{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:42:08Z","timestamp":1784126528582,"version":"3.55.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.phymed.2023.155068","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T18:58:36Z","timestamp":1693853916000},"page":"155068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Microbial modifications with Lycium barbarum L. oligosaccharides decrease hepatic fibrosis and mitochondrial abnormalities in mice"],"prefix":"10.1016","volume":"120","author":[{"given":"Zheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.phymed.2023.155068_bib0001","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"Bajaj","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2023.155068_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2005.10.004","article-title":"Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it","volume":"6","author":"Begriche","year":"2006","journal-title":"Mitochondrion"},{"issue":"4","key":"10.1016\/j.phymed.2023.155068_bib0003","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/hep.26226","article-title":"Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease","volume":"58","author":"Begriche","year":"2013","journal-title":"Hepatology"},{"issue":"15","key":"10.1016\/j.phymed.2023.155068_bib0004","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phymed.2023.155068_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.05.016","article-title":"Pathophysiology of liver fibrosis and the methodological barriers to the development of anti-fibrogenic agents","volume":"121","author":"B\u00f6ttcher","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2023.155068_bib0006","doi-asserted-by":"crossref","first-page":"9829","DOI":"10.1039\/D1FO01200B","article-title":"An arabinogalactan from Lycium barbarum attenuates DSS-induced chronic colitis in C57BL\/6J mice associated with the modulation of intestinal barrier function and gut microbiota","volume":"12","author":"Cao","year":"2021","journal-title":"Food Funct."},{"issue":"5","key":"10.1016\/j.phymed.2023.155068_bib0007","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.phymed.2023.155068_bib0008","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/hep.29892","article-title":"Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD","volume":"68","author":"Caussy","year":"2018","journal-title":"Hepatology"},{"issue":"S1","key":"10.1016\/j.phymed.2023.155068_bib0009","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1096\/fasebj.31.1_supplement.793.5","article-title":"Effects of Lycium Barbarum polysaccharides extract and betaine on cell activation and liver fibrosis in rat hepatic stellate HSC-T6 Cells","volume":"31","author":"Chao","year":"2017","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.phymed.2023.155068_bib0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12967-023-03953-7","article-title":"Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data","volume":"21","author":"Chen","year":"2023","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.phymed.2023.155068_bib0011","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/acs.jafc.9b07368","article-title":"Combination of chronic alcohol consumption and high-salt intake elicits gut microbial alterations and liver steatosis in mice","volume":"68","author":"Chen","year":"2020","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.phymed.2023.155068_bib0012","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1113\/EP085248","article-title":"Tissue and sex specificities in Ca2+ handling by isolated mitochondria in conditions avoiding the permeability transition","volume":"100","author":"Chweih","year":"2015","journal-title":"Exp. Physiol."},{"issue":"1","key":"10.1016\/j.phymed.2023.155068_bib0013","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/hep.1840100103","article-title":"Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver","volume":"10","author":"Corasanti","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2023.155068_bib0014","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/ecco-jcc\/jjw142","article-title":"Reduced mucosa-associated butyricicoccus activity in patients with ulcerative colitis correlates with aberrant Claudin-1 expression","volume":"11","author":"Devriese","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.phymed.2023.155068_bib0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Anal. Chem."},{"key":"10.1016\/j.phymed.2023.155068_bib0016","doi-asserted-by":"crossref","first-page":"14327","DOI":"10.1038\/s41598-018-32309-1","article-title":"Anti-fibrotic impact of Carvedilol in a CCl4 model of liver fibrosis via serum microRNA-200a\/SMAD7 enhancement to bridle TGF-\u03b21\/EMT track","volume":"8","author":"El-Wakeel","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2023.155068_bib0017","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.foodchem.2014.02.106","article-title":"Effects of soybean oligosaccharides on antioxidant enzyme activities and insulin resistance in pregnant women with gestational diabetes mellitus","volume":"158","author":"Fei","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2023.155068_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109777","article-title":"Polysaccharides from Atractylodes macrocephala Koidz. Ameliorate ulcerative colitis via extensive modification of gut microbiota and host metabolism","volume":"138","author":"Feng","year":"2020","journal-title":"Food Res. Int."},{"issue":"6","key":"10.1016\/j.phymed.2023.155068_bib0020","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/hep.510280612","article-title":"Antifibrotic and hemodynamic effects of the early and chronic administration of octreotide in two models of liver fibrosis in rats","volume":"28","author":"Fort","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2023.155068_bib0021","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.lfs.2017.11.047","article-title":"Lycium barbarum polysaccharides improve CCl 4 -induced liver fibrosis, inflammatory response and TLRs\/NF-kB signaling pathway expression in wistar rats","volume":"192","author":"Gan","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2023.155068_bib0022","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.ijbiomac.2021.05.066","article-title":"Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation","volume":"183","author":"Gao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2023.155068_bib0023","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.carbpol.2012.10.072","article-title":"Artificial simulated saliva, gastric and intestinal digestion of polysaccharide from the seeds of Plantago asiatica L","volume":"92","author":"Hu","year":"2013","journal-title":"Carbohyd. Polym."},{"key":"10.1016\/j.phymed.2023.155068_bib0024","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijbiomac.2012.11.023","article-title":"Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L","volume":"54","author":"Jin","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.phymed.2023.155068_bib0025","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.phymed.2023.155068_bib0026","first-page":"27","article-title":"Growth behaviour of probiotic bacteria in culture media with carbohydrates of prebiotic importance","volume":"12","author":"Kneifel","year":"2011","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.phymed.2023.155068_bib0027","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1091\/mbc.e05-02-0159","article-title":"A Role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells","volume":"16","author":"Koch","year":"2005","journal-title":"Mol. Biol. Cell"},{"issue":"5","key":"10.1016\/j.phymed.2023.155068_bib0028","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cmet.2015.04.004","article-title":"Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver Is lost in steatohepatitis","volume":"21","author":"Koliaki","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.phymed.2023.155068_bib0029","doi-asserted-by":"crossref","first-page":"e9302","DOI":"10.15252\/emmm.201809302","article-title":"The role of the microbiome in NAFLD and NASH","volume":"11","author":"Kolodziejczyk","year":"2018","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.phymed.2023.155068_bib0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.phymed.2023.155068_bib0031","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40168-019-0621-x","article-title":"Short-term consumption of a high-fat diet increases host susceptibility to Listeria monocytogenes infection","volume":"18","author":"Las Heras","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.phymed.2023.155068_bib0032","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/foods12081617","article-title":"Lycium barbarum oligosaccharides alleviate hepatic steatosis by modulating gut microbiota in C57BL\/6J mice fed a high-fat diet","volume":"12","author":"Li","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2023.155068_bib0033","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/BF02356048","article-title":"A colorimetric estimation of reducing sugars in potatoes with 3, 5-dinitrosalicylic acid","volume":"16","author":"Lindsay","year":"1973","journal-title":"Potato Res."},{"key":"10.1016\/j.phymed.2023.155068_bib0034","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ijbiomac.2019.12.041","article-title":"Structural features and anti-gastric cancer activity of polysaccharides from stem, root, leaf and flower of cultivated Dendrobium huoshanense","volume":"143","author":"Liu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2023.155068_bib0035","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1039\/D1FO02667D","article-title":"Oligosaccharides derived from Lycium barbarum ameliorate glycolipid metabolism and modulate the gut microbiota community and the faecal metabolites in type 2 diabetes mouse model: metabolomic bioinformatic analysis","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2023.155068_bib0036","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijbiomac.2021.08.139","article-title":"Poria cocos polysaccharides attenuate chronic nonbacterial prostatitis by targeting the gut microbiota: comparative study of Poria cocos polysaccharides and finasteride in treating chronic prostatitis","volume":"189","author":"Liu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.phymed.2023.155068_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102461","article-title":"Effects of fermented Andrographis paniculata on growth performance, carcass traits, immune function, and intestinal health in Muscovy ducks","volume":"102","author":"Liu","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.phymed.2023.155068_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112100","article-title":"Effect of in vitro simulated gastrointestinal digestion on structural characteristics and anti-proliferative activities of the polysaccharides from the shells of Juglans regia L","volume":"150","author":"Luo","year":"2021","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.phymed.2023.155068_bib0041","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/01635581.2017.1263750","article-title":"Intestinal proportion of Blautia sp. is associated with clinical stage and histoprognostic grade in patients with early-stage breast cancer","volume":"69","author":"Luu","year":"2017","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.phymed.2023.155068_bib0042","doi-asserted-by":"crossref","first-page":"44625","DOI":"10.18632\/oncotarget.17886","article-title":"Dimethyl fumarate reduces the risk of mycotoxins via improving intestinal barrier and microbiota","volume":"8","author":"Ma","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.phymed.2023.155068_bib0043","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2478\/v10019-009-0006-z","article-title":"MRI-based texture analysis: a potential technique to assess protectors against induced-liver fibrosis in rats","volume":"43","author":"Mahmoud-Ghoneim","year":"2009","journal-title":"Radiol. Oncol."},{"key":"10.1016\/j.phymed.2023.155068_bib0044","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00253-006-0561-9","article-title":"In vitro evaluation of the prebiotic activity of pectic oligosaccharide-rich extract enzymatically derived from bergamot peel","volume":"73","author":"Mandalari","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.phymed.2023.155068_bib0045","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2147\/JHC.S370255","article-title":"Vitamin B6 metabolic pathway is involved in the pathogenesis of liver diseases via multi-omics analysis","volume":"9","author":"Mei","year":"2022","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.phymed.2023.155068_bib0046","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1211\/jpp.59.6.0016","article-title":"An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties","volume":"59","author":"Mencherini","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"issue":"5","key":"10.1016\/j.phymed.2023.155068_bib0047","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1021\/acs.jafc.2c08436","article-title":"Biosynthesis of human milk oligosaccharides: enzyme cascade and metabolic engineering approaches","volume":"71","author":"Meng","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.phymed.2023.155068_bib0048","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/ijfs.12681","article-title":"Oligosaccharide production by hydrolysis of polysaccharides: a review","volume":"50","author":"Moura","year":"2014","journal-title":"Int. J. Food Sci. Technol."},{"issue":"11","key":"10.1016\/j.phymed.2023.155068_bib0049","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3109\/10715762.2013.833331","article-title":"Redox signaling mediated by the gut microbiota","volume":"47","author":"Neish","year":"2013","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.phymed.2023.155068_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.112657","article-title":"Effects of dragon fruit oligosaccharides on immunity, gut microbiome, and their metabolites in healthy adults \u2013 A randomized double-blind placebo controlled study","volume":"167","author":"Pansai","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.phymed.2023.155068_bib0051","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.abf8403","article-title":"Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis","volume":"374","author":"Pernigoni","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.phymed.2023.155068_bib0052","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbi.2018.02.016","article-title":"Alteration of the fecal microbiota in Chinese patients with Parkinson's disease","volume":"70","author":"Qian","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.phymed.2023.155068_bib0053","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1152\/ajpgi.00521.2005","article-title":"Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation","volume":"290","author":"Reddy","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver"},{"issue":"5","key":"10.1016\/j.phymed.2023.155068_bib0054","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nbt.2170","article-title":"FLASH assembly of TALENs enables high-throughput genome editing","volume":"30","author":"Reyon","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phymed.2023.155068_bib0055","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1091\/mbc.12.8.2245","article-title":"Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells","volume":"12","author":"Smirnova","year":"2001","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.phymed.2023.155068_bib0056","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0005-2728(05)80070-2","article-title":"The interaction between chronic ethanol consumption and oxygen tension in influencing the energy state of rat liver","volume":"1056","author":"Spach","year":"1991","journal-title":"BBA Bioenergetics"},{"issue":"1","key":"10.1016\/j.phymed.2023.155068_bib0057","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2128605","article-title":"Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production","volume":"14","author":"Sugiyama","year":"2022","journal-title":"Gut Microbes"},{"issue":"11","key":"10.1016\/j.phymed.2023.155068_bib0058","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3109\/10715762.2013.837577","article-title":"Involvement of free radicals and oxidative stress in NAFLD\/NASH","volume":"47","author":"Sumida","year":"2013","journal-title":"Free Radic. Res."},{"issue":"5","key":"10.1016\/j.phymed.2023.155068_bib0059","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jhep.2022.06.033","article-title":"Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation","volume":"77","author":"Tripathi","year":"2022","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.phymed.2023.155068_bib0060","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1863133","article-title":"The prebiotic effects of omega-3 fatty acid supplementation: a six-week randomised intervention trial","volume":"13","author":"Vijay","year":"2021","journal-title":"Gut Microbes"},{"issue":"658","key":"10.1016\/j.phymed.2023.155068_bib0061","doi-asserted-by":"crossref","first-page":"eabl3927","DOI":"10.1126\/scitranslmed.abl3927","article-title":"The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces","volume":"14","author":"Vujkovic-Cvijin","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"16","key":"10.1016\/j.phymed.2023.155068_bib0062","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Na\u00efve Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microb."},{"key":"10.1016\/j.phymed.2023.155068_bib0063","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.intimp.2016.06.008","article-title":"Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition","volume":"38","author":"Wang","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2023.155068_bib0064","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/jam.12105","article-title":"Selective carbohydrate utilization by lactobacilli and bifidobacteria","volume":"114","author":"Watson","year":"2013","journal-title":"J. Appl. Microbiol."},{"issue":"4","key":"10.1016\/j.phymed.2023.155068_bib0065","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/gutjnl-2019-319664","article-title":"Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites","volume":"70","author":"Xiang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2023.155068_bib0066","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1111\/1750-3841.13813","article-title":"Effects of polysaccharides in lycium barbarum berries from different regions of China on macrophages function and their correlation to the glycosidic linkages","volume":"82","author":"Xie","year":"2017","journal-title":"J. Food Sci."},{"key":"10.1016\/j.phymed.2023.155068_bib0067","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6020247","article-title":"Metabolic profiling by UPLC\u2013Orbitrap\u2013MS\/MS of Liver from C57BL\/6 mice with DSS-induced inflammatory bowel disease","volume":"2020","author":"Xin","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phymed.2023.155068_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128081","article-title":"Physicochemical characteristics and in vitro biological activities of polysaccharides derived from raw garlic (Allium sativum L.) bulbs via three-phase partitioning combined with gradient ethanol precipitation method","volume":"339","author":"Yan","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2023.155068_bib0069","article-title":"Effects of long-term consumption of polysaccharides from the fruit of Lycium barbarum on host's health","volume":"139","author":"Yu","year":"2021","journal-title":"Food Res. Int."},{"issue":"8","key":"10.1016\/j.phymed.2023.155068_bib0070","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s10571-008-9284-z","article-title":"Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation","volume":"28","author":"Yu","year":"2008","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2023.155068_bib0071","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cmet.2019.08.018","article-title":"Fatty liver disease caused by high-alcohol-producing Klebsiella pneumoniae","volume":"30","author":"Yuan","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2023.155068_bib0072","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1074\/mcp.M500410-MCP200","article-title":"A proteome reference map and proteomic analysis of Bifidobacterium longum NCC2705","volume":"5","author":"Yuan","year":"2006","journal-title":"Mol. Cell. Proteom."},{"issue":"44","key":"10.1016\/j.phymed.2023.155068_bib0073","doi-asserted-by":"crossref","first-page":"13093","DOI":"10.1021\/acs.jafc.1c05411","article-title":"A novel sialoglycopeptide from gadus morhua eggs prevents liver fibrosis induced by CCl4 via downregulating FXR\/FGF15 and TLR4\/TGF-\u03b2\/Smad pathways","volume":"69","author":"Yue","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.phymed.2023.155068_bib0074","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1038\/s41467-022-31227-1","article-title":"Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2023.155068_bib0075","doi-asserted-by":"crossref","first-page":"7786","DOI":"10.1021\/jf4018492","article-title":"Isolation, characterization, and hepatoprotective effects of the raffinose family oligosaccharides from Rehmannia glutinosa libosch","volume":"61","author":"Zhang","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2023.155068_bib0076","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1039\/D1FO00249J","article-title":"Modulation of the fecal microbiome and metabolome by resistant dextrin ameliorates hepatic steatosis and mitochondrial abnormalities in mice","volume":"12","author":"Zhang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2023.155068_bib0077","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109778","article-title":"Lycium barbarum polysaccharide attenuates myocardial injury in high-fat diet-fed mice through manipulating the gut microbiome and fecal metabolome","volume":"138","author":"Zhang","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.phymed.2023.155068_bib0079","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.carbpol.2018.05.022","article-title":"An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of A \u03b2 42","volume":"195","author":"Zhou","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2023.155068_bib0080","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/s41588-018-0135-7","article-title":"The fecal metabolome as a functional readout of the gut microbiome","volume":"50","author":"Zierer","year":"2018","journal-title":"Nat. Genet."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:51:17Z","timestamp":1760554277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323004282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":76,"alternative-id":["S0944711323004282"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155068","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbial modifications with Lycium barbarum L. oligosaccharides decrease hepatic fibrosis and mitochondrial abnormalities in mice","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"155068"}}