{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:11:21Z","timestamp":1792494681192,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.phymed.2023.155137","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:08:17Z","timestamp":1696507697000},"page":"155137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Jiangu granules ameliorate postmenopausal osteoporosis via rectifying bone homeostasis imbalance: A network pharmacology analysis based on multi-omics validation"],"prefix":"10.1016","volume":"122","author":[{"given":"Chaoxiong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangquan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5309-0958","authenticated-orcid":false,"given":"Haiming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155137_bib0001","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/0976-9668.92322","article-title":"Preventive effects of phytoestrogens against postmenopausal osteoporosis as compared to the available therapeutic choices: an overview","volume":"2","author":"Al-Anazi","year":"2011","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0002","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.intimp.2016.04.024","article-title":"Natural products for treatment of bone erosive diseases: the effects and mechanisms on inhibiting osteoclastogenesis and bone resorption","volume":"36","author":"An","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2023.155137_bib0003","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/14656566.2020.1717468","article-title":"Combination and sequential treatment in women with postmenopausal osteoporosis","volume":"21","author":"Anastasilakis","year":"2020","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155137_bib0004","article-title":"Effect of exercise on bone mineral density and quality of life among postmenopausal women with osteoporosis without fracture: a systematic review","volume":"39","author":"Anupama","year":"2020","journal-title":"Int. J. Orthop. Trauma Nurs."},{"key":"10.1016\/j.phymed.2023.155137_bib0005","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1074\/jbc.M707000200","article-title":"NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells","volume":"283","author":"Bai","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.155137_bib0006","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa062462","article-title":"Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women","volume":"355","author":"Barrett-Connor","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0007","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Postmenopausal Osteoporosis","volume":"374","author":"Black","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0008","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2023.155137_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.959417","article-title":"The immune factors have complex causal regulation effects on bone mineral density","volume":"13","author":"Cao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2023.155137_bib0010","doi-asserted-by":"crossref","first-page":"e580","DOI":"10.1016\/S2666-7568(21)00172-0","article-title":"Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019","volume":"2","author":"Collaborators","year":"2021","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.phymed.2023.155137_bib0011","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3109\/08820139.2013.822764","article-title":"The immune system and postmenopausal osteoporosis","volume":"42","author":"D'Amelio","year":"2013","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.phymed.2023.155137_bib0012","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1021\/acsnano.1c08728","article-title":"Biomaterial-mediated presentation of jagged-1 mimetic ligand enhances cellular activation of notch signaling and bone regeneration","volume":"16","author":"Deng","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.phymed.2023.155137_bib0013","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI200317215","article-title":"Role of RANK ligand in mediating increased bone resorption in early postmenopausal women","volume":"111","author":"Eghbali-Fatourechi","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2023.155137_bib0014","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00011-012-0506-y","article-title":"Modulation of heat shock proteins during macrophage differentiation","volume":"61","author":"Fagone","year":"2012","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.phymed.2023.155137_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9661200","article-title":"Bortezomib rescues ovariectomy-induced bone loss via SMURF-mediated ubiquitination pathway","volume":"2021","author":"Fang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2023.155137_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.902947","article-title":"Inhibition of notch signaling stimulates osteoclastogenesis from the common trilineage progenitor under inflammatory conditions","volume":"13","author":"Filipovic","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2023.155137_bib0017","first-page":"1017","article-title":"Osteoporosis: pathophysiology and therapeutic options","volume":"19","author":"Foger-Samwald","year":"2020","journal-title":"EXCLI J."},{"key":"10.1016\/j.phymed.2023.155137_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1204497","article-title":"Burden of falls attributable to low bone mineral density among people aged 60 years and over in China from 1990 to 2019","volume":"11","author":"Fu","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.phymed.2023.155137_bib0019","first-page":"9","article-title":"Notch and TLR signaling coordinate monocyte cell fate and inflammation","author":"Gamrekelashvili","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.phymed.2023.155137_bib0020","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.clinbiochem.2012.03.006","article-title":"The relationship between adipose tissue and bone metabolism","volume":"45","author":"Gimble","year":"2012","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.phymed.2023.155137_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108820","article-title":"Pro-Osteogenic and anti-inflammatory synergistic effect of orthosilicic acid, vitamin K2, curcumin, polydatin and quercetin combination in young and senescent bone marrow-derived mesenchymal stromal cells","volume":"24","author":"Giordani","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155137_bib0022","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/s41419-021-04161-1","article-title":"Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone","volume":"12","author":"He","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2023.155137_bib0023","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMoa1505241","article-title":"Vascular effects of early versus late postmenopausal treatment with estradiol","volume":"374","author":"Hodis","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0024","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nbt1007-1110","article-title":"Network pharmacology","volume":"25","author":"Hopkins","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phymed.2023.155137_bib0025","doi-asserted-by":"crossref","first-page":"8420","DOI":"10.3892\/mmr.2017.7645","article-title":"Molecular mechanisms of the inhibitory effects of jiangu granule-containing serum on RANKL-induced osteoclastogenesis","volume":"16","author":"Huang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2023.155137_bib0026","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3390\/molecules23051143","article-title":"Network medicine for Alzheimer's disease and traditional chinese medicine","volume":"23","author":"Jarrell","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155137_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115181","article-title":"The mechanism of metformin combined with total flavonoids of Rhizoma Drynariae on ovariectomy-induced osteoporotic rats","volume":"165","author":"Jiang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155137_bib0028","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.7150\/thno.29617","article-title":"CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes\/macrophages","volume":"9","author":"Jiang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2023.155137_bib0029","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11684-014-0362-y","article-title":"Mechanisms of \"kidney governing bones\" theory in traditional Chinese medicine","volume":"8","author":"Ju","year":"2014","journal-title":"Front. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0030","first-page":"26","article-title":"The biology of normal bone remodelling","author":"Katsimbri","year":"2017","journal-title":"Eur. J. Cancer Care (Engl.)"},{"key":"10.1016\/j.phymed.2023.155137_bib0031","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ecl.2022.10.009","article-title":"Osteoporosis: review of etiology, mechanisms, and approach to management in the aging population","volume":"52","author":"Khandelwal","year":"2023","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.phymed.2023.155137_bib0032","doi-asserted-by":"crossref","first-page":"21526","DOI":"10.1074\/jbc.M113.465120","article-title":"Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE)","volume":"288","author":"Larabee","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.155137_bib0033","article-title":"Anti-osteoporotic effect of morroniside on osteoblast and osteoclast differentiation in vitro and ovariectomized mice in vivo","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155137_bib0034","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3892\/etm.2015.2616","article-title":"Effect of serum from postmenopausal women with osteoporosis exhibiting the Kidney-Yang deficiency pattern on bone formation in an hFOB 1.19 human osteoblastic cell line","volume":"10","author":"Li","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1052922","article-title":"4D label-free quantitative proteomics analysis to screen potential drug targets of Jiangu Granules treatment for postmenopausal osteoporotic rats","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155137_bib0036","first-page":"431","article-title":"[Effect of jiangu granule on quality of bone in model rats with osteoporosis induced by ovariectomy]","volume":"24","author":"Lin","year":"2004","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.phymed.2023.155137_bib0037","doi-asserted-by":"crossref","first-page":"eadg0731","DOI":"10.1126\/sciadv.adg0731","article-title":"The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts","volume":"9","author":"Liu","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2023.155137_bib0038","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1472-6882-12-67","article-title":"Therapeutic effects of radix dipsaci, pyrola herb, and Cynomorium songaricum on bone metabolism of ovariectomized rats","volume":"12","author":"Liu","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0039","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ajpath.2019.05.005","article-title":"Notch signaling in osteogenesis, osteoclastogenesis, and angiogenesis","volume":"189","author":"Luo","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2023.155137_bib0040","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.3389\/fphar.2020.01316","article-title":"Unveiling the pharmacological mechanisms of eleutheroside E against postmenopausal osteoporosis through UPLC-Q\/TOF-MS-based metabolomics","volume":"11","author":"Ma","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155137_bib0041","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/GME.0000000000001831","article-title":"Management of osteoporosis in postmenopausal women: the 2021 position statement of the North American menopause society","volume":"28","year":"2021","journal-title":"Menopause"},{"key":"10.1016\/j.phymed.2023.155137_bib0042","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1359\/JBMR.050803","article-title":"Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption","volume":"20","author":"Michael","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phymed.2023.155137_bib0043","doi-asserted-by":"crossref","first-page":"16568","DOI":"10.1073\/pnas.1308755110","article-title":"HIF1alpha is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis","volume":"110","author":"Miyauchi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2023.155137_bib0044","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3109\/13880209.2014.884606","article-title":"Chinese herbal medicine for bone health","volume":"52","author":"Mukwaya","year":"2014","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2023.155137_bib0045","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4874195","article-title":"RANK expression and osteoclastogenesis in human monocytes in peripheral blood from rheumatoid arthritis patients","volume":"2016","author":"Nanke","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phymed.2023.155137_bib0046","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4122253","article-title":"A comparison of the antiosteoporotic effects of cornelian cherry (Cornus mas L.) extracts from red and yellow fruits containing different constituents of polyphenols and iridoids in osteoblasts and osteoclasts","volume":"2022","author":"Park","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2023.155137_bib0047","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.911326","article-title":"Role of traditional chinese medicine in bone regeneration and osteoporosis","volume":"10","author":"Peng","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.phymed.2023.155137_bib0048","first-page":"3018","article-title":"The prion protein inhibits monocytic cell migration by stimulating beta1 integrin adhesion and uropod formation","volume":"128","author":"Richardson","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phymed.2023.155137_bib0049","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1210\/edrv.23.3.0465","article-title":"Sex steroids and the construction and conservation of the adult skeleton","volume":"23","author":"Riggs","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phymed.2023.155137_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154739","article-title":"Safranal inhibits estrogen-deficiency osteoporosis by targeting Sirt1 to interfere with NF-kappaB acetylation","volume":"114","author":"Sheng","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155137_bib0051","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/sj.ebd.6401243","article-title":"Treatment for bisphosphonate-related osteonecrosis of the jaw","volume":"18","author":"Spivakovsky","year":"2017","journal-title":"Evid. Based Dent."},{"key":"10.1016\/j.phymed.2023.155137_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112975","article-title":"Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg\/Th17 axis","volume":"150","author":"Sun","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155137_bib0053","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3389\/fphar.2018.00981","article-title":"Bone health and natural products- an insight","volume":"9","author":"Suvarna","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155137_bib0054","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s10856-021-06627-2","article-title":"Hydrogel contained valproic acid accelerates bone-defect repair via activating Notch signaling pathway in ovariectomized rats","volume":"33","author":"Tao","year":"2021","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0055","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13020-023-00788-8","article-title":"Effects of genus Epimedium in the treatment of osteoarthritis and relevant signaling pathways","volume":"18","author":"Tong","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0056","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-019-0178-8","article-title":"Osteoimmunology: evolving concepts in bone-immune interactions in health and disease","volume":"19","author":"Tsukasaki","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2023.155137_bib0057","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1172\/JCI80672","article-title":"NOTCH signaling in skeletal progenitors is critical for fracture repair","volume":"126","author":"Wang","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2023.155137_bib0058","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/1440-1681.13591","article-title":"Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2\/STAT3 signalling","volume":"49","author":"Wang","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.phymed.2023.155137_bib0059","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/732562","article-title":"Chinese herbal medicine for osteoporosis: a systematic review of randomized controlled trails","volume":"2013","author":"Wang","year":"2013","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11655-011-0613-6","article-title":"Clinical practice guideline of traditional medicine for primary osteoporosis","volume":"17","author":"Xie","year":"2011","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phymed.2023.155137_bib0061","first-page":"11","article-title":"Induction of osteogenesis by bone-targeted Notch activation","author":"Xu","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.phymed.2023.155137_bib0062","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/1061186X.2021.2013488","article-title":"Effects and mechanisms of natural plant active compounds for the treatment of osteoclast-mediated bone destructive diseases","volume":"30","author":"Xu","year":"2022","journal-title":"J. Drug Target"},{"key":"10.1016\/j.phymed.2023.155137_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172794","article-title":"Icariin promotes osteogenic differentiation by suppressing Notch signaling","volume":"865","author":"Xu","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155137_bib0064","article-title":"Roles of altered macrophages and cytokines: implications for pathological mechanisms of postmenopausal osteoporosis, rheumatoid arthritis, and Alzheimer's disease","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phymed.2023.155137_bib0065","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.7754\/Clin.Lab.2016.160408","article-title":"Elevated CCL2\/MCP-1 levels are related to disease severity in postmenopausal osteoporotic patients","volume":"62","author":"Yang","year":"2016","journal-title":"Clin. Lab."},{"key":"10.1016\/j.phymed.2023.155137_bib0066","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1359\/jbmr.070405","article-title":"Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial","volume":"22","author":"Zhang","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phymed.2023.155137_bib0067","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7150\/ijms.5180","article-title":"Immune regulation of osteoclast function in postmenopausal osteoporosis: a critical interdisciplinary perspective","volume":"9","author":"Zhao","year":"2012","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.phymed.2023.155137_bib0068","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00198-011-1577-2","article-title":"The first multicenter and randomized clinical trial of herbal Fufang for treatment of postmenopausal osteoporosis","volume":"23","author":"Zhu","year":"2012","journal-title":"Osteoporos. Int."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323004968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:48:31Z","timestamp":1760554111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323004968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":68,"alternative-id":["S0944711323004968"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155137","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jiangu granules ameliorate postmenopausal osteoporosis via rectifying bone homeostasis imbalance: A network pharmacology analysis based on multi-omics validation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155137"}}