{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:16:43Z","timestamp":1793060203766,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8207121098"],"award-info":[{"award-number":["8207121098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.phymed.2023.155327","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T11:59:48Z","timestamp":1704196788000},"page":"155327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Pterostilbene targets the molecular oscillator ROR\u03b3 to restore circadian rhythm oscillation and protect against sleep restriction induced metabolic disorders"],"prefix":"10.1016","volume":"125","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedong","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mantian","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2023.155327_bib0001","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140424","article-title":"Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice","volume":"131","author":"Adlanmerini","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.phymed.2023.155327_bib0002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1073\/pnas.1118034108","article-title":"Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening","volume":"109","author":"Chen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phymed.2023.155327_bib0003","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1007\/s00018-012-1207-y","article-title":"Small molecule modifiers of circadian clocks","volume":"70","author":"Chen","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.phymed.2023.155327_bib0004","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1530\/JME-19-0153","article-title":"Circadian clock genes and the transcriptional architecture of the clock mechanism","volume":"63","author":"Cox","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.phymed.2023.155327_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119048","article-title":"Pterostilbene influences glycemia and lipidemia and enhances antioxidant status in the liver of rats that consumed sucrose solution","volume":"269","author":"de Morais","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2023.155327_bib0006","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.cub.2019.01.069","article-title":"Ad libitum weekend recovery sleep fails to prevent metabolic dysregulation during a repeating pattern of insufficient sleep and weekend recovery sleep","volume":"29","author":"Depner","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.phymed.2023.155327_bib0007","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/joim.12347","article-title":"Circadian timing of metabolism in animal models and humans","volume":"277","author":"Dibner","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.phymed.2023.155327_bib0008","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201500906","article-title":"Pterostilbene-induced changes in gut microbiota composition in relation to obesity","volume":"61","author":"Etxeberria","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2023.155327_bib0009","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1039\/D0FO03320K","article-title":"Pterostilbene modifies triglyceride metabolism in hepatic steatosis induced by high-fat high-fructose feeding: a comparison with its analog resveratrol","volume":"12","author":"Gomez-Zorita","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2023.155327_bib0010","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cmet.2016.03.007","article-title":"The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome","volume":"23","author":"He","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2023.155327_bib0011","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030535","article-title":"The effects of resveratrol in the treatment of metabolic syndrome","volume":"20","author":"Hou","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2023.155327_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109767","article-title":"A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications","volume":"125","author":"Huang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2023.155327_bib0013","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-pharmtox-010919-023711","article-title":"(Inverse) Agonists of retinoic acid\u2013related orphan receptor \u03b3: regulation of immune responses, inflammation, and autoimmune disease","volume":"60","author":"Jetten","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2023.155327_bib0014","doi-asserted-by":"crossref","first-page":"12836","DOI":"10.1021\/acs.jafc.0c00070","article-title":"Chemistry of pterostilbene and its metabolic effects","volume":"68","author":"Kim","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2023.155327_bib0015","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/jcmm.16178","article-title":"Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells","volume":"25","author":"Kolahdouz-Mohammadi","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phymed.2023.155327_bib0016","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.cell.2019.04.025","article-title":"Defining the Independence of the liver circadian clock","volume":"177","author":"Koronowski","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2023.155327_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900991","article-title":"The preventive effects of pterostilbene on the exercise intolerance and circadian misalignment of mice subjected to sleep restriction","volume":"64","author":"Liu","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2023.155327_bib0018","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/obr.12503","article-title":"Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease","volume":"18","author":"McHill","year":"2017","journal-title":"Obes. Rev."},{"key":"10.1016\/j.phymed.2023.155327_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154409","article-title":"Pharmacological activation of REV-ERB\u03b1 improves nonalcoholic steatohepatitis by regulating intestinal permeability","volume":"114","author":"Ni","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2023.155327_bib0020","article-title":"Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology","volume":"32","author":"Niu","year":"2021","journal-title":"Brain Pathol."},{"key":"10.1016\/j.phymed.2023.155327_bib0021","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2023.155327_bib0022","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.metabol.2017.11.017","article-title":"Circadian regulation of glucose, lipid, and energy metabolism in humans","volume":"84","author":"Poggiogalle","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2023.155327_bib0023","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bbalip.2018.02.009","article-title":"Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes","volume":"1863","author":"Qi","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.phymed.2023.155327_bib0024","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.metabol.2018.02.010","article-title":"Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes","volume":"84","author":"Reutrakul","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2023.155327_bib0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2021.05.034","article-title":"Sleep timing and the circadian clock in mammals: past, present and the road ahead","volume":"126","author":"Sanchez","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2023.155327_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154561","article-title":"Pterostilbene alleviated NAFLD via AMPK\/mTOR signaling pathways and autophagy by promoting Nrf2","volume":"109","author":"Shen","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2023.155327_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131213","article-title":"Gastrointestinal biotransformation and tissue distribution of pterostilbene after long-term dietary administration in mice","volume":"372","author":"Sun","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2023.155327_bib0028","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13498","article-title":"Skeletal muscle insulin signaling and whole-body glucose metabolism following acute sleep restriction in healthy males","volume":"5","author":"Sweeney","year":"2017","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.phymed.2023.155327_bib0029","doi-asserted-by":"crossref","first-page":"8510","DOI":"10.1021\/acs.jafc.9b03368","article-title":"Resveratrol prevents acrylamide-induced mitochondrial dysfunction and inflammatory responses via targeting circadian regulator Bmal1 and Cry1 in hepatocytes","volume":"67","author":"Tan","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2023.155327_bib0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12929-015-0133-3","article-title":"The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice","volume":"22","author":"Tseng","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.phymed.2023.155327_bib0031","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.7150\/thno.43834","article-title":"Targeting REV-ERB\u03b1 for therapeutic purposes: promises and challenges","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2023.155327_bib0032","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1080\/10408398.2018.1493678","article-title":"The effects of phytochemicals on circadian rhythm and related diseases","volume":"59","author":"Xu","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2023.155327_bib0033","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.semcdb.2021.03.012","article-title":"The molecular clockwork of mammalian cells","volume":"126","author":"Yi","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2023.155327_bib0034","article-title":"Pterostilbene improves insulin resistance caused by advanced glycation end products (AGEs) in hepatocytes and mice","volume":"65","author":"Yu","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2023.155327_bib0035","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41467-019-08299-7","article-title":"The circadian clock components BMAL1 and REV-ERBalpha regulate flavivirus replication","volume":"10","author":"Zhuang","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323006852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711323006852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:53:58Z","timestamp":1760554438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711323006852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":35,"alternative-id":["S0944711323006852"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155327","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pterostilbene targets the molecular oscillator ROR\u03b3 to restore circadian rhythm oscillation and protect against sleep restriction induced metabolic disorders","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2023.155327","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"155327"}}