{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:07:26Z","timestamp":1791925646037,"version":"4.3.4"},"reference-count":281,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"am","delay-in-days":311,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.phymed.2023.155150","type":"journal-article","created":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T10:00:37Z","timestamp":1697364037000},"page":"155150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1516-5161","authenticated-orcid":false,"given":"Vinayak","family":"Nayak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7942-9621","authenticated-orcid":false,"given":"Sushmita","family":"Patra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrushti","family":"Rout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1690-7913","authenticated-orcid":false,"given":"Atala Bihari","family":"Jena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3682-3573","authenticated-orcid":false,"given":"Rohit","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kali Prasad","family":"Pattanaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-0450","authenticated-orcid":false,"given":"Jay","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam S.","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra Pratap","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanatan","family":"Majhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-0010","authenticated-orcid":false,"given":"Kshitij RB","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2943-3681","authenticated-orcid":false,"given":"Rout George","family":"Kerry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155150_bib0001","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/1061186X.2017.1354002","article-title":"Neuroprotective effects of a biodegradable poly(lactic-co-glycolic acid)-ginsenoside Rg3 nanoformulation: a potential nanotherapy for Alzheimer's disease?","volume":"26","author":"Aalinkeel","year":"2018","journal-title":"J. Drug Target."},{"key":"10.1016\/j.phymed.2023.155150_bib0002","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ffj.3615","article-title":"Anti-cholinesterase and antioxidant properties of alkaloid and phenolic-rich extracts from pawpaw (Carica papaya) leaf: a comparative study","volume":"36","author":"Adedayo","year":"2021","journal-title":"Flavour Fragr. J."},{"key":"10.1016\/j.phymed.2023.155150_bib0003","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.phymed.2023.155150_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119546","article-title":"The effect of baicalein-loaded Y-shaped miktoarm copolymer on spatial memory and hippocampal expression of DHCR24, SELADIN and SIRT6 genes in rat model of Alzheimer","volume":"586","author":"Aghajanzadeh","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0005","first-page":"070","article-title":"Evaluation of plant food extracts in experimental model of Alzheimer's like disease induced by aluminum lactate in rats","volume":"7","author":"Al-Okbi","year":"2017","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0006","doi-asserted-by":"crossref","first-page":"26","DOI":"10.15282\/ijsecs.7.2.2021.4.0087","article-title":"Machine learning and deep learning-based approaches on various biomarkers for Alzheimer's disease early detection: a review","volume":"7","author":"Alqubati","year":"2021","journal-title":"Int. J. Softw. Eng. Comput. Syst."},{"key":"10.1016\/j.phymed.2023.155150_bib0007","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6661937","article-title":"6-gingerol, a major ingredient of ginger attenuates Diethylnitrosamine-induced liver injury in rats through the modulation of oxidative stress and anti-inflammatory activity","volume":"2021","author":"Alsahli","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phymed.2023.155150_bib0008","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1073\/pnas.0511065103","article-title":"NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK\/MAPK activation","volume":"103","author":"Amadoro","year":"2006","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1016\/j.phymed.2023.155150_bib0009","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.phymed.2023.155150_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104511","article-title":"The complex genetic architecture of Alzheimer's disease: novel insights and future directions","volume":"90","author":"Andrews","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phymed.2023.155150_bib0011","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.3390\/molecules28093899","article-title":"Novel derivatives of eugenol as a new class of PPAR\u03b3 agonists in treating inflammation: design, synthesis, SAR analysis and in vitro anti-inflammatory activity","volume":"28","author":"Anjum","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155150_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.788128","article-title":"An insight to brain targeting utilizing polymeric nanoparticles: effective treatment modalities for neurological disorders and brain tumor","volume":"10","author":"Annu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.phymed.2023.155150_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.615147","article-title":"A review of the toxicity and phytochemistry of medicinal plant species used by herbalists in treating people living with HIV\/AIDS in Uganda","volume":"12","author":"Anywar","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0014","first-page":"217","article-title":"Potential of medicinal plant compounds to targeting tau protein in the therapy of Alzheimer's disease\u2013 a review","volume":"39","author":"Armand","year":"2020","journal-title":"Biomedicine (Taipei)"},{"key":"10.1016\/j.phymed.2023.155150_bib0015","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.ijbiomac.2022.03.203","article-title":"Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model","volume":"208","author":"Arora","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2023.155150_bib0016","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/nano12050746","article-title":"Tempranillo grape extract in transfersomes: a nanoproduct with antioxidant activity","volume":"12","author":"Asensio-Regalado","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.phymed.2023.155150_bib0017","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/ptr.6577","article-title":"Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress","volume":"34","author":"Ashrafizadeh","year":"2020","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0018","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1021\/ci100340w","article-title":"Sequence, structure, and active site analyses of p38 MAP kinase: exploiting DFG-out conformation as a strategy to design new type II leads","volume":"51","author":"Badrinarayan","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.phymed.2023.155150_bib0019","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1021\/acsmacrolett.2c00239","article-title":"Autoxidation-resistant, ROS-scavenging, and anti-inflammatory micellar nanoparticles self-assembled from poly(acrylic acid)\u2013green tea catechin conjugates","volume":"11","author":"Bae","year":"2022","journal-title":"ACS Macro Lett."},{"key":"10.1016\/j.phymed.2023.155150_bib0020","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.3390\/molecules27217223","article-title":"Effect of ginger on inflammatory diseases","volume":"27","author":"Ballester","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155150_bib0021","article-title":"Neurodegeneration cell per cell","volume":"0","author":"Balusu","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2023.155150_bib0022","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainres.2018.10.001","article-title":"Coconut oil decreases expression of amyloid precursor protein (APP) and secretion of amyloid peptides through inhibition of ADP-ribosylation factor 1 (ARF1)","volume":"1704","author":"Bansal","year":"2019","journal-title":"Brain Res"},{"key":"10.1016\/j.phymed.2023.155150_bib0023","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejphar.2017.01.006","article-title":"Cucurbitacin B purified from Ecballium elaterium (L.) A. Rich from Tunisia inhibits \u03b15\u03b21 integrin-mediated adhesion, migration, proliferation of human glioblastoma cell line and angiogenesis","volume":"797","author":"Barakati","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0024","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/624801","article-title":"Oxidative stress in patients with Aalzheimer's disease: effect of extracts of fermented papaya powder","volume":"2015","author":"Barbagallo","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phymed.2023.155150_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6064\/2012\/246210","article-title":"The genetics of Alzheimer's disease","volume":"2012","author":"Barber","year":"2012","journal-title":"Scientifica (Cairo)"},{"key":"10.1016\/j.phymed.2023.155150_bib0027","doi-asserted-by":"crossref","first-page":"9236","DOI":"10.3390\/ijms24119236","article-title":"Effects of flavonoids on cancer, cardiovascular and neurodegenerative diseases: role of NF-\u03baB signaling pathway","volume":"24","author":"Barreca","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0028","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.phymed.2023.155150_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.579052","article-title":"Neuroprotective potency of saffron against neuropsychiatric diseases, neurodegenerative diseases, and other brain disorders: from bench to bedside","volume":"11","author":"Bian","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4103\/0973-8258.91229","article-title":"Psychopharmacological investigations on the benefits of Ageratum conyzoides in the modulation of neurodegenerative disorder of Alzheimer's type","volume":"5","author":"Biradar","year":"2011","journal-title":"Int. J. Green Pharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0031","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1523\/JNEUROSCI.0800-08.2008","article-title":"Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in alzheimer's disease","volume":"28","author":"Boland","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2023.155150_bib0032","doi-asserted-by":"crossref","first-page":"e17578","DOI":"10.7554\/eLife.17578","article-title":"The amyloid-beta forming tripeptide cleavage mechanism of \u03b3-secretase","volume":"5","author":"Bolduc","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.phymed.2023.155150_bib0033","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1021\/acs.molpharmaceut.8b00870","article-title":"Transferrin receptor-mediated uptake at the blood-brain barrier is not impaired by Alzheimer's disease neuropathology","volume":"16","author":"Bourassa","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0034","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/jdv.17710","article-title":"Epigallocatechin-3-gallate exhibits anti-inflammatory effects in a human interface dermatitis model\u2014Implications for therapy","volume":"36","author":"Braegelmann","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.phymed.2023.155150_bib0035","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3390\/ph14100982","article-title":"Plant polyphenols for aging health: implication from their autophagy modulating properties in age-associated diseases","volume":"14","author":"Brimson","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.phymed.2023.155150_bib0036","doi-asserted-by":"crossref","first-page":"8122","DOI":"10.1039\/D0FO01511C","article-title":"Amyloid \u03b2 fibril disruption by oleuropein aglycone: long-time molecular dynamics simulation to gain insight into the mechanism of action of this polyphenol from extra virgin olive oil","volume":"11","author":"Brogi","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2023.155150_bib0037","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3233\/JAD-170543","article-title":"Oxidative stress, amyloid-\u03b2 peptide, and altered key molecular pathways in the pathogenesis and progression of Alzheimer's disease","volume":"62","author":"Butterfield","year":"2018","journal-title":"J. Alzheimer. Dis."},{"key":"10.1016\/j.phymed.2023.155150_bib0038","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2019.03.010","article-title":"Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)\/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe\/PS1dE9 Alzheimer's disease mice model","volume":"301","author":"Cano","year":"2019","journal-title":"J. Control. Relea."},{"key":"10.1016\/j.phymed.2023.155150_bib0039","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neulet.2019.03.016","article-title":"Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis","volume":"703","author":"Cao","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phymed.2023.155150_bib0040","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.1074\/jbc.M409106200","article-title":"\u03b3-secretase complex assembly within the early secretory pathway","volume":"280","author":"Capell","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.155150_bib0041","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.nano.2017.12.006","article-title":"Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model","volume":"14","author":"Carradori","year":"2018","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0042","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.3390\/ijms24033005","article-title":"PDIA3 expression is altered in the limbic brain regions of triple-transgenic mouse model of Alzheimer's disease","volume":"24","author":"Cassano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0043","doi-asserted-by":"crossref","DOI":"10.2174\/156802606776743066","article-title":"The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease","volume":"6","author":"Catalano","year":"2006","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.phymed.2023.155150_bib0044","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20220324","article-title":"Impact of nanoparticles on amyloid \u03b2-induced Alzheimer's disease, tuberculosis, leprosy and cancer: a systematic review","volume":"43","author":"Chakraborty","year":"2023","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.phymed.2023.155150_bib0045","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/aps.2017.28","article-title":"Amyloid beta: structure, biology and structure-based therapeutic development","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2023.155150_bib0046","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cyto.2019.01.001","article-title":"Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-\u03b1-activated retinal pigment epithelial cells","volume":"116","author":"Cheng","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.phymed.2023.155150_bib0047","series-title":"Therapeutic Drug Monitoring","first-page":"417","article-title":"Chapter 19 - Effect of herbal supplement\u2013drug interactions on therapeutic drug monitoring","author":"Chin","year":"2012"},{"key":"10.1016\/j.phymed.2023.155150_bib0048","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci9090213","article-title":"Biomarker-based signature of Alzheimer's disease in pre-MCI individuals","volume":"9","author":"Chipi","year":"2019","journal-title":"Brain Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0049","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3831\/KPI.2022.25.2.79","article-title":"Potential role of bioactive phytochemicals in combination therapies against antimicrobial activity","volume":"25","author":"Choudhury","year":"2022","journal-title":"J. Pharmacopunct."},{"key":"10.1016\/j.phymed.2023.155150_bib0050","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.pneurobio.2010.01.002","article-title":"Epigenetic regulation in the pathophysiology of Alzheimer's disease","volume":"90","author":"Chouliaras","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2023.155150_bib0051","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205856","article-title":"Toward personalized nanomedicine: the critical evaluation of micro and nanodevices for cancer biomarker analysis in liquid biopsy","volume":"19","author":"Clack","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.phymed.2023.155150_bib0052","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1080\/14756366.2017.1347783","article-title":"Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to \u03b2 sheet in tau protein linked to Alzheimer's disease","volume":"32","author":"Cornejo","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.phymed.2023.155150_bib0053","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1039\/C4MB00703D","article-title":"Reversible redox modifications in the microglial proteome challenged by beta amyloid","volume":"11","author":"Correani","year":"2015","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.phymed.2023.155150_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106587","article-title":"Cucurbitacin B: a review of its pharmacology, toxicity, and pharmacokinetics","volume":"187","author":"Dai","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0055","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.2147\/IJN.S413680","article-title":"Subcellular organelle-targeted nanostructured lipid carriers for the treatment of metastatic breast cancer","volume":"18","author":"Dang","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.phymed.2023.155150_bib0056","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1476-5381.2012.02057.x","article-title":"Alzheimer's disease, \u03b2-amyloid, glutamate, NMDA receptors and memantine \u2013 searching for the connections","volume":"167","author":"Danysz","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0057","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3390\/antiox10071034","article-title":"An Overview on Topical Administration of Carotenoids and Coenzyme Q10 Loaded in Lipid Nanoparticles","volume":"10","author":"De Souza Guedes","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2023.155150_bib0058","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006304","article-title":"Presenilins and \u03b3-secretase: structure, function, and role in Alzheimer disease","volume":"2","author":"De Strooper","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114397","article-title":"Therapeutic nanotechnologies for Alzheimer's disease: a critical analysis of recent trends and findings","volume":"187","author":"Delbreil","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.phymed.2023.155150_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119553","article-title":"Cationic biopolymer functionalized nanoparticles encapsulating lutein to attenuate oxidative stress in effective treatment of Alzheimer's disease: a non-invasive approach","volume":"586","author":"Dhas","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0061","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3389\/fneur.2019.01140","article-title":"Amyloid beta oligomers target to extracellular and intracellular neuronal synaptic proteins in Alzheimer's disease","volume":"10","author":"Ding","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.phymed.2023.155150_bib0062","series-title":"Dassault Syst\u00e8mes BIOVIA, Discovery Studio Modeling environment, Release 2021","first-page":"2021","year":"2002"},{"key":"10.1016\/j.phymed.2023.155150_bib0063","first-page":"288","article-title":"Anti-inflammatory property of lycopene, vitamin e and their combination \u2013 in vitro study","volume":"30","author":"Divyadharsini","year":"2023","journal-title":"J. Popul. Ther. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0064","series-title":"Chapter 21 - Target identification and Polypharmacology of Nutraceuticals","first-page":"263","author":"Dorm\u00e1n","year":"2016"},{"key":"10.1016\/j.phymed.2023.155150_bib0065","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3390\/biom10091323","article-title":"Curcumin inhibits the primary nucleation of amyloid-beta peptide: a molecular dynamics study","volume":"10","author":"Doytchinova","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2023.155150_bib0066","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1002\/j.1460-2075.1992.tb05272.x","article-title":"Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state","volume":"11","author":"Drewes","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/j.phymed.2023.155150_bib0067","first-page":"3332","article-title":"Action mechanisms of curcumin in Alzheimer's disease and its brain targeted delivery","volume":"14","author":"Ege","year":"2021","journal-title":"Mater. Basel Switz."},{"key":"10.1016\/j.phymed.2023.155150_bib0069","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000369101","article-title":"Amyloid-beta: a crucial factor in Alzheimer's disease","volume":"24","author":"Eteghad","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.phymed.2023.155150_bib0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1125093","article-title":"Lipid-engineered nanotherapeutics for cancer management","volume":"14","author":"Fernandez-Fernandez","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0071","series-title":"Comprehensive Medicinal Chemistry III","first-page":"495","article-title":"5.16 - Small-molecule drugs for the treatment of inflammatory bowel disease","author":"Fitzpatrick","year":"2017"},{"key":"10.1016\/j.phymed.2023.155150_bib0072","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/brain\/awr038","article-title":"18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease","volume":"134","author":"Fodero-Tavoletti","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.phymed.2023.155150_bib0073","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/jpm7040012","article-title":"Personalized nanomedicine: a revolution at the nanoscale","volume":"7","author":"Fornaguera","year":"2017","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0074","article-title":"Effect of nanoencapsulation of blueberry (Vaccinium myrtillus): a green source of flavonoids with antioxidant and photoprotective properties","volume":"23","author":"Franco","year":"2021","journal-title":"Sustain. Chem. Pharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0075","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3390\/molecules24061170","article-title":"Antineuroinflammatory Activities and Neurotoxicological Assessment of Curcumin Loaded Solid Lipid Nanoparticles on LPS-Stimulated BV-2 Microglia Cell Models","volume":"24","author":"Ganesan","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155150_bib0076","first-page":"1135","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019 - The Lancet","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2023.155150_bib0077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2013.00160","article-title":"Tangles, toxicity, and tau secretion in AD \u2013 new approaches to a vexing problem","volume":"4","author":"Gendreau","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.phymed.2023.155150_bib0078","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.1021\/jf300589c","article-title":"Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies","volume":"60","author":"Geromichalos","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2023.155150_bib0079","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijpharm.2019.01.043","article-title":"Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: an in vivo study","volume":"559","author":"Ghiasi","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0080","first-page":"1","article-title":"Revealing the cholinergic inhibition mechanism of Alzheimer's by galantamine: a metadynamics simulation study","volume":"0","author":"Ghosh","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.phymed.2023.155150_bib0081","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/antiox8020035","article-title":"Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of apigenin","volume":"8","author":"Ginwala","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2023.155150_bib0082","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.3390\/ijms24032944","article-title":"Lipoprotein metabolism, protein aggregation, and Alzheimer's disease: a literature review","volume":"24","author":"Grao-Cruces","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0083","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/1479-5876-10-217","article-title":"Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation","volume":"10","author":"Greco","year":"2012","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0084","doi-asserted-by":"crossref","first-page":"113","DOI":"10.7150\/ntno.51955","article-title":"Resveratrol loaded polymeric micelles for theranostic targeting of breast cancer cells","volume":"5","author":"Gregoriou","year":"2021","journal-title":"Nanotheranostics"},{"key":"10.1016\/j.phymed.2023.155150_bib0085","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.3390\/molecules25246018","article-title":"Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: a Systematic Review","volume":"25","author":"Gruendler","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155150_bib0086","first-page":"1629","article-title":"Anti-neuroinflammatory effect of sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK\/STAT and Nrf2\/HO-1 signaling pathways","volume":"23","author":"Guo","year":"2016","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0087","doi-asserted-by":"crossref","first-page":"11333","DOI":"10.1111\/jcmm.17019","article-title":"Berberine as a promising natural compound for the treatment of periodontal disease: a focus on anti-inflammatory properties","volume":"25","author":"Haftcheshmeh","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0088","article-title":"Preparation, characterization and evaluation of Ginkgo biloba solid lipid nanoparticles","volume":"3","author":"Haghighi","year":"2018","journal-title":"Nanomed. Res. J."},{"key":"10.1016\/j.phymed.2023.155150_bib0089","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111271","article-title":"Modified magnetic core-shell mesoporous silica nano-formulations with encapsulated quercetin exhibit anti-amyloid and antioxidant activity","volume":"213","author":"Halevas","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.phymed.2023.155150_bib0090","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.2174\/1567205015666181004143432","article-title":"The implications of autophagy in Alzheimer's disease","volume":"15","author":"Hamano","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0091","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fimmu.2020.00456","article-title":"A path toward precision medicine for neuroinflammatory mechanisms in Alzheimer's disease","volume":"11","author":"Hampel","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2023.155150_bib0092","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.180024","article-title":"Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease","volume":"8","author":"Hashimoto","year":"2018","journal-title":"Open Biol."},{"key":"10.1016\/j.phymed.2023.155150_bib0093","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00702-010-0438-z","article-title":"Neuroinflammatory processes in Alzheimer's disease","volume":"117","author":"Heneka","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.phymed.2023.155150_bib0094","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1021\/acschemneuro.0c00381","article-title":"Potential role of natural polyphenols against protein aggregation toxicity: in vitro, in vivo, and clinical studies","volume":"11","author":"Henr\u00edquez","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.phymed.2023.155150_bib0095","first-page":"1","article-title":"PSA-NCAM regulatory gene expression changes in the Alzheimer's disease entorhinal cortex revealed with multiplexed in situ hybridization","author":"Highet","year":"2023","journal-title":"J. Alzheimers Dis. Preprint"},{"key":"10.1016\/j.phymed.2023.155150_bib0096","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1365-2044.2002.02781.x","article-title":"The peri-operative implications of herbal medicines","volume":"57","author":"Hodges","year":"2002","journal-title":"Anaesthesia"},{"key":"10.1016\/j.phymed.2023.155150_bib0097","first-page":"157","article-title":"Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology","volume":"24","author":"Hoozemans","year":"2006","journal-title":"Int. J. Dev. Neurosci., Neur. Signal Transduct. Health Dis. - Cytokines Mitochondr. Dysfunct. Transp. Process."},{"key":"10.1016\/j.phymed.2023.155150_bib0098","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.wneu.2013.02.039","article-title":"Nanotechnology-based strategies for the diagnosis and treatment of intracranial neoplasms","volume":"80","author":"Horowitz","year":"2013","journal-title":"World Neurosurg."},{"key":"10.1016\/j.phymed.2023.155150_bib0099","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102007","article-title":"The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated \u03b1-MSH in keratinocytes via Nrf2-mediated antioxidant pathways","volume":"44","author":"Hseu","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.phymed.2023.155150_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-03516-y","article-title":"Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential","volume":"12","author":"Huang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2023.155150_bib0101","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jphotobiol.2018.11.008","article-title":"A novel synthesis of selenium nanoparticles encapsulated PLGA nanospheres with curcumin molecules for the inhibition of amyloid \u03b2 aggregation in Alzheimer's disease","volume":"190","author":"Huo","year":"2019","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.phymed.2023.155150_bib0102","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s12276-022-00754-8","article-title":"\u03b3-secretase in Alzheimer's disease","volume":"54","author":"Hur","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0103","series-title":"Conservation and Sustainable Utilization of Bioresources, Sustainable Development and Biodiversity","first-page":"531","article-title":"Computational approaches for identifying therapeutic potential of phytocompounds","author":"Ibrahim","year":"2023"},{"key":"10.1016\/j.phymed.2023.155150_bib0104","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.nic.2005.09.009","article-title":"Pathophysiology of Alzheimer's disease","volume":"15","author":"Imbimbo","year":"2005","journal-title":"Neuroimaging Clin. N. Am."},{"key":"10.1016\/j.phymed.2023.155150_bib0105","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3390\/antiox9080706","article-title":"Lycopene as a natural antioxidant used to prevent human health disorders","volume":"9","author":"Imran","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2023.155150_bib0106","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.3390\/ma16093492","article-title":"Polygonum cuspidatum loaded nanostructured lipid carriers for dual inhibition of TNF-\u03b1- and IL-6 cytokines and free radical species","volume":"16","author":"Iordache","year":"2023","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.phymed.2023.155150_bib0107","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ptr.2871","article-title":"Neuroprotective effects of Triticum aestivum l. against \u03b2-amyloid-induced cell death and memory impairments: neuroprotection by Triticum aestivum l. in Alzheimer's disease","volume":"24","author":"Jang","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0108","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.nano.2019.02.004","article-title":"Vitamin d-binding protein-loaded PLGA nanoparticles suppress Alzheimer's disease-related pathology in 5XFAD mice","volume":"17","author":"Jeon","year":"2019","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0109","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8825640","article-title":"Multiple-coated PLGAnanoparticles loading triptolide attenuate injury of a cellular model of Alzheimer's Disease","volume":"2021","author":"Jia","year":"2021","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.phymed.2023.155150_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104042","article-title":"Cucurbitacins: bioactivities and synergistic effect with small-molecule drugs","volume":"72","author":"Jing","year":"2020","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2023.155150_bib0111","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1109\/TCBB.2017.2776910","article-title":"Early diagnosis of Alzheimer's disease based on resting-state brain networks and deep learning","volume":"16","author":"Ju","year":"2019","journal-title":"IEEE\/ACM Trans. Comput. Biol. Bioinform."},{"key":"10.1016\/j.phymed.2023.155150_bib0112","first-page":"3548","article-title":"Alzheimer disease \u2013Etiology, pathophysiology and treatment: an overview","volume":"25","author":"Kabra","year":"2021","journal-title":"Ann. Roman. Soc. Cell Biol."},{"key":"10.1016\/j.phymed.2023.155150_bib0113","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.4103\/1673-5374.355982","article-title":"Decoding degeneration: the implementation of machine learning for clinical detection of neurodegenerative disorders","volume":"18","author":"Khaliq","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0114","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1055\/s-0035-1546244","article-title":"Mechanisms involved in the anti-inflammatory and vascular effects of Iberis amara extract","volume":"81","author":"Khayyal","year":"2015","journal-title":"Planta Med"},{"key":"10.1016\/j.phymed.2023.155150_bib0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1515\/revneuro-2018-0008","article-title":"Role of p38\/MAPKs in Alzheimer's disease: implications for amyloid beta toxicity targeted therapy","volume":"30","author":"Kheiri","year":"2018","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.phymed.2023.155150_bib0116","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.biopha.2017.11.047","article-title":"Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease","volume":"97","author":"Kheradmand","year":"2018","journal-title":"Biomed. Pharmacother. Biomedecine Pharmacother."},{"key":"10.1016\/j.phymed.2023.155150_bib0117","series-title":"Stimuli-Responsive Materials for Biomedical Applications, ACS Symposium Series","first-page":"1","article-title":"Introduction to Stimuli-Responsive Materials and Their Biomedical Applications","author":"Khizar","year":"2023"},{"key":"10.1016\/j.phymed.2023.155150_bib0118","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/13880209.2018.1447972","article-title":"Anti-neuroinflammatory effects of cudraflavanone A isolated from the chloroform fraction of Cudrania tricuspidata root bark","volume":"56","author":"Kim","year":"2018","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2023.155150_bib0119","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41401-021-00672-x","article-title":"Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells","volume":"43","author":"Kim","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2023.155150_bib0120","doi-asserted-by":"crossref","first-page":"17386","DOI":"10.1016\/S0021-9258(17)32449-3","article-title":"Evidence that production and release of amyloid beta-protein involves the endocytic pathway","volume":"269","author":"Koo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.155150_bib0121","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3390\/life13040999","article-title":"Phytochemicals: a promising alternative for the prevention of Alzheimer's disease","volume":"13","author":"Koul","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.phymed.2023.155150_bib0122","first-page":"63","article-title":"Therapeutic potentials of herbal drugs for Alzheimer's disease\u2014an overview","volume":"55","author":"Kumar","year":"2017","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.phymed.2023.155150_bib0123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtice.2018.03.001","article-title":"Use of functionalized liposomes loaded with antioxidants to permeate the blood\u2013brain barrier and inhibit \u03b2-amyloid-induced neurodegeneration in the brain","volume":"87","author":"Kuo","year":"2018","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"10.1016\/j.phymed.2023.155150_bib0124","unstructured":"LadyofHats, 2007. English: complete neuron cell diagram. Neurons (also known as neurones and nerve cells) are electrically excitable cells in the nervous system that process and transmit information. In Vertebrate Animals, Neurons are the Core Components of the Brain, Spinal Cord and Peripheral Nerves. URL https:\/\/commons.wikimedia.org\/wiki\/File:Complete_neuron_cell_diagram_en.svg (accessed 6.3.23)."},{"key":"10.1016\/j.phymed.2023.155150_bib0125","unstructured":"LadyofHats, M., Ruiz, M., 2011. English: This is an Indonesian Translation of File: Cell Membrane Detailed Diagram en.svg. URL https:\/\/commons.wikimedia.org\/wiki\/File:Cell_membrane_detailed_diagram_id.svg (accessed 6.3.23)."},{"key":"10.1016\/j.phymed.2023.155150_bib0126","unstructured":"LadyofHats, M., Ruiz, M., 2006. English: the Diagram Shows a Endomembrane System on a Eukaryote Cell. URL https:\/\/commons.wikimedia.org\/wiki\/File:Endomembrane_system_diagram_en.svg (accessed 3.3.23)."},{"key":"10.1016\/j.phymed.2023.155150_bib0127","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1100\/tsw.2010.44","article-title":"Cucurbitacin: ancient compound shedding new light on cancer treatment","volume":"10","author":"Lee","year":"2010","journal-title":"Sci. World J."},{"key":"10.1016\/j.phymed.2023.155150_bib0128","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.neuroscience.2010.04.078","article-title":"Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines","volume":"169","author":"Lee","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.phymed.2023.155150_bib0129","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phymed.2023.155150_bib0130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fneur.2013.00161","article-title":"Tau in MAPK activation","volume":"4","author":"Leugers","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.phymed.2023.155150_bib0131","doi-asserted-by":"crossref","first-page":"18843","DOI":"10.1039\/D1CP01913A","article-title":"Molecular mechanisms of resveratrol and EGCG in the inhibition of A\u03b242 aggregation and disruption of A\u03b242 protofibril: similarities and differences","volume":"23","author":"Li","year":"2021","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.phymed.2023.155150_bib0132","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1039\/D3NH00145H","article-title":"Selective organ targeting nanoparticles: from design to clinical translation","volume":"8","author":"Li","year":"2023","journal-title":"Nanoscale Horiz."},{"key":"10.1016\/j.phymed.2023.155150_bib0133","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101654","article-title":"Nanotechnology for the diagnosis and treatment of Alzheimer's disease: a bibliometric analysis","volume":"47","author":"Li","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.phymed.2023.155150_bib0134","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/antiox12020527","article-title":"Evidence of flavonoids on disease prevention","volume":"12","author":"Li","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2023.155150_bib0135","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10571-016-0386-8","article-title":"Autophagy and Alzheimer's disease","volume":"37","author":"Li","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2023.155150_bib0136","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/15548627.2021.1937897","article-title":"Piperine promotes autophagy flux by P2RX4 activation in SNCA \/\u03b1-synuclein-induced Parkinson disease model","volume":"18","author":"Li","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2023.155150_bib0137","article-title":"Genistein mitigates high glucose-induced podocyte adhesion injury by modulating autophagy via Mtor signal (preprint)","author":"Lian","year":"2021","journal-title":"In Review"},{"key":"10.1016\/j.phymed.2023.155150_bib0138","doi-asserted-by":"crossref","first-page":"519","DOI":"10.4062\/biomolther.2016.224","article-title":"A new neolignan derivative, balanophonin isolated from Firmiana simplex delays the progress of neuronal cell death by inhibiting microglial activation","volume":"25","author":"Lim","year":"2017","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.phymed.2023.155150_bib0139","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3390\/antiox9101022","article-title":"Merging the multi-target effects of phytochemicals in neurodegeneration: from oxidative stress to protein aggregation and inflammation","volume":"9","author":"Limanaqi","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2023.155150_bib0140","doi-asserted-by":"crossref","first-page":"14164","DOI":"10.1073\/pnas.1009485107","article-title":"Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease","volume":"107","author":"Lipinski","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0141","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3892\/ol.2022.13307","article-title":"6-Gingerol suppresses cell viability, migration and invasion via inhibiting EMT, and inducing autophagy and ferroptosis in LPS-stimulated and LPS-unstimulated prostate cancer cells","volume":"23","author":"Liu","year":"2022","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.phymed.2023.155150_bib0142","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3389\/fnmol.2019.00203","article-title":"Targeting autophagy for the treatment of Alzheimer's disease: challenges and opportunities","volume":"12","author":"Liu","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.phymed.2023.155150_bib0143","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/2558415","article-title":"Development of novel herbal compound formulations targeting neuroinflammation: network pharmacology, molecular docking, and experimental verification","volume":"2023","author":"Liu","year":"2023","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0144","first-page":"1","article-title":"The ambiguous relationship of oxidative stress, tau hyperphosphorylation, and autophagy dysfunction in Alzheimer's disease","volume":"2015","author":"Liu","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2023.155150_bib0145","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/nu13020537","article-title":"Potential of caffeine in Alzheimer's disease\u2014a review of experimental studies","volume":"13","author":"Londzin","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2023.155150_bib0146","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/jcb.22580","article-title":"Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia","volume":"110","author":"Lu","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.phymed.2023.155150_bib0147","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/01635581.2020.1750661","article-title":"Hydroxytyrosol and oleuropein inhibit migration and invasion via induction of autophagy in ER-positive breast cancer cell lines (MCF7 and T47D)","volume":"73","author":"Lu","year":"2021","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.phymed.2023.155150_bib0148","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.neuron.2013.06.046","article-title":"Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease","volume":"79","author":"Lucin","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2023.155150_bib0149","doi-asserted-by":"crossref","first-page":"17342","DOI":"10.1073\/pnas.0506723102","article-title":"3D structure of Alzheimer's amyloid-beta(1-42) fibrils","volume":"102","author":"L\u00fchrs","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2023.155150_bib0150","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s12668-020-00819-w","article-title":"Formulation development and characterization of Withaferin-A loaded polymeric nanoparticles for Alzheimer's Disease","volume":"11","author":"Madhu","year":"2021","journal-title":"Bionanoscience"},{"key":"10.1016\/j.phymed.2023.155150_bib0151","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4103\/2221-1691.250849","article-title":"Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease","volume":"9","author":"Mahboubi","year":"2019","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.phymed.2023.155150_bib0152","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006247","article-title":"Biochemistry and cell biology of tau protein in neurofibrillary degeneration","volume":"2","author":"Mandelkow","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0153","unstructured":"Mario, R., 2011. English: tau proteins provide structural support for neural microtubules. Tauopathy is when they clump to one another instead of to the neuron structure, causing it to degenerate; this is one of the major symptoms of neural degenerative disorders such as Alzheimer's disease. URL https:\/\/commons.wikimedia.org\/wiki\/File:Taupathy.svg (accessed 16.3.23)."},{"key":"10.1016\/j.phymed.2023.155150_bib0154","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.3390\/ijms23105536","article-title":"Design and development of a new type of Hybrid PLGA\/lipid nanoparticle as an ursolic acid delivery system against pancreatic ductal adenocarcinoma cells","volume":"23","author":"Markowski","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0155","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3389\/fphar.2019.01008","article-title":"Neuroinflammation as a common feature of neurodegenerative disorders","volume":"10","author":"Martinez","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/781938","article-title":"Neuroprotective effect of Brassica oleracea sprouts crude juice in a cellular model of Alzheimer's disease","volume":"2015","author":"Masci","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2023.155150_bib0157","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.ijbiomac.2018.06.190","article-title":"In vitro neuroprotective effects of naringenin nanoemulsion against \u03b2-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation","volume":"118","author":"Md","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2023.155150_bib0158","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2217\/nnm-2023-0074","article-title":"Exosomes as a novel nanomedicine platform for personalized triple-negative breast cancer therapy","volume":"18","author":"Mehata","year":"2023","journal-title":"Nanomed."},{"key":"10.1016\/j.phymed.2023.155150_bib0159","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/molecules26010229","article-title":"Anti-inflammatory action and mechanisms of resveratrol","volume":"26","author":"Meng","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155150_bib0160","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.4103\/1673-5374.193234","article-title":"Neurofibrillary tangles in Alzheimer\u2032s disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics","volume":"11","author":"Metaxas","year":"2016","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0161","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/msj.20163","article-title":"Relationship between tau pathology and neuroinflammation in Alzheimer's disease","volume":"77","author":"Metcalfe","year":"2010","journal-title":"Mt. Sinai J. Med. J. Transl. Pers. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0162","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154014","article-title":"Biosynthesis and cytotoxic effect of silymarin-functionalized selenium nanoparticles induced autophagy mediated cellular apoptosis via downregulation of PI3K\/Akt\/mTOR pathway in gastric cancer","volume":"99","author":"Mi","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155150_bib0163","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2023.155150_bib282","doi-asserted-by":"crossref","first-page":"a011254","DOI":"10.1101\/cshperspect.a011254","article-title":"MAP kinase pathways","volume":"4","author":"Morrison","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.phymed.2023.155150_bib0164","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.827263","article-title":"Neuroinflammation: a possible link between chronic vascular disorders and neurodegenerative diseases","volume":"14","author":"Moyse","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.phymed.2023.155150_bib0165","series-title":"Textbook of Natural Medicine (Fifth Edition)","first-page":"965","article-title":"130 - Zingiber officinale (Ginger)","author":"Murray","year":"2020"},{"key":"10.1016\/j.phymed.2023.155150_bib0166","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106163","article-title":"Rutin ameliorates inflammation and improves metabolic function: a comprehensive analysis of scientific literature","volume":"178","author":"Muvhulawa","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0167","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1038\/s41598-023-30475-5","article-title":"In vitro and in silico studies of 7\u2032\u2032,8\u2032\u2032-buddlenol D anti-inflammatory lignans from Carallia brachiata as p38 MAP kinase inhibitors","volume":"13","author":"Nalinratana","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2023.155150_bib0168","series-title":"PubChem Compound Summary for CID 5281316, Cucurbitacin B","year":"2023"},{"key":"10.1016\/j.phymed.2023.155150_bib0169","series-title":"PubChem Compound Summary for CID 442793, Gingerol","year":"2023"},{"key":"10.1016\/j.phymed.2023.155150_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116573","article-title":"Advancement in precision diagnosis and therapeutic for triple-negative breast cancer: harnessing diagnostic potential of CRISPR-cas & engineered CAR T-cells mediated therapeutics","volume":"235","author":"Nayak","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0171","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3233\/JAD-170161","article-title":"Bryostatin effects on cognitive function and pkc\u025b in Alzheimer's disease phase iia and expanded access trials","volume":"58","author":"Nelson","year":"2017","journal-title":"J. Alzheimers Dis. JAD"},{"key":"10.1016\/j.phymed.2023.155150_bib0172","doi-asserted-by":"crossref","first-page":"S659","DOI":"10.3233\/JAD-179902","article-title":"Amyloid-\u03b2\/drug interactions from computer simulations and cell-based assays","volume":"64","author":"Nguyen","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.phymed.2023.155150_bib0173","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nbd.2011.01.021","article-title":"Autophagy failure in Alzheimer's disease\u2014Locating the primary defect","volume":"43","author":"Nixon","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2023.155150_bib0174","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: an open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminformatics"},{"key":"10.1016\/j.phymed.2023.155150_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/9347468","article-title":"Potential properties of plant sprout extracts on amyloid \u03b2","volume":"2016","author":"Okada","year":"2016","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.phymed.2023.155150_bib0177","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.nano.2014.09.015","article-title":"Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-\u03b2 levels in APP\/PS1 transgenic mice","volume":"11","author":"Ord\u00f3\u00f1ez-Guti\u00e9rrez","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0178","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1039\/C8CS00034D","article-title":"Effects of in vivo conditions on amyloid aggregation","volume":"48","author":"Owen","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.phymed.2023.155150_bib0179","first-page":"1","article-title":"Extemporaneous combination of donepezil and memantine to treat dementia in Alzheimer disease: evidence from Italian real-world data","volume":"0","author":"Padovani","year":"2023","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.phymed.2023.155150_bib0180","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s11095-021-03053-5","article-title":"Ethosomes as nanocarriers for the development of skin delivery formulations","volume":"38","author":"Paiva-Santos","year":"2021","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0181","series-title":"Drug Discovery from Medicinal Plants And Phytochemicals Against Neuropathic Pain, In: Phytochemical Drug Discovery for Central Nervous System Disorders","first-page":"137","author":"Palai","year":"2023"},{"key":"10.1016\/j.phymed.2023.155150_bib0182","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.arr.2012.03.008","article-title":"Autophagy, polyphenols and healthy ageing","volume":"12","author":"Pallauf","year":"2013","journal-title":"Ageing Res. Rev., Spec. Issue: Inverteb. Model. Aging"},{"key":"10.1016\/j.phymed.2023.155150_bib0183","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF00124014","article-title":"Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies","volume":"8","author":"Pang","year":"1994","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.phymed.2023.155150_bib0184","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jconrel.2022.09.058","article-title":"Neuroprotective effect of phytoconstituents via nanotechnology for treatment of Alzheimer diseases","volume":"351","author":"Paramanick","year":"2022","journal-title":"J. Control. Relea."},{"key":"10.1016\/j.phymed.2023.155150_bib0185","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug transport across the blood-brain barrier","volume":"32","author":"Pardridge","year":"2012","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.phymed.2023.155150_bib0186","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/acs.jnatprod.9b01158","article-title":"Antineurodegenerative labdane diterpenoid glycosides from the twigs of Pinus koraiensis","volume":"83","author":"Park","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2023.155150_bib0187","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3390\/metabo10100392","article-title":"Daily use of extra virgin olive oil with high oleocanthal concentration reduced body weight, waist circumference, alanine transaminase, inflammatory cytokines and hepatic steatosis in subjects with the metabolic syndrome: a 2-month intervention study","volume":"10","author":"Patti","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.phymed.2023.155150_bib0188","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.3390\/ijms24065383","article-title":"New pathways identify novel drug targets for the prevention and treatment of Alzheimer's disease","volume":"24","author":"Penke","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0189","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1007\/s12035-021-02715-0","article-title":"p38 inhibition decreases tau toxicity in microglia and improves their phagocytic function","volume":"59","author":"Perea","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2023.155150_bib0190","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s10787-022-01014-x","article-title":"Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy","volume":"30","author":"Piao","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.phymed.2023.155150_bib0191","doi-asserted-by":"crossref","first-page":"767","DOI":"10.4103\/aian.AIAN_610_19","article-title":"Efficacy of Bacopa monnieri (brahmi) and donepezil in Alzheimer's disease and mild cognitive impairment: a randomized double-blind parallel phase 2b study","volume":"23","author":"Prabhakar","year":"2020","journal-title":"Ann. Indian Acad. Neurol."},{"key":"10.1016\/j.phymed.2023.155150_bib0192","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/413808","article-title":"Amyloidosis in Alzheimer's disease: the toxicity of amyloid beta (A \u03b2), mechanisms of its accumulation and implications of medicinal plants for therapy","volume":"2013","author":"Prasansuklab","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0193","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2589276","article-title":"Therapies for prevention and treatment of Alzheimer's disease","volume":"2016","author":"Precoma","year":"2016","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.phymed.2023.155150_bib0194","doi-asserted-by":"crossref","first-page":"e1527","DOI":"10.1002\/wnan.1527","article-title":"Stimuli-responsive nanotherapeutics for precision drug delivery and cancer therapy","volume":"11","author":"Qiao","year":"2019","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.phymed.2023.155150_bib0195","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/antiox10010023","article-title":"Potential therapeutic role of phytochemicals to mitigate mitochondrial dysfunctions in Alzheimer's disease","volume":"10","author":"Rahman","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2023.155150_bib0196","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s13233-023-00114-z","article-title":"Formulation and characterization of chitosan nanoparticles loaded with neuroprotective flavonoid from Phyllanthus niruri Linn","volume":"31","author":"Rajamanickam","year":"2023","journal-title":"Macromol. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0197","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1208\/s12249-020-01832-8","article-title":"Lipid nanoparticles improve the uptake of \u03b1-asarone into the brain parenchyma: formulation, characterization, in vivo pharmacokinetics, and brain delivery","volume":"21","author":"Ramalingam","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.phymed.2023.155150_bib0198","series-title":"Exploring the Genetic Heterogeneity of Alzheimer's Disease: Evidence for Disease-Relevant and Disease-Specific Clustering","author":"Rangan","year":"2023"},{"key":"10.1016\/j.phymed.2023.155150_bib0199","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/pharmaceutics11010008","article-title":"Intranasal delivery of genistein-loaded nanoparticles as a potential preventive system against neurodegenerative disorders","volume":"11","author":"Rassu","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phymed.2023.155150_bib0200","series-title":"RCSB PDB - 5O3L: Paired Helical Filament in Alzheimer's Disease Brain","year":"2017"},{"key":"10.1016\/j.phymed.2023.155150_bib0201","series-title":"RCSB PDB - 5A63: cryo-EM Structure of the Human Gamma-Secretase Complex at 3.4 Angstrom Resolution","year":"2015"},{"key":"10.1016\/j.phymed.2023.155150_bib0202","series-title":"RCSB PDB - 3ZYA: Human p38 MAP Kinase in Complex with 2-Amino-Phenylamino- Dibenzosuberone","year":"2011"},{"key":"10.1016\/j.phymed.2023.155150_bib0203","series-title":"RCSB PDB - 2BEG: 3D Structure of Alzheimer's Abeta(1-42) Fibrils","year":"2005"},{"key":"10.1016\/j.phymed.2023.155150_bib0204","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1007310","article-title":"Phytochemical and toxicological evaluation of Zephyranthes citrina","volume":"13","author":"Rehman","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0205","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.3390\/pharmaceutics14091976","article-title":"Curcumin-loaded mesoporous silica nanoparticles dispersed in thermo-responsive hydrogel as potential Alzheimer disease therapy","volume":"14","author":"Ribeiro","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phymed.2023.155150_bib0206","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.3390\/pharmaceutics13122045","article-title":"Polymeric nanoparticles properties and brain delivery","volume":"13","author":"Ribovski","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phymed.2023.155150_bib0207","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2020.101795","article-title":"Neuroprotective effect of quercetin nanoparticles: a possible prophylactic and therapeutic role in Alzheimer's disease","volume":"107","author":"Rifaai","year":"2020","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.phymed.2023.155150_bib0208","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.3390\/ijms24054353","article-title":"Molecular mechanisms of the protective effects of olive leaf polyphenols against Alzheimer's disease","volume":"24","author":"Romero-M\u00e1rquez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0209","article-title":"Mechanisms of aging and potential role of selected polyphenols in extending healthspan","volume":"173","author":"Russo","year":"2020","journal-title":"Biochem. Pharmacol., Nat. Product. Hallmark. Chron. Dis."},{"key":"10.1016\/j.phymed.2023.155150_bib0210","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/jfb14010050","article-title":"A review on phyto-therapeutic approaches in Alzheimer's disease","volume":"14","author":"Sahiner","year":"2023","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.phymed.2023.155150_bib0211","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jep.2017.12.015","article-title":"Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease","volume":"215","author":"Sahoo","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0212","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111838","article-title":"Systematically designed chitosan-coated solid lipid nanoparticles of ferulic acid for effective management of Alzheimer's disease: a preclinical evidence","volume":"205","author":"Saini","year":"2021","journal-title":"Colloids Surf. B Biointerface."},{"key":"10.1016\/j.phymed.2023.155150_bib0213","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3390\/ijms20061305","article-title":"The therapeutic potential of apigenin","volume":"20","author":"Salehi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0214","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41578-021-00396-8","article-title":"Organelle-level precision with next-generation targeting technologies","volume":"7","author":"Saminathan","year":"2022","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.phymed.2023.155150_bib0215","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejpb.2023.01.006","article-title":"Enhancement of mitochondrial function using NO releasing nanoparticles; A potential approach for therapy of Alzheimer's disease","volume":"184","author":"Samir","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0216","doi-asserted-by":"crossref","first-page":"e20043","DOI":"10.7554\/eLife.20043","article-title":"How \u03b3-secretase hits a moving target","volume":"5","author":"Sanders","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.phymed.2023.155150_bib0217","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118787","article-title":"Nanotechnological breakthroughs in the development of topical phytocompounds-based formulations","volume":"572","author":"Santos","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0218","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171479","article-title":"Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation","volume":"12","author":"Sapkota","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2023.155150_bib0219","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.110948","article-title":"Deciphering the anti-apoptotic potential of \u03b1-bisabolol loaded solid lipid nanoparticles against A\u03b2 induced neurotoxicity in Neuro-2a cells","volume":"190","author":"Sathya","year":"2020","journal-title":"Colloids Surf. B Biointerface."},{"key":"10.1016\/j.phymed.2023.155150_bib0220","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ddr.21605","article-title":"Autophagy induction in the treatment of Alzheimer's disease","volume":"81","author":"Schmukler","year":"2020","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0221","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/life12030330","article-title":"Impact of caffeine on Alzheimer's disease pathogenesis\u2014protective or risk factor?","volume":"12","author":"Schreiner","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.phymed.2023.155150_bib0222","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1038\/s41467-022-32951-4","article-title":"Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro","volume":"13","author":"Seidler","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2023.155150_bib0223","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3389\/fphar.2018.00548","article-title":"Anti-neuroinflammatory potential of natural products in attenuation of Alzheimer's disease","volume":"9","author":"Shal","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0224","article-title":"Review on theranostic and neuroprotective applications of nanotechnology in multiple sclerosis","volume":"81","author":"Sharma","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.phymed.2023.155150_bib0225","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.2174\/1381612826666200928161721","article-title":"Phytochemicals for drug discovery in Alzheimer's disease: in silico advances","volume":"27","author":"Sharma","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.phymed.2023.155150_bib0226","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114192","article-title":"Ginsenoside Rk3 ameliorates A\u03b2-induced neurotoxicity in APP\/PS1 model mice via AMPK signaling pathway","volume":"158","author":"She","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155150_bib0227","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3390\/pharmaceutics15030749","article-title":"Plant-derived bioactive compounds in the management of neurodegenerative disorders: challenges, future directions and molecular mechanisms involved in neuroprotection","volume":"15","author":"Shoaib","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phymed.2023.155150_bib0228","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.intimp.2014.01.011","article-title":"Tangeretin exerts anti-neuroinflammatory effects via NF-\u03baB modulation in lipopolysaccharide-stimulated microglial cells","volume":"19","author":"Shu","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0229","first-page":"708","article-title":"Targeting neuroinflammation in Alzheimer's disease: from mechanisms to clinical applications","volume":"18","author":"Si","year":"2022","journal-title":"Neur. Regen. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0230","unstructured":"Silvatica, 2021. Latvie\u0161u: mitohondrija uzb\u016bve. https:\/\/commons.wikimedia.org\/wiki\/File:Mitohondrijs.svg (accessed 6.9.21)."},{"key":"10.1016\/j.phymed.2023.155150_bib0231","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.ijbiomac.2020.02.041","article-title":"Silymarin encapsulated nanoliquid crystals for improved activity against beta amyloid induced cytotoxicity","volume":"149","author":"Singh","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2023.155150_bib0232","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1021\/acsbiomaterials.1c00514","article-title":"Lipid-coated MCM-41 mesoporous silica nanoparticles loaded with berberine improved inhibition of acetylcholine esterase and amyloid formation","volume":"7","author":"Singh","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.phymed.2023.155150_bib0233","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/02652048.2018.1441916","article-title":"Development and characterization of morin hydrate-loaded micellar nanocarriers for the effective management of Alzheimer's disease","volume":"35","author":"Singh","year":"2018","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.phymed.2023.155150_bib0234","first-page":"129","article-title":"A review: in vivo studies of phytochemicals acting on neurological disorders","volume":"12","author":"Singh","year":"2023","journal-title":"J. Pharmacogn. Phytochem."},{"key":"10.1016\/j.phymed.2023.155150_bib0235","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.addr.2019.02.009","article-title":"Leveraging the interplay of nanotechnology and neuroscience: designing new avenues for treating central nervous system disorders","volume":"148","author":"Smith","year":"2019","journal-title":"Adv. Drug Deliv. Rev., Nanotechnol. Enabl. Regenerat. Med. Neurolog. Disord."},{"key":"10.1016\/j.phymed.2023.155150_bib0236","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103145","article-title":"Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activities","volume":"91","author":"So","year":"2019","journal-title":"Bioorgan. Chem."},{"key":"10.1016\/j.phymed.2023.155150_bib0237","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jacc.2019.12.033","article-title":"The Alzheimer's disease amyloid-beta hypothesis in cardiovascular aging and disease: JACC focus seminar","volume":"75","author":"Stakos","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2023.155150_bib0238","first-page":"872","article-title":"Anti-neuroinflammatory and neuroprotective effects of the Lindera neesiana fruit in vitro","volume":"23","author":"Subedi","year":"2016","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.phymed.2023.155150_bib0239","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3390\/nu9030207","article-title":"Equol, a dietary daidzein gut metabolite attenuates microglial activation and potentiates neuroprotection in vitro","volume":"9","author":"Subedi","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2023.155150_bib0240","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3390\/antiox9090792","article-title":"Sulforaphane inhibits MGO-AGE-mediated neuroinflammation by suppressing NF-\u03baB, MAPK, and AGE\u2013RAGE signaling pathways in microglial cells","volume":"9","author":"Subedi","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2023.155150_bib0241","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bioorg.2017.04.003","article-title":"A biphenyl derivative from the twigs of Chaenomeles speciosa","volume":"72","author":"Suh","year":"2017","journal-title":"Bioorgan. Chem."},{"key":"10.1016\/j.phymed.2023.155150_bib0242","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.colsurfb.2016.08.052","article-title":"Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer's disease","volume":"148","author":"Sun","year":"2016","journal-title":"Colloids Surf. B Biointerface."},{"key":"10.1016\/j.phymed.2023.155150_bib283","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/biology12020244","article-title":"Tau; One protein, so many diseases","volume":"12","author":"Tabeshmehr","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.phymed.2023.155150_bib0243","doi-asserted-by":"crossref","first-page":"8490","DOI":"10.1038\/ncomms9490","article-title":"Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain","volume":"6","author":"Takeda","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2023.155150_bib0244","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3390\/pharmaceutics15041317","article-title":"Natural compounds: co-delivery strategies with chemotherapeutic agents or nucleic acids using lipid-based nanocarriers","volume":"15","author":"Teixeira","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phymed.2023.155150_bib0245","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.3390\/ijms24043380","article-title":"Aggregation of disordered proteins associated with neurodegeneration","volume":"24","author":"Tsoi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0246","series-title":"Studies in Natural Products Chemistry","first-page":"1","article-title":"Chapter 1 - Recent insights into the emerging role of triterpenoids in cancer therapy: part II","author":"Tundis","year":"2014"},{"key":"10.1016\/j.phymed.2023.155150_bib0247","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1002\/ptr.6781","article-title":"Naringenin, a flavanone with antiviral and anti-inflammatory effects: a promising treatment strategy against COVID -19","volume":"34","author":"Tutunchi","year":"2020","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0248","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ibneur.2023.01.006","article-title":"Pathways to healing: plants with therapeutic potential for neurodegenerative diseases","volume":"14","author":"Tyler","year":"2023","journal-title":"IBRO Neurosci. Rep."},{"key":"10.1016\/j.phymed.2023.155150_bib0249","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106479","article-title":"Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease","volume":"84","author":"Uddin","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0250","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.dsx.2020.04.012","article-title":"Artificial intelligence (AI) applications for COVID-19 pandemic","volume":"14","author":"Vaishya","year":"2020","journal-title":"Diabet. Metab. Syndr. Clin. Res. Rev."},{"key":"10.1016\/j.phymed.2023.155150_bib0251","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1186\/s12967-022-03828-3","article-title":"Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms","volume":"20","author":"Varela","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2023.155150_bib0252","series-title":"Advances in Protein Chemistry and Structural Biology, Apoptosis in Health and Disease - Part A","first-page":"275","article-title":"Chapter Ten - Phyto-drug conjugated nanomaterials enhance apoptotic activity in cancer","author":"Vimala","year":"2021"},{"key":"10.1016\/j.phymed.2023.155150_bib0253","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1038\/s41598-021-84879-2","article-title":"Cannabidiol induces autophagy via ERK1\/2 activation in neural cells","volume":"11","author":"Vrechi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2023.155150_bib0254","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1039\/C4FO00723A","article-title":"Development of food-grade nanoemulsions and emulsions for delivery of omega-3 fatty acids: opportunities and obstacles in the food industry","volume":"6","author":"Walker","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2023.155150_bib0255","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1038\/s41598-023-34355-w","article-title":"N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models","volume":"13","author":"Wei","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2023.155150_bib0256","doi-asserted-by":"crossref","first-page":"17670","DOI":"10.1074\/jbc.M602487200","article-title":"Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity","volume":"281","author":"White","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.155150_bib0257","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.1021\/bi060799c","article-title":"The \u03b3-secretase complex: membrane-embedded proteolytic ensemble","volume":"45","author":"Wolfe","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.phymed.2023.155150_bib0258","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1248\/cpb.c18-00537","article-title":"Three new lignan glycosides from the Firmiana simplex","volume":"67","author":"Woo","year":"2019","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.phymed.2023.155150_bib0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101577","article-title":"Nanotechnology reinforced neutrophil-based therapeutic strategies for inflammatory diseases therapy","volume":"46","author":"Wu","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.phymed.2023.155150_bib0259","author":"World Health Organization"},{"key":"10.1016\/j.phymed.2023.155150_bib0261","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40035-019-0159-7","article-title":"Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy","volume":"8","author":"Wu","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.phymed.2023.155150_bib0262","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s11277-017-5224-x","article-title":"Development and application of artificial neural network","volume":"102","author":"Wu","year":"2018","journal-title":"Wirel. Pers. Commun."},{"key":"10.1016\/j.phymed.2023.155150_bib0263","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/4857814","article-title":"Allicin inhibits osteosarcoma growth by promoting oxidative stress and autophagy via the inactivation of the lncRNA MALAT1-miR-376a-Wnt\/\u03b2-catenin signaling pathway","volume":"2022","author":"Xie","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2023.155150_bib0264","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphys.2020.00113","article-title":"Luteolin attenuates doxorubicin-induced cardiotoxicity through promoting mitochondrial autophagy","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2023.155150_bib0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41538-021-00084-5","article-title":"Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway","volume":"5","author":"Yamamoto","year":"2021","journal-title":"Npj Sci. Food"},{"key":"10.1016\/j.phymed.2023.155150_bib0266","first-page":"1","article-title":"Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology","volume":"7","author":"Yang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2023.155150_bib0267","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/19466315.2021.1884129","article-title":"Deep learning based multimodal progression modeling for Alzheimer's disease","volume":"13","author":"Yang","year":"2021","journal-title":"Stat. Biopharm. Res."},{"key":"10.1016\/j.phymed.2023.155150_bib0268","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.fshw.2021.12.006","article-title":"Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer's disease: an overview of pre-clinical studies focused on \u03b2-amyloid peptide","volume":"11","author":"Youn","year":"2022","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.phymed.2023.155150_bib0269","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/pro.3434","article-title":"Surface enhanced Raman spectroscopy distinguishes amyloid \u03b2-protein isoforms and conformational states: SERS monitoring of amyloid \u03b2-protein assembly state","volume":"27","author":"Yu","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.phymed.2023.155150_bib0270","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.902551","article-title":"Immunomodulatory and anti-inflammatory therapeutic potential of gingerols and their nanoformulations","volume":"13","author":"Y\u00fccel","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155150_bib0271","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3109\/1061186X.2012.747529","article-title":"Preparation, characterization, in vivo and biochemical evaluation of brain targeted Piperine solid lipid nanoparticles in an experimentally induced Alzheimer's disease model","volume":"21","author":"Yusuf","year":"2013","journal-title":"J. Drug Target."},{"key":"10.1016\/j.phymed.2023.155150_bib0272","doi-asserted-by":"crossref","DOI":"10.1515\/revneuro-2014-0076","article-title":"Autophagy in Alzheimer's disease","volume":"26","author":"Zare-shahabadi","year":"2015","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.phymed.2023.155150_bib0273","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112379","article-title":"GR-mediated anti-inflammation of \u03b1-boswellic acid: insights from in vitro and in silico studies","volume":"155","author":"Zhang","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2023.155150_bib0274","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2047-9158-2-15","article-title":"Biological function of presenilin and its role in AD pathogenesis","volume":"2","author":"Zhang","year":"2013","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.phymed.2023.155150_bib0275","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12987-020-00209-0","article-title":"Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human","volume":"17","author":"Zhang","year":"2020","journal-title":"Fluid. Barrier. CNS"},{"key":"10.1016\/j.phymed.2023.155150_bib0276","first-page":"1","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2023.155150_bib0277","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120492","article-title":"Advances in nanomedicines for diagnosis of central nervous system disorders","volume":"269","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.phymed.2023.155150_bib0278","doi-asserted-by":"crossref","first-page":"17020","DOI":"10.1074\/jbc.M409467200","article-title":"Nicastrin is critical for stability and trafficking but not association of other presenilin\/\u03b3-secretase components","volume":"280","author":"Zhang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.155150_bib0279","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154406","article-title":"Isoliquiritigenin inhibits pancreatic cancer progression through blockade of p38 MAPK-regulated autophagy","volume":"106","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155150_bib0280","doi-asserted-by":"crossref","DOI":"10.3389\/fncom.2023.1038636","article-title":"Conventional machine learning and deep learning in Alzheimer's disease diagnosis using neuroimaging: a review","volume":"17","author":"Zhao","year":"2023","journal-title":"Front. Comput. Neurosci."},{"key":"10.1016\/j.phymed.2023.155150_bib284","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/jnen\/59.10.880","article-title":"Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease","volume":"59","author":"Zhu","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.phymed.2023.155150_bib0281","first-page":"1930","article-title":"Pharmacokinetics of 6-, 8-, 10-gingerols and 6-shogaol and conjugate metabolites in healthy human subjects","volume":"17","author":"Zick","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev. Publ. Am. Assoc. Cancer Res. Cosponsored Am. Soc. Prev. Oncol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323005093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323005093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:53:56Z","timestamp":1760554436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323005093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":281,"alternative-id":["S0944711323005093"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155150","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155150","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155150"}}