","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.phymed.2023.154689_bib0001","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.ajem.2018.08.045","article-title":"Correlation between sodium, potassium, hemoglobin, hematocrit, and glucose values as measured by a laboratory autoanalyzer and a blood gas analyzer","volume":"37","author":"Altunok","year":"2019","journal-title":"Am. J. Emerg. Med."},{"issue":"25","key":"10.1016\/j.phymed.2023.154689_bib0002","doi-asserted-by":"crossref","first-page":"17635","DOI":"10.1074\/jbc.M800109200","article-title":"Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells","volume":"283","author":"Bourguignon","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.phymed.2023.154689_bib0003","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nsb1203-980","article-title":"Announcing the worldwide Protein Data Bank","volume":"10","author":"Berman","year":"2003","journal-title":"Nat. Struct. Biol."},{"issue":"3","key":"10.1016\/j.phymed.2023.154689_bib0004","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/japplphysiol.00268.2006","article-title":"Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1alpha and its downstream target genes","volume":"101","author":"Calvert","year":"2006","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.phymed.2023.154689_bib0005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12885-019-5397-7","article-title":"Increased NHE1 expression is targeted by specific inhibitor cariporide to sensitize resistant breast cancer cells to doxorubicin in vitro and in vivo","volume":"19","author":"Chen","year":"2019","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.phymed.2023.154689_bib0006","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/15321810500403722","article-title":"A quantitative nitroblue tetrazolium assay for determining intracellular superoxide anion production in phagocytic cells","volume":"27","author":"Choi","year":"2006","journal-title":"J. Immunoassay Immunochem."},{"issue":"11","key":"10.1016\/j.phymed.2023.154689_bib0007","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A BOILED-Egg to predict gastrointestinal absorption and brain penetration of small molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"issue":"6","key":"10.1016\/j.phymed.2023.154689_bib0008","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/j.1939-4640.2003.tb03137.x","article-title":"Utility of the nitroblue tetrazolium reduction test for assessment of reactive oxygen species production by seminal leukocytes and spermatozoa","volume":"24","author":"Esfandiari","year":"2003","journal-title":"J. Androl."},{"issue":"22","key":"10.1016\/j.phymed.2023.154689_bib0009","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.7150\/thno.28721","article-title":"CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism","volume":"8","author":"Gao","year":"2018","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.phymed.2023.154689_bib0010","doi-asserted-by":"crossref","first-page":"F77","DOI":"10.1152\/ajprenal.00581.2009","article-title":"Ouabain stimulates Na-K-ATPase through a sodium\/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells","volume":"299","author":"Holthouser","year":"2010","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.phymed.2023.154689_bib0011","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.12659\/MSM.915730","article-title":"Knockdown of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) promotes autophagy and inhibits phosphatidylinositol 3-Kinase (PI3K)\/AKT\/Mammalian Target of rapamycin (mTOR) signaling pathway in ovarian cancer cells","volume":"25","author":"Huang","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.phymed.2023.154689_bib0012","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3389\/fcell.2020.00764","article-title":"An efficient nitroblue tetrazolium staining and bright-field microscopy based method for detecting and quantifying intracellular reactive oxygen species in oocytes, Cumulus cells and embryos","volume":"8","author":"Javvaji","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.phymed.2023.154689_bib0013","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.gendis.2015.07.003","article-title":"Promising molecular mechanisms responsible for gemcitabine resistance in cancer","volume":"2","author":"Jia","year":"2015","journal-title":"Genes Dis"},{"issue":"4","key":"10.1016\/j.phymed.2023.154689_bib0014","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/carcin\/bgn032","article-title":"Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells","volume":"29","author":"Jung","year":"2008","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.phymed.2023.154689_bib0015","first-page":"82","article-title":"Autophagy in cancer cell death","volume":"8","author":"Linder","year":"2019","journal-title":"Biology (Basel)."},{"issue":"5","key":"10.1016\/j.phymed.2023.154689_bib0016","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive oxygen species in cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic Res"},{"issue":"Pt B","key":"10.1016\/j.phymed.2023.154689_bib0017","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ymben.2016.11.005","article-title":"Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors","volume":"43","author":"Lorendeau","year":"2017","journal-title":"Metab. Eng."},{"key":"10.1016\/j.phymed.2023.154689_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.115887","article-title":"Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil","volume":"437","author":"Nandi","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.phymed.2023.154689_bib0020","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/bjc.1991.456","article-title":"Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression","volume":"64","author":"Nygren","year":"1991","journal-title":"Br. J. Cancer"},{"issue":"10","key":"10.1016\/j.phymed.2023.154689_bib0021","doi-asserted-by":"crossref","first-page":"e76524","DOI":"10.1371\/journal.pone.0076524","article-title":"Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer","volume":"8","author":"Rajaram","year":"2013","journal-title":"PLoS ONE"},{"issue":"14","key":"10.1016\/j.phymed.2023.154689_bib0022","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1158\/0008-5472.CAN-14-2097","article-title":"Vacuolar-ATPase inhibition blocks iron metabolism to mediate therapeutic effects in breast cancer","volume":"75","author":"Schneider","year":"2015","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.phymed.2023.154689_bib0023","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb2718","article-title":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop","volume":"15","author":"Settembre","year":"2013","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.phymed.2023.154689_bib0024","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1158\/1535-7163.MCT-06-0788","article-title":"Kaempferol induces apoptosis in glioblastoma cells through oxidative stress","volume":"6","author":"Sharma","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.phymed.2023.154689_bib0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.semcancer.2016.12.001","article-title":"Roles of pH and the Na+\/H+ exchanger NHE1 in cancer: from cell biology and animal models to an emerging translational perspective?","volume":"43","author":"Stock","year":"2017","journal-title":"Semin. Cancer Biol."},{"issue":"3","key":"10.1016\/j.phymed.2023.154689_bib0026","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3892\/ol.2021.12919","article-title":"Clinical significance of P-class pumps in cancer","volume":"22","author":"Themistocleous","year":"2021","journal-title":"Oncol Lett"},{"issue":"12","key":"10.1016\/j.phymed.2023.154689_bib0027","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/mc.21922","article-title":"Hyperglycemia of tumor microenvironment modulates stage-dependent tumor progression and multidrug resistance: implication of cell survival regulatory molecules and altered glucose transport","volume":"52","author":"Vishvakarma","year":"2013","journal-title":"Mol. Carcinog."},{"issue":"5","key":"10.1016\/j.phymed.2023.154689_bib0028","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tem.2022.02.002","article-title":"The membrane receptor CD44: novel insights into metabolism","volume":"33","author":"Weng","year":"2022","journal-title":"Rends Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.phymed.2023.154689_bib0029","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1073\/pnas.93.5.1847","article-title":"Expression of the fructose transporter GLUT5 in human breast cancer","volume":"93","author":"Zamora-Le\u00f3n","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A.,"},{"issue":"10","key":"10.1016\/j.phymed.2023.154689_bib0031","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1080\/15548627.2016.1212787","article-title":"Lysosome calcium in ROS regulation of autophagy","volume":"12","author":"Zhang","year":"2016","journal-title":"Autophagy"},{"issue":"7213","key":"10.1016\/j.phymed.2023.154689_bib0033","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In vivo reprogramming of adult pancreatic exocrine cells to beta-cells","volume":"455","author":"Zhou","year":"2008","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.phymed.2023.154689_bib0035","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/s41419-018-1227-0","article-title":"Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity","volume":"9","author":"Zhitomirsky","year":"2018","journal-title":"Cell Death. Dis."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323000491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323000491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:46:29Z","timestamp":1760553989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323000491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":31,"alternative-id":["S0944711323000491"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154689","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kaempferol with Verapamil impeded panoramic chemoevasion pathways in breast cancer through ROS overproduction and disruption of lysosomal biogenesis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154689"}}