{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:22:46Z","timestamp":1792606966293,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.phymed.2023.154710","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T03:22:53Z","timestamp":1675912973000},"page":"154710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays"],"prefix":"10.1016","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6442-8442","authenticated-orcid":false,"given":"Yanchao","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.phymed.2023.154710_bib0001","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/bcp.13490","article-title":"Critical evaluation of causality assessment of herb-drug interactions in patients","volume":"84","author":"Awortwe","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"8","key":"10.1016\/j.phymed.2023.154710_bib0002","first-page":"44","article-title":"Herb-drug interactions: worlds intersect with the patient at the center","volume":"8","author":"Babos","year":"2021","journal-title":"Medicines (Basel)"},{"issue":"6","key":"10.1016\/j.phymed.2023.154710_bib0003","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1124\/dmd.110.037663","article-title":"Studies on the metabolism and biological activity of the epimers of sulindac","volume":"39","author":"Brunell","year":"2011","journal-title":"Drug. Metab. Dispos."},{"issue":"1","key":"10.1016\/j.phymed.2023.154710_bib0004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/ptr.3473","article-title":"Assessment of extracts from mistletoe (Viscum album) for herb-drug interaction by inhibition and induction of cytochrome P450 activities","volume":"26","author":"Doehmer","year":"2012","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2023.154710_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108825","article-title":"Reviewing the mechanisms of natural product-drug interactions involving efflux transporters and metabolic enzymes","volume":"314","author":"Feltrin","year":"2019","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.phymed.2023.154710_bib0006","first-page":"318","article-title":"Caffeine, the most frequently consumed psychostimulant: a narrative review article","volume":"88","author":"Gahr","year":"2020","journal-title":"Fortschr. Neurol. Psychiatr."},{"issue":"11","key":"10.1016\/j.phymed.2023.154710_bib0007","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/s11655-021-3442-2","article-title":"Landscape of hepatobiliary adverse drug reactions related to preparations containing psoraleae fructus and its application in pharmacovigilance","volume":"27","author":"Ge","year":"2021","journal-title":"Chin. J. Integr. Med."},{"issue":"4","key":"10.1016\/j.phymed.2023.154710_bib0008","doi-asserted-by":"crossref","first-page":"493","DOI":"10.5009\/gnl.2011.5.4.493","article-title":"Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum thunb","volume":"5","author":"Jung","year":"2011","journal-title":"Gut Liver"},{"key":"10.1016\/j.phymed.2023.154710_bib0009","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1475-2891-6-33","article-title":"Medicinal importance of grapefruit juice and its interaction with various drugs","volume":"6","author":"Kiani","year":"2007","journal-title":"Nutr. J."},{"issue":"8","key":"10.1016\/j.phymed.2023.154710_bib0010","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/ptr.5365","article-title":"Modulation of cytochrome P450 Activity by 18\u03b2-glycyrrhetic acid and its consequence on buspirone pharmacokinetics in rats","volume":"29","author":"Kim","year":"2015","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.phymed.2023.154710_bib0011","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/00498254.2016.1195028","article-title":"Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities","volume":"47","author":"Kope\u010dn\u00e1-Zapletalov\u00e1","year":"2017","journal-title":"Xenobiotica"},{"issue":"2","key":"10.1016\/j.phymed.2023.154710_bib0012","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1472-8206.2004.00224.x","article-title":"Nonsteroidal anti-inflammatory drug-induced liver injury: a case-control study in primary care","volume":"18","author":"Lacroix","year":"2004","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2023.154710_bib0013","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1472-8206.2006.00416.x","article-title":"Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems","volume":"20","author":"Lapeyre-Mestre","year":"2006","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2023.154710_bib0014","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.foodchem.2012.08.069","article-title":"In vitro and in vivo assessment of cytochrome P450-mediated herb-drug interaction of Ssang-hwa-tang","volume":"136","author":"Lee","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2023.154710_bib0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fct.2015.06.004","article-title":"Systematic review on herb-induced liver injury in Korea","volume":"84","author":"Lee","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2023.154710_bib0016","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biopha.2016.06.012","article-title":"Review on mechanisms and interactions in concomitant use of herbs and warfarin therapy","volume":"83","author":"Leite","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.154710_bib0017","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2021.12.007","article-title":"Lovastatin enhances chemosensitivity of paclitaxel-resistant prostate cancer cells through inhibition of CYP2C8","volume":"589","author":"Li","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2023.154710_bib0018","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jep.2014.11.009","article-title":"Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review","volume":"159","author":"Lin","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.154710_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115437","article-title":"Herb-drug interaction between Shaoyao-Gancao-Fuzi decoction and tofacitinib via CYP450 enzymes","volume":"295","author":"Lin","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.phymed.2023.154710_bib0020","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1002\/jps.20884","article-title":"In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC\/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography","volume":"96","author":"Lin","year":"2007","journal-title":"J. Pharm. Sci."},{"issue":"15","key":"10.1016\/j.phymed.2023.154710_bib0021","first-page":"3594","article-title":"Research progress of liver injury induced by polygoni mulitiflori radix","volume":"45","author":"Ma","year":"2020","journal-title":"Chin. J. Chin. Mater. Med."},{"issue":"1","key":"10.1016\/j.phymed.2023.154710_bib0022","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1389450118666170125144557","article-title":"Cytochrome P450 structure, function and clinical significance: a review","volume":"19","author":"Manikandan","year":"2018","journal-title":"Curr. Drug. Targets"},{"key":"10.1016\/j.phymed.2023.154710_bib0023","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.toxlet.2020.01.026","article-title":"Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury","volume":"323","author":"Pan","year":"2020","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.phymed.2023.154710_bib0024","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1440-1746.2001.02309.x","article-title":"Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum","volume":"16","author":"Park","year":"2001","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.phymed.2023.154710_bib0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/1389200220666190325141422","article-title":"Herb-Drug Interactions and Hepatotoxicity","volume":"20","author":"Parvez","year":"2019","journal-title":"Curr. Drug. Metab."},{"issue":"8","key":"10.1016\/j.phymed.2023.154710_bib0026","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1080\/00498254.2021.1942311","article-title":"Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats","volume":"51","author":"Pingili","year":"2021","journal-title":"Xenobiotica"},{"key":"10.1016\/j.phymed.2023.154710_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9105261","article-title":"Green tea catechins: their use in treating and preventing infectious diseases","volume":"2018","author":"Reygaert","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"6","key":"10.1016\/j.phymed.2023.154710_bib0028","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2174\/1389200221666200620210522","article-title":"2020 FDA drug-drug interaction guidance: a comparison analysis and action plan by pharmaceutical industrial scientists","volume":"21","author":"Sudsakorn","year":"2020","journal-title":"Curr. Drug. Metab."},{"issue":"7","key":"10.1016\/j.phymed.2023.154710_bib0029","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073441","article-title":"Idiosyncratic drug induced liver injury, cytochrome P450, metabolic risk factors and lipophilicity: highlights and controversies","volume":"22","author":"Teschke","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2023.154710_bib0030","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/apt.12798","article-title":"Review article: herbal hepatotoxicity\u2013an update on traditional Chinese medicine preparations","volume":"40","author":"Teschke","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.phymed.2023.154710_bib0031","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.etap.2013.07.011","article-title":"Evaluating the inhibitory potential of sulindac against the bleomycin-induced pulmonary fibrosis in wistar rats","volume":"36","author":"Verma","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2023.154710_bib0032","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/cld.386","article-title":"Overview of drug-induced liver injury in China","volume":"4","author":"Wang","year":"2014","journal-title":"Clin. Liver. Dis. (Hoboken)"},{"issue":"1","key":"10.1016\/j.phymed.2023.154710_bib0033","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jep.2012.08.028","article-title":"Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of Fructus Psoraleae","volume":"144","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.phymed.2023.154710_bib0034","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2174\/1389200218666161123124253","article-title":"Mechanism-based inhibitors from phytomedicine: risks of hepatotoxicity and their potential hepatotoxic substructures","volume":"17","author":"Wang","year":"2016","journal-title":"Curr. Drug. Metab."},{"key":"10.1016\/j.phymed.2023.154710_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461666","article-title":"Orthogonality in the selection of biphasic solvent systems for off-line two-dimensional countercurrent chromatography from Polygonum cuspidatum Sieb. et Zucc","volume":"1634","author":"Wang","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.phymed.2023.154710_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107352","article-title":"Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury","volume":"92","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2023.154710_bib0037","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.fct.2018.12.047","article-title":"Hepatotoxicity induced by psoralen and isopsoralen from Fructus Psoraleae: wistar rats are more vulnerable than ICR mice","volume":"125","author":"Wang","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2023.154710_bib0038","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jpba.2019.07.001","article-title":"Development of an UHPLC-MS\/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms","volume":"174","author":"Xie","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.phymed.2023.154710_bib0039","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jpba.2018.11.034","article-title":"Pharmacokinetic studies unveiled the drug-drug interaction between trans-2,3,5,4\u2032-tetrahydroxystilbene-2-O-\u03b2-D-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix","volume":"164","author":"Xing","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.phymed.2023.154710_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114328","article-title":"An effective strategy for distinguishing the processing degree of Polygonum multiflorum based on the analysis of substance and taste by LC-MS, ICP-OES and electronic tongue","volume":"205","author":"Xing","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.phymed.2023.154710_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113121","article-title":"A review of the processed Polygonum multiflorum (Thunb.) for hepatoprotection: clinical use, pharmacology and toxicology","volume":"261","author":"Xue","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.154710_bib0042","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cbi.2015.06.018","article-title":"Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2","volume":"237","author":"Yang","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2023.154710_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153287","article-title":"Herb-drug interaction between Styrax and warfarin: molecular basis and mechanism","volume":"77","author":"Zhang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.154710_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.111998","article-title":"Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: implication of herb-drug interactions in COVID-19 pharmacotherapy","volume":"149","author":"Zhang","year":"2021","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.phymed.2023.154710_bib0045","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s41401-021-00697-2","article-title":"Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb-drug interactions in antiviral therapy","volume":"43","author":"Zhang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2023.154710_bib0046","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jpba.2019.04.002","article-title":"Pharmacokinetic comparisons of major bioactive components after oral administration of raw and steamed rhubarb by UPLC-MS\/MS","volume":"171","author":"Zhang","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.phymed.2023.154710_bib0047","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jep.2013.03.005","article-title":"Rutaecarpine effects on expression of hepatic phase-1, phase-2 metabolism and transporter genes as a basis of herb-drug interactions","volume":"147","author":"Zhu","year":"2013","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323000685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323000685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:45:45Z","timestamp":1760553945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323000685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":47,"alternative-id":["S0944711323000685"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154710","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154710","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154710"}}