{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T02:10:35Z","timestamp":1772071835382,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573553"],"award-info":[{"award-number":["81573553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773982"],"award-info":[{"award-number":["81773982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002857","name":"China Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.phymed.2023.154963","type":"journal-article","created":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T16:56:54Z","timestamp":1689526614000},"page":"154963","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Ameliorative effects of the Coptis inflorescence extract against lung injury in diabetic mice by regulating AMPK\/NEU1 signaling"],"prefix":"10.1016","volume":"118","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaoyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-305X","authenticated-orcid":false,"given":"Chaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.phymed.2023.154963_bib0001","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.cellsig.2014.02.015","article-title":"A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes","volume":"26","author":"Alghamdi","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.phymed.2023.154963_bib0002","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.exer.2014.07.011","article-title":"Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport","volume":"127","author":"Baptista","year":"2014","journal-title":"Exp. Eye Res."},{"issue":"11","key":"10.1016\/j.phymed.2023.154963_bib0003","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.2337\/db13-0039","article-title":"C-peptide activates AMPK\u03b1 and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes","volume":"62","author":"Bhatt","year":"2013","journal-title":"Diabetes"},{"issue":"10085","key":"10.1016\/j.phymed.2023.154963_bib0004","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/S0140-6736(17)30058-2","article-title":"Type 2 diabetes","volume":"389","author":"Chatterjee","year":"2017","journal-title":"Lancet"},{"issue":"14","key":"10.1016\/j.phymed.2023.154963_bib0005","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1021\/jf201627w","article-title":"Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice","volume":"59","author":"Chueh","year":"2011","journal-title":"J. Agric. Food Chem."},{"issue":"7","key":"10.1016\/j.phymed.2023.154963_bib0006","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.2337\/db12-1825","article-title":"Positive regulation of insulin signaling by neuraminidase 1","volume":"62","author":"Dridi","year":"2013","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.phymed.2023.154963_bib0007","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1017\/S1431927620024824","article-title":"Pathological alternations of mediastinal fat-associated lymphoid cluster and lung in a streptozotocin-induced diabetic mouse model","volume":"27","author":"Elewa","year":"2021","journal-title":"Microsc. Microanal."},{"issue":"5","key":"10.1016\/j.phymed.2023.154963_bib0008","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1159\/000264920","article-title":"Protective effect of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate in lung injury in rats with streptozotocin-induced diabetes","volume":"79","author":"Eren","year":"2010","journal-title":"Respiration"},{"key":"10.1016\/j.phymed.2023.154963_bib0009","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molmet.2018.03.017","article-title":"Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice","volume":"12","author":"Fougerat","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phymed.2023.154963_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5943322","article-title":"Glycyrrhizic acid inhibits core fucosylation modification modulated EMT and attenuates bleomycin-induced pulmonary fibrosis","volume":"2022","author":"Gao","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"3","key":"10.1016\/j.phymed.2023.154963_bib0011","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s12011-014-0021-9","article-title":"Iron increases diabetes-induced kidney injury and oxidative stress in rats","volume":"160","author":"Gao","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.phymed.2023.154963_bib0012","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1074\/jbc.M306205200","article-title":"Knockout of the alpha2 but not alpha1 5\u2032-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle","volume":"279","author":"J\u00f8rgensen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.154963_bib0013","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/ijms17111853","article-title":"Diabetic microvascular disease and pulmonary fibrosis: the contribution of platelets and systemic inflammation","volume":"17","author":"Jagadapillai","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.phymed.2023.154963_bib0014","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial-mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.phymed.2023.154963_bib0015","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2023.154963_bib0016","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.2147\/DDDT.S171025","article-title":"The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats","volume":"12","author":"Li","year":"2018","journal-title":"Drug Des. Devel Ther."},{"issue":"1","key":"10.1016\/j.phymed.2023.154963_bib0017","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/13880209.2020.1756349","article-title":"Berberine attenuates fructose-induced insulin resistance by stimulating the hepatic LKB1\/AMPK\/PGC1\u03b1 pathway in mice","volume":"58","author":"Li","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2023.154963_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153427","article-title":"Mogrol, an aglycone of mogrosides, attenuates ulcerative colitis by promoting AMPK activation","volume":"81","author":"Liang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.154963_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111175","article-title":"Corrigendum to \"Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells\" [Biomed. Pharmacother. 123 (2020) 109794]","volume":"136","author":"Lopes","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.phymed.2023.154963_bib0020","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11655-019-3064-0","article-title":"Network pharmacology in research of chinese medicine formula: methodology, application and prospective","volume":"26","author":"Luo","year":"2020","journal-title":"Chin. J. Integr. Med."},{"issue":"6","key":"10.1016\/j.phymed.2023.154963_bib0021","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1248\/bpb.b12-00995","article-title":"Acidic sialidase activity is aberrant in obese and diabetic mice","volume":"36","author":"Natori","year":"2013","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.phymed.2023.154963_bib0022","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1900\/RDS.2012.9.23","article-title":"The diabetic lung\u2013a new target organ?","volume":"9","author":"Pitocco","year":"2012","journal-title":"Rev. Diabet. Stud."},{"issue":"7","key":"10.1016\/j.phymed.2023.154963_bib0023","first-page":"736","article-title":"Desialylation of surface receptors as a new dimension in cell signaling","volume":"78","author":"Pshezhetsky","year":"2013","journal-title":"Biochemistry"},{"issue":"9","key":"10.1016\/j.phymed.2023.154963_bib0024","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.bcp.2013.02.007","article-title":"Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway","volume":"85","author":"Quan","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2023.154963_bib0025","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3389\/fphar.2020.00647","article-title":"Berberine improves glucose and lipid metabolism in HepG2 cells through AMPK\u03b11 activation","volume":"11","author":"Ren","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2023.154963_bib0026","doi-asserted-by":"crossref","first-page":"R225","DOI":"10.1530\/JME-16-0249","article-title":"Lipid metabolism and its implications for type 1 diabetes-associated cardiomyopathy","volume":"58","author":"Ritchie","year":"2017","journal-title":"J. Mol. Endocrinol."},{"issue":"3","key":"10.1016\/j.phymed.2023.154963_bib0027","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4239\/wjd.v1.i3.68","article-title":"Molecular mechanisms of insulin resistance in type 2 diabetes mellitus","volume":"1","author":"Saini","year":"2010","journal-title":"World J. Diabetes"},{"issue":"4","key":"10.1016\/j.phymed.2023.154963_bib0028","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0092-8674(01)00239-2","article-title":"New perspectives into the molecular pathogenesis and treatment of type 2 diabetes","volume":"104","author":"Saltiel","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2023.154963_bib0029","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pharmthera.2017.08.009","article-title":"EMT: mechanisms and therapeutic implications","volume":"182","author":"Singh","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.phymed.2023.154963_bib0030","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1203\/00006450-198109000-00014","article-title":"Insulin receptors in the fetal rat lung. A transient characteristic of fetal cells?","volume":"15","author":"Sodoyez-Goffaux","year":"1981","journal-title":"Pediatr. Res."},{"issue":"4","key":"10.1016\/j.phymed.2023.154963_bib0031","first-page":"893","article-title":"Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse","volume":"120","author":"Szapiel","year":"1979","journal-title":"Am. Rev. Respir. Dis."},{"issue":"1","key":"10.1016\/j.phymed.2023.154963_bib0032","doi-asserted-by":"crossref","first-page":"11920","DOI":"10.1038\/s41598-018-30449-y","article-title":"Diabetes induces fibrotic changes in the lung through the activation of TGF-\u03b2 signaling pathways","volume":"8","author":"Talakatta","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.phymed.2023.154963_bib0033","doi-asserted-by":"crossref","first-page":"e563","DOI":"10.1152\/ajpendo.00086.2017","article-title":"Dapagliflozin slows the progression of the renal and liver fibrosis associated with type 2 diabetes","volume":"313","author":"Tang","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.phymed.2023.154963_bib0034","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.jdiacomp.2016.07.005","article-title":"Lung damage induced by hyperglycemia in diabetic rats: the role of signal transducer and activator of transcription 3 (STAT3)","volume":"30","author":"Wang","year":"2016","journal-title":"J. Diabetes Complicat."},{"issue":"4","key":"10.1016\/j.phymed.2023.154963_bib0035","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1142\/S0192415X22500434","article-title":"Polyphenols from Chinese herbal medicine: molecular mechanisms and therapeutic targets in pulmonary fibrosis","volume":"50","author":"Wang","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2023.154963_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106083","article-title":"Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1\/IL17A pathway","volume":"176","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.phymed.2023.154963_bib0037","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.phymed.2023.154963_bib0038","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00253-019-10174-w","article-title":"Scutellariae radix and coptidis rhizoma ameliorate glycolipid metabolism of type 2 diabetic rats by modulating gut microbiota and its metabolites","volume":"104","author":"Xiao","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"2","key":"10.1016\/j.phymed.2023.154963_bib0039","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/pr.2014.181","article-title":"The expression of epithelial-mesenchymal transition-related proteins in biliary epithelial cells is associated with liver fibrosis in biliary atresia","volume":"77","author":"Xiao","year":"2015","journal-title":"Pediatr. Res."},{"issue":"3","key":"10.1016\/j.phymed.2023.154963_bib0040","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.intimp.2012.04.020","article-title":"Diabetes increases inflammation and lung injury associated with protective ventilation strategy in mice","volume":"13","author":"Xiong","year":"2012","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2023.154963_bib0041","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/dmrr.1175","article-title":"Pulmonary fibrosis: a possible diabetic complication","volume":"27","author":"Yang","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.phymed.2023.154963_bib0042","article-title":"Catalpol attenuates pulmonary fibrosis by inhibiting Ang II\/AT(1) and TGF-\u03b2\/Smad-mediated epithelial mesenchymal transition","volume":"9","author":"Yu","year":"2022","journal-title":"Front. Med."},{"issue":"3","key":"10.1016\/j.phymed.2023.154963_bib0043","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11130-006-0023-7","article-title":"Hypoglycemic and hypocholesterolemic effects of Coptis chinensis franch inflorescence","volume":"61","author":"Yuan","year":"2006","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.phymed.2023.154963_bib0044","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4701570","article-title":"Linarin enriched extract attenuates liver injury and inflammation induced by high-fat high-cholesterol diet in rats","volume":"2017","author":"Zhuang","year":"2017","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.phymed.2023.154963_bib0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pupt.2017.03.012","article-title":"Involvement of epithelial-mesenchymal transition afforded by activation of LOX-1\/TGF-\u03b21\/KLF6 signaling pathway in diabetic pulmonary fibrosis","volume":"44","author":"Zou","year":"2017","journal-title":"Pulm. Pharmacol. Ther."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323003240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323003240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:51:19Z","timestamp":1760554279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323003240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":45,"alternative-id":["S0944711323003240"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154963","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ameliorative effects of the Coptis inflorescence extract against lung injury in diabetic mice by regulating AMPK\/NEU1 signaling","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.154963","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154963"}}