{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:10:38Z","timestamp":1787634638258,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["035062005001"],"award-info":[{"award-number":["035062005001"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","award":["QNRC2016641"],"award-info":[{"award-number":["QNRC2016641"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174197"],"award-info":[{"award-number":["82174197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374274"],"award-info":[{"award-number":["82374274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973609"],"award-info":[{"award-number":["81973609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211392"],"award-info":[{"award-number":["BK20211392"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.phymed.2024.155413","type":"journal-article","created":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T17:34:24Z","timestamp":1707068064000},"page":"155413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Gut microbiota-dependent modulation of pre-metastatic niches by Jianpi Yangzheng decoction in the prevention of lung metastasis of gastric cancer"],"prefix":"10.1016","volume":"128","author":[{"given":"Xiaofei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaizhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cancan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155413_bib0001","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2021.5197","article-title":"Association of the microbiome with colorectal cancer development (Review)","volume":"58","author":"Abdulla","year":"2021","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.phymed.2024.155413_bib0002","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/carcin\/bgt392","article-title":"Emerging roles of the microbiome in cancer","volume":"35","author":"Bultman","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.phymed.2024.155413_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1076245","article-title":"Clostridium butyricum potentially improves inflammation and immunity through alteration of the microbiota and metabolism of gastric cancer patients after gastrectomy","volume":"13","author":"Cao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155413_bib0004","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2941248","article-title":"Interplay between dysbiosis of gut microbiome, lipid metabolism, and tumorigenesis: can gut dysbiosis stand as a prognostic marker in cancer?","volume":"2022","author":"Chattopadhyay","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.phymed.2024.155413_bib0005","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2023-329650","article-title":"Emerging interleukin targets in the tumour microenvironment: implications for the treatment of gastrointestinal tumours","author":"Dickerson","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.155413_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1139391","article-title":"Schlafen4(+)-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases","volume":"14","author":"Ding","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155413_bib0007","doi-asserted-by":"crossref","first-page":"eaba1590","DOI":"10.1126\/sciadv.aba1590","article-title":"Bioinorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancer","volume":"6","author":"Dong","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2024.155413_bib0008","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1158200","article-title":"Gut microbiota-derived short-chain fatty acids regulate gastrointestinal tumor immunity: a novel therapeutic strategy?","volume":"14","author":"Dong","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155413_bib0009","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.phymed.2024.155413_bib0010","first-page":"12","article-title":"The influence of helicobacter pylori on human gastric and gut microbiota","author":"Fiorani","year":"2023","journal-title":"Antibiotics. (Basel)"},{"key":"10.1016\/j.phymed.2024.155413_bib0011","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3748\/wjg.v22.i2.501","article-title":"Gut microbiota imbalance and colorectal cancer","volume":"22","author":"Gagniere","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2024.155413_bib0012","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/ijc.33731","article-title":"Tumor promoting capacity of polymorphonuclear myeloid-derived suppressor cells and their neutralization","volume":"149","author":"Groth","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.phymed.2024.155413_bib0013","doi-asserted-by":"crossref","first-page":"e21775","DOI":"10.1097\/MD.0000000000021775","article-title":"A clinical study of Yiqi Huayu Jiedu decoction reducing the risk of postoperative gastric cancer recurrence and metastasis: study protocol for a randomized controlled trail","volume":"99","author":"Hu","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.phymed.2024.155413_bib0014","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41575-022-00726-3","article-title":"Updated epidemiology of gastrointestinal cancers in East Asia","volume":"20","author":"Huang","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2024.155413_bib0015","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2206507","article-title":"The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset","volume":"15","author":"Ito","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phymed.2024.155413_bib0016","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3389\/fphar.2020.01210","article-title":"Synergistic effect of berberine-based chinese medicine assembled nanostructures on diarrhea-predominant irritable bowel syndrome in vivo","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155413_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116215","article-title":"Pulsatilla chinensis saponins improve SCFAs regulating GPR43-NLRP3 signaling pathway in the treatment of ulcerative colitis","volume":"308","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155413_bib0018","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/s41388-020-01571-x","article-title":"Lymphatic metastasis-related TBL1XR1 enhances stemness and metastasis in gastric cancer stem-like cells by activating ERK1\/2-SOX2 signaling","volume":"40","author":"Lu","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2024.155413_bib0019","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/ijc.33411","article-title":"The combined action of monocytic myeloid-derived suppressor cells and mucosal-associated invariant T cells promotes the progression of cervical cancer","volume":"148","author":"Lu","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.phymed.2024.155413_bib0020","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41586-020-2054-x","article-title":"Epigenetic therapy inhibits metastases by disrupting premetastatic niches","volume":"579","author":"Lu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155413_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/nu14142826","article-title":"Differential effects of short-chain fatty acids on L6 myotube inflammatory mediator production in response to lipopolysaccharide- or palmitic acid-stimulation","volume":"14","author":"Martin","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.155413_bib0022","article-title":"The temporal progression of immune remodeling during metastasis","author":"McGinnis","year":"2023","journal-title":"bioRxiv."},{"key":"10.1016\/j.phymed.2024.155413_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.tim.2023.04.001","article-title":"The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis","author":"Nabavi-Rad","year":"2023","journal-title":"Trends. Microbiol."},{"key":"10.1016\/j.phymed.2024.155413_bib0024","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.230014","article-title":"Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections","volume":"13","author":"Ney","year":"2023","journal-title":"Open. Biol."},{"key":"10.1016\/j.phymed.2024.155413_bib0025","doi-asserted-by":"crossref","first-page":"e19757","DOI":"10.1097\/MD.0000000000019757","article-title":"A clinical study of traditional Chinese medicine prolonging the survival of advanced gastric cancer patients by regulating the immunosuppressive cell population: a study protocol for a multicenter, randomized controlled trail","volume":"99","author":"Pan","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.phymed.2024.155413_bib0026","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.ccell.2023.02.018","article-title":"Immune determinants of the pre-metastatic niche","volume":"41","author":"Patras","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2024.155413_bib0027","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41571-021-00588-9","article-title":"Harnessing cytokines and chemokines for cancer therapy","volume":"19","author":"Propper","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phymed.2024.155413_bib0028","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1002\/jcp.26075","article-title":"Myeloid-derived suppressor cells: important contributors to tumor progression and metastasis","volume":"233","author":"Safarzadeh","year":"2018","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.phymed.2024.155413_bib0029","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1038\/nprot.2006.435","article-title":"Isolation of CD4+ T cells from murine lungs: a method to analyze ongoing immune responses in the lung","volume":"1","author":"Sauer","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2024.155413_bib0030","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.aac4255","article-title":"Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy","volume":"350","author":"Sivan","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.phymed.2024.155413_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1127743","article-title":"Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity","volume":"14","author":"Su","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155413_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.767116","article-title":"PKM2 is the target of a multi-herb-combined decoction during the inhibition of gastric cancer progression","volume":"11","author":"Sun","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phymed.2024.155413_bib0033","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1240537","article-title":"The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide","volume":"342","author":"Viaud","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.phymed.2024.155413_bib0034","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.intimp.2019.04.058","article-title":"Juglone eliminates MDSCs accumulation and enhances antitumor immunity","volume":"73","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155413_bib0035","article-title":"Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis","volume":"12","author":"Wang","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2024.155413_bib0036","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fimmu.2019.00172","article-title":"MDSCs: key criminals of tumor pre-metastatic niche formation","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155413_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154229","article-title":"Effect of modified Jianpi Yangzheng on regulating content of PKM2 in gastric cancer cells-derived exosomes","volume":"103","author":"Wu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155413_bib0038","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jep.2019.02.003","article-title":"The effect of Jianpi Yangzheng Xiaozheng Decoction and its components on gastric cancer","volume":"235","author":"Wu","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155413_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116450","article-title":"Jianpi Yangzheng decoction suppresses gastric cancer progression via modulating the miR-448\/CLDN18.2 mediated YAP\/TAZ signaling","volume":"311","author":"Xu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155413_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.975261","article-title":"Role of myeloid-derived suppressor cells in the formation of pre-metastatic niche","volume":"12","author":"Ya","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phymed.2024.155413_bib0041","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1186\/s12967-022-03650-x","article-title":"Microbiota and metabolites alterations in proximal and distal gastric cancer patients","volume":"20","author":"Yang","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2024.155413_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110440","article-title":"Modified Jian-pi-yang-zheng decoction inhibits gastric cancer progression via the macrophage immune checkpoint PI3Kgamma","volume":"129","author":"Yuan","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2024.155413_bib0043","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.4049\/jimmunol.2300016","article-title":"Immunomodulatory effects of microbiota-derived short-chain fatty acids in autoimmune liver diseases","volume":"210","author":"Zhang","year":"2023","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2024.155413_bib0044","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-023-01406-7","article-title":"Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2024.155413_bib0045","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1010465","article-title":"A literature review on the potential clinical implications of streptococci in gastric cancer","volume":"13","author":"Zi","year":"2022","journal-title":"Front. Microbiol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324000783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324000783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:31:22Z","timestamp":1778776282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324000783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":45,"alternative-id":["S0944711324000783"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155413","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbiota-dependent modulation of pre-metastatic niches by Jianpi Yangzheng decoction in the prevention of lung metastasis of gastric cancer","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155413"}}