{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:59:33Z","timestamp":1793473173245,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2022ZFJH003"],"award-info":[{"award-number":["2022ZFJH003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.phymed.2024.155586","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T02:36:11Z","timestamp":1712025371000},"page":"155586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Glycyrrhizic acid alleviates concanavalin A-induced acute liver injury by regulating monocyte-derived macrophages"],"prefix":"10.1016","volume":"133","author":[{"given":"Juan","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmiao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfei","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyi","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155586_bib0001","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3389\/fimmu.2019.00803","article-title":"The antidepressant mirtazapine inhibits hepatic innate immune networks to attenuate immune-mediated liver injury in mice","volume":"10","author":"Almishri","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155586_bib0002","doi-asserted-by":"crossref","unstructured":"Ambade A., Lowe P., Kodys K., Catalano D., Gyongyosi B., Cho Y., et al. Pharmacological inhibition of CCR2\/5 signaling prevents and reverses alcohol-induced liver damage, steatosis, and inflammation in mice. Hepatology 2019;69:1105\u20131121. 10.1002\/hep.30249.","DOI":"10.1002\/hep.30249"},{"key":"10.1016\/j.phymed.2024.155586_bib0003","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/gutjnl-2011-300304","article-title":"Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury","volume":"61","author":"Baeck","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.155586_bib0004","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1471-4906(02)02223-8","article-title":"CD200 and membrane protein interactions in the control of myeloid cells","volume":"23","author":"Barclay","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.phymed.2024.155586_bib0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1142\/S0192415X23500209","article-title":"Efficacy and safety of glycyrrhizic acid in treatment of autoimmune hepatitis","volume":"51","author":"Bi","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2024.155586_bib0006","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phymed.2024.155586_bib0007","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10753-021-01542-8","article-title":"Glycyrrhizic acid alleviates lipopolysaccharide (LPS)-induced acute lung injury by regulating angiotensin-converting enzyme-2 (ACE2) and caveolin-1 signaling pathway","volume":"45","author":"Chen","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2024.155586_bib0008","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jhep.2010.07.018","article-title":"NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism","volume":"54","author":"Cheng","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2024.155586_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108612","article-title":"EZH2-mediated H3K27me3 promotes autoimmune hepatitis progression by regulating macrophage polarization","volume":"106","author":"Chi","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155586_bib0010","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/ten.teb.2016.0463","article-title":"Collagen membrane and immune response in guided bone regeneration: recent progress and perspectives","volume":"23","author":"Chu","year":"2017","journal-title":"Tissue Eng. Part B"},{"key":"10.1016\/j.phymed.2024.155586_bib0011","doi-asserted-by":"crossref","unstructured":"Erhardt A., Biburger M., Papadopoulos T., and Tiegs G. IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice. Hepatology 2007;45:475\u2013485.","DOI":"10.1002\/hep.21498"},{"key":"10.1016\/j.phymed.2024.155586_bib0012","article-title":"Impact of antigen presentation mechanisms on immune response in autoimmune hepatitis","volume":"12","author":"Fasano","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155586_bib0013","doi-asserted-by":"crossref","unstructured":"Gantner F., Leist M., Lohse A.W., Germann P.G., and Tiegs G. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology . 1995;21:190\u2013198.","DOI":"10.1002\/hep.1840210131"},{"key":"10.1016\/j.phymed.2024.155586_bib0014","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1002\/hep.30954","article-title":"Hypoxia-inducible factor-2\u03b1 reprograms liver macrophages to protect against acute liver injury through the production of interleukin-6","volume":"71","author":"Gao","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2024.155586_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153942","article-title":"Comparative effectiveness of glycyrrhizic acid preparations aimed at preventing and treating anti-tuberculosis drug-induced liver injury: a network meta-analysis of 97 randomized controlled trials","volume":"98","author":"Gong","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155586_bib0016","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/apt.13801","article-title":"Single-centre experience of the macrophage activation marker soluble (s)CD163 - associations with disease activity and treatment response in patients with autoimmune hepatitis","volume":"44","author":"Gr\u00f8nbaek","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2024.155586_bib0017","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.immuni.2022.08.002","article-title":"Liver macrophages in health and disease","volume":"55","author":"Guilliams","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2024.155586_bib0018","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1136\/gutjnl-2015-311247","article-title":"PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury","volume":"66","author":"He","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.155586_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106138","article-title":"Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: molecular insights","volume":"178","author":"Jain","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.155586_bib0020","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/386181a0","article-title":"A family of proteins that inhibit signalling through tyrosine kinase receptors","volume":"386","author":"Kharitonenkov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155586_bib0021","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13046-016-0412-1","article-title":"Deletion of interleukin-6 in monocytes\/macrophages suppresses the initiation of hepatocellular carcinoma in mice","volume":"35","author":"Kong","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2024.155586_bib0022","doi-asserted-by":"crossref","unstructured":"Krenkel O., Puengel T., Govaere O., Abdallah A.T., Mossanen J.C., Kohlhepp M., et al. Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis. Hepatology. 2018;67:1270\u20131283. 10.1002\/hep.29544.","DOI":"10.1002\/hep.29544"},{"key":"10.1016\/j.phymed.2024.155586_bib0023","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2024.155586_bib0024","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.phrs.2019.04.025","article-title":"Natural products in licorice for the therapy of liver diseases: progress and future opportunities","volume":"144","author":"Li","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.155586_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102904","article-title":"zVAD alleviates experimental autoimmune hepatitis in mice by increasing the sensitivity of macrophage to TNFR1-dependent necroptosis","volume":"133","author":"Li","year":"2022","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.phymed.2024.155586_bib0026","doi-asserted-by":"crossref","unstructured":"Li Y., Wang W., Tang L., He X., Yan X., Zhang X., et al. Chemokine (C-X-C motif) ligand 13 promotes intrahepatic chemokine (C-X-C motif) receptor 5+ lymphocyte homing and aberrant B-cell immune responses in primary biliary cirrhosis. Hepatology. 2015;61:1998\u20132007. 10.1002\/hep.27725.","DOI":"10.1002\/hep.27725"},{"key":"10.1016\/j.phymed.2024.155586_bib0027","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S2468-1253(20)30328-9","article-title":"Established and novel therapeutic options for autoimmune hepatitis","volume":"6","author":"Liberal","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2024.155586_bib0028","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144801","article-title":"Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2","volume":"131","author":"Liu","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2024.155586_bib0029","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7150\/ijbs.65402","article-title":"RIP3 blockade prevents immune-mediated hepatitis through a myeloid-derived suppressor cell dependent mechanism","volume":"18","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2024.155586_bib0030","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1182\/bloodadvances.2022007104","article-title":"SIRP\u03b1+ macrophages are increased in patients with FL who progress or relapse after frontline lenalidomide and rituximab","volume":"6","author":"Marques-Piubelli","year":"2022","journal-title":"Blood Adv."},{"key":"10.1016\/j.phymed.2024.155586_bib0031","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.phrs.2008.05.012","article-title":"Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice","volume":"58","author":"Menegazzi","year":"2008","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.155586_bib0032","doi-asserted-by":"crossref","first-page":"18017","DOI":"10.1038\/nrdp.2018.17","article-title":"Autoimmune hepatitis","volume":"4","author":"Mieli-Vergani","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.phymed.2024.155586_bib0033","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jhep.2022.02.016","article-title":"Multi-parametric analysis of human livers reveals variation in intrahepatic inflammation across phases of chronic hepatitis B infection","volume":"77","author":"Montanari","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2024.155586_bib0034","article-title":"Diagnosis and management of autoimmune hepatitis","volume":"380","author":"Muratori","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.phymed.2024.155586_bib0035","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/ptr.5893","article-title":"Toxicological effects of Glycyrrhiza glabra (Licorice): a review","volume":"31","author":"Nazari","year":"2017","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2024.155586_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155272","article-title":"CX3CL1\/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1\/M2 status","volume":"136","author":"Ni","year":"2022","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.phymed.2024.155586_bib0037","article-title":"Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma","volume":"4","author":"Ochoa","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.phymed.2024.155586_bib0038","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.31790","article-title":"Macrophage heterogeneity in NASH: more than just nomenclature","volume":"74","author":"Parthasarathy","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2024.155586_bib0039","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/ptr.6178","article-title":"Liquorice (Glycyrrhiza glabra): a phytochemical and pharmacological review","volume":"32","author":"Pastorino","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2024.155586_bib0040","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202200521","article-title":"Immunoregulation in diabetic wound repair with a photoenhanced glycyrrhizic acid hydrogel Scaffold","volume":"34","author":"Qian","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.phymed.2024.155586_bib0041","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nbt.1991","article-title":"Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE","volume":"29","author":"Qiu","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phymed.2024.155586_bib0042","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phymed.2024.155586_bib0043","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nmeth.3863","article-title":"Automated mapping of phenotype space with single-cell data","volume":"13","author":"Samusik","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phymed.2024.155586_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2020.10.006","article-title":"Increased mortality risk in autoimmune hepatitis: a nationwide population-based cohort study with histopathology","volume":"19","author":"Sharma","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2024.155586_bib0045","first-page":"7122","article-title":"Glycyrrhizin improves inflammation and apoptosis via suppressing HMGB1 and PI3K\/mTOR pathway in lipopolysaccharide-induced acute liver injury","volume":"24","author":"Shen","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2024.155586_bib0046","doi-asserted-by":"crossref","first-page":"10523","DOI":"10.1038\/ncomms10523","article-title":"Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury","volume":"7","author":"Shi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.155586_bib0047","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/liv.15573","article-title":"Research gaps and opportunities in autoimmune hepatitis-Results of the international autoimmune hepatitis group research workshop 2022","volume":"43","author":"Snijders","year":"2023","journal-title":"Liver Int."},{"key":"10.1016\/j.phymed.2024.155586_bib0048","first-page":"4845","article-title":"CXCL9 regulates acetaminophen-induced liver injury via CXCR3","volume":"18","author":"Song","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2024.155586_bib0049","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2016.04.019","article-title":"Single cells, many features","volume":"165","author":"Spitzer","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.155586_bib0050","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ymeth.2014.08.016","article-title":"Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis","volume":"70","author":"Stack","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.phymed.2024.155586_bib0051","doi-asserted-by":"crossref","DOI":"10.1007\/s12016-008-8091-0","article-title":"Inflammatory pathways in liver homeostasis and liver injury","volume":"36","author":"Tacke","year":"2009","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.phymed.2024.155586_bib0052","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nmeth.1315","article-title":"mRNA-Seq whole-transcriptome analysis of a single cell","volume":"6","author":"Tang","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phymed.2024.155586_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2017.02.006","article-title":"Incidence and determinants of hepatocellular carcinoma in autoimmune hepatitis: a systematic review and meta-analysis","volume":"15","author":"Tansel","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2024.155586_bib0054","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41423-021-00768-8","article-title":"Autoimmmune hepatitis","volume":"19","author":"Terziroli Beretta-Piccoli","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phymed.2024.155586_bib0055","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2024.155586_bib0056","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1189\/jlb.3RU0316-144R","article-title":"Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage","volume":"100","author":"Ushach","year":"2016","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.phymed.2024.155586_bib0057","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev-immunol-032414-112220","article-title":"Macrophages: development and tissue specialization","volume":"33","author":"Varol","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.phymed.2024.155586_bib0058","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155586_bib0059","article-title":"CXCL13-CXCR5 axis: regulation in inflammatory diseases and cancer","volume":"1877","author":"Wang","year":"2022","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2024.155586_bib0060","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/apt.16902","article-title":"Corticosteroid plus glycyrrhizin therapy for chronic drug- or herb-induced liver injury achieves biochemical and histological improvements: a randomised open-label trial","volume":"55","author":"Wang","year":"2022","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2024.155586_bib0061","article-title":"Multi-omics analysis reveals the protection of Gasdermin D in Concanavalin A-induced autoimmune hepatitis","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"10.1016\/j.phymed.2024.155586_bib0062","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.7150\/thno.35972","article-title":"Co-delivery of glycyrrhizin and doxorubicin by alginate nanogel particles attenuates the activation of macrophage and enhances the therapeutic efficacy for hepatocellular carcinoma","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2024.155586_bib0063","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12111128","article-title":"Glycyrrhizic acid mitigates tripterygium-glycoside-tablet-induced acute liver injury via pkm2 regulated oxidative stress","volume":"12","author":"Wang","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.phymed.2024.155586_bib0064","article-title":"Splenectomy promotes macrophage polarization in a mouse model of Concanavalin A- (ConA-) induced liver fibrosis","volume":"2019","author":"Wang","year":"2019","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.phymed.2024.155586_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2018.04.029","article-title":"Glycyrrhizin ameliorates atopic dermatitis-like symptoms through inhibition of HMGB1","volume":"60","author":"Wang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155586_bib0066","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phymed.2024.155586_bib0067","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41419-021-03768-8","article-title":"Prevention of d-GalN\/LPS-induced ALI by 18\u03b2-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation","volume":"12","author":"Wu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2024.155586_bib0068","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2010.06.011","article-title":"Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action","volume":"12","author":"Wunderlich","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2024.155586_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154914","article-title":"CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1\/M2 status in mice","volume":"125","author":"Xu","year":"2021","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.phymed.2024.155586_bib0070","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.immuni.2014.01.006","article-title":"Transcriptome-based network analysis reveals a spectrum model of human macrophage activation","volume":"40","author":"Xue","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2024.155586_bib0071","first-page":"443","article-title":"Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4(+)CD25(-)CD69(+) subset proliferation","volume":"10","author":"Yang","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.phymed.2024.155586_bib0072","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bioorg.2017.03.009","article-title":"Protective effects of hepatocyte-specific glycyrrhetic derivatives against carbon tetrachloride-induced liver damage in mice","volume":"72","author":"Yang","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2024.155586_bib0073","doi-asserted-by":"crossref","first-page":"e643","DOI":"10.1002\/iid3.643","article-title":"Inducible nitric oxide synthase regulates macrophage polarization via the MAPK signals in concanavalin A-induced hepatitis","volume":"10","author":"Yao","year":"2022","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.phymed.2024.155586_bib0074","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41401-022-00863-0","article-title":"Hepatic NCoR1 deletion exacerbates alcohol-induced liver injury in mice by promoting CCL2-mediated monocyte-derived macrophage infiltration","volume":"43","author":"Yin","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2024.155586_bib0075","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bcp.2013.07.006","article-title":"Role of hepatic resident and infiltrating macrophages in liver repair after acute injury","volume":"86","author":"You","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155586_bib0076","article-title":"Leaky gut driven by dysbiosis augments activation and accumulation of liver macrophages via RIP3 signaling pathway in autoimmune hepatitis","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2024.155586_bib0077","doi-asserted-by":"crossref","first-page":"14049","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324002514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324002514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T12:38:08Z","timestamp":1725712688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324002514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":77,"alternative-id":["S0944711324002514"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155586","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycyrrhizic acid alleviates concanavalin A-induced acute liver injury by regulating monocyte-derived macrophages","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155586"}}