{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:32:28Z","timestamp":1793298748935,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.phymed.2023.155312","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T13:49:53Z","timestamp":1703425793000},"page":"155312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Nuciferine reduces inflammation induced by cerebral ischemia-reperfusion injury through the PI3K\/Akt\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"125","author":[{"given":"Jinhua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5148-9094","authenticated-orcid":false,"given":"Shuze","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155312_bib0001","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ni.3772","article-title":"Limiting inflammation-the negative regulation of NF-\u03baB and the NLRP3 inflammasome","volume":"18","author":"Afonina","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2023.155312_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102022","article-title":"Protease-activated receptor 2 induces ROS-mediated inflammation through Akt-mediated NF-\u03baB and FoxO6 modulation during skin photoaging","volume":"44","author":"Bang","year":"2021","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2023.155312_bib0003","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","article-title":"NF-\u03baB: blending metabolism, immunity, and inflammation","volume":"43","author":"Capece","year":"2022","journal-title":"Trends Immunol."},{"key":"10.1016\/j.phymed.2023.155312_bib0004","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1039\/D2MO00158F","article-title":"Nuciferine attenuates acute ischemic stroke in a rat model: a metabolomic approach for the mechanistic study","volume":"18","author":"Chen","year":"2022","journal-title":"Mol. Omics"},{"key":"10.1016\/j.phymed.2023.155312_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.716825","article-title":"Cerebral edema formation after stroke: emphasis on blood-brain barrier and the lymphatic drainage system of the brain","volume":"15","author":"Chen","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.phymed.2023.155312_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.bj.2023.100624","article-title":"Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease","volume":"46","author":"Cho","year":"2023","journal-title":"Biomed. J."},{"key":"10.1016\/j.phymed.2023.155312_bib0007","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12906-021-03389-w","article-title":"Molecular mechanism of Epicedium treatment for depression based on network pharmacology and molecular docking technology","volume":"21","author":"Dong","year":"2021","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.phymed.2023.155312_bib0008","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s13760-023-02202-4","article-title":"Stroke in Parkinson's disease: a review of epidemiological studies and potential pathophysiological mechanisms","volume":"123","author":"Elfil","year":"2023","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.phymed.2023.155312_bib0009","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41582-021-00605-6","article-title":"Pharmacological brain cytoprotection in acute ischaemic stroke - renewed hope in the reperfusion era","volume":"18","author":"Fisher","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.phymed.2023.155312_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.988283","article-title":"Cerebral edema after ischemic stroke: pathophysiology and underlying mechanisms","volume":"16","author":"Gu","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.phymed.2023.155312_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116298","article-title":"Annao Pingchong decoction alleviate the neurological impairment by attenuating neuroinflammation and apoptosis in intracerebral hemorrhage rats","volume":"310","author":"Guo","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155312_bib0012","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/cns.13569","article-title":"Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms","volume":"27","author":"Huang","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2023.155312_bib0013","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2174\/1570159X18666200620230321","article-title":"Crosstalk between Inflammation and the BBB in Stroke","volume":"18","author":"Huang","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.phymed.2023.155312_bib0014","first-page":"e358","article-title":"Association of alternative anticoagulation strategies and outcomes in patients with ischemic stroke while taking a direct oral anticoagulant","volume":"101","author":"Ip","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.phymed.2023.155312_bib0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010014","article-title":"Neuroinflammation in cerebral ischemia and ischemia\/reperfusion injuries: from pathophysiology to therapeutic strategies","volume":"23","author":"Jurcau","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155312_bib0016","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12035-021-02611-7","article-title":"Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease","volume":"59","author":"Kumar","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2023.155312_bib0017","series-title":"Basedon thePERK\/Nrf2 Signaling Pathway Discuss the Treatment of Nuciferine on Cerebralischemia Reperfusion Injury","author":"Liu","year":"2023"},{"key":"10.1016\/j.phymed.2023.155312_bib0018","doi-asserted-by":"crossref","first-page":"293","DOI":"10.26599\/1671-5411.2023.04.002","article-title":"Safety of butylphthalide and edaravone in patients with ischemic stroke: a multicenter real-world study","volume":"20","author":"Lyu","year":"2023","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.phymed.2023.155312_bib0019","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s12264-022-00859-0","article-title":"Neuronal death mechanisms and therapeutic strategy in Ischemic stroke","volume":"38","author":"Mao","year":"2022","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.phymed.2023.155312_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.636653","article-title":"Brain ischemia as a prelude to Alzheimer's disease","volume":"13","author":"Pluta","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.phymed.2023.155312_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.782569","article-title":"Understanding the connection between common stroke comorbidities, their associated inflammation, and the course of the cerebral ischemia\/reperfusion cascade","volume":"12","author":"Przykaza","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2023.155312_bib0022","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.7150\/thno.68304","article-title":"Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment","volume":"12","author":"Rajeev","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2023.155312_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2022.106026","article-title":"Processing tactics for low-cost production of pure nuciferine from lotus leaf","volume":"86","author":"Ruan","year":"2022","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.phymed.2023.155312_bib0024","first-page":"5284","article-title":"[Protection of salidroside on endothelial cell barrier in cerebral ischemia-reperfusion model rats]","volume":"47","author":"Song","year":"2022","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.phymed.2023.155312_bib0025","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1080\/07391102.2020.1776638","article-title":"Molecular docking of potential cytotoxic alkylating carmustine derivatives 2-chloroethylnitrososulfamides analogues of 2-chloroethylnitrosoureas","volume":"39","author":"Soudani","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.phymed.2023.155312_bib0026","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jphs.2020.11.007","article-title":"Microglial metabolic disturbances and neuroinflammation in cerebral infarction","volume":"145","author":"Takeda","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2023.155312_bib0027","doi-asserted-by":"crossref","first-page":"11174","DOI":"10.1039\/D1FO02714J","article-title":"Nuciferine administration in C57BL\/6J mice with gestational diabetes mellitus induced by a high-fat diet: the improvement of glycolipid disorders and intestinal dysbacteriosis","volume":"12","author":"Tang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2023.155312_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23116224","article-title":"Neuroinflammation in vascular cognitive impairment and dementia: current evidence, advances, and prospects","volume":"23","author":"Tian","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155312_bib0029","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s11739-023-03201-2","article-title":"Inflammatory biomarkers of ischemic stroke","volume":"18","author":"Tirandi","year":"2023","journal-title":"Intern. Emerg. Med."},{"key":"10.1016\/j.phymed.2023.155312_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106002","article-title":"Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases","volume":"175","author":"Wan","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.155312_bib0031","first-page":"11","article-title":"Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke","author":"Wang","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2023.155312_bib0032","first-page":"9601","article-title":"Inflammation, apoptosis and autophagy as critical players in vascular dementia","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2023.155312_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cnc.2022.10.003","article-title":"Strokes and Predictors of Outcomes","volume":"35","author":"Williams","year":"2023","journal-title":"Crit. Care Nurs. Clin. North. Am."},{"key":"10.1016\/j.phymed.2023.155312_bib0034","doi-asserted-by":"crossref","first-page":"33433","DOI":"10.1021\/acsomega.0c05388","article-title":"UPLC-Q-TOF\/MS-based serum metabolomics reveals the anti-ischemic stroke mechanism of nuciferine in MCAO rats","volume":"5","author":"Wu","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.phymed.2023.155312_bib0035","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s12276-022-00734-y","article-title":"TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury","volume":"54","author":"Xia","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2023.155312_bib0036","first-page":"783","article-title":"PI3K\/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (Review)","volume":"19","author":"Xie","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2023.155312_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153687","article-title":"Aesculin suppresses the NLRP3 inflammasome-mediated pyroptosis via the Akt\/GSK3\u03b2\/NF-\u03baB pathway to mitigate myocardial ischemia\/reperfusion injury","volume":"92","author":"Xu","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155312_bib0038","first-page":"370","article-title":"Clinical efficacy and short-term prognosis of butylphthalide and sodium chloride injection compared to edaravone in the treatment of patients with acute stroke","volume":"29","author":"Yang","year":"2023","journal-title":"Altern. Ther. Health. Med."},{"key":"10.1016\/j.phymed.2023.155312_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1013933","article-title":"New insight into neurological degeneration: inflammatory cytokines and blood-brain barrier","volume":"15","author":"Yang","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.phymed.2023.155312_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113999","article-title":"Research progress on pyroptosis-mediated immune-inflammatory response in ischemic stroke and the role of natural plant components as regulator of pyroptosis: a review","volume":"157","author":"Yang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155312_bib0041","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1007\/s11064-022-03697-8","article-title":"Cell death mechanisms in cerebral ischemia-reperfusion injury","volume":"47","author":"Zhang","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2023.155312_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106820","article-title":"Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases","volume":"193","author":"Zhao","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2023.155312_bib0043","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1111\/cns.13961","article-title":"Lomitapide ameliorates middle cerebral artery occlusion-induced cerebral ischemia\/reperfusion injury by promoting neuronal autophagy and inhibiting microglial migration","volume":"28","author":"Zheng","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2023.155312_bib0044","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.seizure.2022.11.007","article-title":"Intracellular calcium homeostasis and its dysregulation underlying epileptic seizures","volume":"103","author":"Zhou","year":"2022","journal-title":"Seizure"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323006700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323006700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:51:42Z","timestamp":1760554302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323006700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":44,"alternative-id":["S0944711323006700"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155312","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuciferine reduces inflammation induced by cerebral ischemia-reperfusion injury through the PI3K\/Akt\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155312","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155312"}}