{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:02:06Z","timestamp":1787770926946,"version":"build-2784847793"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.phymed.2023.155154","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T03:10:47Z","timestamp":1697598647000},"page":"155154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Multi-omic analysis revealed the therapeutic mechanisms of Alpinia oxyphylla fructus water extract against bladder overactivity in spontaneously hypertensive rats"],"prefix":"10.1016","volume":"123","author":[{"given":"Yan","family":"Tie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingxiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-7851","authenticated-orcid":false,"given":"Xuelin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155154_bib0001","article-title":"Update on overactive bladder therapeutic options","author":"Babin","year":"2023","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.phymed.2023.155154_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114155","article-title":"Insight into SLC9A3 deficiency-mediated micturition dysfunction caused by electrolyte imbalance","volume":"158","author":"Chen","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155154_bib0003","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/luts.12193","article-title":"Prevalence of overactive bladder in China, Taiwan and South Korea: results from a cross-sectional, population-based study","volume":"11","author":"Chuang","year":"2019","journal-title":"Low Urin Tract Symptoms"},{"key":"10.1016\/j.phymed.2023.155154_bib0004","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ijbiomac.2019.01.193","article-title":"Therapeutic effect and mechanism of polysaccharide from Alpiniae oxyphyllae fructus on urinary incontinence","volume":"128","author":"Han","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2023.155154_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108674","article-title":"The role of interleukin-6\/interleukin-6 receptor signaling in the mechanical stress-induced extracellular matrix remodeling of bladder smooth muscle","volume":"702","author":"He","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2023.155154_bib0006","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.3390\/foods11121748","article-title":"Analysis of fungal microbiomes in edible medicinal Morindae officinalis radix and Alpiniae oxyphyllae fructus using DNA metabarcoding","volume":"11","author":"Jiang","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2023.155154_bib0007","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/s41467-023-36911-4","article-title":"Two-step structural changes in M3 muscarinic receptor activation rely on the coupled G(q) protein cycle","volume":"14","author":"Kim","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2023.155154_bib0008","article-title":"Alpiniae oxyphyllae fructus possesses neuroprotective effects on H2O2 stimulated PC12 cells via regulation of the PI3K\/Akt signaling pathway","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155154_bib0009","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/metabo11110778","article-title":"l-theanine protects bladder function by suppressing chronic sympathetic hyperactivity in spontaneously hypertensive rat","volume":"11","author":"Matsuoka","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.phymed.2023.155154_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113666","article-title":"An inhibitory effect of Berberine from herbal Coptis chinensis Franch on rat detrusor contraction in benign prostatic hyperplasia associated with lower urinary tract symptoms","volume":"268","author":"Miao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155154_bib0011","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/iju.14171","article-title":"Effects of silodosin and tadalafil on bladder dysfunction in spontaneously hypertensive rats: possible role of bladder blood flow","volume":"27","author":"Nagao","year":"2020","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.phymed.2023.155154_bib0012","doi-asserted-by":"crossref","first-page":"C787","DOI":"10.1152\/ajpcell.00441.2022","article-title":"The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria","volume":"324","author":"Phelps","year":"2023","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.phymed.2023.155154_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110585","article-title":"Uro-protective role of chrysin against cyclophosphamide-induced hemorrhagic cystitis in rats involving the turning-off NF-\u03baB\/P38-MAPK, NO\/PARP-1 and STAT-3 signaling cascades","author":"Saleh","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2023.155154_bib0014","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.3390\/ijms24054462","article-title":"Myostatin overexpression and smad pathway in detrusor derived from pediatric patients with end-stage lower urinary tract dysfunction","volume":"24","author":"Salemi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155154_bib0015","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.3892\/etm.2021.10879","article-title":"Overactive bladder: a review and update","volume":"22","author":"Scarneciu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2023.155154_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119855","article-title":"Aging-related severe hypertension induces detrusor underactivity in rats","volume":"283","author":"Shimizu","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2023.155154_bib0017","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11325-019-01983-4","article-title":"Therapeutic effects and modulatory mechanism of Alpiniae oxyphyllae fructus in chronic intermittent hypoxia induced enuresis in rats","volume":"24","author":"Su","year":"2020","journal-title":"Sleep Breath."},{"key":"10.1016\/j.phymed.2023.155154_bib0018","article-title":"Multi-omics approaches revealed the therapeutic mechanisms of Suo-Quan-Wan for treating overactive bladder in spontaneously hypertensive rats","volume":"318","author":"Sun","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155154_bib0019","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.050054","article-title":"Lack of expression of miR-29a\/b1 impairs bladder function in male mice","volume":"16","author":"Wang","year":"2023","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.phymed.2023.155154_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105329","article-title":"Stimulation of atypical cannabinoid receptor GPR55 abolishes the symptoms of detrusor overactivity in spontaneously hypertensive rats","volume":"150","author":"Wr\u00f3bel","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.phymed.2023.155154_bib0021","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11010-022-04484-3","article-title":"Exosomes from human urine-derived stem cells carry NRF1 to alleviate bladder fibrosis via regulating miR-301b-3p\/TGF\u03b2R1 pathway","volume":"478","author":"Wu","year":"2023","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.phymed.2023.155154_bib0022","doi-asserted-by":"crossref","first-page":"6014","DOI":"10.3390\/ijms22116014","article-title":"Bladder hyperactivity induced by oxidative stress and bladder ischemia: a review of treatment strategies with antioxidants","volume":"22","author":"Wu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155154_bib0023","doi-asserted-by":"crossref","first-page":"11862","DOI":"10.3390\/ijms222111862","article-title":"Cellular stress and molecular responses in bladder ischemia","volume":"22","author":"Yang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155154_bib0024","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41392-022-01254-x","article-title":"FFAR4 improves the senescence of tubular epithelial cells by AMPK\/SirT3 signaling in acute kidney injury","volume":"7","author":"Yang","year":"2022","journal-title":"Signal. Transduct. Target Ther."},{"key":"10.1016\/j.phymed.2023.155154_bib0025","doi-asserted-by":"crossref","first-page":"9285","DOI":"10.1038\/s41598-022-13470-0","article-title":"Activation of the TGF-\u03b21\/Smads\/\u03b1-SMA pathway is related to histological and functional changes in children with neurogenic bladder","volume":"12","author":"Yang","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2023.155154_bib0026","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1021\/acs.jafc.2c07543","article-title":"Production, function, and applications of the sesquiterpenes valencene and nootkatone: a comprehensive review","volume":"71","author":"Zhang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2023.155154_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1030315","article-title":"Unraveling the impact of Lactobacillus spp. and other urinary microorganisms on the efficacy of mirabegron in female patients with overactive bladder","volume":"12","author":"Zhou","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323005135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323005135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:49:19Z","timestamp":1760554159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323005135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":27,"alternative-id":["S0944711323005135"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155154","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omic analysis revealed the therapeutic mechanisms of Alpinia oxyphylla fructus water extract against bladder overactivity in spontaneously hypertensive rats","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155154"}}