{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:42:08Z","timestamp":1793032928702,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.phymed.2023.155050","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T01:53:30Z","timestamp":1693014810000},"page":"155050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Lagopsis supina ameliorates myocardial ischemia injury by regulating angiogenesis, thrombosis, inflammation, and energy metabolism through VEGF, ROS and HMGB1 signaling pathways in rats"],"prefix":"10.1016","volume":"120","author":[{"given":"Junwei","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingcui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9098-694X","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155050_bib0001","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jep.2016.04.039","article-title":"Anti-myocardial ischemia effect of Syringa pinnatifolia Hemsl. by inhibiting expression of cyclooxygenase-1 and-2 in myocardial tissues of mice","volume":"187","author":"Cao","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0002","doi-asserted-by":"crossref","first-page":"24383","DOI":"10.1038\/srep24383","article-title":"Qishen Yiqi Drop Pill improves cardiac function after myocardial ischemia","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2023.155050_bib0003","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jep.2017.11.005","article-title":"Anti-thrombotic and pro-angiogenic effects of Rubia cordifolia extract in zebrafish","volume":"219","author":"Chen","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0004","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.lfs.2018.10.047","article-title":"Sphingosine 1-phosphate promotes mesenchymal stem cell-mediated cardioprotection against myocardial infarction via ERK1\/2-MMP-9 and Akt signaling axis","volume":"215","author":"Chen","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2023.155050_bib0005","article-title":"The protective effects of Shengmai formula against myocardial injury induced by ultrafine particulate matter exposure and myocardial ischemia are mediated by the PI3K\/AKT\/p38 MAPK\/Nrf2 pathway","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0006","doi-asserted-by":"crossref","first-page":"536","DOI":"10.7326\/0003-4819-130-6-199903160-00011","article-title":"Myocardial infarction associated with buprenorphine","volume":"130","author":"Cracowski","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.phymed.2023.155050_bib0007","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10557-020-06949-3","article-title":"Oestrogen receptor \u03b2 activation protects against myocardial infraction via Notch1 signaling","volume":"34","author":"Du","year":"2020","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.phymed.2023.155050_bib0008","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.2147\/IJN.S338937","article-title":"Peripheral serum exosomes isolated from patients with acute myocardial infarction promote endothelial cell angiogenesis via the miR-126-3p\/TSC1\/mTORC1\/HIF-1 alpha pathway","volume":"17","author":"Duan","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.phymed.2023.155050_bib0009","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1111\/bph.15904","article-title":"Caspase-4\/11 is critical for angiogenesis by repressing Notch1 signaling via inhibiting \u03b3-secretase activity","volume":"179","author":"Fan","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0010","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/eurheartj\/ehac223","article-title":"Left ventricular remodelling post-myocardial infraction: pathophysiology, imaging, and novel therapies","volume":"43","author":"Frantz","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phymed.2023.155050_bib0011","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s10753-017-0702-6","article-title":"Umbelliferone alleviates myocardial ischemia: the role of inflammation and apoptosis","volume":"41","author":"Gan","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2023.155050_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104627","article-title":"Omics strategies decipher therapeutic discoveries of traditional Chinese medicine against different diseases at multiple layers molecular-level","volume":"152","author":"Guo","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.155050_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113082","article-title":"Protective mechanisms of 10-gingerol against myocardial ischemia may involve activation of JAK2\/STAT3 pathway and regulation of Ca2+ homeostasis","volume":"151","author":"Han","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155050_bib0014","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jep.2018.10.034","article-title":"Lagopsis supina exerts its diuretic effect via inhibition of aquaporin-1, 2 and 3 expression in a rat model of traumatic blood stasis","volume":"231","author":"He","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111554","article-title":"Diuretic effect of Lagopsis supina fraction in saline-loaded rats is mediated through inhibition of aquaporin and renin-angiotensin-aldosterone systems and up-regulation of atriopeptin","volume":"139","author":"He","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155050_bib0016","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1039\/D2RA07623C","article-title":"Anti-inflammatory constituents isolated from the flowers of Hosta plantaginea via suppression of the NF-\u03baB signaling pathway in LPS-stimulated RAW 264.7 macrophages","volume":"13","author":"He","year":"2023","journal-title":"RSC Adv."},{"key":"10.1016\/j.phymed.2023.155050_bib0017","doi-asserted-by":"crossref","first-page":"50","DOI":"10.21037\/atm-22-6409","article-title":"The impact of hypertension for metabolites in patients with acute coronary syndrome","volume":"11","author":"Hu","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phymed.2023.155050_bib0018","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biopha.2017.06.002","article-title":"Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-beta 1\/SMADs and PI3K\/AKT signaling pathways","volume":"93","author":"Li","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155050_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152918","article-title":"Exploring the protective effects of Danqi Tongmai tablet on acute myocardial ischemia rats by comprehensive metabolomics profiling","volume":"74","author":"Li","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155050_bib0020","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1142\/S0192415X22500525","article-title":"Lupeol alleviates myocardial ischemia-reperfusion injury in rats by regulating NF-\u03baB and Nrf2 pathways","volume":"50","author":"Li","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2023.155050_bib0021","article-title":"Identification of the antithrombotic mechanism of Leonurine in adrenalin hydrochloride-induced thrombosis zebrafish via regulating oxidative stress and coagulation cascade","volume":"12","author":"Liao","year":"2021","journal-title":"Front. Pharmcol."},{"key":"10.1016\/j.phymed.2023.155050_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106077","article-title":"Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models","volume":"176","author":"Liao","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.155050_bib0023","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6927374","article-title":"Diuretic and anti-diuretic activities of ethanol extract and fractions of Lagopsis supina in normal rats","volume":"2019","author":"Liu","year":"2019","journal-title":"BioMed. Res. Int."},{"issue":"1","key":"10.1016\/j.phymed.2023.155050_bib0024","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/bph.15595","article-title":"Preclinical models of myocardial infraction: from mechanism to translation","volume":"179","author":"Martin","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0025","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2131\/jts.38.495","article-title":"Toxic effects of T-2 toxin and deoxynivalenol on the mitochondrial electron transport system of cardiomyocytes in rats","volume":"38","author":"Ngampongsa","year":"2013","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.phymed.2023.155050_bib0027","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.pharmthera.2018.12.005","article-title":"HMGB1 and repair: focus on the heart","volume":"196","author":"Pehhegrini","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2023.155050_bib0028","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.pharmthera.2018.12.005","article-title":"HMGB1 and repair: focus on the heart","volume":"196","author":"Pellegrini","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2023.155050_bib0029","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1161\/CIRCULATIONAHA.120.046290","article-title":"PCSK9 (proprotein convertase subtilisin\/kexin 9) enhances platelet activation, thrombosis, and myocardial infarct expansion by binding to platelet CD36","volume":"143","author":"Qi","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2023.155050_bib0030","article-title":"Pharmacodynamics and pharmacokinetics of Danshen in isoproterenol-induced acute myocardial ischemic injury combined with Honghua","volume":"30","author":"Qu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153263","article-title":"Identification of cryptotanshinone from Tongmai to inhibit thrombosis in zebrafish via regulating oxidative stress and coagulation cascade","volume":"76","author":"Sheng","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155050_bib0033","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/820695","article-title":"The cardioprotective effects of citric acid and L-malic acid on myocardial ischemia\/reperfusion injury","volume":"2013","author":"Tang","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2023.155050_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112737","article-title":"Pro-angiogenic activity of Tongnao decoction on HUVECs in vitro and zebrafish in vivo","volume":"254","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0035","first-page":"974","article-title":"Traditional chinese medicines alleviated myocardial ischemia by regulating Qi and promoting blood circulation","volume":"40","author":"Wang","year":"2020","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2023.155050_bib0036","doi-asserted-by":"crossref","first-page":"942","DOI":"10.7150\/ijbs.65653","article-title":"RhoJ facilitates angiogenesis in glioblastoma via JNK\/VEGFR2 mediated activation of PAK and ERK signaling pathways","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2023.155050_bib0037","article-title":"Protective effect of isosteviol sodium against LPS-induced multiple organ injury by regulating of glycerophospholipid metabolism and reducing macrophage-driven inflammation","volume":"172","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.155050_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116245","article-title":"Amelioration of chronic prostatitis by fractions of Mongolian medicine Hosta plantaginea flowers via inhibition of NF-\u03baB, MAPKs, JAK-STAT, and PI3K-Akt signaling pathways in rats","volume":"307","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116966","article-title":"Therapeutic effect of Hosta plantaginea (Lam.) Aschers flowers on acute pharyngitis through inhibition of multi-inflammatory pathways in rats","volume":"318","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0040","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.4314\/tjpr.v20i11.6","article-title":"Dexmedetomidine mitigates myocardial ischemia reperfusion injury via regulation Dexmedetomidine mitigates myocardial ischemia-reperfusion injury via regulation of HMGB1-TLR4-NF-\u03baB signaling axis","volume":"20","author":"Wei","year":"2021","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.phymed.2023.155050_bib0041","doi-asserted-by":"crossref","DOI":"10.1111\/apt.17533","article-title":"Altered serum bile acid composition is associated with cardiac dysfunction in cirrhosis","author":"Wiese","year":"2023","journal-title":"Aliment. Pharmacol. Ther. Online"},{"key":"10.1016\/j.phymed.2023.155050_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104488","article-title":"Effects and mechanisms of traditional Chinese herbal medicine in the treatment of ischemic cardiomyopathy","volume":"151","author":"Wu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.155050_bib0043","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.apsb.2022.07.006","article-title":"Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS","volume":"13","author":"Wu","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.phymed.2023.155050_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e11176","article-title":"The therapeutic effects of Lagopsis supina (Steph. ex. Willd.) Ikonn.-Gal. fractions in trauma-induced blood stasis model rats","volume":"8","author":"Xia","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2023.155050_bib0045","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s11655-021-2859-y","article-title":"Mechanism of 'invigorating Qi and promoting blood circulation' drug pair Ginseng-Danshen on treatment of ischemic heart disease based on network pharmacology","volume":"27","author":"Xin","year":"2021","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phymed.2023.155050_bib0046","first-page":"e19359","article-title":"Efficacy of Lagopsis supina to promote blood circulation, remove blood stasis, and block inflammation in a rat model of traumatic blood stasis. Braz","volume":"58","author":"Xu","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2023.155050_bib0047","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.3390\/molecules24224098","article-title":"Rapid analysis of the chemical compositions in Semiliquidambar cathayensis roots by ultra high-performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry","volume":"24","author":"Yang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155050_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110899","article-title":"Lagopsis supina extract and its fractions exert prophylactic effects against blood stasis in rats via anti-coagulation, anti-platelet activation and anti-fibrinolysis and chemical characterization by UHPLC-qTOF-MS\/MS","volume":"132","author":"Yang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155050_bib0049","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.584849","article-title":"Chemical composition of Pterospermum heterophyllum root and its anti-arthritis effect on adjuvant-induced arthritis in rats via modulation of inflammatory responses","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0050","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12944-020-01269-9","article-title":"Serum lipids profiling perturbances in patients with ischemic heart disease and ischemic cardiomyopathy","volume":"19","author":"Yang","year":"2020","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.phymed.2023.155050_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113951","article-title":"The chemical profiling of aqueous soluble fraction from Lagopsis supina and its diuretic effects via suppression of AQP and RAAS pathways in saline-loaded rats","volume":"272","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0052","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1007\/s10753-021-01452-9","article-title":"Compounds DRG and DAG, two phenol glycosides inhibit TNF-\u03b1-stimulated inflammatory response through blocking NF-\u03baB\/AKT\/JNK signaling pathways in MH7A cells","volume":"44","author":"Yang","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2023.155050_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107463","article-title":"Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF-\u03b1-induced MH7A cells via inhibition of NF-\u03baB, Akt and JNK signaling pathways","volume":"94","author":"Yang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154268","article-title":"Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine","volume":"104","author":"Yang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155050_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106165","article-title":"Natural phenylethanoid glycosides diuretics derived from Lagopsis supina: biological activity, mechanism, molecular docking, and structure-activity relationship","volume":"129","author":"Yang","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2023.155050_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114605","article-title":"Hostaflavone A from Hosta plantaginea (Lam.) Asch. blocked NF-\u03baB\/iNOS\/COX-2\/MAPKs\/Akt signaling pathways in LPS-induced RAW 264.7 macrophages","volume":"282","author":"Yang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116922","article-title":"Extraction optimization and constituent analysis of total flavonoid from Hosta plantaginea (Lam.) Aschers flowers and its ameliorative effect on chronic prostatitis via inhibition of multiple inflammatory pathways in rats","volume":"318","author":"Yang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0058","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.apsb.2022.08.007","article-title":"Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: cumulative evidence for future cardioprotective strategies","volume":"13","author":"Yanpiset","year":"2023","journal-title":"Acta. Pharma. Sin. B."},{"key":"10.1016\/j.phymed.2023.155050_bib0059","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.2147\/DDDT.S362754","article-title":"Isoliquiritigenin ameliorates ischemia-induced myocardial injury via modulating the Nrf2\/HO-1 pathway in mice","volume":"16","author":"Yao","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.phymed.2023.155050_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113475","article-title":"Chinese medicine GeGen-DanShen extract protects from myocardial ischemic injury through promoting angiogenesis via up-regulation of VEGF\/VEGFR2 signaling pathway","volume":"267","author":"Zhai","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154269","article-title":"LC-MS-based metabolomics reveals metabolic changes in short- and long-term administration of Compound Danshen Dripping Pills against acute myocardial infarction in rats","volume":"104","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155050_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115530","article-title":"Integration of metabolomics and transcriptomics to reveal anti-chronic myocardial ischemia mechanism of Gualou Xiebai decoction","volume":"297","author":"Zhang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0063","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202201176","article-title":"Activating blood circulation, anti-inflammatory and diuretic effects of Leonurus japonicus extract on a rat model of trauma blood stasis and its phytochemical profiling","volume":"20","author":"Zhang","year":"2023","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.phymed.2023.155050_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112893","article-title":"Meconopsis horridula Hook. F. & Thomson extract and its alkaloid oleracein E exert cardioprotective effects against acute myocardial ischaemic injury in mice","volume":"258","author":"Zhao","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155050_bib0065","article-title":"Rhaponticum carthamoides improved energy metabolism and oxidative stress through the SIRT6\/Nrf2 pathway to ameliorate myocardial injury","volume":"105","author":"Zheng","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155050_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110724","article-title":"Stachydrine promotes angiogenesis by regulating the VEGFR2\/MEK\/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells","volume":"131","author":"Zhou","year":"2020","journal-title":"Biomed. Pharmacother."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:51:45Z","timestamp":1760554305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323004117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":64,"alternative-id":["S0944711323004117"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155050","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lagopsis supina ameliorates myocardial ischemia injury by regulating angiogenesis, thrombosis, inflammation, and energy metabolism through VEGF, ROS and HMGB1 signaling pathways in rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155050"}}