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Int."},{"key":"10.1016\/j.phymed.2023.155234_bib0110","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3019794","article-title":"Curcumin and alpha\/beta-Adrenergic antagonists cotreatment reverse liver cirrhosis in hamsters: participation of Nrf-2 and NF-kappaB","volume":"2019","author":"Macias-Perez","year":"2019","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.phymed.2023.155234_bib0111","doi-asserted-by":"crossref","first-page":"S706","DOI":"10.1016\/S2221-1691(12)60300-1","article-title":"Hepatoprotective efficacy of curcumin against arsenic trioxide toxicity. Asian Pac","volume":"2","author":"Mathews","year":"2012","journal-title":"J. Trop. Biomed."},{"key":"10.1016\/j.phymed.2023.155234_bib0112","first-page":"120","article-title":"Effects of lead acetate, endurance training and curcumin supplementation on heat shock protein levels in liver tissue","volume":"13","author":"Memar Moghadam","year":"2011","journal-title":"Iran. J. Endocrinol. 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