{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:07:41Z","timestamp":1793156861137,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2022YFS0433"],"award-info":[{"award-number":["2022YFS0433"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204724"],"award-info":[{"award-number":["82204724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004300","name":"Senior Talent Foundation of Jiangsu University","doi-asserted-by":"publisher","award":["5501290014"],"award-info":[{"award-number":["5501290014"]}],"id":[{"id":"10.13039\/501100004300","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.phymed.2023.155305","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T23:37:43Z","timestamp":1702942663000},"page":"155305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters"],"prefix":"10.1016","volume":"124","author":[{"given":"Jiana","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0877-0427","authenticated-orcid":false,"given":"Yanbei","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155305_bib0001","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.3390\/nu12123835","article-title":"The association between purine-rich food intake and hyperuricemia: a cross-sectional study in Chinese adult residents","volume":"12","author":"Aihemaitijiang","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2023.155305_bib0002","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/art.40807","article-title":"Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the National Health and Nutrition Examination Survey, 2007\u20132016","volume":"71","author":"Chen-Xu","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.phymed.2023.155305_bib0003","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cclet.2016.05.022","article-title":"Screening the anti-gout traditional herbs from TCM using an in vitro method","volume":"27","author":"Chen","year":"2016","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.phymed.2023.155305_bib0004","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cca.2022.09.022","article-title":"Serum biomarkers for liver fibrosis","volume":"537","author":"Chen","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.phymed.2023.155305_bib0005","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41572-019-0115-y","article-title":"Gout","volume":"5","author":"Dalbeth","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.phymed.2023.155305_bib0006","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3724\/SP.J.1009.2013.00214","article-title":"Wuling San ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice","volume":"11","author":"Ding","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2023.155305_bib0007","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20220041","article-title":"Ultrasmall iron-gallic acid coordination polymer nanodots with antioxidative neuroprotection for PET\/MR imaging-guided ischemia stroke therapy","volume":"3","author":"Du","year":"2023","journal-title":"Exploration"},{"key":"10.1016\/j.phymed.2023.155305_bib0008","doi-asserted-by":"crossref","first-page":"15683","DOI":"10.1038\/s41598-020-72780-3","article-title":"Prevalence and associated factors of hyperuricemia among urban adults aged 35\u201379 years in southwestern China: a community-based cross-sectional study","volume":"10","author":"Huang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2023.155305_bib0009","article-title":"Mobile mechanical signal generator for macrophage polarization","volume":"3","author":"Jiang","year":"2023","journal-title":"Exploration"},{"key":"10.1016\/j.phymed.2023.155305_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113054","article-title":"Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine-and ethambutol-induced hyperuricaemia in rats","volume":"261","author":"Kang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155305_bib0011","series-title":"Data Mining: Concepts, Models, Methods, and Algorithms","author":"Kantardzic","year":"2011"},{"key":"10.1016\/j.phymed.2023.155305_bib0012","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.jacc.2017.12.052","article-title":"Cardiovascular risks of probenecid versus allopurinol in older patients with gout","volume":"71","author":"Kim","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2023.155305_bib0013","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/rcm.3848","article-title":"High-speed separation and characterization of major constituents in Radix Paeoniae Rubra by fast high-performance liquid chromatography coupled with diode-array detection and time-of-flight mass spectrometry","volume":"23","author":"Liu","year":"2009","journal-title":"Rapid Commun. Mass Sp."},{"key":"10.1016\/j.phymed.2023.155305_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2022.100343","article-title":"Characterization of xanthine oxidase inhibitory activities of phenols from pickled radish with molecular simulation","volume":"14","author":"Liu","year":"2022","journal-title":"Food Chem. X"},{"key":"10.1016\/j.phymed.2023.155305_bib0015","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/cmdc.201900034","article-title":"Inhibitors of xanthine oxidase: scaffold diversity and structure-based drug design","volume":"14","author":"Luna","year":"2019","journal-title":"ChemMedChem"},{"key":"10.1016\/j.phymed.2023.155305_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.911968","article-title":"Excess uric acid induces gouty nephropathy through crystal formation: a review of recent insights","volume":"13","author":"Mei","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.phymed.2023.155305_bib0017","doi-asserted-by":"crossref","first-page":"e15333","DOI":"10.1016\/j.heliyon.2023.e15333","article-title":"Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats","volume":"9","author":"Meng","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2023.155305_bib0018","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13075-016-1107-x","article-title":"Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney","volume":"18","author":"Miner","year":"2016","journal-title":"Arthrit. Res. Ther."},{"key":"10.1016\/j.phymed.2023.155305_bib0019","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s13539-012-0079-1","article-title":"Serum creatinine as a marker of muscle mass in chronic kidney disease: results of a cross-sectional study and review of literature","volume":"4","author":"Patel","year":"2013","journal-title":"J. Cachexia Sarcopeni"},{"key":"10.1016\/j.phymed.2023.155305_bib0020","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.3389\/fphar.2022.811030","article-title":"Network pharmacology and data mining approach reveal the medication rule of traditional Chinese medicine in the treatment of premenstrual syndrome\/premenstrual dysphoric disorder","volume":"13","author":"Qu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155305_bib0021","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.3390\/jpm13091409","article-title":"The role of uric acid in human health: insights from the uricase gene","volume":"13","author":"Roman","year":"2023","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.phymed.2023.155305_bib0022","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fphys.2018.00476","article-title":"Human mutations in SLC2A9 (Glut9) affect transport capacity for urate","volume":"9","author":"Ruiz","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2023.155305_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102636","article-title":"Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis","volume":"62","author":"Schmidt","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2023.155305_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114890","article-title":"Recent advances in gout drugs","volume":"245","author":"Shi","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phymed.2023.155305_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2021.101719","article-title":"Treatment advances in gout","volume":"35","author":"Stamp","year":"2021","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.phymed.2023.155305_bib0026","article-title":"Function of uric acid transporters and their inhibitors in hyperuricaemia","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155305_bib0027","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1002\/jssc.201700690","article-title":"Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactiflora using chromatography combined with a multi-mode microplate reader","volume":"40","author":"Wang","year":"2017","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.phymed.2023.155305_bib0028","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.chroma.2008.04.064","article-title":"Species differentiation and quality assessment of Radix Paeoniae Rubra (Chi-shao) by means of high-performance liquid chromatographic fingerprint","volume":"1216","author":"Xu","year":"2009","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.phymed.2023.155305_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1026246","article-title":"New insight into the management of renal excretion and hyperuricemia: potential therapeutic strategies with natural bioactive compounds","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155305_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106320","article-title":"Chalcone derivatives as xanthine oxidase inhibitors: synthesis, binding mode investigation, biological evaluation, and ADMET prediction","volume":"131","author":"Yang","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2023.155305_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154256","article-title":"Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3","volume":"103","author":"Yong","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155305_bib0032","doi-asserted-by":"crossref","first-page":"10781","DOI":"10.1039\/C8RA09926J","article-title":"The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects","volume":"9","author":"Yuan","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.phymed.2023.155305_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153765","article-title":"Antihyperuricemia and antigouty arthritis effects of Persicaria capitata herba in mice","volume":"93","author":"Zhang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155305_bib0034","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.aninu.2022.01.008","article-title":"The role of rumen epithelial urea transport proteins in urea nitrogen salvage: a review","volume":"9","author":"Zhong","year":"2022","journal-title":"Anim. Nutr."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323006633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323006633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:30:36Z","timestamp":1775723436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323006633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":34,"alternative-id":["S0944711323006633"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155305","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155305","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155305"}}