{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:46:49Z","timestamp":1793699209207,"version":"4.5.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20230484467"],"award-info":[{"award-number":["20230484467"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402892"],"award-info":[{"award-number":["81402892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374061"],"award-info":[{"award-number":["82374061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104254"],"award-info":[{"award-number":["82104254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2022-I2M-1-016"],"award-info":[{"award-number":["2022-I2M-1-016"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.phymed.2024.155470","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T15:51:57Z","timestamp":1708444317000},"page":"155470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Alleviation of allergic asthma by rosmarinic acid via gut-lung axis"],"prefix":"10.1016","volume":"126","author":[{"given":"Hui-Hui","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Xing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Juan","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Ran","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Fei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Dan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Zhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Le","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1541-6407","authenticated-orcid":false,"given":"Cai","family":"Tie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Dong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155470_bib0001","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1017\/S1466252317000081","article-title":"Rosmarinic acid: modes of action, medicinal values and health benefits","volume":"18","author":"Alagawany","year":"2017","journal-title":"Anim. Health. Res. Rev."},{"key":"10.1016\/j.phymed.2024.155470_bib0002","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jaut.2014.02.012","article-title":"Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation","volume":"55","author":"Bessa","year":"2014","journal-title":"J. Autoimmun"},{"key":"10.1016\/j.phymed.2024.155470_bib0003","article-title":"Short chain (\u2264C4) esterification increases bioavailability of rosmarinic acid and its potency to inhibit vascular smooth muscle cell proliferation","volume":"11","author":"Bla\u017eevi\u0107","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155470_bib0004","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00210-002-0579-1","article-title":"Vasodilator and vasoconstrictor responses induced by 5-hydroxytryptamine in the in situ blood autoperfused hindquarters of the anaesthetized rat","volume":"366","author":"Calama","year":"2002","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155470_bib0005","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/pai.13096","article-title":"Gut microbial-derived butyrate is inversely associated with IgE responses to allergens in childhood asthma","volume":"30","author":"Chiu","year":"2019","journal-title":"Pediatr. Allergy. Immunol."},{"key":"10.1016\/j.phymed.2024.155470_bib0006","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0009-8981(89)90231-3","article-title":"Pharmacokinetic study of butyric acid administered in vivo as sodium and arginine butyrate salts","volume":"181","author":"Daniel","year":"1989","journal-title":"Clin. Chim. Acta."},{"key":"10.1016\/j.phymed.2024.155470_bib0007","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-981-15-1792-1_25","article-title":"Exercise and Asthma","volume":"1228","author":"Ding","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2024.155470_bib0008","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1034\/j.1399-3003.1999.14c26.x","article-title":"The effects of 5-HT on cholinergic contraction in human airways in vitro","volume":"14","author":"Dupont","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.phymed.2024.155470_bib0009","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/j.phytochem.2011.07.008","article-title":"Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae)","volume":"72","author":"Furukawa","year":"2011","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2024.155470_bib0010","first-page":"118","article-title":"Understanding the immunology of asthma: pathophysiology, biomarkers, and treatments for asthma endotypes","volume":"36","author":"Gans","year":"2020","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.phymed.2024.155470_bib0011","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01247-2017","article-title":"The mode of action of anticholinergics in asthma","volume":"52","author":"Gosens","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.phymed.2024.155470_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201808197","article-title":"Dual-stimuli-responsive gut microbiota-targeting Berberine-CS\/PT-NPs improved metabolic status in obese hamsters","volume":"29","author":"Guo","year":"2019","journal-title":"Adv. Funct. Mater"},{"key":"10.1016\/j.phymed.2024.155470_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116158","article-title":"Microbiota-derived short-chain fatty acids mediate the effects of dengzhan shengmai in ameliorating cerebral ischemia via the gut-brain axis","volume":"306","author":"Guo","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155470_bib0014","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jaip.2018.01.025","article-title":"Inhaled corticosteroids safety and adverse effects in patients with asthma","volume":"6","author":"Heffler","year":"2018","journal-title":"J. Allergy. Clin. Immunol. Pract."},{"key":"10.1016\/j.phymed.2024.155470_bib0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1055\/a-1301-8648","article-title":"Rosmarinic acid-human pharmacokinetics and health benefits","volume":"87","author":"Hitl","year":"2021","journal-title":"Planta. Med."},{"key":"10.1016\/j.phymed.2024.155470_bib0016","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3904\/kjim.2016.227","article-title":"Fundamental role of dendritic cells in inducing Th2 responses","volume":"33","author":"Kim","year":"2018","journal-title":"Korean. J. Intern. Med."},{"key":"10.1016\/j.phymed.2024.155470_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107496","article-title":"Berberine in the treatment of metabolism-related chronic diseases: a drug cloud (dCloud) effect to target multifactorial disorders","volume":"209","author":"Kong","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2024.155470_bib0018","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2500\/aap.2019.40.4256","article-title":"Asthma in adults: principles of treatment","volume":"40","author":"Kwah","year":"2019","journal-title":"Allergy. Asthma. Proc."},{"key":"10.1016\/j.phymed.2024.155470_bib0019","doi-asserted-by":"crossref","first-page":"S502","DOI":"10.1067\/mai.2003.94","article-title":"Asthma","volume":"111","author":"Lemanske","year":"2003","journal-title":"J. Allergy. Clin. Immunol."},{"key":"10.1016\/j.phymed.2024.155470_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.790658","article-title":"Immune metabolism of IL-4-activated B cells and Th2 cells in the context of allergic diseases","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155470_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1066643","article-title":"The influence of hyssopus cuspidatus boriss extract on lipid mediators metabolism network in asthmatic mice","volume":"14","author":"Ling-Fei","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155470_bib0022","article-title":"PM2.5 exposure and asthma development: the key role of oxidative stress","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2024.155470_bib0023","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.tips.2012.06.002","article-title":"IgE-dependent signaling as a therapeutic target for allergies","volume":"33","author":"MacGlashan","year":"2012","journal-title":"Trends Pharmacol. Sci"},{"key":"10.1016\/j.phymed.2024.155470_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.101026","article-title":"Molecular mechanisms of oxidative stress in asthma","volume":"85","author":"Michaeloudes","year":"2022","journal-title":"Mol. Aspects. Med."},{"key":"10.1016\/j.phymed.2024.155470_bib0025","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.3389\/fimmu.2018.02220","article-title":"Involvement and possible role of eosinophils in asthma exacerbation","volume":"9","author":"Nakagome","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155470_bib0026","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.3390\/nu14091893","article-title":"Intestinal barrier permeability in allergic diseases","volume":"14","author":"Niewiem","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.155470_bib0027","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/978-1-0716-1237-8_21","article-title":"Regulatory and IgE(+) B cells in allergic asthma","volume":"2270","author":"Oliveria","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.phymed.2024.155470_bib0028","first-page":"783","volume":"391","author":"Papi","year":"2018","journal-title":"Asthma Lan."},{"key":"10.1016\/j.phymed.2024.155470_bib0029","doi-asserted-by":"crossref","first-page":"797","DOI":"10.4049\/jimmunol.129.2.797","article-title":"The modulation of human basophil histamine release by products of the 5-lipoxygenase pathway","volume":"129","author":"Peters","year":"1982","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2024.155470_bib0030","doi-asserted-by":"crossref","first-page":"859","DOI":"10.20452\/pamw.3168","article-title":"Current role of anticholinergic drugs in the treatment of asthma: key messages for clinical practice","volume":"125","author":"Pizzichini","year":"2015","journal-title":"Pol. Arch. Med. Wewn"},{"key":"10.1016\/j.phymed.2024.155470_bib0031","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10863-012-9418-3","article-title":"Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate","volume":"44","author":"Queir\u00f3s","year":"2012","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.phymed.2024.155470_bib0032","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/0006-291X(80)90058-3","article-title":"Augmentation of IgE-mediated release of histamine by 5-hydroxyeicosatetraenoic acid and 12-hydroxyeicosatetraenoic acid","volume":"96","author":"Stenson","year":"1980","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2024.155470_bib0033","doi-asserted-by":"crossref","first-page":"6949","DOI":"10.3390\/molecules26226949","article-title":"Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2\/ROS\/NF-kB in Lung Epithelial Cells","volume":"26","author":"Sul","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.155470_bib0034","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/phrs.1998.0345","article-title":"Correlative alteration of thromboxane A2 with antigen-induced bronchoconstriction and the role of platelets as a source of TXA2 synthesis in guinea pigs: effect of DP-1904, an inhibitor of thromboxane synthetase","volume":"38","author":"Takami","year":"1998","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.155470_bib0035","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jaci.2019.05.002","article-title":"Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival","volume":"144","author":"Theiler","year":"2019","journal-title":"J. Allergy. Clin. Immunol."},{"key":"10.1016\/j.phymed.2024.155470_bib0036","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12967-022-03337-3","article-title":"Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4\/NF-kB signaling pathway","volume":"20","author":"Wu","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2024.155470_bib0037","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.155470_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.628453","article-title":"Butyrate shapes immune cell fate and function in allergic asthma","volume":"12","author":"Yip","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132400134X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132400134X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:00:27Z","timestamp":1760554827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132400134X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":38,"alternative-id":["S094471132400134X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155470","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alleviation of allergic asthma by rosmarinic acid via gut-lung axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155470","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155470"}}