{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:40:09Z","timestamp":1793835609363,"version":"4.6.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.phymed.2024.155635","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T02:00:08Z","timestamp":1713578408000},"page":"155635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":225,"special_numbering":"C","title":["Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia\/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization"],"prefix":"10.1016","volume":"129","author":[{"given":"Ziwei","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengbo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JunJiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aojie","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155635_bib0001","article-title":"Age-related alterations in immune function and inflammation: focus on ischemic stroke","author":"Chen","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.phymed.2024.155635_bib0002","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1002\/jcb.26227","article-title":"TNF-\u03b1-Induced NOD2 and RIP2 contribute to the up-regulation of cytokines induced by MDP in monocytic THP-1 cells","volume":"119","author":"Chen","year":"2018","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2024.155635_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108006","article-title":"Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway","volume":"99","author":"Cheng","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155635_bib0004","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12974-019-1571-8","article-title":"Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles","volume":"16","author":"Dabrowska","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2024.155635_bib0005","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1243659","article-title":"Secretome of olfactory mucosa mesenchymal stem cell, a multiple potential stem cell","volume":"2016","author":"Ge","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.phymed.2024.155635_bib0006","doi-asserted-by":"crossref","first-page":"e3080","DOI":"10.1038\/cddis.2017.465","article-title":"RTN1-C mediates cerebral ischemia\/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways","volume":"8","author":"Gong","year":"2017","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2024.155635_bib0007","first-page":"11","article-title":"It's All in the PAN: crosstalk, plasticity, redundancies, switches, and interconnectedness encompassed by PANoptosis underlying the totality of cell death-associated biological effects","author":"Gullett","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2024.155635_bib0008","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1161\/01.STR.31.8.1939","article-title":"Cognitive deficits after focal cerebral ischemia in mice","volume":"31","author":"Hattori","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2024.155635_bib0009","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1177\/0963689718816990","article-title":"Potential of Exosomes for the Treatment of Stroke","volume":"28","author":"Hong","year":"2019","journal-title":"Cell Trans. Plant"},{"key":"10.1016\/j.phymed.2024.155635_bib0010","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7150\/thno.21234","article-title":"Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function","volume":"8","author":"Hu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2024.155635_bib0011","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13578-022-00776-9","article-title":"UBIAD1 alleviates ferroptotic neuronal death by enhancing antioxidative capacity by cooperatively restoring impaired mitochondria and Golgi apparatus upon cerebral ischemic\/reperfusion insult","volume":"12","author":"Huang","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.phymed.2024.155635_bib0012","doi-asserted-by":"crossref","first-page":"e17874","DOI":"10.1016\/j.heliyon.2023.e17874","article-title":"Curcumin preconditioning enhances the neuroprotective effects of olfactory mucosa-derived mesenchymal stem cells on experimental intracerebral hemorrhage","volume":"9","author":"Huang","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2024.155635_bib0013","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.18632\/aging.103307","article-title":"Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia\/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1\u03b1","volume":"12","author":"Huang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.phymed.2024.155635_bib0014","first-page":"24","article-title":"Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects","author":"Kotha","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2024.155635_bib0015","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","article-title":"AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence","volume":"597","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155635_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.580206","article-title":"Olfactory mucosa mesenchymal stem cells ameliorate cerebral ischemic\/reperfusion injury through modulation of UBIAD1 expression","volume":"14","author":"Liu","year":"2020","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.phymed.2024.155635_bib0017","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.4049\/jimmunol.1801166","article-title":"Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-\u03baB p65\/Hif-1\u03b1 Signaling Pathway","volume":"202","author":"Liu","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2024.155635_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113700","article-title":"Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1\/M2 phenotypes","volume":"341","author":"Liu","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2024.155635_bib0019","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13287-023-03458-6","article-title":"Autologous olfactory mucosa mesenchymal stem cells treatment improves the neural network in chronic refractory epilepsy","volume":"14","author":"Liu","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.phymed.2024.155635_bib0020","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41419-022-04664-5","article-title":"STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)","volume":"13","author":"Messaoud-Nacer","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2024.155635_bib0021","first-page":"22","article-title":"Cellular expansion of MSCs: shifting the regenerative potential","author":"Miclau","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.phymed.2024.155635_bib0022","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/01902148.2021.1887967","article-title":"Silencing of long noncoding RNA H19 alleviates pulmonary injury, inflammation, and fibrosis of acute respiratory distress syndrome through regulating the microRNA-423-5p\/FOXA1 axis","volume":"47","author":"Mu","year":"2021","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.phymed.2024.155635_bib0023","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1038\/s41467-020-18961-0","article-title":"T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis","volume":"11","author":"Napier","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.155635_bib0024","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12967-020-02234-x","article-title":"Improved therapeutics of modified mesenchymal stem cells: an update","volume":"18","author":"Ocansey","year":"2020","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2024.155635_bib0025","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.2200508","article-title":"PANoptosis: a unique innate immune inflammatory cell death modality","volume":"209","author":"Pandian","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2024.155635_bib0026","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s13287-017-0734-8","article-title":"Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway","volume":"8","author":"Pedrazza","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.phymed.2024.155635_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1552127","article-title":"Curcumin ameliorates white matter injury after ischemic stroke by inhibiting microglia\/macrophage pyroptosis through NF-kappaB suppression and NLRP3 inflammasome inhibition","volume":"2021","author":"Ran","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2024.155635_bib0028","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/ptr.6482","article-title":"Stem Cell Therapy: curcumin Does the Trick","volume":"33","author":"Sharifi","year":"2019","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2024.155635_bib0029","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jphs.2020.11.007","article-title":"Microglial metabolic disturbances and neuroinflammation in cerebral infarction","volume":"145","author":"Takeda","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2024.155635_bib0030","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/imr.12902","article-title":"NOD1 and NOD2 in inflammatory and infectious diseases","volume":"297","author":"Trindade","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2024.155635_bib0031","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-014-0228-x","article-title":"Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism","volume":"12","author":"Viceconte","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2024.155635_bib0032","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainresbull.2020.02.006","article-title":"NOD2 regulates microglial inflammation through the TAK1-NF-kappaB pathway and autophagy activation in murine pneumococcal meningitis","volume":"158","author":"Wang","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.phymed.2024.155635_bib0033","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/jpp\/rgad027","article-title":"Isoliquiritigenin regulates microglial M1\/M2 polarisation by mediating the P38\/MAPK pathway in cerebral stroke","volume":"75","author":"Wang","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155635_bib0034","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s10571-020-01018-7","article-title":"Curcumin improves human umbilical cord-derived mesenchymal stem cell survival via ERK1\/2 signaling and promotes motor outcomes after spinal cord injury","volume":"42","author":"Wanjiang","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2024.155635_bib0035","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s12031-019-01466-x","article-title":"Phenotypic differences in primary murine microglia treated with NOD1, NOD2, and NOD1\/2 agonists","volume":"70","author":"Wasmuth","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.phymed.2024.155635_bib0036","first-page":"23","article-title":"Relationship between the pyroptosis of fibroblast\u2011like synoviocytes and HMGB1 secretion in knee osteoarthritis","author":"Xiao","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2024.155635_bib0037","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s13287-022-02969-y","article-title":"Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1\/NF-\u03baB p65 pathway","volume":"13","author":"Xiong","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.phymed.2024.155635_bib0038","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2174\/1567202616666191029113633","article-title":"Curcumin prevents brain damage and cognitive dysfunction during ischemic-reperfusion through the regulation of miR-7-5p","volume":"16","author":"Xu","year":"2019","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.phymed.2024.155635_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154845","article-title":"Calycosin alleviates cerebral ischemia\/reperfusion injury by repressing autophagy via STAT3\/FOXO3a signaling pathway","volume":"115","author":"Xu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155635_bib0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12974-021-02174-3","article-title":"Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia\/macrophage polarization via FPR2\/ALX-dependent AMPK-mTOR pathway","volume":"18","author":"Xu","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.phymed.2024.155635_bib0041","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3389\/fncel.2018.00529","article-title":"Idebenone alleviates neuroinflammation and modulates microglial polarization in LPS-stimulated BV2 cells and MPTP-induced Parkinson's disease mice","volume":"12","author":"Yan","year":"2018","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.phymed.2024.155635_bib0042","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.4103\/1673-5374.331539","article-title":"Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies","volume":"17","author":"Yan","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2024.155635_bib0043","first-page":"357","article-title":"PANoptosis-like cell death in ischemia\/reperfusion injury of retinal neurons","volume":"18","author":"Yan","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2024.155635_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166785","article-title":"Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats","volume":"1869","author":"Yawoot","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"key":"10.1016\/j.phymed.2024.155635_bib0045","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s10020-022-00573-7","article-title":"Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF-\u03baB signaling pathway","volume":"28","author":"Yu","year":"2022","journal-title":"Mol. Med."},{"key":"10.1016\/j.phymed.2024.155635_bib0046","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/aps.2016.162","article-title":"Regulation of microglial activation in stroke","volume":"38","author":"Zhao","year":"2017","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324002940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324002940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T19:56:23Z","timestamp":1717271783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324002940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":46,"alternative-id":["S0944711324002940"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155635","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia\/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"155635"}}