{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:23:51Z","timestamp":1793741031268,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903916"],"award-info":[{"award-number":["81903916"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.phymed.2023.155055","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:16:14Z","timestamp":1693912574000},"page":"155055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Kaempferol ameliorated alcoholic liver disease through inhibiting hepatic bile acid synthesis by targeting intestinal FXR-FGF15 signaling"],"prefix":"10.1016","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-2513","authenticated-orcid":false,"given":"Li","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155055_bib0001","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2023.155055_bib0002","article-title":"Hepatoprotective effect of kaempferol: a review of the dietary sources, bioavailability, mechanisms of action, and safety","volume":"2023","author":"Alkandahri","year":"2023","journal-title":"Adv. Pharm. Pharm. SCI"},{"key":"10.1016\/j.phymed.2023.155055_bib0003","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.dld.2019.01.014","article-title":"FXR deficiency and alcoholic liver disease: tissue is the issue","volume":"51","author":"Alpini","year":"2019","journal-title":"Digest. Liver Dis."},{"key":"10.1016\/j.phymed.2023.155055_bib0004","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1053\/j.gastro.2014.01.018","article-title":"A histologic scoring system for prognosis of patients with alcoholic hepatitis","volume":"146","author":"Altamirano","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2023.155055_bib0005","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"Bajaj","year":"2019","journal-title":"Nat. Rev. Gastro. Hepat."},{"key":"10.1016\/j.phymed.2023.155055_bib0006","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/acer.13498","article-title":"Continued alcohol misuse in human cirrhosis is associated with an impaired gut-liver axis","volume":"41","author":"Bajaj","year":"2017","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.phymed.2023.155055_bib0007","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2023.155055_bib0008","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jhep.2018.03.031","article-title":"Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis","volume":"69","author":"Brandl","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2023.155055_bib0009","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.bbadis.2017.09.019","article-title":"Nuclear receptor FXR, bile acids and liver damage: introducing the progressive familial intrahepatic cholestasis with FXR mutations","author":"Cariello","year":"2018","journal-title":"BBA-Mol. Basis Dis. 1864"},{"key":"10.1016\/j.phymed.2023.155055_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152338","article-title":"Kaempferol alleviates acute alcoholic liver injury in mice by regulating intestinal tight junction proteins and butyrate receptors and transporters","volume":"429","author":"Chen","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2023.155055_bib0011","first-page":"G554","article-title":"Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy","volume":"318","author":"Chiang","year":"2020","journal-title":"Am. J. Physiol.-Gastr. L"},{"key":"10.1016\/j.phymed.2023.155055_bib0012","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/apt.14949","article-title":"Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis","volume":"48","author":"Ciocan","year":"2018","journal-title":"Aliment Pharm Ther."},{"key":"10.1016\/j.phymed.2023.155055_bib0013","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/hep.30866","article-title":"Diagnosis and treatment of alcohol-associated liver diseases: 2019 practice guidance from the American association for the study of liver diseases","volume":"71","author":"Crabb","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2023.155055_bib0014","first-page":"673","article-title":"Comparing the protective effects of curcumin and ursodeoxycholic acid after ethanol-induced hepatotoxicity in rat liver","volume":"31","author":"Farashbandi","year":"2021","journal-title":"Ethiop. J. Health SCI"},{"key":"10.1016\/j.phymed.2023.155055_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2021.104317","article-title":"The spectrum of progressive familial intrahepatic cholestasis diseases: update on pathophysiology and emerging treatments","volume":"64","author":"Felzen","year":"2021","journal-title":"Eur. J. Med. Genet"},{"key":"10.1016\/j.phymed.2023.155055_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101094","article-title":"Bile acids and their receptors in metabolic disorders","volume":"82","author":"Fiorucci","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.phymed.2023.155055_bib0017","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/alcalc\/agaa005","article-title":"Chronic alcohol consumption increased bile acid levels in enterohepatic circulation and reduced efficacy of irinotecan","volume":"55","author":"Gong","year":"2020","journal-title":"Alcohol Alcoholism"},{"key":"10.1016\/j.phymed.2023.155055_bib0018","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00005792-196703000-00008","article-title":"Steatonecrosis\u2013Mallory body type","volume":"46","author":"Harinasuta","year":"1967","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.phymed.2023.155055_bib0019","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1002\/hep.29676","article-title":"Modulation of the intestinal bile acid\/farnesoid X receptor\/fibroblast growth factor 15 axis improves alcoholic liver disease in mice","volume":"67","author":"Hartmann","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2023.155055_bib0020","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/s41374-020-0439-y","article-title":"Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency","volume":"100","author":"Huang","year":"2020","journal-title":"Lab. Invest."},{"key":"10.1016\/j.phymed.2023.155055_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115717","article-title":"Pathophysiological aspects of alcohol metabolism in the liver","volume":"22","author":"Hyun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155055_bib0022","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ptr.6227","article-title":"Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: a comprehensive review","volume":"33","author":"Imran","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2023.155055_bib0023","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/hep4.1256","article-title":"FXR and TGR5 agonists ameliorate liver injury, steatosis, and inflammation after binge or prolonged alcohol feeding in mice","volume":"2","author":"Iracheta-Vellve","year":"2018","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.phymed.2023.155055_bib0024","doi-asserted-by":"crossref","unstructured":"Jan, R., Khan, M., Asaf, S., Lubna, Asif, S., Kim, K.M., 2022, Bioactivity and therapeutic potential of Kaempferol and quercetin: new insights for plant and human health. Plants-Basel 11.","DOI":"10.3390\/plants11192623"},{"key":"10.1016\/j.phymed.2023.155055_bib0025","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/hep.32608","article-title":"Probiotic-derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation","volume":"77","author":"Jiang","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2023.155055_bib0026","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.dld.2018.12.026","article-title":"FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury","volume":"51","author":"Kong","year":"2019","journal-title":"Digest Liver Dis."},{"key":"10.1016\/j.phymed.2023.155055_bib0027","doi-asserted-by":"crossref","first-page":"152","DOI":"10.21037\/hbsn.2019.09.03","article-title":"Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease","volume":"9","author":"Li","year":"2020","journal-title":"Hepatobil. Surg. Nutr."},{"key":"10.1016\/j.phymed.2023.155055_bib0028","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/acer.14619","article-title":"Gut-restricted apical sodium-dependent bile acid transporter inhibitor attenuates alcohol-induced liver steatosis and injury in mice","volume":"45","author":"Matye","year":"2021","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.phymed.2023.155055_bib0029","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0140-6736(78)91111-X","article-title":"Cholestasis in acute alcoholic liver disease","volume":"1","author":"Mills","year":"1978","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2023.155055_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315054","article-title":"Kaempferol: antimicrobial properties, sources, clinical, and traditional applications","volume":"23","author":"Periferakis","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155055_bib0031","first-page":"2759","article-title":"Recent progress regarding kaempferol for the treatment of various diseases","volume":"18","author":"Ren","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2023.155055_bib0032","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000371678","article-title":"Gut microbiota, cirrhosis, and alcohol regulate bile acid metabolism in the gut","volume":"33","author":"Ridlon","year":"2015","journal-title":"Digest. Dis."},{"key":"10.1016\/j.phymed.2023.155055_bib0033","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13023-021-01887-1","article-title":"Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy","volume":"16","author":"Shao","year":"2021","journal-title":"Orphanet. J. Rare. Dis."},{"key":"10.1016\/j.phymed.2023.155055_bib0034","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jhep.2018.10.026","article-title":"Current trials and novel therapeutic targets for alcoholic hepatitis","volume":"70","author":"Singal","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2023.155055_bib0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-230X-11-115","article-title":"Early liver biopsy, intraparenchymal cholestasis, and prognosis in patients with alcoholic steatohepatitis","volume":"11","author":"Spahr","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.phymed.2023.155055_bib0036","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/j.2040-4603.2020.tb00108.x","article-title":"Intestinal absorption of bile acids in health and disease","volume":"10","author":"Ticho","year":"2019","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.phymed.2023.155055_bib0037","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbrc.2013.11.057","article-title":"Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease","volume":"443","author":"Wu","year":"2014","journal-title":"Biochem. Bioph. Res. Co."},{"key":"10.1016\/j.phymed.2023.155055_bib0038","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2019.03.004","article-title":"Global liver disease burdens and research trends: analysis from a Chinese perspective","volume":"71","author":"Xiao","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2023.155055_bib0039","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1096\/fj.13-231860","article-title":"Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption","volume":"27","author":"Xie","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2023.155055_bib0040","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.dld.2018.04.009","article-title":"FXR deletion in hepatocytes does not affect the severity of alcoholic liver disease in mice","volume":"50","author":"Zhang","year":"2018","journal-title":"Digest. Liver Dis."},{"key":"10.1016\/j.phymed.2023.155055_bib0041","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1142\/S0192415X1850057X","article-title":"Kaempferol's protective effect on ethanol-induced mouse primary hepatocytes injury involved in the synchronous inhibition of SP1, Hsp70 and CYP2E1","volume":"46","author":"Zhou","year":"2018","journal-title":"Am. J. Chinese Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:50:35Z","timestamp":1760554235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323004154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":41,"alternative-id":["S0944711323004154"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155055","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kaempferol ameliorated alcoholic liver disease through inhibiting hepatic bile acid synthesis by targeting intestinal FXR-FGF15 signaling","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155055"}}