{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:47:53Z","timestamp":1793299673312,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013770","name":"Beihua University","doi-asserted-by":"publisher","award":["160323189"],"award-info":[{"award-number":["160323189"]}],"id":[{"id":"10.13039\/501100013770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.phymed.2024.155464","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T04:56:04Z","timestamp":1710132964000},"page":"155464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"128","author":[{"given":"Pingping","family":"Tuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gege","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7340-1568","authenticated-orcid":false,"given":"Mengyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155464_bib0001","first-page":"23","article-title":"Anticancer effects of fucoxanthin through cell cycle arrest, apoptosis induction, angiogenesis inhibition, and autophagy modulation","author":"Ahmed","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155464_bib0002","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1124\/pr.118.017129","article-title":"Novel therapeutic approaches targeting the renin-angiotensin system and associated peptides in hypertension and heart failure","volume":"71","author":"Arendse","year":"2019","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phymed.2024.155464_bib0003","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.micpath.2017.12.037","article-title":"Antibacterial activity and virtual screening by molecular docking of lycorine from Pancratium foetidum Pom (Moroccan endemic Amaryllidaceae)","volume":"115","author":"Bendaif","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.phymed.2024.155464_bib0004","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1007\/s11426-013-4967-9","article-title":"Multiple biological functions and pharmacological effects of lycorine","volume":"56","author":"Cao","year":"2013","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.phymed.2024.155464_bib0005","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1016\/j.bmcl.2011.09.097","article-title":"Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases","volume":"21","author":"Casu","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2024.155464_bib0006","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/annonc\/mdv615","article-title":"Regulation of PD-L1: a novel role of pro-survival signalling in cancer","volume":"27","author":"Chen","year":"2016","journal-title":"Annal. Oncol.: Off. J. Eur. Soc. Med. Oncol."},{"key":"10.1016\/j.phymed.2024.155464_bib0007","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1101\/gad.1662308","article-title":"Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK","volume":"22","author":"Dan","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.phymed.2024.155464_bib0008","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/CIRCRESAHA.119.315767","article-title":"Mitochondrial deacetylase Sirt3 reduces vascular dysfunction and hypertension while Sirt3 depletion in essential hypertension is linked to vascular inflammation and oxidative stress","volume":"126","author":"Dikalova","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2024.155464_bib0009","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s13205-020-02364-5","article-title":"Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1\/TLRs\/NF-\u03baB pathway","volume":"10","author":"Ge","year":"2020","journal-title":"3 Biotech"},{"key":"10.1016\/j.phymed.2024.155464_bib0010","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/HYPERTENSIONAHA.118.11860","article-title":"Angiotensin II causes biphasic STAT3 activation through TLR4 to initiate cardiac remodeling","volume":"72","author":"Han","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2024.155464_bib0011","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/CIRCRESAHA.108.193318","article-title":"The I{kappa}B kinase {beta}\/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression","volume":"105","author":"Hikoso","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2024.155464_bib0012","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.antiviral.2007.12.009","article-title":"Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay","volume":"77","author":"Hwang","year":"2008","journal-title":"Antiviral Res."},{"key":"10.1016\/j.phymed.2024.155464_bib0013","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1161\/01.HYP.0000203148.42892.7a","article-title":"Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts","volume":"47","author":"Kobayashi","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2024.155464_bib0014","doi-asserted-by":"crossref","first-page":"142","DOI":"10.32725\/jab.2021.014","article-title":"Protective effect of sinomenine on isoproterenol-induced cardiac hypertrophy in mice","volume":"19","author":"Li","year":"2021","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.phymed.2024.155464_bib0015","first-page":"377","article-title":"Apoptosis induced by lycorine in KM3 cells is associated with the G0\/G1 cell cycle arrest","volume":"17","author":"Li","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.phymed.2024.155464_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104884","article-title":"Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis","volume":"158","author":"Liang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.155464_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114728","article-title":"Aqueous extract of Solanum nigrum attenuates Angiotensin-II induced cardiac hypertrophy and improves cardiac function by repressing protein kinase C-zeta to restore HSF2 deSUMOlyation and Mel-18-IGF-IIR signaling suppression","volume":"284","author":"Lin","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155464_bib0018","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.febslet.2004.10.095","article-title":"Effects of lycorine on HL-60 cells via arresting cell cycle and inducing apoptosis","volume":"578","author":"Liu","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2024.155464_bib0019","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.7150\/jca.75597","article-title":"In vitro and anticancer activity of Lycorine in prostate cancer by inhibiting NF-\u03baB signaling pathway","volume":"13","author":"Liu","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.phymed.2024.155464_bib0020","first-page":"305","article-title":"JAK\/STAT and PI3K\/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology","volume":"21","author":"Lu","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155464_bib0021","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jim.2015.03.018","article-title":"Simultaneous assessment of NF-kappaB\/p65 phosphorylation and nuclear localization using imaging flow cytometry","volume":"423","author":"Maguire","year":"2015","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.phymed.2024.155464_bib0022","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1042\/CS20210192","article-title":"The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension","volume":"135","author":"Meijles","year":"2021","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.phymed.2024.155464_bib0023","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1248\/bpb.22.674","article-title":"Suppressive activity of lycoricidinol (narciclasine) against cytotoxicity of neutrophil-derived calprotectin, and its suppressive effect on rat adjuvant arthritis model","volume":"22","author":"Mikami","year":"1999","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2024.155464_bib0024","first-page":"22","article-title":"Hypoxia enhances the expression of RNASET2 in human monocyte-derived dendritic cells: role of PI3K\/AKT pathway","author":"Monaci","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2024.155464_bib0025","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11906-014-0431-2","article-title":"Angiotensin II and vascular injury","volume":"16","author":"Montezano","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.phymed.2024.155464_bib0026","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yjmcc.2013.07.010","article-title":"Impact of the renin-angiotensin system on cardiac energy metabolism in heart failure","volume":"63","author":"Mori","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.phymed.2024.155464_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100950","article-title":"Isolation, culture, and immunostaining of neonatal rat ventricular myocytes","volume":"2","author":"Pereira","year":"2021","journal-title":"STAR Protocol."},{"key":"10.1016\/j.phymed.2024.155464_bib0028","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1007\/s11010-021-04219-w","article-title":"Role of PI3K\/Akt signaling pathway in cardiac fibrosis","volume":"476","author":"Qin","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.phymed.2024.155464_bib0029","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.119.042559","article-title":"Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction","volume":"141","author":"Schimmel","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2024.155464_bib0030","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/ptr.1346","article-title":"Antimalarial activity screening of some alkaloids and the plant extracts from Amaryllidaceae","volume":"17","author":"Sener","year":"2003","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2024.155464_bib0031","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1021\/jf200452z","article-title":"Activity of lycorine analogues against the fish bacterial pathogen Flavobacterium columnare","volume":"59","author":"Tan","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.155464_bib0032","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/abbs\/gmx076","article-title":"Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway","volume":"49","author":"Wang","year":"2017","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.phymed.2024.155464_bib0033","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/cvr\/cvt258","article-title":"Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation","volume":"101","author":"Wang","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2024.155464_bib0034","first-page":"131","article-title":"Transcriptomics study on mechanism of Aconiti Lateralis Radix Praeparata in treatment of rats with acute heart failure","volume":"44","author":"Wang","year":"2019","journal-title":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi=China J. Chin. Materia Med."},{"key":"10.1016\/j.phymed.2024.155464_bib0035","series-title":"Hypertension","first-page":"2023","year":"2023"},{"key":"10.1016\/j.phymed.2024.155464_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.709703","article-title":"The Role of the Inflammasome in Heart Failure","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2024.155464_bib0037","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.1080\/21655979.2021.1967019","article-title":"Lycorine ameliorates isoproterenol-induced cardiac dysfunction mainly via inhibiting inflammation, fibrosis, oxidative stress and apoptosis","volume":"12","author":"Wu","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.phymed.2024.155464_bib0038","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/cam4.2108","article-title":"Traditional Chinese medicine as a cancer treatment: modern perspectives of ancient but advanced science","volume":"8","author":"Xiang","year":"2019","journal-title":"Cancer Med."},{"key":"10.1016\/j.phymed.2024.155464_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110071","article-title":"Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"126","author":"Xu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2024.155464_bib0040","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv171","article-title":"Integrated Akt\/PKB signaling in immunomodulation and its potential role in cancer immunotherapy","volume":"107","author":"Xue","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.phymed.2024.155464_bib0041","first-page":"4708","article-title":"Lycorine suppresses cell growth and invasion via down-regulation of NEDD4 ligase in bladder cancer","volume":"12","author":"Yang","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.phymed.2024.155464_bib0042","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.trsl.2021.02.011","article-title":"Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling","volume":"233","author":"Ye","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.phymed.2024.155464_bib0043","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/CIRCRESAHA.119.315861","article-title":"Celastrol attenuates angiotensin ii-induced cardiac remodeling by targeting STAT3","volume":"126","author":"Ye","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2024.155464_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103745","article-title":"Elevated Wnt2 and Wnt4 activate NF-\u03baB signaling to promote cardiac fibrosis by cooperation of Fzd4\/2 and LRP6 following myocardial infarction","volume":"74","author":"Yin","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phymed.2024.155464_bib0045","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s11427-016-0368-y","article-title":"Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src\/FAK-involved pathway","volume":"60","author":"Ying","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.phymed.2024.155464_bib0046","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-kappaB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.phymed.2024.155464_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108812","article-title":"Molecular targets of \u03b2-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: a review","volume":"114","author":"Zhai","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2024.155464_bib0048","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12933-019-0914-1","article-title":"Dapagliflozin improves left ventricular remodeling and aorta sympathetic tone in a pig model of heart failure with preserved ejection fraction","volume":"18","author":"Zhang","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.phymed.2024.155464_bib0049","doi-asserted-by":"crossref","first-page":"7970","DOI":"10.3892\/or.2021.7970","article-title":"In vitro Lycorine inhibits cell proliferation, migration and invasion, and primarily exerts cytostatic effects in human colorectal cancer via activating the ROS\/p38 and AKT signaling pathways","volume":"45","author":"Zhang","year":"2021","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.phymed.2024.155464_bib0050","doi-asserted-by":"crossref","DOI":"10.1177\/03000605211031433","article-title":"The mechanism of myocardial fibrosis is ameliorated by myocardial infarction-associated transcript through the PI3K\/Akt signaling pathway to relieve heart failure","volume":"49","author":"Zhao","year":"2021","journal-title":"J. Int. Med. Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324001284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324001284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T21:30:35Z","timestamp":1731533435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324001284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":50,"alternative-id":["S0944711324001284"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155464","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155464"}}