{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:59:46Z","timestamp":1784764786966,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["402339\/2021-5"],"award-info":[{"award-number":["402339\/2021-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["006\/2023"],"award-info":[{"award-number":["006\/2023"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009730","name":"Federal University of Ouro Preto","doi-asserted-by":"publisher","award":["23109.000928\/2020-33"],"award-info":[{"award-number":["23109.000928\/2020-33"]}],"id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.phymed.2023.155197","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T22:20:43Z","timestamp":1699309243000},"page":"155197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Exploring the antiviral potential of justicidin B and four glycosylated lignans from Phyllanthus brasiliensis against Zika virus: A promising pharmacological approach"],"prefix":"10.1016","volume":"123","author":[{"given":"Ariane Coelho","family":"Ferraz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-2448","authenticated-orcid":false,"given":"Paulo Wender P.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Bueno da Silva","family":"Menegatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Lameira Souza","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-4521","authenticated-orcid":false,"given":"Jos\u00e9 Diogo Evangelista","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-845X","authenticated-orcid":false,"given":"Alice Rhelly Veloso","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f4nia das Gra\u00e7as Santa Rosa","family":"Pamplona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abra\u00e3o de Jesus Barbosa","family":"Muribeca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"de Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo Yumiko","family":"Yoshioka e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-4058","authenticated-orcid":false,"given":"Milton Nascimento","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2500-0798","authenticated-orcid":false,"given":"Cintia Lopes de Brito","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155197_bib0001","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0031-9422(96)00024-6","article-title":"Antiviral activity of lignans and their glycosides from Justicia procumbens","volume":"42","author":"Asano","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2023.155197_bib0002","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/1472-6882-13-289","article-title":"Antimicrobial activity and cytotoxicity of the ethanol extract, fractions and eight compounds isolated from Eriosema robustum (Fabaceae)","volume":"13","author":"Awouafack","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2023.155197_bib0003","first-page":"e30062","article-title":"Emerging and re-emerging viral infections: an Indian Perspective","volume":"14","author":"Bankar","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.phymed.2023.155197_bib0004","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/17460441.2021.1973999","article-title":"An update on preclinical pregnancy models of Zika virus infection for drug and vaccine discovery","volume":"17","author":"Benazzato","year":"2022","journal-title":"Expert. Opin. Drug. Discov."},{"key":"10.1016\/j.phymed.2023.155197_bib0005","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3390\/molecules23040941","article-title":"Anti-inflammatory and antinociceptive studies of hydroalcoholic extract from the leaves of Phyllanthus brasiliensis (Aubl.) Poir. and isolation of 5-O-\u03b2-d-glucopyranosyljusticidin B and six other lignans","volume":"18","author":"Borges","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155197_bib0006","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/(SICI)1098-1128(199807)18:4<225::AID-MED2>3.0.CO;2-X","article-title":"A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential","volume":"18","author":"Calixto","year":"1998","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.phymed.2023.155197_bib0007","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/pca.3259","article-title":"Untargeted-based metabolomics analysis and in vitro\/in silico antiviral activity of extracts from Phyllanthus brasiliensis (Aubl.)","volume":"34","author":"Carvalho","year":"2023","journal-title":"Poir. Phytochem. Anal"},{"key":"10.1016\/j.phymed.2023.155197_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.amsu.2022.103985","article-title":"Comparative overview of emerging RNA viruses: epidemiology, pathogenesis, diagnosis and current treatment","volume":"79","author":"Chakrabartty","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.phymed.2023.155197_bib0009","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1139\/v00-059","article-title":"Antiviral activity of arylnaphthalene and aryldihydronaphthalene lignans","volume":"78","author":"Cow","year":"2000","journal-title":"Can. J. Chem. Rev. Can. Chim."},{"key":"10.1016\/j.phymed.2023.155197_bib0010","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1021\/np0101651","article-title":"Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages","volume":"65","author":"Day","year":"2002","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2023.155197_bib0011","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1073\/pnas.38.8.747","article-title":"Production of plaques in monolayer tissue cultures by single particles of an animal virus","volume":"38","author":"Dulbecco","year":"1952","journal-title":"Proc. Natl. Acad."},{"key":"10.1016\/j.phymed.2023.155197_bib0012","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.micinf.2019.04.005","article-title":"Zika virus infection: an update","volume":"21","author":"Ferraris","year":"2019","journal-title":"Microb. Infect."},{"key":"10.1016\/j.phymed.2023.155197_bib0013","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.antiviral.2019.05.008","article-title":"Virucidal activity of proanthocyanidin against Mayaro virus","volume":"168","author":"Ferraz","year":"2019","journal-title":"Antivir. Res."},{"key":"10.1016\/j.phymed.2023.155197_bib0014","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3390\/molecules27051542","article-title":"Antiviral plants from Maraj\u00f3 Islands, Brazilian Amazon: a narrative review","volume":"24","author":"Gomes","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155197_bib0015","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.3390\/molecules25102316","article-title":"The geraniin-rich extract from Reunion Island endemic medicinal plant Phyllanthus phillyreifolius inhibits Zika and Dengue virus infection at non-toxic effect doses in Zebrafish","volume":"25","author":"Haddad","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155197_bib0016","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.micinf.2016.03.009","article-title":"Zika virus: epidemiology, clinical features and host-virus interactions","volume":"18","author":"Hamel","year":"2016","journal-title":"Microb. Infect."},{"key":"10.1016\/j.phymed.2023.155197_bib0018","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s10529-014-1612-4","article-title":"Cytotoxic effect of the biotechnologically-derived justicidin B on human lymphoma cells","volume":"36","author":"Ilieva","year":"2014","journal-title":"Biotechnol. Lett"},{"key":"10.1016\/j.phymed.2023.155197_bib0019","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/bs.podrm.2020.07.005","article-title":"Chapter Six - Validation of in-vitro bioassay methods: application in herbal drug research","volume":"46","author":"Indrayanto","year":"2021","journal-title":"Profile. Drug Subst. Excip. Relat. Methodol."},{"key":"10.1016\/j.phymed.2023.155197_bib0020","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1046\/j.1365-2362.1996.410595.x","article-title":"Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication","volume":"26","author":"Lee","year":"1996","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.phymed.2023.155197_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115392","article-title":"Effective components and mechanism analysis of anti-platelet aggregation effect of Justicia procumbens L","volume":"294","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155197_bib0022","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1055\/s-2006-962087","article-title":"The antiviral action of lignans","volume":"55","author":"MacRae","year":"1989","journal-title":"Planta Med."},{"key":"10.1016\/j.phymed.2023.155197_bib0023","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.eimc.2016.02.016","article-title":"Zika fever","volume":"34","author":"Mart\u00ednez de Salazar","year":"2016","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"10.1016\/j.phymed.2023.155197_bib0024","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.toxrep.2014.08.006","article-title":"Sub-chronic toxicological evaluation of cleistanthin A and cleistanthin B from the leaves of Cleistanthus collinus (Roxb.)","volume":"1","author":"Parasuraman","year":"2014","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.phymed.2023.155197_bib0025","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/j.fct.2007.03.012","article-title":"Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: a comparative study","volume":"45","author":"Rao","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2023.155197_bib0026","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1590\/0037-8682-0105-2019","article-title":"Descriptive study of suspected congenital Zika syndrome cases during the 2015-2016 epidemic in Brazil","volume":"52","author":"Roma","year":"2019","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.phymed.2023.155197_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2020.105613","article-title":"Antiviral effect of silymarin against Zika virus in vitro","volume":"211","author":"Silva","year":"2020","journal-title":"Acta Trop."},{"key":"10.1016\/j.phymed.2023.155197_bib0028","doi-asserted-by":"crossref","first-page":"7208","DOI":"10.1074\/jbc.M116.756635","article-title":"Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness","volume":"292","author":"Snyder","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phymed.2023.155197_bib0029","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3390\/v14020354","article-title":"Diphyllin shows a broad-spectrum antiviral activity against multiple medically important enveloped RNA and DNA viruses","volume":"14","author":"\u0160tef\u00e1nik","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.phymed.2023.155197_bib0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1053\/j.gastro.2017.10.041","article-title":"Pan-genotype hepatitis E virus replication in stem cell\u2013derived hepatocellular systems","volume":"154","author":"Wu","year":"2018","journal-title":"Gastroenterology"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323005561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323005561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:48:42Z","timestamp":1760554122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323005561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":29,"alternative-id":["S0944711323005561"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155197","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the antiviral potential of justicidin B and four glycosylated lignans from Phyllanthus brasiliensis against Zika virus: A promising pharmacological approach","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155197","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155197"}}