{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:26:09Z","timestamp":1792736769536,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.phymed.2023.155182","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T22:26:04Z","timestamp":1698877564000},"page":"155182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Yohimbine ameliorates liver inflammation and fibrosis by regulating oxidative stress and Wnt\/\u03b2-catenin pathway"],"prefix":"10.1016","volume":"123","author":[{"given":"Nidhi","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-2762","authenticated-orcid":false,"given":"Ramakrishna","family":"Sistla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-737X","authenticated-orcid":false,"given":"Sai Balaji","family":"Andugulapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155182_bib0001","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fphar.2021.671640","article-title":"Cellular mechanisms of liver fibrosis","volume":"12","author":"Acharya","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155182_bib0002","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1745-7262.2007.00276.x","article-title":"Yohimbine in the treatment of orgasmic dysfunction","volume":"9","author":"Adeniyi","year":"2007","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.phymed.2023.155182_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2613.2003.00235.x","article-title":"Role of cell adhesion molecules in leukocyte recruitment in the liver and gut","volume":"84","author":"Ala","year":"2003","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.phymed.2023.155182_bib0004","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1242\/dmm.049203","article-title":"AMP-activated protein kinase promotes breast cancer stemness and drug resistance","volume":"15","author":"Andugulapati","year":"2022","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.phymed.2023.155182_bib0005","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/bph.12098","article-title":"Glycogen synthase kinase-3 (GSK-3) regulates TGF-\u03b21-induced differentiation of pulmonary fibroblasts","volume":"169","author":"Baarsma","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155182_bib0006","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s002280050298","article-title":"A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs","volume":"52","author":"Bagheri","year":"1997","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155182_bib0007","doi-asserted-by":"crossref","first-page":"G723","DOI":"10.1152\/ajpgi.00414.2010","article-title":"Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages","volume":"300","author":"Barron","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.phymed.2023.155182_bib0008","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2023.155182_bib0010","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/cld.1061","article-title":"Global epidemiology of chronic liver disease","volume":"17","author":"Cheemerla","year":"2021","journal-title":"Clin. Liver Dis. (Hoboken)"},{"key":"10.1016\/j.phymed.2023.155182_bib0011","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3389\/fphys.2020.00433","article-title":"Targeting myeloperoxidase (MPO) mediated oxidative stress and inflammation for reducing brain ischemia injury: potential application of natural compounds","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2023.155182_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101092","article-title":"Dysregulated lipid metabolism links NAFLD to cardiovascular disease","volume":"42","author":"Deprince","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phymed.2023.155182_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111419","article-title":"TGF-\u03b2 in hepatic stellate cell activation and liver fibrogenesis-updated 2019","volume":"8","author":"Dewidar","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2023.155182_bib0015","first-page":"365","article-title":"CD 34 expression in chronic and neoplastic liver diseases","volume":"44","author":"Di Carlo","year":"2002","journal-title":"Panminerva Med."},{"key":"10.1016\/j.phymed.2023.155182_bib0016","doi-asserted-by":"crossref","first-page":"435","DOI":"10.5114\/ada.2016.63882","article-title":"Contribution of myeloperoxidase and inducible nitric oxide synthase to pathogenesis of psoriasis","volume":"33","author":"Dilek","year":"2016","journal-title":"Postepy Dermatol. Alergol."},{"key":"10.1016\/j.phymed.2023.155182_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113247","article-title":"Acanthoic acid, unique potential pimaradiene diterpene isolated from Acanthopanax koreanum Nakai (Araliaceae): a review on its pharmacology, molecular mechanism, and structural modification","volume":"200","author":"Dou","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2023.155182_bib0018","first-page":"960","article-title":"Targeting the Wnt signaling pathway in liver fibrosis for drug options: an update","volume":"9","author":"Duspara","year":"2021","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.phymed.2023.155182_bib0019","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.3748\/wjg.v21.i24.7427","article-title":"Liver fibrosis markers of nonalcoholic steatohepatitis","volume":"21","author":"Enomoto","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2023.155182_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.775382","article-title":"Differential effects of oleic and palmitic acids on lipid droplet-mitochondria interaction in the hepatic cell line HepG2","volume":"8","author":"Eynaudi","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2023.155182_bib0021","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ajg.2018.03.002","article-title":"Oxidative stress is bane in chronic liver diseases: clinical and experimental perspective","volume":"19","author":"Ezhilarasan","year":"2018","journal-title":"Arab. J. Gastroenterol."},{"key":"10.1016\/j.phymed.2023.155182_bib0022","doi-asserted-by":"crossref","first-page":"29965","DOI":"10.1074\/jbc.M110.128694","article-title":"The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways","volume":"285","author":"Gao","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.155182_bib0023","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ajpath.2021.09.007","article-title":"Role and regulation of Wnt\/\u03b2-catenin in hepatic perivenous zonation and physiological homeostasis","volume":"192","author":"Goel","year":"2022","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2023.155182_bib0025","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/j.1538-7836.2006.02042.x","article-title":"Lipopolysaccharide-induced decreased protein S expression in liver cells is mediated by MEK\/ERK signaling and NFkappaB activation: involvement of membrane-bound CD14 and toll-like receptor-4","volume":"4","author":"Hayashi","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.phymed.2023.155182_bib0027","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1007\/s00018-018-2888-7","article-title":"Cellular mechanisms and signals that coordinate plasma membrane repair","volume":"75","author":"Horn","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phymed.2023.155182_bib0028","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.2337\/db11-0364","article-title":"Genetic analysis of adult-onset autoimmune diabetes","volume":"60","author":"Howson","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2023.155182_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101063","article-title":"Wnt signaling pathway in aging-related tissue fibrosis and therapies","volume":"60","author":"Hu","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2023.155182_bib0030","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10787-022-01133-5","article-title":"Anti-inflammatory and antioxidant activities of Gymnema Sylvestre extract rescue acute respiratory distress syndrome in rats via modulating the NF-\u03baB\/MAPK pathway","volume":"31","author":"Jangam","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.phymed.2023.155182_bib0031","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101249","article-title":"Mechanisms Underlying Hepatitis C Virus-Associated Hepatic Fibrosis","volume":"8","author":"Khatun","year":"2019","journal-title":"Cells"},{"issue":"Suppl 1","key":"10.1016\/j.phymed.2023.155182_bib0032","first-page":"S73","article-title":"Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis","volume":"22","author":"Kisseleva","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2023.155182_bib0033","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1053\/j.gastro.2009.09.015","article-title":"Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition","volume":"138","author":"Kluwe","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2023.155182_bib0034","doi-asserted-by":"crossref","first-page":"717","DOI":"10.33549\/physiolres.933270","article-title":"Electrocardiography in rats: a comparison to human","volume":"65","author":"Konopelski","year":"2016","journal-title":"Physiol. Res."},{"key":"10.1016\/j.phymed.2023.155182_bib0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2023.155182_bib0036","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2023.155182_bib0037","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040929","article-title":"The Endothelium as a driver of liver fibrosis and regeneration","volume":"9","author":"Lafoz","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2023.155182_bib0038","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1365-2362.2006.01620.x","article-title":"A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited","volume":"36","author":"Laleman","year":"2006","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.phymed.2023.155182_bib0039","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/ijo.2017.102","article-title":"Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in non-alcoholic fatty liver disease","volume":"41","author":"Lefere","year":"2017","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.phymed.2023.155182_bib0040","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bbrc.2015.05.042","article-title":"Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK","volume":"463","author":"Liu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2023.155182_bib0041","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1016\/j.cell.2021.10.001","article-title":"Glycogen accumulation and phase separation drives liver tumor initiation","volume":"184","author":"Liu","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2023.155182_bib0042","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.acthis.2013.02.012","article-title":"Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish","volume":"115","author":"Lu","year":"2013","journal-title":"Acta Histochem."},{"key":"10.1016\/j.phymed.2023.155182_bib0043","doi-asserted-by":"crossref","first-page":"e5504","DOI":"10.1371\/journal.pone.0005504","article-title":"Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis","volume":"4","author":"Miksa","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2023.155182_bib0044","doi-asserted-by":"crossref","first-page":"9392","DOI":"10.3390\/ijms21249392","article-title":"Effect of adrenergic agonists on high-fat diet-induced hepatic steatosis in mice","volume":"21","author":"Nakade","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155182_bib0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/0960327112438929","article-title":"Dietary flaxseed oil supplementation ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine","volume":"32","author":"Naqshbandi","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.phymed.2023.155182_bib0046","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/tox.22264","article-title":"Yohimbine hydrochloride ameliorates collagen type-II-induced arthritis targeting oxidative stress and inflammatory cytokines in Wistar rats","volume":"32","author":"Neha","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.phymed.2023.155182_bib0048","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103103","article-title":"Wnt\/\u03b2-catenin signaling as a potential target for the treatment of liver cirrhosis using antifibrotic drugs","volume":"19","author":"Nishikawa","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155182_bib0049","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1126\/science.1188280","article-title":"Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity","volume":"329","author":"Ouchi","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.phymed.2023.155182_bib0050","series-title":"Serine Proteinases: Overview","first-page":"1","author":"Owen","year":"2006"},{"key":"10.1016\/j.phymed.2023.155182_bib0051","doi-asserted-by":"crossref","DOI":"10.21037\/dmr-21-87","article-title":"Role of the chemokine system in liver fibrosis: a narrative review","volume":"5","author":"Poulsen","year":"2022","journal-title":"Dig. Med. Res."},{"key":"10.1016\/j.phymed.2023.155182_bib0052","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2023.155182_bib0053","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"S\u00e1nchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phymed.2023.155182_bib0055","first-page":"131","article-title":"AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation","author":"Saxena","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.phymed.2023.155182_bib0056","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020456","article-title":"\u03b12-adrenergic receptor in liver fibrosis: implications for the adrenoblocker mesedin","volume":"9","author":"Schwinghammer","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2023.155182_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175366","article-title":"Dehydrozingerone ameliorates thioacetamide-induced liver fibrosis via inhibition of hepatic stellate cells activation through modulation of the MAPK pathway","volume":"937","author":"Sharma","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155182_bib0058","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1161\/HYPERTENSIONAHA.110.154898","article-title":"Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure","volume":"56","author":"Shibao","year":"2010","journal-title":"Hypertens. (Dallas, Tex.: 1979)"},{"key":"10.1016\/j.phymed.2023.155182_bib0059","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1083\/jcb.149.2.249","article-title":"The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression","volume":"149","author":"Takemaru","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2023.155182_bib0060","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.jhep.2015.02.039","article-title":"Hepatic fibrosis: concept to treatment","volume":"62","author":"Trautwein","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2023.155182_bib0061","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/0023677215573040","article-title":"Standard operating procedures in experimental liver research: thioacetamide model in mice and rats","volume":"49","author":"Wallace","year":"2015","journal-title":"Lab. Anim."},{"key":"10.1016\/j.phymed.2023.155182_bib0062","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3892\/ijmm.2016.2630","article-title":"p-CREB-1 promotes hepatic fibrosis through the transactivation of transforming growth factor-\u03b21 expression in rats","volume":"38","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2023.155182_bib0063","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3389\/fphys.2020.00990","article-title":"The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver","volume":"11","author":"Wilkinson","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2023.155182_bib0064","doi-asserted-by":"crossref","first-page":"21015","DOI":"10.18632\/oncotarget.15472","article-title":"Imidazoline I2 receptor inhibitor idazoxan regulates the progression of hepatic fibrosis via Akt-Nrf2-Smad2\/3 signaling pathway","volume":"8","author":"Xuanfei","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.phymed.2023.155182_bib0065","first-page":"751","article-title":"Hepatic stellate cells secretes type I collagen to trigger epithelial mesenchymal transition of hepatoma cells","volume":"4","author":"Yang","year":"2014","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.phymed.2023.155182_bib0066","doi-asserted-by":"crossref","first-page":"7879","DOI":"10.3892\/mmr.2017.7641","article-title":"PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review)","volume":"16","author":"Ying","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2023.155182_bib0067","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/hep.21473","article-title":"Wnt'er in liver: expression of Wnt and frizzled genes in mouse","volume":"45","author":"Zeng","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2023.155182_bib0068","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3727\/105221618X15373858350141","article-title":"Elimination of Wnt secretion from stellate cells is dispensable for zonation and development of liver fibrosis following hepatobiliary injury","volume":"19","author":"Zhang","year":"2019","journal-title":"Gene Expr."},{"key":"10.1016\/j.phymed.2023.155182_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174334","article-title":"Yohimbine hydrochloride inhibits benign prostatic hyperplasia by downregulating steroid 5\u03b1-reductase type 2","volume":"908","author":"Zhao","year":"2021","journal-title":"Eur. J. Pharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132300541X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132300541X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:48:10Z","timestamp":1760554090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132300541X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":63,"alternative-id":["S094471132300541X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155182","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Yohimbine ameliorates liver inflammation and fibrosis by regulating oxidative stress and Wnt\/\u03b2-catenin pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155182"}}