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Chem."},{"key":"10.1016\/j.phymed.2023.154721_bib0116","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1096\/fba.2019-00070","article-title":"Pharmacological inhibition of STAT3 pathway ameliorates acute liver injury in vivo via inactivation of inflammatory macrophages and hepatic stellate cells","volume":"2","author":"\u00d6zt\u00fcrk Akcora","year":"2020","journal-title":"FASEB Bioadv."},{"key":"10.1016\/j.phymed.2023.154721_bib0117","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2022.36.S1.L7959","article-title":"FoxO1 promotes liver fibrosis through TGF-\u03b21 mediated hepatic stellate cell activation","volume":"36","author":"Pan","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2023.154721_bib0118","doi-asserted-by":"crossref","first-page":"e23097","DOI":"10.1002\/jbt.23097","article-title":"Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl-2 in hepatic stellate cells","author":"Pang","year":"2022","journal-title":"J. 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Med."},{"key":"10.1016\/j.phymed.2023.154721_bib0130","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3390\/cells9030558","article-title":"Src inhibition attenuates liver fibrosis by preventing hepatic stellate cell activation and decreasing connective tissue growth factor","volume":"9","author":"Seo","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2023.154721_bib0131","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1007\/s11033-021-07097-z","article-title":"Effect of Quercetin on the fructose-activated human hepatic stellate cells, LX-2, an in-vitro study","volume":"49","author":"Shakerian","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.phymed.2023.154721_bib0132","first-page":"246","article-title":"m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells. Free Radic","volume":"182","author":"Shen","year":"2022","journal-title":"Biol. 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