{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:54:21Z","timestamp":1791924861260,"version":"4.3.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ3050"],"award-info":[{"award-number":["2021JJ3050"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603415"],"award-info":[{"award-number":["81603415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174176"],"award-info":[{"award-number":["82174176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004346"],"award-info":[{"award-number":["82004346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.phymed.2023.155001","type":"journal-article","created":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T09:51:17Z","timestamp":1690710677000},"page":"155001","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro"],"prefix":"10.1016","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-744X","authenticated-orcid":false,"given":"Yan","family":"She","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-8546","authenticated-orcid":false,"given":"Le","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-5851","authenticated-orcid":false,"given":"Hongping","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-756X","authenticated-orcid":false,"given":"Changsong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155001_bib0001","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pharmthera.2015.11.003","article-title":"Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases","volume":"157","author":"Buendia","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2023.155001_bib0002","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1177\/0271678X18794839","article-title":"Modulator of apoptosis-1 is a potential therapeutic target in acute ischemic injury","volume":"39","author":"Chan","year":"2019","journal-title":"J. Cerebral Blood Flow Metabolism"},{"key":"10.1016\/j.phymed.2023.155001_bib0003","doi-asserted-by":"crossref","unstructured":"Dong, Y., Niu, S., Qiao, Y., Huang, C., Wang, H., Sun, L., 2022. [Determination of 19 illegally added chemical ingredients in hair loss prevention cosmetics by ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry]. Se pu\u00a0=\u00a0Chinese journal of chromatography 40, 343\u2013353.","DOI":"10.3724\/SP.J.1123.2021.08019"},{"key":"10.1016\/j.phymed.2023.155001_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154385","article-title":"Glycosides from Buyang Huanwu Decoction inhibit atherosclerotic inflammation via JAK\/STAT signaling pathway","volume":"105","author":"Fu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155001_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21134777","article-title":"NRF2, a transcription factor for stress response and beyond","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155001_bib0006","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1097\/CCM.0000000000004597","article-title":"Management of acute ischemic stroke","volume":"48","author":"Herpich","year":"2020","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.phymed.2023.155001_bib0007","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2017.06.027","article-title":"Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1\/TXNIP complex in cerebral ischemia reperfusion injury","volume":"336","author":"Hou","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phymed.2023.155001_bib0008","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s12011-022-03170-1","article-title":"Molybdenum and cadmium co-induce pyroptosis via inhibiting Nrf2-mediated antioxidant defense response in the brain of ducks","volume":"201","author":"Hu","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.phymed.2023.155001_bib0009","doi-asserted-by":"crossref","unstructured":"Ke, Q., Li, S., Wang, D., Zhou, Q., Zhou, F., Bei, Y., Chen, X., Wang, Y., 2022. [Rapid screening and confirmation of 86 illegally added chemicals in fishery drugs by ultra performance liquid chromatography-quadrupole-time-of-flight mass spectrometry]. Se pu\u00a0=\u00a0Chinese journal of chromatography 40, 520\u2013530.","DOI":"10.3724\/SP.J.1123.2021.11023"},{"key":"10.1016\/j.phymed.2023.155001_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115836","article-title":"Protective effect of Xingnaojing injection on ferroptosis after cerebral ischemia injury in MCAO rats and SH-SY5Y cells","volume":"301","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155001_bib0011","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41420-022-01002-8","article-title":"MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2\/TXNIP\/NLRP3 axis","volume":"8","author":"Ma","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.phymed.2023.155001_bib0012","doi-asserted-by":"crossref","first-page":"22188","DOI":"10.18632\/aging.203526","article-title":"Cx32 inhibits the autophagic effect of Nur77 in SH-SY5Y cells and rat brain with ischemic stroke","volume":"13","author":"Ping","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.phymed.2023.155001_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120561","article-title":"Targeting Nrf2 in ischemia-reperfusion alleviation: from signaling networks to therapeutic targeting","volume":"300","author":"Sadrkhanloo","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2023.155001_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154312","article-title":"An evidence-based evaluation of Buyang Huanwu decoction for the treatment of the sequelae of stroke: a PRISMA-compliant systematic review and meta-analysis of randomized controlled trials","volume":"104","author":"Shao","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155001_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112051","article-title":"Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats","volume":"242","author":"She","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2023.155001_bib0016","first-page":"44","article-title":"Update of intravenous thrombolytic therapy in acute ischemic stroke","volume":"30","author":"Tsai","year":"2021","journal-title":"Acta Neurol. Taiwan."},{"key":"10.1016\/j.phymed.2023.155001_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175516","article-title":"Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62\/Keap1\/Nrf2 pathway-mediated ferroptosis","volume":"944","author":"Wang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155001_bib0018","doi-asserted-by":"crossref","unstructured":"Yu, P., Zhang, X., Liu, N., Tang, L., Peng, C., Chen, X., 2021. Pyroptosis: mechanisms and diseases. Signal transduction and targeted therapy 6, 128.","DOI":"10.1038\/s41392-021-00507-5"},{"key":"10.1016\/j.phymed.2023.155001_bib0019","first-page":"25","article-title":"Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1\/RIP3-exosome axis","volume":"9","author":"Zeng","year":"2022","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.phymed.2023.155001_bib0020","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/WNR.0000000000001884","article-title":"Paeoniflorin protects 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mice by inhibiting oxidative stress and neuronal apoptosis through activating the Nrf2\/HO-1 signaling pathway","volume":"34","author":"Zhang","year":"2023","journal-title":"Neuroreport"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323003628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323003628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:15:51Z","timestamp":1778559351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323003628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":20,"alternative-id":["S0944711323003628"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155001","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155001"}}