{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:24:29Z","timestamp":1789673069898,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017544","name":"Lianyungang City Health and Family Planning Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.phymed.2024.155433","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T16:42:56Z","timestamp":1707324176000},"page":"155433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Echinacoside ameliorates post-stroke depression by activating BDNF signaling through modulation of Nrf2 acetylation"],"prefix":"10.1016","volume":"128","author":[{"given":"Zhou","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxia","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155433_bib0001","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.freeradbiomed.2013.08.190","article-title":"Sulforaphane preconditioning of the Nrf2\/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke","volume":"65","author":"Alfieri","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2024.155433_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118020","article-title":"The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease","volume":"257","author":"Amidfar","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2024.155433_bib0003","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fncel.2013.00068","article-title":"Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses","volume":"7","author":"Audet","year":"2013","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.phymed.2024.155433_bib0004","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopsych.2021.05.008","article-title":"Brain-Derived neurotrophic factor signaling in depression and antidepressant action","volume":"90","author":"Castr\u00e9n","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phymed.2024.155433_bib0005","doi-asserted-by":"crossref","first-page":"e22792","DOI":"10.1096\/fj.202201430R","article-title":"Echinacoside from Cistanche tubulosa ameliorates alcohol-induced liver injury and oxidative stress by targeting Nrf2","volume":"37","author":"Ding","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2024.155433_bib0006","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bcp.2018.04.010","article-title":"Nrf2 as a therapeutic target for rheumatic diseases","volume":"152","author":"Ferr\u00e1ndiz","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155433_bib0007","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/1073858420914509","article-title":"Wnt\/\u03b2-Catenin signaling in neural stem cell homeostasis and neurological diseases","volume":"27","author":"Gao","year":"2021","journal-title":"Neuroscientist"},{"key":"10.1016\/j.phymed.2024.155433_bib0008","first-page":"11","article-title":"Vitamin D3 and ischemic stroke: a narrative review","author":"Laso\u0144","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2024.155433_bib0009","article-title":"Therapeutic potential and molecular mechanisms of echinacoside in neurodegenerative diseases","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155433_bib0010","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.biopha.2018.05.072","article-title":"Echinacoside alleviated LPS-induced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR\/STAT3 pathway","volume":"104","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2024.155433_bib0011","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1111\/cns.13732","article-title":"Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation","volume":"27","author":"Li","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2024.155433_bib0012","article-title":"Echinacoside, an inestimable natural product in treatment of neurological and other disorders","volume":"23","author":"Liu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.155433_bib0013","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/j.1582-4934.2012.01555.x","article-title":"Post-stroke depression: mechanisms, translation and therapy","volume":"16","author":"Loubinoux","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phymed.2024.155433_bib0014","article-title":"Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation via regulating microglia M1\/M2 polarization and JAK1\/STAT3 pathway","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155433_bib0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13045-019-0724-7","article-title":"CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K\/AKT signaling by inducing Rap1-mediated membrane localization of P110\u03b2 and predicts poor prognosis","volume":"12","author":"Ma","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.phymed.2024.155433_bib0016","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2024.155433_bib0017","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1177\/0271678X211029060","article-title":"Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences","volume":"41","author":"Ren","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.phymed.2024.155433_bib0018","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41419-019-1813-9","article-title":"The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression","volume":"10","author":"Shu","year":"2019","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2024.155433_bib0019","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.pharmthera.2017.11.005","article-title":"Post-stroke depression: mechanisms and pharmacological treatment","volume":"184","author":"Villa","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2024.155433_bib0020","first-page":"11","article-title":"Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2024.155433_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106951","article-title":"Echinacoside: a promising active natural products and pharmacological agents","volume":"197","author":"Wang","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.155433_bib0022","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s12975-016-0484-4","article-title":"cPKC\u03b3-modulated autophagy in neurons alleviates ischemic injury in brain of mice with ischemic stroke through Akt-mTOR pathway","volume":"7","author":"Wei","year":"2016","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.phymed.2024.155433_bib0023","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1007\/s11064-019-02782-9","article-title":"Echinacoside alleviates hypoxic-ischemic brain injury in neonatal rat by enhancing antioxidant capacity and inhibiting apoptosis","volume":"44","author":"Wei","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2024.155433_bib0024","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122679","article-title":"An oldie but goodie: lithium in the treatment of bipolar disorder through neuroprotective and neurotrophic mechanisms","volume":"18","author":"Won","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155433_bib0025","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/med.21717","article-title":"Therapeutic potential of phenylethanoid glycosides: a systematic review","volume":"40","author":"Wu","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.phymed.2024.155433_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.111952","article-title":"Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus","volume":"370","author":"Xu","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phymed.2024.155433_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1181973","article-title":"Lipopolysaccharide-induced depression-like model in mice: meta-analysis and systematic evaluation","volume":"14","author":"Yin","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155433_bib0028","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6635460","article-title":"The Keap1-Nrf2 system: a mediator between oxidative stress and aging","volume":"2021","author":"Yu","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2024.155433_bib0029","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jnr.24510","article-title":"Brain-derived neurotrophic factor and post-stroke depression","volume":"98","author":"Zhang","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.phymed.2024.155433_bib0030","article-title":"Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment (Review)","volume":"49","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2024.155433_bib0031","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/ptr.6310","article-title":"Echinacoside alleviates hypobaric hypoxia-induced memory impairment in C57 mice","volume":"33","author":"Zheng","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2024.155433_bib0032","article-title":"Antidepressant effect of Perilla frutescens essential oil through monoamine neurotransmitters and BDNF\/TrkB signal pathway","volume":"318","author":"Zhong","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155433_bib0033","article-title":"Research progress on post-stroke depression","volume":"373","author":"Zhou","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2024.155433_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102522","article-title":"Nrf2: an all-rounder in depression","volume":"58","author":"Zuo","year":"2022","journal-title":"Redox. Biol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324000989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324000989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T15:18:24Z","timestamp":1724080704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324000989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":34,"alternative-id":["S0944711324000989"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155433","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Echinacoside ameliorates post-stroke depression by activating BDNF signaling through modulation of Nrf2 acetylation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155433","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155433"}}