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Lett."},{"key":"10.1016\/j.phymed.2023.154986_bib0191","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.canlet.2021.03.009","article-title":"Tumor microenvironment in head and neck squamous cell carcinoma: functions and regulatory mechanisms","volume":"507","author":"Wang","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2023.154986_bib244","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1158\/1078-0432.CCR-07-5177","article-title":"Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway","volume":"14","author":"Wang","year":"2008","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. 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