{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:42:41Z","timestamp":1793378561767,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.phymed.2024.155591","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:05:04Z","timestamp":1713175504000},"page":"155591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Syringic acid attenuates acute lung injury by modulating macrophage polarization in LPS-induced mice"],"prefix":"10.1016","volume":"129","author":[{"given":"Wei-Ting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2318-356X","authenticated-orcid":false,"given":"Juan-Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Shan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-0556","authenticated-orcid":false,"given":"Hua-Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Chou","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu-Dan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3223-1797","authenticated-orcid":false,"given":"Ying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-3690","authenticated-orcid":false,"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155591_bib0001","doi-asserted-by":"crossref","first-page":"N100","DOI":"10.1097\/00003246-200004001-00012","article-title":"NF-kappaB activation","volume":"28","author":"Abraham","year":"2000","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.phymed.2024.155591_bib0002","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3109\/08820139.2016.1157814","article-title":"Dexamethasone attenuates LPS-induced acute lung injury through Inhibition of NF-\u03baB, COX-2, and Pro-inflammatory mediators","volume":"45","author":"Al-Harbi","year":"2016","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.phymed.2024.155591_bib0004","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ccm.2016.07.004","article-title":"Ventilator-induced Lung Injury","volume":"37","author":"Beitler","year":"2016","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.phymed.2024.155591_bib0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/AIA.0000000000000172","article-title":"One-lung ventilation and acute lung injury","volume":"56","author":"Bender","year":"2018","journal-title":"Int. Anesthesiol. Clin."},{"key":"10.1016\/j.phymed.2024.155591_bib0006","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American-European consensus conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination","volume":"149","author":"Bernard","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.phymed.2024.155591_bib0007","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.1700223","article-title":"Macrophage-mediated inflammation in normal and diabetic wound healing","volume":"199","author":"Boniakowski","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2024.155591_bib0008","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5858\/arpa.2015-0519-RA","article-title":"Acute lung injury: a clinical and molecular review","volume":"140","author":"Butt","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.phymed.2024.155591_bib0009","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00011-020-01378-2","article-title":"Macrophage polarization and its role in the pathogenesis of acute lung injury\/acute respiratory distress syndrome","volume":"69","author":"Chen","year":"2020","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.phymed.2024.155591_bib0011","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.CCM.0000250319.91575.BB","article-title":"Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis","volume":"35","author":"Da","year":"2007","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.phymed.2024.155591_bib0012","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s00068-023-02227-7","article-title":"Syringic acid ameliorates ischemia\/reperfusion-induced testicular injury in rats via suppressing of HMGB1\/NF-\u03baB axis and endoplasmic reticulum stress","volume":"49","author":"Demir","year":"2023","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"10.1016\/j.phymed.2024.155591_bib0013","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/jth.14844","article-title":"Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19","volume":"18","author":"Dolhnikoff","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.phymed.2024.155591_bib0014","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/089583700196257","article-title":"Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice","volume":"12","author":"Elder","year":"2000","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.phymed.2024.155591_bib0015","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/tox.23557","article-title":"Syringic acid and silymarin concurrent administration inhibits sodium valproate-induced liver injury in rats","volume":"37","author":"Gheena","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.phymed.2024.155591_bib0016","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1038\/sj.onc.1209954","article-title":"Introduction to NF-kappaB: players, pathways, perspectives","volume":"25","author":"Gilmore","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2024.155591_bib0017","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jss.2016.11.007","article-title":"Accumulation and cellular localization of nanoparticles in an ex vivo model of acute lung injury","volume":"210","author":"Grimm","year":"2017","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.phymed.2024.155591_bib0018","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.phymed.2024.155591_bib0019","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13223-019-0332-7","article-title":"Tumor necrosis factor-alpha and Fas\/Fas ligand signaling pathways in chronic spontaneous urticaria","volume":"15","author":"Grzanka","year":"2019","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.phymed.2024.155591_bib0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ajpath.2020.08.009","article-title":"Immunopathology of Hyperinflammation in COVID-19","volume":"191","author":"Gustine","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2024.155591_bib0021","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1039\/D0FO02966A","article-title":"Fermented blueberry and black rice containing Lactobacillus plantarum MG4221: a novel functional food for particulate matter (PM 2.5)\/dinitrochlorobenzene (DNCB)-induced atopic dermatitis","volume":"12","author":"Hong","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.155591_bib0022","doi-asserted-by":"crossref","first-page":"11947","DOI":"10.1038\/s41598-019-48462-0","article-title":"Pathophysiologic characterization of a novel rabbit model of biliary tract infection-derived sepsis","volume":"9","author":"Hu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2024.155591_bib0023","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1039\/C7FO01794D","article-title":"Polyphenols-rich extract from Pleurotus eryngii with growth inhibitory of HCT116 colon cancer cells and anti-inflammatory function in RAW264.7 cells","volume":"9","author":"Hu","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2024.155591_bib0024","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan","volume":"395","author":"Huang","year":"2020","journal-title":"China. Lancet"},{"key":"10.1016\/j.phymed.2024.155591_bib0025","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3390\/cells10040897","article-title":"The role of macrophages in the development of acute and chronic inflammatory lung diseases","volume":"10","author":"Lee","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2024.155591_bib0026","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s11658-018-0117-x","article-title":"Elevated IL-33 promotes expression of MMP2 and MMP9 via activating STAT3 in alveolar macrophages during LPS-induced acute lung injury","volume":"23","author":"Liang","year":"2018","journal-title":"Cell Mol. Biol. Lett."},{"key":"10.1016\/j.phymed.2024.155591_bib0027","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2217\/nnm-2020-0042","article-title":"Syringic acid delivered via mPEG-PLGA-PLL nanoparticles enhances peripheral nerve regeneration effect","volume":"15","author":"Lin","year":"2020","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.phymed.2024.155591_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155190","article-title":"Fuzhengjiedu formula exerts protective effect against LPS-induced acute lung injury via gut-lung axis","volume":"123","author":"Lu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155591_bib0029","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.resp.2018.07.001","article-title":"The anti-inflammatory and anti-oxidative actions of eugenol improve lipopolysaccharide-induced lung injury","volume":"259","author":"Magalh\u00e3es","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.phymed.2024.155591_bib0030","series-title":"Comprehensive Physiology","first-page":"2471","article-title":"Fluid flux and clearance in acute lung injury","author":"Martin","year":"2012"},{"key":"10.1016\/j.phymed.2024.155591_bib0031","doi-asserted-by":"crossref","unstructured":"Matthay, M.A., 2019. Acute respiratory distress syndrome 22.","DOI":"10.1016\/S2213-2600(18)30507-1"},{"key":"10.1016\/j.phymed.2024.155591_bib0032","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American thoracic society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.phymed.2024.155591_bib0033","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.phymed.2024.155591_bib0034","doi-asserted-by":"crossref","first-page":"S353","DOI":"10.33549\/physiolres.934602","article-title":"Acute Lung Injury \u2013 From Pathophysiology to Treatment","author":"Mokra","year":"2021","journal-title":"Physiol. Res."},{"key":"10.1016\/j.phymed.2024.155591_bib0035","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrd.2017.170","article-title":"Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease","volume":"16","author":"Mora","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2024.155591_bib0036","article-title":"Acute lung injury","volume":"20","author":"Mowery","year":"2020","journal-title":"Curr. Probl. Surg."},{"key":"10.1016\/j.phymed.2024.155591_bib0037","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.drudis.2016.08.006","article-title":"Macrophage polarization in response to epigenetic modifiers during infection and inflammation","volume":"22","author":"Patel","year":"2017","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.phymed.2024.155591_bib0038","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.12688\/f1000research.20411.1","article-title":"Recent advances in the understanding and management of ARDS","volume":"8","author":"Peck","year":"2019","journal-title":"F1000Res."},{"key":"10.1016\/j.phymed.2024.155591_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2020.103455","article-title":"Distinct phenotypes require distinct respiratory management strategies in severe COVID-19","volume":"279","author":"Robba","year":"2020","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.phymed.2024.155591_bib0040","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/ame2.12087","article-title":"Outlining key inflammation-associated parameters during early phase of an experimental gram-negative sepsis model in rhesus macaques (Macaca mulatta)","volume":"2","author":"Rosado-Franco","year":"2019","journal-title":"Anim. Models Exp. Med."},{"key":"10.1016\/j.phymed.2024.155591_bib0041","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.shk.0000209529.43367.00","article-title":"Infusion of increasing doses of endotoxin induces progressive acute lung injury but prevents early pulmonary hypertension in pigs","volume":"25","author":"Schmidhammer","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.phymed.2024.155591_bib0043","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1172\/JCI110985","article-title":"Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep","volume":"72","author":"Snapper","year":"1983","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2024.155591_bib0044","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bbrc.2012.02.005","article-title":"Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-\u03baB signaling pathway","volume":"419","author":"Soromou","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2024.155591_bib0045","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.biopha.2018.09.069","article-title":"Syringic acid (SA) \u2012 a review of its occurrence, biosynthesis, pharmacological and industrial importance","volume":"108","author":"Srinivasulu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2024.155591_bib0046","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1039\/C7MB00251C","article-title":"Role of GARP in the activation of latent TGF-\u03b21","volume":"13","author":"Stockis","year":"2017","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.phymed.2024.155591_bib0047","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3390\/ma12071026","article-title":"Amorphous silica nanoparticles obtained by laser ablation induce inflammatory response in human lung fibroblasts","volume":"12","author":"Voicu","year":"2019","journal-title":"Materials. (Basel)"},{"key":"10.1016\/j.phymed.2024.155591_bib0048","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1440-1843.2008.01344.x","article-title":"Low-dose dexamethasone alleviates lipopolysaccharide-induced acute lung injury in rats and upregulates pulmonary glucocorticoid receptors","volume":"13","author":"Wang","year":"2008","journal-title":"Respirology."},{"key":"10.1016\/j.phymed.2024.155591_bib0049","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1165\/rcmb.2008-0348TR","article-title":"Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury","volume":"40","author":"Zemans","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.phymed.2024.155591_bib0050","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/jpi.12322","article-title":"Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome","volume":"60","author":"Zhang","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.phymed.2024.155591_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106310","article-title":"(9S,13R)-12-oxo-phytodienoic acid attenuates inflammation by inhibiting mPGES-1 and modulating macrophage polarization via NF-\u03baB and Nrf2\/HO-1 pathways","volume":"182","author":"Zhang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2024.155591_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104009","article-title":"Neuroprotective effects of Syringic acid against aluminium chloride induced oxidative stress mediated neuroinflammation in rat model of Alzheimer's disease","volume":"71","author":"Zhao","year":"2020","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.phymed.2024.155591_bib0053","doi-asserted-by":"crossref","unstructured":"Zhou, Y., 2019. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury 12.","DOI":"10.1186\/s13054-019-2339-3"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324002563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324002563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T19:53:53Z","timestamp":1717271633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324002563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":50,"alternative-id":["S0944711324002563"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155591","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Syringic acid attenuates acute lung injury by modulating macrophage polarization in LPS-induced mice","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"155591"}}