{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:41:02Z","timestamp":1792698062811,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.phymed.2023.155111","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:23:02Z","timestamp":1695496982000},"page":"155111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Xie Zhuo Tiao Zhi formula modulates intestinal microbiota and liver purine metabolism to suppress hepatic steatosis and pyroptosis in NAFLD therapy"],"prefix":"10.1016","volume":"121","author":[{"given":"Jiannan","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-0823","authenticated-orcid":false,"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guonong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0008-0712","authenticated-orcid":false,"given":"Zhongyan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-9608","authenticated-orcid":false,"given":"Zhiling","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-673X","authenticated-orcid":false,"given":"Songtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155111_bib0001","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41575-020-00406-0","article-title":"Nonalcoholic fatty liver disease: another leap forward","volume":"18","author":"Abdelmalek","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2023.155111_bib0002","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/imr.12891","article-title":"Lipids, inflammasomes, metabolism, and disease","volume":"297","author":"Anand","year":"2020","journal-title":"Immonol. Rev."},{"key":"10.1016\/j.phymed.2023.155111_bib0003","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/hep.32320","article-title":"NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH","volume":"76","author":"Calcagno","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2023.155111_bib0004","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/apt.16262","article-title":"Cross-linkage between bacterial taxonomy and gene functions: a study of metagenome-assembled genomes of gut microbiota in adult non-alcoholic fatty liver disease","volume":"53","author":"Canivet","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2023.155111_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.858795","article-title":"Multi-omics integration analysis identifies lipid disorder of a non-alcoholic fatty liver disease (NAFLD) mouse model improved by Zexie-Baizhu decoction","volume":"13","author":"Cao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155111_bib0006","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1056\/NEJMra1503519","article-title":"Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis","volume":"377","author":"Diehl","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2023.155111_bib0007","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.apsb.2021.09.019","article-title":"Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2023.155111_bib0008","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/j.apsb.2021.12.012","article-title":"Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2023.155111_bib0009","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2020.07.041","article-title":"Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis","volume":"74","author":"Gaul","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2023.155111_bib0010","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/hep.31628","article-title":"neutral ceramidase mediates nonalcoholic steatohepatitis by regulating monounsaturated fatty acids and gut IgA(+) B cells","volume":"73","author":"Gu","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2023.155111_bib0011","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2023.155111_bib0012","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.chom.2020.07.007","article-title":"Microbiota and fatty liver disease-the known, the unknown, and the future","volume":"28","author":"Lang","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.phymed.2023.155111_bib0013","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/s41591-018-0060-4","article-title":"Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health","volume":"24","author":"Laurans","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2023.155111_bib0014","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.abc3421","article-title":"Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy","volume":"369","author":"Mager","year":"2020","journal-title":"ScienceScience"},{"key":"10.1016\/j.phymed.2023.155111_bib0015","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jhep.2021.12.035","article-title":"A disease-promoting role of the intestinal mycobiome in non-alcoholic fatty liver disease","volume":"76","author":"Mehal","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2023.155111_bib0016","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cmet.2018.07.001","article-title":"Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome","volume":"28","author":"Natividad","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2023.155111_bib0017","article-title":"Increased risk of young-onset digestive tract cancers among young adults age 20-39 years with nonalcoholic fatty liver disease: a nationwide cohort study","author":"Park","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phymed.2023.155111_bib0018","article-title":"Metabolomics analysis delineates the therapeutic effects of Huangqi decoction and astragalosides on alpha-naphthylisothiocyanate (ANIT) -induced cholestasis in rats","volume":"268","author":"Qiu","year":"2021","journal-title":"J. Ethnopharmaol."},{"key":"10.1016\/j.phymed.2023.155111_bib0019","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.phymed.2023.155111_bib0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/ajcn\/nqz042","article-title":"Gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression","volume":"110","author":"Sharpton","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2023.155111_bib0021","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nutres.2017.03.005","article-title":"Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction","volume":"40","author":"Shen","year":"2017","journal-title":"Nutr. Res."},{"key":"10.1016\/j.phymed.2023.155111_bib0023","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1194\/jlr.R800084-JLR200","article-title":"Structural and functional analysis of fatty acid-binding proteins","volume":"50","author":"Storch","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phymed.2023.155111_bib0024","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.nut.2015.08.020","article-title":"High-fat-diet-induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Peyer's patches","volume":"32","author":"Sun","year":"2016","journal-title":"Nutrition"},{"key":"10.1016\/j.phymed.2023.155111_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154208","article-title":"The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-kappaB\/CCL3\/CCR1 axis","volume":"103","author":"Tan","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155111_bib0026","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/s42255-021-00501-9","article-title":"Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity","volume":"3","author":"Tilg","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phymed.2023.155111_bib0027","first-page":"489","article-title":"The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans","volume":"24","author":"Tirosh","year":"2019","journal-title":"SCI Trans. Med."},{"key":"10.1016\/j.phymed.2023.155111_bib0028","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/s41423-022-00905-x","article-title":"Role of pyroptosis in inflammation and cancer","volume":"19","author":"Wei","year":"2022","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.phymed.2023.155111_bib0029","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat. Immubol."},{"key":"10.1016\/j.phymed.2023.155111_bib0030","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41586-023-05857-4","article-title":"Clonal haematopoiesis and risk of chronic liver disease","volume":"616","author":"Wong","year":"2023","journal-title":"Nature"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:51:39Z","timestamp":1760554299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323004713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":29,"alternative-id":["S0944711323004713"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155111","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xie Zhuo Tiao Zhi formula modulates intestinal microbiota and liver purine metabolism to suppress hepatic steatosis and pyroptosis in NAFLD therapy","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"155111"}}