{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:25:00Z","timestamp":1790112300652,"version":"4.0.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.phymed.2023.154747","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T09:26:03Z","timestamp":1678008363000},"page":"154747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Baicalin inhibits pressure overload-induced cardiac hypertrophy by regulating the SIRT3-dependent signaling pathway"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-222X","authenticated-orcid":false,"given":"Yi","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shisheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1559-3895","authenticated-orcid":false,"given":"Ao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichuan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingdong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6892-016X","authenticated-orcid":false,"given":"Chunpeng","family":"(Craig) Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.154747_bib0001","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.RES.0000267723.65696.4a","article-title":"Sirt1 regulates aging and resistance to oxidative stress in the heart","volume":"100","author":"Alcendor","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0002","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/01.RES.0000147557.75257.ff","article-title":"Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes","volume":"95","author":"Alcendor","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0003","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1002\/ptr.7046","article-title":"Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: a review","volume":"35","author":"Baradaran Rahimi","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0004","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev-biochem-062917-011931","article-title":"Structure and Function of the 26S Proteasome","volume":"87","author":"Bard","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.phymed.2023.154747_bib0005","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.cmet.2014.11.003","article-title":"Activation of SIRT3 by the NAD(+) precursor nicotinamide riboside protects from noise-induced hearing loss","volume":"20","author":"Brown","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2023.154747_bib0006","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.febslet.2012.02.014","article-title":"Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6","volume":"586","author":"Cai","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2023.154747_bib0007","doi-asserted-by":"crossref","first-page":"e13602","DOI":"10.1111\/apha.13602","article-title":"EGCG inhibits pressure overload-induced cardiac hypertrophy via the PSMB5\/Nmnat2\/SIRT6-dependent signalling pathways","volume":"231","author":"Cai","year":"2021","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.phymed.2023.154747_bib0008","doi-asserted-by":"crossref","first-page":"11802","DOI":"10.1038\/srep11802","article-title":"QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2023.154747_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2018.01.012","article-title":"The ubiquitin proteasome pathway in neuropsychiatric disorders","volume":"165","author":"Cheon","year":"2019","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.phymed.2023.154747_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174858","article-title":"Acacetin ameliorates cardiac hypertrophy by activating Sirt1\/AMPK\/PGC-1alpha pathway","volume":"920","author":"Cui","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154747_bib0011","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4939-8988-1_11","article-title":"CalCleaveMKL: a tool for calpain cleavage prediction","volume":"1915","author":"duVerle","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.phymed.2023.154747_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.628988","article-title":"Baicalin prevents myocardial ischemia\/reperfusion injury through inhibiting ACSL4 mediated ferroptosis","volume":"12","author":"Fan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154747_bib0013","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.18632\/aging.102862","article-title":"SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity","volume":"12","author":"Feng","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.phymed.2023.154747_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arcmed.2020.09.007","article-title":"Proteasome subunits involved in neurodegenerative diseases","volume":"52","author":"Fernandez-Cruz","year":"2021","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0015","doi-asserted-by":"crossref","first-page":"153","DOI":"10.21037\/atm.2018.04.14","article-title":"Traditional Chinese medicine Qiliqiangxin attenuates phenylephrine-induced cardiac hypertrophy via upregulating PPARgamma and PGC-1alpha","volume":"6","author":"Gao","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phymed.2023.154747_bib0016","doi-asserted-by":"crossref","first-page":"19767","DOI":"10.1074\/jbc.M117.809897","article-title":"Sirtuin 5 is required for mouse survival in response to cardiac pressure overload","volume":"292","author":"Hershberger","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.154747_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154122","article-title":"Sirtuins: research advances on the therapeutic role in acute kidney injury","volume":"101","author":"Huang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.154747_bib0018","doi-asserted-by":"crossref","first-page":"H1378","DOI":"10.1152\/ajpheart.00731.2018","article-title":"A novel traditional Chinese medicine ameliorates fatigue-induced cardiac hypertrophy and dysfunction via regulation of energy metabolism","volume":"316","author":"Huang","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phymed.2023.154747_bib0019","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2217\/dmt.13.6","article-title":"Targeting sirtuins for the treatment of diabetes","volume":"3","author":"Huynh","year":"2013","journal-title":"Diabetes Manag. (Lond.)"},{"key":"10.1016\/j.phymed.2023.154747_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116107","article-title":"Molecular pathogenesis of pulmonary fibrosis, with focus on pathways related to TGF-beta and the ubiquitin-proteasome pathway","volume":"22","author":"Inui","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.154747_bib0021","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jgg.2021.11.005","article-title":"Mitochondrial sirtuins, metabolism, and aging","volume":"49","author":"Ji","year":"2022","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.phymed.2023.154747_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2019.01.010","article-title":"Curcumin, the golden spice in treating cardiovascular diseases","volume":"38","author":"Li","year":"2020","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.phymed.2023.154747_bib0023","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4751349","article-title":"Baicalin ameliorates cognitive impairment and protects microglia from LPS-induced neuroinflammation via the SIRT1\/HMGB1 pathway","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2023.154747_bib0024","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/cvr\/cvz016","article-title":"Lansoprazole alleviates pressure overload-induced cardiac hypertrophy and heart failure in mice by blocking the activation of beta-catenin","volume":"116","author":"Lin","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110451","article-title":"Ubiquitin proteasome system (UPS) activation in the cardiac hypertrophy of hyperthyroidism","volume":"493","author":"Lino","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phymed.2023.154747_bib0026","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1111\/bph.15899","article-title":"Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy","volume":"179","author":"Liu","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154747_bib0027","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1128\/MCB.01636-07","article-title":"Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation","volume":"27","author":"Lombard","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phymed.2023.154747_bib0028","first-page":"1389","article-title":"SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity","volume":"38","author":"Luo","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phymed.2023.154747_bib0029","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1074\/jbc.M109.077271","article-title":"Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway","volume":"285","author":"Pillai","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.154747_bib0030","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1054-3589(10)59008-2","article-title":"The role of calpain in diabetes-associated platelet hyperactivation","volume":"59","author":"Randriamboavonjy","year":"2010","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154747_bib0031","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1161\/CIRCRESAHA.119.315483","article-title":"Metabolic remodeling promotes cardiac hypertrophy by directing glucose to aspartate biosynthesis","volume":"126","author":"Ritterhoff","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0032","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.yjmcc.2011.11.004","article-title":"The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging","volume":"52","author":"Sack","year":"2012","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.phymed.2023.154747_bib0033","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.trsl.2018.09.003","article-title":"Proteasome biology and therapeutics in cardiac diseases","volume":"205","author":"Shukla","year":"2019","journal-title":"Transl. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0034","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9111574","article-title":"Sirtuin 3 (SIRT3) pathways in age-related cardiovascular and neurodegenerative diseases","volume":"9","author":"Silaghi","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.phymed.2023.154747_bib0035","first-page":"2758","article-title":"Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2023.154747_bib0036","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1161\/CIRCULATIONAHA.117.028728","article-title":"SIRT2 acts as a cardioprotective deacetylase in pathological cardiac hypertrophy","volume":"136","author":"Tang","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2023.154747_bib0037","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCRESAHA.107.164558","article-title":"Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice","volume":"102","author":"Vakhrusheva","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0038","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbrc.2022.11.014","article-title":"Sirtuin 1 aggravates hypertrophic heart failure caused by pressure overload via shifting energy metabolism","volume":"637","author":"Van Le","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2023.154747_bib0039","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.2147\/CMAR.S194337","article-title":"Bortezomib sensitivity is tissue dependent and high expression of the 20S proteasome precludes good response in malignant pleural mesothelioma","volume":"11","author":"Walter","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2020.08.021","article-title":"Advances in characterization of SIRT3 deacetylation targets in mitochondrial function","volume":"179","author":"Wang","year":"2020","journal-title":"Biochimie"},{"key":"10.1016\/j.phymed.2023.154747_bib0041","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/MNH.0000000000000660","article-title":"Research progress of sirtuins in renal and cardiovascular diseases","volume":"30","author":"Wang","year":"2021","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.phymed.2023.154747_bib0042","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/s41419-021-04059-y","article-title":"Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2023.154747_bib0043","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.abb.2018.01.006","article-title":"Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK\/TGF-beta\/Smads signaling pathway","volume":"640","author":"Xiao","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2023.154747_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.583200","article-title":"Regulatory mechanisms of baicalin in cardiovascular diseases: a review","volume":"11","author":"Xin","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154747_bib0045","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.phrs.2018.08.018","article-title":"Baicalin regulates SirT1\/STAT3 pathway and restrains excessive hepatic glucose production","volume":"136","author":"Xu","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0046","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/HYPERTENSIONAHA.119.13357","article-title":"Cardiomyocyte sirt (sirtuin) 7 ameliorates stress-induced cardiac hypertrophy by interacting with and deacetylating GATA4","volume":"75","author":"Yamamura","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2023.154747_bib0047","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2174\/1871520620666200811114159","article-title":"The ubiquitin-proteasome pathway and epigenetic modifications in cancer","volume":"21","author":"Yerlikaya","year":"2021","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.phymed.2023.154747_bib0048","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.12659\/MSM.909627","article-title":"Baicalin, a Chinese herbal medicine, inhibits the proliferation and migration of human non-small cell lung carcinoma (NSCLC) Cells, A549 and H1299, by activating the SIRT1\/AMPK signaling pathway","volume":"24","author":"You","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.phymed.2023.154747_bib0049","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1002\/ptr.6340","article-title":"Baicalin reverse depressive-like behaviors through regulation SIRT1-NF-kB signaling pathway in olfactory bulbectomized rats","volume":"33","author":"Yu","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1476-5381.2012.01903.x","article-title":"Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-kappaB-dependent transcriptional activity","volume":"168","author":"Yu","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154747_bib0051","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.yexcr.2016.07.006","article-title":"NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy","volume":"347","author":"Yue","year":"2016","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0052","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1159\/000459708","article-title":"Baicalin attenuates cardiac dysfunction and myocardial remodeling in a chronic pressure-overload mice model","volume":"41","author":"Zhang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.phymed.2023.154747_bib0053","doi-asserted-by":"crossref","DOI":"10.1177\/1479164120977441","article-title":"Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice","volume":"17","author":"Zhao","year":"2020","journal-title":"Diab. Vasc. Dis. Res."},{"key":"10.1016\/j.phymed.2023.154747_bib0054","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1038\/s41401-021-00828-9","article-title":"S-nitrosylation of Hsp90 promotes cardiac hypertrophy in mice through GSK3beta signaling","volume":"43","author":"Zhao","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2023.154747_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.858330","article-title":"Redox homeostasis in cardiovascular disease: the role of mitochondrial sirtuins","volume":"13","author":"Zullo","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323001058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323001058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:44:16Z","timestamp":1760553856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323001058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":55,"alternative-id":["S0944711323001058"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154747","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalin inhibits pressure overload-induced cardiac hypertrophy by regulating the SIRT3-dependent signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154747","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154747"}}