{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:30:57Z","timestamp":1792632657676,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["K921310261"],"award-info":[{"award-number":["K921310261"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.phymed.2023.154797","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T21:15:17Z","timestamp":1680124517000},"page":"154797","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Modified Erchen decoction ameliorates cognitive dysfunction in vascular dementia rats via inhibiting JAK2\/STAT3 and JNK\/BAX signaling pathways"],"prefix":"10.1016","volume":"114","author":[{"given":"Yinhuang","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuting","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.154797_bib0001","doi-asserted-by":"crossref","first-page":"E29","DOI":"10.1111\/chf.12025","article-title":"Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure","volume":"19","author":"Alosco","year":"2013","journal-title":"Congest. Heart Fail."},{"key":"10.1016\/j.phymed.2023.154797_bib0002","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1007\/s12035-018-1225-3","article-title":"Spatial dynamics of vascular and biochemical injury in rat hippocampus following striatal injury and abeta toxicity","volume":"56","author":"Amtul","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2023.154797_bib0003","doi-asserted-by":"crossref","first-page":"8833","DOI":"10.3390\/molecules16108833","article-title":"Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects","volume":"16","author":"Bae","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.154797_bib0004","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1212\/WNL.0b013e318295d71a","article-title":"Severe carotid stenosis and impaired cerebral hemodynamics can influence cognitive deterioration","volume":"80","author":"Balestrini","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.phymed.2023.154797_bib60","doi-asserted-by":"crossref","first-page":"106827","DOI":"10.1016\/j.vph.2020.106827","article-title":"Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dementia","volume":"137","author":"Bhatia","year":"2021","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154797_bib0005","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S2213-8587(13)70088-3","article-title":"Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions","volume":"2","author":"Biessels","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.phymed.2023.154797_bib0007","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/jnnp-2011-301308","article-title":"Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum","volume":"83","author":"Charidimou","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.phymed.2023.154797_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114645","article-title":"Protective effect of the combination of essential oil from patchouli and tangerine peel against gastric ulcer in rats","volume":"282","author":"Chen","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.154797_bib0009","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0149-7634(01)00011-2","article-title":"A detailed ethological analysis of the mouse open \u00aeeld test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic \u00aeeld","volume":"23","author":"Choleris","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phymed.2023.154797_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.846631","article-title":"Sigesbeckia orientalis L. Derived active fraction ameliorates perioperative neurocognitive disorders through alleviating hippocampal neuroinflammation","volume":"13","author":"Chu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154797_bib0011","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0028-3908(99)00009-X","article-title":"Effects of repeated fluoxetine on anxiety-related behaviours, central serotonergic systems, and the corticotropic axis in HR and WKY rats","volume":"38","author":"Durand","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2023.154797_bib0012","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cca.2015.07.017","article-title":"Evaluation of dementia by acrolein, amyloid-beta and creatinine","volume":"450","author":"Igarashi","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2023.154797_bib0013","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fcell.2020.00117","article-title":"A positive feedback loop of hippo- and c-Jun-amino-terminal kinase signaling pathways regulates amyloid-beta-mediated neurodegeneration","volume":"8","author":"Irwin","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2023.154797_bib0014","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnagi.2013.00017","article-title":"Pathology and pathogenesis of vascular cognitive impairment-a critical update","volume":"5","author":"Jellinger","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.phymed.2023.154797_bib0015","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/ijms21041505","article-title":"Lipids and Alzheimer\u2019s disease","volume":"21","author":"Kao","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.154797_bib0016","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/08977194.2012.660936","article-title":"Biology and significance of the JAK\/STAT signalling pathways","volume":"30","author":"Kiu","year":"2012","journal-title":"Growth Factors"},{"key":"10.1016\/j.phymed.2023.154797_bib61","doi-asserted-by":"crossref","first-page":"730672","DOI":"10.3389\/fimmu.2021.730672","article-title":"Production of IL-6 and Phagocytosis Are the Most Resilient Immune Functions in Metabolically Compromised Human Monocytes","volume":"12","author":"Krauss","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2023.154797_bib0017","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neures.2017.04.012","article-title":"Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats","volume":"123","author":"Kuniishi","year":"2017","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.phymed.2023.154797_bib0018","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12944-019-1072-x","article-title":"Active compound chrysophanol of Cassia tora seeds suppresses heat-induced lipogenesis via inactivation of JNK\/p38 MAPK signaling in human sebocytes","volume":"18","author":"Kwon","year":"2019","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.phymed.2023.154797_bib68","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.chroma.2016.10.033","article-title":"Comprehensive chemical profiling of Pinellia species tuber and processed Pinellia tuber by gas chromatography-mass spectrometry and liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry","volume":"1471","author":"Lee","year":"2016","journal-title":"J. Chromatogr A"},{"key":"10.1016\/j.phymed.2023.154797_bib57","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1080\/21691401.2019.1632322","article-title":"OB-RGRP regulates the phosphorylation of JAK2 and STAT3 in primary rat adipocytes","volume":"47","author":"Li","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.phymed.2023.154797_bib0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbi.2022.06.003","article-title":"Mitofusin 2 confers the suppression of microglial activation by cannabidiol: insights from in vitro and in vivo models","volume":"104","author":"Li","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phymed.2023.154797_bib62","first-page":"154","article-title":"Research Progress on Chemical Constituents and Pharmacological Effects of Banxia (Pinelliae Rhizoma)","volume":"23","author":"Li","year":"2021","journal-title":"Journal of Liaoning University of TCM"},{"key":"10.1016\/j.phymed.2023.154797_bib0021","first-page":"509","article-title":"Clinical study on vascular dementia of phlegm and blood stasis obstructing collateral syndrome treated by siwu erchen decoction and its disassembled prescriptions","volume":"35","author":"Lu","year":"2016","journal-title":"Shandong J. Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2023.154797_bib0022","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.phymed.2018.09.009","article-title":"Anti-renal fibrosis effect of asperulosidic acid via TGF-beta1\/smad2\/smad3 and NF-kappaB signaling pathways in a rat model of unilateral ureteral obstruction","volume":"53","author":"Lu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.154797_bib67","first-page":"1163","article-title":"Experimental Research in Decoction and Alcohol Sedimentation Technique of Herba Leonuri Combined with Rhizoma Chuanxiong","volume":"10","author":"Luo","year":"2007","journal-title":"China Pharmacist"},{"key":"10.1016\/j.phymed.2023.154797_bib0023","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s40478-021-01293-5","article-title":"STAT3 inhibitor mitigates cerebral amyloid angiopathy and parenchymal amyloid plaques while improving cognitive functions and brain networks","volume":"9","author":"Mehla","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.phymed.2023.154797_bib0024","article-title":"Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4\/NF-kappaB signaling","volume":"11, 648","author":"Muhammad","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2023.154797_bib0025","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41586-021-04212-9","article-title":"Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter","volume":"601","author":"Niu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2023.154797_bib0026","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O'Brien","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2023.154797_bib65","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.sjbs.2018.04.007","article-title":"1H-NMR based metabolite profiling for optimizing the ethanol extraction of Wolfiporia cocos","volume":"25","author":"Oh","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.phymed.2023.154797_bib0027","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1037\/neu0000335","article-title":"Triglycerides are negatively correlated with cognitive function in nondemented aging adults","volume":"31","author":"Parthasarathy","year":"2017","journal-title":"Neuropsychology"},{"key":"10.1016\/j.phymed.2023.154797_bib0028","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.46928","article-title":"Restricted mean survival time analysis to estimate SGLT2i-associated heterogeneous treatment effects on primary and secondary prevention of cardiorenal outcomes in patients with type 2 diabetes in Taiwan","volume":"5","author":"Peng","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.phymed.2023.154797_bib0029","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.physbeh.2014.11.053","article-title":"Preliminary evidence that abscisic acid improves spatial memory in rats","volume":"139","author":"Qi","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.phymed.2023.154797_bib70","first-page":"1418","article-title":"Chemical study on aerial parts of Ligusticum chuanxiong","volume":"32","author":"Ren","year":"2007","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.phymed.2023.154797_bib69","doi-asserted-by":"crossref","first-page":"125308","DOI":"10.1016\/j.foodchem.2019.125308","article-title":"Effect of microwave blanching on antioxidant activity, phenolic compounds and browning behaviour of some fruit peelings","volume":"302","author":"Romelle","year":"2020","journal-title":"Food Chem"},{"key":"10.1016\/j.phymed.2023.154797_bib0030","first-page":"193","article-title":"Research progress on traditional Chinese medicine in the treatment ofvascular dementia","volume":"20","author":"Ruofei","year":"2022","journal-title":"Chin. Med. Mod. Distance Educ. China"},{"key":"10.1016\/j.phymed.2023.154797_bib0031","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neuroscience.2013.07.055","article-title":"Spatial memory impairments in a prediabetic rat model","volume":"250","author":"Soares","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2023.154797_bib0032","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbr.2013.04.010","article-title":"Cognitive impairment and persistent anxiety-related responses following bilateral common carotid artery occlusion in mice","volume":"249","author":"Soares","year":"2013","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.phymed.2023.154797_bib0033","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2803496","article-title":"Erchen plus huiyanzhuyu decoction inhibits the growth of laryngeal carcinoma in a mouse model of phlegm-coagulation-blood-stasis syndrome via the STAT3\/Cyclin D1 pathway","volume":"2020","author":"Tan","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2023.154797_bib0034","doi-asserted-by":"crossref","first-page":"e24361","DOI":"10.1371\/journal.pone.0024361","article-title":"Activation of JNK signaling mediates amyloid-ss-dependent cell death","volume":"6","author":"Tare","year":"2011","journal-title":"PLOS One"},{"key":"10.1016\/j.phymed.2023.154797_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153637","article-title":"Uncovering the mechanism of the Shenzhi Jiannao formula against vascular dementia using a combined network pharmacology approach and molecular biology","volume":"90","author":"Tian","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.154797_bib0036","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1142\/S0192415X13500699","article-title":"Curcumin induces ABCA1 expression and apolipoprotein A-I-mediated cholesterol transmembrane in the chronic cerebral hypoperfusion aging rats","volume":"41","author":"Tian","year":"2013","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2023.154797_bib0037","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1038\/sj.emboj.7600194","article-title":"JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins","volume":"23","author":"Tsuruta","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.phymed.2023.154797_bib0038","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1007\/s12035-021-02283-3","article-title":"Targeting insulin resistance to treat cognitive dysfunction","volume":"58","author":"Tyagi","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2023.154797_bib0039","doi-asserted-by":"crossref","first-page":"18003","DOI":"10.1038\/nrdp.2018.3","article-title":"Vascular cognitive impairment","volume":"4","author":"Van der Flier","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.phymed.2023.154797_bib0040","article-title":"The potential mechanisms of cinobufotalin treating colon adenocarcinoma by network pharmacology","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154797_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111696","article-title":"Neuroprotective effects of Senkyunolide I against glutamate-induced cells death by attenuating JNK\/caspase-3 activation and apoptosis","volume":"140","author":"Wang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.154797_bib0042","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3390\/antiox10121958","article-title":"Jak2 inhibitor AG490 improved poststroke central and peripheral inflammation and metabolic abnormalities in a rat model of ischemic stroke","volume":"10","author":"Wang","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2023.154797_bib0043","first-page":"9601","article-title":"Inflammation, apoptosis and autophagy as critical players in vascular dementia","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2023.154797_bib0044","series-title":"Global Action Plan On the Public Health Response to Dementia 2017\u20132025","first-page":"44","year":"2017"},{"key":"10.1016\/j.phymed.2023.154797_bib0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.intimp.2016.05.027","article-title":"Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-kappaB and ERK pathway","volume":"38","author":"Xu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2023.154797_bib64","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s11418-021-01550-w","article-title":"UHPLC\u2011MS\u2011based metabolomic approach for the quality evaluation of Pinellia ternata tubers grown in shaded environments","volume":"75","author":"Xue","year":"2021","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.phymed.2023.154797_bib71","first-page":"840","article-title":"Analysis of flavonoids in roots of six Glycyrrhiza species by high performance liquid chromatography","volume":"25","author":"Yang","year":"1990","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phymed.2023.154797_bib0046","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuro.2013.08.012","article-title":"Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells","volume":"39","author":"Yang","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.phymed.2023.154797_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111966","article-title":"Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance","volume":"187","author":"Yang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2023.154797_bib59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1155\/2021\/6693955","article-title":"Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy","volume":"2021","author":"Yang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2023.154797_bib0048","doi-asserted-by":"crossref","first-page":"13041","DOI":"10.3390\/molecules200713041","article-title":"Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver","volume":"20","author":"Yu","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.154797_bib0049","doi-asserted-by":"crossref","first-page":"112836","DOI":"10.1016\/j.biopha.2022.112836","article-title":"Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury in rats by targeting the JAK2\/STAT3 signaling pathway","volume":"149","author":"Yu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.154797_bib0050","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuroscience.2021.08.006","article-title":"Neuroprotective effect of alpha-asarone on the rats model of cerebral ischemia-reperfusion stroke via ameliorating glial activation and autophagy","volume":"473","author":"Zhang","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2023.154797_bib58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.21037\/atm-21-6390","article-title":"Proteomics reveals the role of Eucommia ulmoides-Tribulus terrestris in the central regulation of antihypertension by improving the hypothalamus in spontaneously hypertensive rats","volume":"10","author":"Zhang","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phymed.2023.154797_bib0006","first-page":"24","article-title":"Study on Neuroprotective Effect of Foshou San in MPTP Model Induced by Parkinson Disease*","volume":"38","author":"Zhao","year":"2022","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"10.1016\/j.phymed.2023.154797_bib0051","article-title":"The effects of erchen decoction on gut microbiota and lipid metabolism disorders in zucker diabetic fatty rats","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154797_bib0052","first-page":"249","article-title":"Clinical efficacy of erzhu erchen decoction combined with baduanjin exercise in the treatment of type 2 diabetes mellitus patients with abdominal obesity and its effect on interleukin 6","volume":"39","author":"Zheng","year":"2022","journal-title":"J. Guangzhou Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2023.154797_bib66","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/pca.2812","article-title":"Characterisation and classification of Citri Reticulatae Pericarpium varieties based on UHPLC\u2010Q\u2010TOF\u2010MS\/MS combined with multivariate statistical analyses","volume":"30","author":"Zheng","year":"2018","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.phymed.2023.154797_bib0053","first-page":"1431","article-title":"Research advances in mechanism of lipid infiltration of coronary heart disease and simultaneous treatment of phlegm and blood stasis based on phlegm-blood stasis correlation theory","volume":"48","author":"Zhong","year":"2022","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.phymed.2023.154797_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112638","article-title":"Erchen decoction plus huiyanzhuyu decoction inhibits the cell cycle, migration and invasion and induces the apoptosis of laryngeal squamous cell carcinoma cells","volume":"256","author":"Zhou","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.154797_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.714943","article-title":"Janus kinase inhibition ameliorates ischemic stroke injury and neuroinflammation through reducing NLRP3 inflammasome activation via JAK2\/STAT3 pathway inhibition","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2023.154797_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104963","article-title":"Interactions of antithrombotic herbal medicines with Western cardiovascular drugs","volume":"159","author":"Zuo","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.154797_bib63","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1039\/D0FO02978E","article-title":"Physicochemical properties of polysaccharides from Ligusticum chuanxiong and analysis of their anti-tumor potential through immunoregulation","volume":"12","author":"Zhong","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2023.154797_bib0019","first-page":"567","article-title":"Chinese Medicine Treatment of Vascular Dementia Based on Association Rules and Factor Analysis","volume":"28","author":"Zhou","year":"2019","journal-title":"Chinese Journal of Pharmacoepidemiology"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323001587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323001587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:52:12Z","timestamp":1760554332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323001587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":71,"alternative-id":["S0944711323001587"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154797","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modified Erchen decoction ameliorates cognitive dysfunction in vascular dementia rats via inhibiting JAK2\/STAT3 and JNK\/BAX signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154797","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154797"}}