{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:14:02Z","timestamp":1788743642500,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004019"],"award-info":[{"award-number":["82004019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174267"],"award-info":[{"award-number":["82174267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004773","name":"Henan University","doi-asserted-by":"publisher","award":["21IRTSTHN026"],"award-info":[{"award-number":["21IRTSTHN026"]}],"id":[{"id":"10.13039\/501100004773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004773","name":"Henan University","doi-asserted-by":"publisher","award":["22HASTIT048"],"award-info":[{"award-number":["22HASTIT048"]}],"id":[{"id":"10.13039\/501100004773","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.phymed.2023.155313","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T18:25:51Z","timestamp":1703528751000},"page":"155313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Alisol B regulates AMPK\/mTOR\/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia"],"prefix":"10.1016","volume":"128","author":[{"given":"Gai","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0008-9637","authenticated-orcid":false,"given":"Zhishen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155313_bib0001","doi-asserted-by":"crossref","first-page":"52772","DOI":"10.1074\/jbc.M410302200","article-title":"Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs","volume":"279","author":"Adams","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.155313_bib0002","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chembiol.2016.12.017","article-title":"Vitamin D Metabolite, 25-Hydroxyvitamin D, regulates lipid metabolism by inducing degradation of SREBP\/SCAP","volume":"24","author":"Asano","year":"2017","journal-title":"Cell Chem. Biol"},{"key":"10.1016\/j.phymed.2023.155313_bib0003","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-nutr-071714-034355","article-title":"The roles of mTOR complexes in lipid metabolism","volume":"35","author":"Caron","year":"2015","journal-title":"Annu. Rev. Nutr."},{"issue":"1","key":"10.1016\/j.phymed.2023.155313_bib0004","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/fsn3.2014","article-title":"Hypolipidemic properties of Chlorella pyrenoidosa organic acids via AMPK\/HMGCR\/SREBP-1c pathway in vivo","volume":"9","author":"Chen","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2023.155313_bib0005","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1007\/s10495-014-1045-5","article-title":"Inhibition of VDAC1 prevents Ca2+-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages","volume":"19","author":"Chen","year":"2014","journal-title":"Apoptosis"},{"key":"10.1016\/j.phymed.2023.155313_bib0006","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nsmb.2841","article-title":"Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1","volume":"21","author":"Choudhary","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.phymed.2023.155313_bib0007","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1126\/science.1150755","article-title":"Structure of a site-2 protease family intramembrane metalloprotease","volume":"318","author":"Feng","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.phymed.2023.155313_bib0008","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel","volume":"38","author":"Ference","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phymed.2023.155313_bib0011","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jmb.2003.08.022","article-title":"Glucose and type 2A protein phosphatase regulate the interaction between catalytic and regulatory subunits of AMP-activated protein kinase","volume":"333","author":"Gimeno-Alca\u00f1iz","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.phymed.2023.155313_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102227","article-title":"Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder","volume":"49","author":"Guo","year":"2022","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2023.155313_bib0013","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature14557","article-title":"The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1","volume":"524","author":"Han","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2023.155313_bib0014","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s13238-017-0409-3","article-title":"mTORC1 signaling in hepatic lipid metabolism","volume":"9","author":"Han","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.phymed.2023.155313_bib0015","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1016\/j.bmcl.2007.06.031","article-title":"Aminopyrrolidineamide inhibitors of site-1 protease","volume":"17","author":"Hay","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2023.155313_bib0016","doi-asserted-by":"crossref","first-page":"E7276","DOI":"10.1073\/pnas.1512867112","article-title":"Antifungal drug itraconazole targets VDAC1 to modulate the AMPK\/mTOR signaling axis in endothelial cells","volume":"112","author":"Head","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.phymed.2023.155313_bib0017","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2023.155313_bib0018","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41586-019-1667-4","article-title":"The ADP\/ATP translocase drives mitophagy independent of nucleotide exchange","volume":"575","author":"Hoshino","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2023.155313_bib0019","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev-pharmtox-010611-134537","article-title":"AMPK and mTOR in cellular energy homeostasis and drug targets","volume":"52","author":"Inoki","year":"2012","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2023.155313_bib0029","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.canlet.2021.06.029","article-title":"NCAPD2 inhibits autophagy by regulating Ca2+\/CAMKK2\/AMPK\/mTORC1 pathway and PARP-1\/SIRT1 axis to promote colorectal cancer","volume":"520","author":"Jing","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2023.155313_bib0020","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2121491119","article-title":"A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics","volume":"119","author":"Karmi","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.phymed.2023.155313_bib0021","first-page":"S139","article-title":"Epidemiology and management of hyperlipidemia","volume":"23","author":"Karr","year":"2017","journal-title":"Am. J. Manag. Care"},{"key":"10.1016\/j.phymed.2023.155313_bib0022","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/cbin.10915","article-title":"Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism","volume":"42","author":"Ke","year":"2018","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.phymed.2023.155313_bib0023","article-title":"Dapagliflozin alleviates hepatic steatosis by restoring autophagy via the AMPK-mTOR pathway","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155313_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113949","article-title":"High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK\/mTOR-mediated autophagy","volume":"348","author":"Li","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2023.155313_bib0025","first-page":"17","article-title":"Hyperlipidemia and statins use for the risk of new diagnosed sarcopenia in patients with chronic Kidney: a population-based study","author":"Lin","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.phymed.2023.155313_bib0026","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cmet.2017.10.009","article-title":"AMPK: sensing glucose as well as cellular energy status","volume":"27","author":"Lin","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2023.155313_bib0028","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jare.2022.10.014","article-title":"Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS\/STING signaling dependent on LKB1\/AMPK\/ULK1-mediated autophagy","volume":"51","author":"Lu","year":"2023","journal-title":"J. Adv. Res."},{"issue":"4","key":"10.1016\/j.phymed.2023.155313_bib65","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41580-019-0190-7","article-title":"Mechanisms and regulation of cholesterol homeostasis","volume":"21","author":"Luo","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2023.155313_bib0027","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1021\/acs.jnatprod.5b00321","article-title":"Protostane triterpenoids from the rhizome of alisma orientale exhibit inhibitory effects on human carboxylesterase 2","volume":"78","author":"Mai","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2023.155313_bib0030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mito.2014.09.002","article-title":"ATP\/ADP ratio, the missed connection between mitochondria and the Warburg effect","author":"Maldonado","year":"2014","journal-title":"Mitochondrion 19 Pt A"},{"issue":"Pt 3","key":"10.1016\/j.phymed.2023.155313_bib0031","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1042\/bj3200801","article-title":"Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha","volume":"320","author":"Marley","year":"1996","journal-title":"Biochem. J."},{"issue":"17","key":"10.1016\/j.phymed.2023.155313_bib0032","doi-asserted-by":"crossref","first-page":"9483","DOI":"10.3390\/ijms22179483","article-title":"AMPK phosphorylation is controlled by glucose transport rate in a PKA-independent manner","volume":"22","author":"Milanesi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155313_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101761","article-title":"CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle","author":"Negoita","year":"2023","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phymed.2023.155313_bib0034","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pop.2012.11.003","article-title":"Hyperlipidemia as a risk factor for cardiovascular disease","volume":"40","author":"Nelson","year":"2013","journal-title":"Prim. Care"},{"key":"10.1016\/j.phymed.2023.155313_bib0035","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1158\/0008-5472.CAN-18-0585","article-title":"CAMKK2 promotes prostate cancer independently of AMPK via increased lipogenesis","volume":"78","author":"Penfold","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2023.155313_bib0036","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1194\/jlr.M091967","article-title":"StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis","volume":"60","author":"Rodriguez-Agudo","year":"2019","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phymed.2023.155313_bib0037","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrendo.2017.91","article-title":"SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology","volume":"13","author":"Shimano","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.phymed.2023.155313_bib0038","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ceca.2017.06.007","article-title":"VDAC1 functions in Ca(2+) homeostasis and cell life and death in health and disease","volume":"69","author":"Shoshan-Barmatz","year":"2018","journal-title":"Cell Calcium"},{"key":"10.1016\/j.phymed.2023.155313_bib0039","first-page":"20","article-title":"VDAC1 and the TSPO: expression, interactions, and associated functions in fealth and disease states","author":"Shoshan-Barmatz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155313_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/biom10111485","article-title":"VDAC1 at the intersection of cell metabolism, apoptosis, and diseases","volume":"10","author":"Shoshan-Barmatz","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2023.155313_bib0041","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","article-title":"New insights into activation and function of the AMPK","volume":"24","author":"Steinberg","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2023.155313_bib0042","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11894-017-0584-7","article-title":"Use of statins in patients with chronic liver disease and cirrhosis: current views and prospects","volume":"19","author":"Vargas","year":"2017","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.phymed.2023.155313_bib0043","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ymthe.2021.06.024","article-title":"The role of the mitochondrial protein VDAC1 in inflammatory bowel disease: a potential therapeutic target","volume":"30","author":"Verma","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.phymed.2023.155313_bib0044","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1016\/j.apsb.2021.03.031","article-title":"Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR\/P70S6K\/SREBPs pathway","volume":"11","author":"Xiao","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2023.155313_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115101","article-title":"Zexie Tang targeting FKBP38\/mTOR\/SREBPs pathway improves hyperlipidemia","volume":"290","author":"Xie","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2023.155313_bib0046","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jff.2017.01.040","article-title":"Carnosic acid alleviates hyperlipidemia and insulin resistance by promoting the degradation of SREBPs via the 26S proteasome","volume":"31","author":"Xie","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2023.155313_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154711","article-title":"Hederagenin improves Alzheimer's disease through PPAR\u03b1\/TFEB-mediated autophagy","volume":"112","author":"Xie","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155313_bib0048","first-page":"746","article-title":"Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs","volume":"14","author":"Xie","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2023.155313_bib0049","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/cr.2013.121","article-title":"Coordinated regulation of AMPK activity by multiple elements in the \u03b1-subunit","volume":"23","author":"Xin","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.phymed.2023.155313_bib0050","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/10408398.2010.500245","article-title":"Cross-talk between AMPK and mTOR in regulating energy balance","volume":"52","author":"Xu","year":"2012","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2023.155313_bib0052","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.abe7565","article-title":"Structure of an AMPK complex in an inactive, ATP-bound state","volume":"373","author":"Yan","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.phymed.2023.155313_bib0053","first-page":"19","article-title":"Structure and physiological regulation of AMPK","author":"Yan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155313_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155200","article-title":"Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK\/mTOR signaling pathway","volume":"131","author":"Yan","year":"2022","journal-title":"Metabolism"},{"issue":"7","key":"10.1016\/j.phymed.2023.155313_bib0010","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/cbin.11583","article-title":"VDAC1 promotes cardiomyocyte autophagy in anoxia\/reoxygenation injury via the PINK1\/Parkin pathway","volume":"45","author":"Yang","year":"2021","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.phymed.2023.155313_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175942","article-title":"Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue","volume":"956","author":"Yang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2023.155313_bib0055","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1074\/jbc.M510104200","article-title":"Nucleotide-binding sites in the voltage-dependent anion channel: characterization and localization","volume":"281","author":"Yehezkel","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2023.155313_bib0056","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1080\/09168451.2016.1268042","article-title":"Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells","volume":"81","author":"Yoshida","year":"2017","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.phymed.2023.155313_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102289","article-title":"IP3R1\/GRP75\/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling","volume":"52","author":"Yuan","year":"2022","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2023.155313_bib0058","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.biopha.2016.12.088","article-title":"Antiproliferative activity of Alisol B in MDA-MB-231 cells is mediated by apoptosis, dysregulation of mitochondrial functions, cell cycle arrest and generation of reactive oxygen species","volume":"87","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.phymed.2023.155313_bib0059","doi-asserted-by":"crossref","first-page":"294","DOI":"10.7150\/ijbs.78097","article-title":"Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury","volume":"19","author":"Zhang","year":"2023","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.phymed.2023.155313_bib0060","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.cmet.2013.09.005","article-title":"AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation","volume":"18","author":"Zhang","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2023.155313_bib0061","doi-asserted-by":"crossref","DOI":"10.3390\/nu14122411","article-title":"Alisol B alleviates hepatocyte lipid accumulation and lipotoxicity via regulating RAR\u03b1-PPAR\u03b3-CD36 cascade and attenuates non-alcoholic steatohepatitis in Mice","volume":"14","author":"Zhao","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2023.155313_bib0062","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.7150\/thno.36505","article-title":"Inhibition of HSP90\u03b2 improves lipid disorders by promoting mature SREBPs degradation via the ubiquitin-proteasome System","volume":"9","author":"Zheng","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2023.155313_bib0063","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1080\/15548627.2020.1757955","article-title":"Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway","volume":"17","author":"Zheng","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2023.155313_bib0064","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/6739691","article-title":"Inhibition of VDAC1 rescues A\u03b2(1-42)-induced mitochondrial dysfunction and ferroptosis via activation of AMPK and Wnt\/\u03b2-Catenin pathways","volume":"2023","author":"Zhou","year":"2023","journal-title":"Mediators Inflamm."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323006712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323006712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:17:47Z","timestamp":1778559467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323006712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":64,"alternative-id":["S0944711323006712"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155313","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alisol B regulates AMPK\/mTOR\/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155313","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155313"}}