{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:08:35Z","timestamp":1793826515915,"version":"4.6.1"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.phymed.2024.155529","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T08:56:49Z","timestamp":1710147409000},"page":"155529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":109,"special_numbering":"C","title":["Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction"],"prefix":"10.1016","volume":"128","author":[{"given":"Ya","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianli","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155529_bib0001","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/ajpcell.00502.2020","article-title":"Molecular nature and physiological role of the mitochondrial calcium uniporter channel","volume":"320","author":"Alevriadou","year":"2021","journal-title":"Am. J. Physiol. Cell. Physiol"},{"key":"10.1016\/j.phymed.2024.155529_bib0002","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/1873-3468.12964","article-title":"Role of mitochondrial ROS in the brain: from physiology to neurodegeneration","volume":"592","author":"Angelova","year":"2018","journal-title":"FEBS Lett"},{"key":"10.1016\/j.phymed.2024.155529_bib0003","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tem.2018.02.002","article-title":"Mitochondria and hypoxia: metabolic crosstalk in cell-fate decisions","volume":"29","author":"Bargiela","year":"2018","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1016\/j.phymed.2024.155529_bib0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2015.10.011","article-title":"Mitochondrial fusion\/fission dynamics in neurodegeneration and neuronal plasticity","volume":"90","author":"Bertholet","year":"2016","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.phymed.2024.155529_bib0005","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s13760-013-0220-8","article-title":"Intermittent hypoxia protects cerebral mitochondrial function from calcium overload","volume":"113","author":"Chen","year":"2013","journal-title":"Acta. Neurol. Belg"},{"key":"10.1016\/j.phymed.2024.155529_bib0006","article-title":"Tibetan medicine Duoxuekang capsule ameliorates high-altitude polycythemia accompanied by brain injury","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0007","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/STROKEAHA.114.007265","article-title":"Norrin protected blood-brain barrier via frizzled-4\/\u03b2-catenin pathway after subarachnoid hemorrhage in rats","volume":"46","author":"Chen","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2024.155529_bib0008","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12929-016-0262-3","article-title":"Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats","volume":"23","author":"Chuang","year":"2016","journal-title":"J. Biomed. Sci"},{"key":"10.1016\/j.phymed.2024.155529_bib0009","doi-asserted-by":"crossref","first-page":"9765","DOI":"10.3390\/ijms22189765","article-title":"AMPK-mTOR signaling and cellular adaptations in hypoxia","volume":"22","author":"Chun","year":"2021","journal-title":"Int. J. Mol. Sci"},{"key":"10.1016\/j.phymed.2024.155529_bib0010","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.3390\/ijms21072428","article-title":"Activation of AMPK under hypoxia: many roads leading to rome","volume":"21","author":"Dengler","year":"2020","journal-title":"Int. J. Mol. Sci"},{"key":"10.1016\/j.phymed.2024.155529_bib0011","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/s41419-021-04343-x","article-title":"Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2","volume":"12","author":"Duan","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.phymed.2024.155529_bib0012","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41586-020-2309-6","article-title":"Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex","volume":"582","author":"Fan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155529_bib0013","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.redox.2017.02.012","article-title":"Mitochondrial composition and function under the control of hypoxia","volume":"12","author":"Fuhrmann","year":"2017","journal-title":"Redox. Biol"},{"key":"10.1016\/j.phymed.2024.155529_bib0014","doi-asserted-by":"crossref","first-page":"7658","DOI":"10.3390\/molecules26247658","article-title":"The potential role of curcumin in modulating the master antioxidant pathway in diabetic hypoxia-induced complications","volume":"26","author":"Ghareghomi","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.155529_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3549704","article-title":"Salidroside ameliorates mitochondria-dependent neuronal apoptosis after spinal cord ischemia-reperfusion injury partially through inhibiting oxidative stress and promoting mitophagy","volume":"2020","author":"Gu","year":"2020","journal-title":"Oxid. Med. Cell Longev"},{"key":"10.1016\/j.phymed.2024.155529_bib0016","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12890-017-0477-4","article-title":"Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway","volume":"17","author":"Gui","year":"2017","journal-title":"BMC Pulm. Med"},{"key":"10.1016\/j.phymed.2024.155529_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.821317","article-title":"NEU1 regulates mitochondrial energy metabolism and oxidative stress post-myocardial infarction in mice via the SIRT1\/PGC-1 Alpha axis","volume":"9","author":"Guo","year":"2022","journal-title":"Front. Cardiovasc. Med"},{"key":"10.1016\/j.phymed.2024.155529_bib0018","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s40478-020-01051-z","article-title":"Mild hypoxia triggers transient blood-brain barrier disruption: a fundamental protective role for microglia","volume":"8","author":"Halder","year":"2020","journal-title":"Acta. Neuropathol. Commun"},{"key":"10.1016\/j.phymed.2024.155529_bib0019","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.talanta.2016.07.014","article-title":"A rapid and sensitive UHPLC-FT-ICR MS\/MS method for identification of chemical constituents in Rhodiola crenulata extract, rat plasma and rat brain after oral administration","volume":"160","author":"Han","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.phymed.2024.155529_bib0020","article-title":"Propofol via antioxidant property attenuated hypoxia-mediated mitochondrial dynamic imbalance and malfunction in primary rat hippocampal neurons","volume":"18","author":"Han","year":"2022","journal-title":"Oxid. Med. Cell. Longev"},{"key":"10.1016\/j.phymed.2024.155529_bib0021","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jgr.2021.08.001","article-title":"Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice","volume":"46","author":"Han","year":"2022","journal-title":"J. Ginseng. Res"},{"key":"10.1016\/j.phymed.2024.155529_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154568","article-title":"Salidroside intensifies mitochondrial function of CoCl2-damaged HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway","volume":"109","author":"Hou","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155529_bib0023","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.bbabio.2008.12.005","article-title":"Calcium regulation of mitochondria motility and morphology","volume":"1787","author":"Jeyaraju","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2024.155529_bib0024","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3233\/JAD-170589","article-title":"Hypoxia-induced signaling activation in neurodegenerative diseases: targets for new therapeutic strategies","volume":"62","author":"Jha","year":"2018","journal-title":"J. Alzheimers. Dis"},{"key":"10.1016\/j.phymed.2024.155529_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175015","article-title":"Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-\u03baB\/NLRP3 pathway","volume":"925","author":"Jiang","year":"2022","journal-title":"Eur. J. Pharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0026","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tox.2016.07.022","article-title":"Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells","volume":"365","author":"Lee","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2024.155529_bib0027","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1042\/BST20230012","article-title":"Beyond the TCA cycle: new insights into mitochondrial calcium regulation of oxidative phosphorylation","volume":"51","author":"Lee","year":"2023","journal-title":"Biochem. Soc. Trans"},{"key":"10.1016\/j.phymed.2024.155529_bib0028","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s12192-020-01117-w","article-title":"The multiple organs insult and compensation mechanism in mice exposed to hypobaric hypoxia","volume":"25","author":"Li","year":"2020","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.phymed.2024.155529_bib0029","article-title":"The role of PRRC2B in cerebral vascular remodeling under acute hypoxia in mice","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2024.155529_bib0030","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.31635\/ccschem.022.202101547","article-title":"Small-molecule fluorophores for Near-infrared IIb imaging and image-guided therapy of vascular diseases","volume":"4","author":"Li","year":"2022","journal-title":"CCS. Chem."},{"key":"10.1016\/j.phymed.2024.155529_bib0031","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3389\/fphar.2020.00352","article-title":"Mitochondrial MPTP: a novel target of ethnomedicine for stroke treatment by apoptosis inhibition","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0032","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41392-020-0155-5","article-title":"MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth","volume":"5","author":"Liu","year":"2020","journal-title":"Signal. Transduct. Target Ther"},{"key":"10.1016\/j.phymed.2024.155529_bib0033","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1021\/acs.chemrev.1c00553","article-title":"Versatile types of inorganic\/organic NIR-IIa\/IIb fluorophores: from strategic design toward molecular imaging and theranostics","volume":"122","author":"Liu","year":"2022","journal-title":"Chem. Rev"},{"key":"10.1016\/j.phymed.2024.155529_bib0034","doi-asserted-by":"crossref","first-page":"993","DOI":"10.7150\/ijms.73012","article-title":"SIRT1: a novel protective molecule in pre-eclampsia","volume":"19","author":"Liu","year":"2022","journal-title":"Int. J. Med. Sci"},{"key":"10.1016\/j.phymed.2024.155529_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115345","article-title":"Chemical characteristics of Rhodiola crenulata and its mechanism in acute mountain sickness using UHPLC-Q-TOF-MS\/MS combined with network pharmacology analysis","volume":"294","author":"Ma","year":"2022","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0036","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1038\/s41467-021-23363-x","article-title":"Sulfide catabolism ameliorates hypoxic brain injury","volume":"12","author":"Marutani","year":"2021","journal-title":"Nat. Commun"},{"key":"10.1016\/j.phymed.2024.155529_bib0037","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2018.03.042","article-title":"Hypoxia, oxidative stress and inflammation","volume":"125","author":"McGarry","year":"2018","journal-title":"Free. Radic. Biol. Med"},{"key":"10.1016\/j.phymed.2024.155529_bib0038","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10571-016-0355-2","article-title":"Sirt1: role under the condition of ischemia\/hypoxia","volume":"37","author":"Meng","year":"2017","journal-title":"Cell Mol. Neurobiol"},{"key":"10.1016\/j.phymed.2024.155529_bib0039","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/jat.3749","article-title":"The use of cobalt chloride as a chemical hypoxia model","volume":"39","author":"Mu\u00f1oz-S\u00e1nchez","year":"2019","journal-title":"J. Appl. Toxicol"},{"key":"10.1016\/j.phymed.2024.155529_bib0040","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-physiol-031920-092419","article-title":"Regulation of mitochondrial Ca2+ uptake","volume":"83","author":"Murphy","year":"2021","journal-title":"Annu. Rev. Physiol"},{"key":"10.1016\/j.phymed.2024.155529_bib0041","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.3390\/ijms24021688","article-title":"FM1-43 dye memorizes Piezo1 activation in the trigeminal nociceptive system implicated in migraine pain","volume":"24","author":"Pietra","year":"2023","journal-title":"Int. J. Mol. Sci"},{"key":"10.1016\/j.phymed.2024.155529_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105497","article-title":"From membrane to nucleus: a three-wave hypothesis of cAMP signaling","volume":"300","author":"Pizzoni","year":"2024","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.phymed.2024.155529_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114329","article-title":"The effect of regulating MCU expression on experimental ischemic brain injury","volume":"362","author":"Qin","year":"2023","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.phymed.2024.155529_bib0044","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41569-022-00703-y","article-title":"The role of mitochondrial fission in cardiovascular health and disease","volume":"19","author":"Quiles","year":"2022","journal-title":"Nat. Rev. Cardiol"},{"key":"10.1016\/j.phymed.2024.155529_bib0045","doi-asserted-by":"crossref","first-page":"e13523","DOI":"10.7717\/peerj.13523","article-title":"Muscone improves hypoxia\/reoxygenation (H\/R)-induced neuronal injury by blocking HMGB1\/TLR4\/NF-\u03baB pathway via modulating microRNA-142","volume":"10","author":"Ren","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.phymed.2024.155529_bib0046","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00395-007-0675-y","article-title":"Opening of mitochondrial permeability transition pore induces hypercontracture in Ca2+ overloaded cardiac myocytes","volume":"102","author":"Ruiz-Meana","year":"2007","journal-title":"Basic. Res. Cardiol"},{"key":"10.1016\/j.phymed.2024.155529_bib0047","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biopha.2016.12.105","article-title":"Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney","volume":"87","author":"Samarghandian","year":"2017","journal-title":"Biomed. Pharmacother"},{"key":"10.1016\/j.phymed.2024.155529_bib0048","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.taap.2013.08.027","article-title":"Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia\/reperfusion injury by inhibition of the mitochondrial calcium uniporter","volume":"273","author":"Schwartz","year":"2013","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0049","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1096\/fj.12-226225","article-title":"Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission","volume":"28","author":"Sharp","year":"2014","journal-title":"Faseb. j"},{"key":"10.1016\/j.phymed.2024.155529_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116677","article-title":"Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway","volume":"315","author":"Si","year":"2023","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0051","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.me.24.020173.001415","article-title":"Metabolism of ketone bodies by the brain","volume":"24","author":"Sokoloff","year":"1973","journal-title":"Annu. Rev. Med"},{"key":"10.1016\/j.phymed.2024.155529_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102047","article-title":"Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia","volume":"45","author":"Sulkshane","year":"2021","journal-title":"Redox. Biol"},{"key":"10.1016\/j.phymed.2024.155529_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152726","article-title":"Cadmium disrupts mitochondrial distribution and activates excessive mitochondrial fission by elevating cytosolic calcium independent of MCU-mediated mitochondrial calcium uptake in its neurotoxicity","volume":"453","author":"Tang","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2024.155529_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174617","article-title":"Salidroside attenuates CoCl2-simulated hypoxia injury in PC12 cells partly by mitochondrial protection","volume":"912","author":"Tang","year":"2021","journal-title":"Eur. J. Pharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0055","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jphs.2019.02.008","article-title":"Pretreatment with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia\/reperfusion injury via AMPK\/SIRT1\/PGC-1 alpha signaling pathway","volume":"139","author":"Tian","year":"2019","journal-title":"J. Pharmacol. Sci"},{"key":"10.1016\/j.phymed.2024.155529_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.136499","article-title":"Untargeted screening and in silico toxicity assessment of semi- and non-volatile compounds migrating from polysaccharide-based food contact materials","volume":"425","author":"Tsochatzis","year":"2023","journal-title":"Food. Chem"},{"key":"10.1016\/j.phymed.2024.155529_bib0057","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.intimp.2016.09.010","article-title":"Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin (AQP) via NF-\u03baB signaling pathway","volume":"40","author":"Wang","year":"2016","journal-title":"Int. Immunopharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0058","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1126\/scitranslmed.abk2756","article-title":"Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis","volume":"14","author":"Wang","year":"2022","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.phymed.2024.155529_bib0059","doi-asserted-by":"crossref","first-page":"12732","DOI":"10.3390\/ijms232112732","article-title":"Antimicrobial peptides mediate apoptosis by changing mitochondrial membrane permeability","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci"},{"key":"10.1016\/j.phymed.2024.155529_bib0060","article-title":"Mitochondrial dynamics, mitophagy, and mitochondria-endoplasmic reticulum contact sites crosstalk under hypoxia","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Cell. Dev. Biol"},{"key":"10.1016\/j.phymed.2024.155529_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.03.028","article-title":"Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia-induced brain injury by regulating the HIF-1\u03b1\/microRNA 210\/ISCU1\/2(COX10) signaling pathway","volume":"241","author":"Wang","year":"2019","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115278","article-title":"Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata, orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating Sirt1\/p53\/Drp1 signaling","volume":"293","author":"Wang","year":"2022","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0063","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1021\/acscentsci.8b00773","article-title":"A selective and cell-permeable mitochondrial calcium uniporter (MCU) inhibitor preserves mitochondrial bioenergetics after hypoxia\/reoxygenation injury","volume":"5","author":"Woods","year":"2019","journal-title":"ACS. Cent. Sci"},{"key":"10.1016\/j.phymed.2024.155529_bib0064","first-page":"282","article-title":"Study on the mechanism of Wuzi-Yanzong-Wan-medicated serum interfering with the mitochondrial permeability transition pore in the GC-2 cell induced by atractyloside","volume":"20","author":"Wu","year":"2022","journal-title":"Chin. J. Nat. Med"},{"key":"10.1016\/j.phymed.2024.155529_bib0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00395-019-0747-9","article-title":"Cardioprotection of post-ischemic moderate ROS against ischemia\/reperfusion via STAT3-induced the inhibition of MCU opening","volume":"114","author":"Wu","year":"2019","journal-title":"Basic. Res. Cardiol"},{"key":"10.1016\/j.phymed.2024.155529_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153884","article-title":"Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK","volume":"95","author":"Wu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155529_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154240","article-title":"Rhodiola crenulate alleviates hypobaric hypoxia-induced brain injury via adjusting NF-\u03baB\/NLRP3-mediated inflammation","volume":"103","author":"Xie","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155529_bib0068","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbrc.2020.06.036","article-title":"Salidroside alleviated hypoxia-induced liver injury by inhibiting endoplasmic reticulum stress-mediated apoptosis via IRE1\u03b1\/JNK pathway","volume":"529","author":"Xiong","year":"2020","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.phymed.2024.155529_bib0069","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1002\/fsn3.2459","article-title":"Protective effect of salidroside on hypoxia-related liver oxidative stress and inflammation via Nrf2 and JAK2\/STAT3 signaling pathways","volume":"9","author":"Xiong","year":"2021","journal-title":"Food. Sci. Nutr"},{"key":"10.1016\/j.phymed.2024.155529_bib0070","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12964-022-00976-3","article-title":"Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema","volume":"20","author":"Xue","year":"2022","journal-title":"Cell. Commun. Signal"},{"key":"10.1016\/j.phymed.2024.155529_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.114988","article-title":"Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia\/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis","volume":"288","author":"Yang","year":"2022","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.phymed.2024.155529_bib0072","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1080\/15548627.2020.1851897","article-title":"Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5)","volume":"17","author":"Yang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2024.155529_bib0073","first-page":"1","article-title":"Hypoxia and aging","volume":"51","author":"Yeo","year":"2019","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.phymed.2024.155529_bib0074","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1093\/brain\/awac084","article-title":"Interrelation of striatal dopamine, brain metabolism and cognition in dementia with Lewy bodies","volume":"145","author":"Yoo","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.phymed.2024.155529_bib0075","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1083\/jcb.200406038","article-title":"Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit","volume":"167","author":"Yi","year":"2004","journal-title":"J. Cell. Biol"},{"key":"10.1016\/j.phymed.2024.155529_bib0076","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1039\/D1FO03436G","article-title":"Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF\/MS","volume":"13","author":"Yue","year":"2022","journal-title":"Food Funct"},{"key":"10.1016\/j.phymed.2024.155529_bib0077","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/s41419-021-04363-7","article-title":"Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-\u03b2\/Smad2\/3 pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death. Dis"},{"key":"10.1016\/j.phymed.2024.155529_bib0078","doi-asserted-by":"crossref","first-page":"e12542","DOI":"10.1111\/jpi.12542","article-title":"Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion\/mitophagy and activating the AMPK-OPA1 signaling pathways","volume":"66","author":"Zhang","year":"2019","journal-title":"J. Pineal. Res"},{"key":"10.1016\/j.phymed.2024.155529_bib0079","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s11658-021-00283-8","article-title":"HIF-1\u03b1\/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injur","volume":"26","author":"Zhao","year":"2021","journal-title":"Cell Mol. Biol. Lett"},{"key":"10.1016\/j.phymed.2024.155529_bib0080","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.3390\/molecules27175545","article-title":"Resveratrol reestablishes mitochondrial quality control in myocardial ischemia\/reperfusion injury through Sirt1\/Sirt3-Mfn2-Parkin-PGC-1\u03b1 pathway","volume":"27","author":"Zheng","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.155529_bib0081","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113828","article-title":"Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats","volume":"345","author":"Zhu","year":"2021","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.phymed.2024.155529_bib0082","doi-asserted-by":"crossref","first-page":"134","DOI":"10.14336\/AD.2018.0511","article-title":"Rosenroot (Rhodiola): potential applications in aging-related diseases","volume":"10","author":"Zhuang","year":"2019","journal-title":"Aging Dis"},{"key":"10.1016\/j.phymed.2024.155529_bib0083","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s12035-016-9732-6","article-title":"Artesunate protected blood-brain barrier via Sphingosine 1 Phosphate Receptor 1\/Phosphatidylinositol 3 Kinase Pathway after subarachnoid hemorrhage in rats","volume":"54","author":"Zuo","year":"2017","journal-title":"Mol. Neurobiol"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324001946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324001946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T15:23:08Z","timestamp":1724080988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324001946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":83,"alternative-id":["S0944711324001946"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155529","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155529","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155529"}}