{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:29:24Z","timestamp":1790000964179,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.phymed.2023.155254","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T09:57:59Z","timestamp":1706781479000},"page":"155254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Neuroprotection of rhubarb extract against cerebral ischaemia-reperfusion injury via the gut-brain axis pathway"],"prefix":"10.1016","volume":"126","author":[{"given":"Mingjiang","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1630-4987","authenticated-orcid":false,"given":"Ying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155254_bib0001","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/bs.acc.2018.02.002","article-title":"Metabolomics and lipidomics of ischemic stroke","volume":"85","author":"Au","year":"2018","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.phymed.2023.155254_bib0002","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1161\/STROKEAHA.122.039005","article-title":"Focused update on stroke neuroimmunology: current progress in preclinical and clinical research and recent mechanistic insight","volume":"53","author":"Boltze","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2023.155254_bib0003","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.molmed.2014.05.002","article-title":"Microbiota and. neurodevelopmental windows: implications for brain disorders","volume":"20","author":"Borre","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.phymed.2023.155254_bib0004","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1021\/acs.biochem.6b00774","article-title":"Quantification of the d-Ala-d-Lac-terminated. Peptidoglycan structure in vancomycin-resistant enterococcus faecalis using a combined solid-state nuclear magnetic resonance and mass spectrometry analysis","volume":"56","author":"Chang","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.phymed.2023.155254_bib0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1142\/S0192415X19500071","article-title":"Rhein, an anthraquinone drug, suppresses the nlrp3 inflammasome and macrophage activation in urate crystal-induced gouty inflammation","volume":"47","author":"Chang","year":"2019","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2023.155254_bib0006","first-page":"7285","article-title":"Research progress on anti-inflammatory effects and mechanism of Rhei Radix et Rhizoma and its active components","volume":"53","author":"Cao","year":"2022","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.phymed.2023.155254_bib0007","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3389\/fneur.2019.00661","article-title":"Persistence. of Gut microbiota dysbiosis and chronic systemic inflammation after cerebral infarction in cynomolgus monkeys","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.phymed.2023.155254_bib0008","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence. on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.phymed.2023.155254_bib0009","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-Gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2023.155254_bib0010","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/00207454.2020.1830085","article-title":"Effects of. chrysophanol on hippocampal damage and mitochondrial autophagy in mice with cerebral ischemia reperfusion","volume":"132","author":"Cui","year":"2022","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.phymed.2023.155254_bib0011","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2147\/DDDT.S267856","article-title":"Physcion protects rats. Against cerebral ischemia-reperfusion injury via inhibition of TLR4\/NF-kB signaling pathway","volume":"15","author":"Dong","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phymed.2023.155254_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10040170","article-title":"Identification of metabolic alterations in. breast cancer using mass spectrometry-based metabolomic analysis","volume":"10","author":"Fan","year":"2020","journal-title":"Metabolites."},{"key":"10.1016\/j.phymed.2023.155254_bib0013","first-page":"745","article-title":"Physcion. 8\u2011O\u2011\u03b2\u2011glucopyranoside extracted from Polygonum cuspidatum exhibits anti\u2011proliferative and anti\u2011inflammatory effects on MH7A rheumatoid arthritis\u2011derived fibroblast\u2011like synoviocytes through the TGF\u2011\u03b2\/MAPK pathway","volume":"42","author":"Geng","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2023.155254_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109119","article-title":"LC-MS\/MS based molecular networking approach for the identification of cocoa phenolic metabolites in human urine","volume":"132","author":"Hakeem Said","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.phymed.2023.155254_bib0015","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.4103\/1673-5374.355821","article-title":"Ischemic accumulation of succinate induces Cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia\/reperfusion","volume":"18","author":"Huang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2023.155254_bib0016","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12864-018-5377-3","article-title":"Innate immunity in the simplest animals - placozoans","volume":"20","author":"Kamm","year":"2019","journal-title":"BMC Genomics."},{"key":"10.1016\/j.phymed.2023.155254_bib0017","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12866-019-1552-1","article-title":"Change of intestinal microbiota in cerebral ischemic stroke patients","volume":"19","author":"Li","year":"2019","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.phymed.2023.155254_bib0018","article-title":"Pharmacodynamics of five anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and reciprocal pharmacokinetic interaction in rats with cerebral ischemia","volume":"24","author":"Li","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155254_bib0019","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3389\/fphar.2018.00943","article-title":"Combined use of emodin. and ginsenoside Rb1 exerts synergistic neuroprotection in cerebral ischemia\/reperfusion rats","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155254_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.05.002","article-title":"Metabolic dynamics and prediction of gestational age and time to delivery in pregnant women","volume":"181","author":"Liang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2023.155254_bib0021","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery. occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2023.155254_bib0022","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.2174\/1568026615666150610142647","article-title":"Neuroprotective effects of ginkgolide b against ischemic stroke: a review of current literature","volume":"15","author":"Nabavi","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.phymed.2023.155254_bib0023","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3389\/fneur.2018.00937","article-title":"Exploratory investigation of intestinal function and bacterial translocation after focal cerebral ischemia in the mouse","volume":"9","author":"Oyama","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.phymed.2023.155254_bib0024","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2174\/138161210790883624","article-title":"Toll-like. receptor 4 mediates LPS-induced release of nitric oxide and tumor necrosis factor-alpha by embryonal cardiomyocytes: biological significance and clinical implications in human pathology","volume":"16","author":"Panaro","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.phymed.2023.155254_bib0025","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2133.2006.07642.x","article-title":"Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis","volume":"156","author":"Peltonen","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.phymed.2023.155254_bib0026","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s12264-019-00388-3","article-title":"Dual functions of microglia in ischemic stroke","volume":"35","author":"Qin","year":"2019","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.phymed.2023.155254_bib0027","doi-asserted-by":"crossref","first-page":"7428","DOI":"10.1523\/JNEUROSCI.1114-16.2016","article-title":"Microbiota dysbiosis controls the neuroinflammatory response after stroke","volume":"36","author":"Singh","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phymed.2023.155254_bib0028","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/nm.4194","article-title":"Translocation and dissemination of commensal bacteria in post-stroke infection","volume":"22","author":"Stanley","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2023.155254_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsb.2014.11.002","article-title":"Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia\/reperfusion-induced cerebral microcirculatory disturbances and neuron damage","volume":"5","author":"Sun","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2023.155254_bib0030","article-title":"Zerumbone protects against carbon. Tetrachloride (CCl4)-induced acute liver injury in mice via inhibiting oxidative stress and the inflammatory response: involving the TLR4\/NF-\u03baB\/COX-2 pathway","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2023.155254_bib0031","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.3748\/wjg.v18.i17.2132","article-title":"Emodin promoted pancreatic claudin-5 and. occludin expression in experimental acute pancreatitis rats","volume":"18","author":"Xia","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2023.155254_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.587284","article-title":"Gut microbiotic features aiding the diagnosis of acute ischemic stroke","volume":"10","author":"Xiang","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.phymed.2023.155254_bib0033","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2020-323263","article-title":"Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn","author":"Xu","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2023.155254_bib0034","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3892\/mmr.2014.2789","article-title":"Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor\u2011\u03baB activation resulting in antioxidation","volume":"11","author":"Yao","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2023.155254_bib0035","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/370530","article-title":"Chrysophanol. inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia\/reperfusion in mice","volume":"2014","author":"Zhang","year":"2014","journal-title":"Mediators. Inflamm."},{"key":"10.1016\/j.phymed.2023.155254_bib0036","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12974-018-1382-3","article-title":"Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke","volume":"15","author":"Zhao","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2023.155254_bib0037","first-page":"2802","article-title":"Rhein protects against cerebral ischemic\u2011\/reperfusion\u2011induced oxidative stress and apoptosis in rats","volume":"41","author":"Zhao","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2023.155254_bib0038","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.biopha.2018.10.201","article-title":"Icariside II attenuates. lipopolysaccharide-induced neuroinflammation through inhibiting TLR4\/MyD88\/NF-\u03baB pathway in rats","volume":"111","author":"Zhou","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155254_bib0039","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(19)30427-1","article-title":"Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"394","author":"Zhou","year":"2019","journal-title":"Lancet"}],"updated-by":[{"DOI":"10.1016\/j.phymed.2024.155525","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000}}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132300613X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132300613X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T01:53:33Z","timestamp":1710899613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132300613X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":39,"alternative-id":["S094471132300613X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155254","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotection of rhubarb extract against cerebral ischaemia-reperfusion injury via the gut-brain axis pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155254"}}