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Lett."},{"issue":"18","key":"10.1016\/j.phymed.2024.155444_bib0095","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.3390\/ijms231810330","article-title":"Isoquinoline alkaloids from Coptis chinensis Franch: focus on coptisine as a potential therapeutic candidate against gastric cancer cells","volume":"23","author":"Nakonieczna","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155444_bib0096","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/978-3-030-41769-7_15","article-title":"Serum albumin, lipid and drug binding","volume":"94","author":"Nishi","year":"2020","journal-title":"Subcell Biochem."},{"issue":"4","key":"10.1016\/j.phymed.2024.155444_bib0097","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/1389200220666190325141422","article-title":"Herb-drug interactions and hepatotoxicity","volume":"20","author":"Parvez","year":"2019","journal-title":"Curr. 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