{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:28:43Z","timestamp":1791491323071,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31702211"],"award-info":[{"award-number":["31702211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.phymed.2024.155741","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T06:30:16Z","timestamp":1715754616000},"page":"155741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Arbutin alleviates intestinal colitis by regulating neutrophil extracellular traps formation and microbiota composition"],"prefix":"10.1016","volume":"130","author":[{"given":"Di","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juxiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoupeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqiu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155741_bib0001","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ibd.20753","article-title":"Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis","volume":"15","author":"Alex","year":"2009","journal-title":"Inflamm. Bowel. Dis."},{"key":"10.1016\/j.phymed.2024.155741_bib0002","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cell.2015.08.058","article-title":"Th17 cell induction by adhesion of microbes to intestinal epithelial cells","volume":"163","author":"Atarashi","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2024.155741_bib0003","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nrgastro.2013.253","article-title":"Tailoring anti-TNF therapy in IBD: drug levels and disease activity","volume":"11","author":"Ben-Horin","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2024.155741_bib0004","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/gutjnl-2012-303329","article-title":"Non-redundant properties of IL-1alpha and IL-1beta during acute colon inflammation in mice","volume":"63","author":"Bersudsky","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2024.155741_bib0005","doi-asserted-by":"crossref","first-page":"eaaw4341","DOI":"10.1126\/sciimmunol.aaw4341","article-title":"A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice","volume":"4","author":"Caruso","year":"2019","journal-title":"Sci. Immunol."},{"issue":"6","key":"10.1016\/j.phymed.2024.155741_bib29","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/ecco-jcc\/jjy215","article-title":"Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis","volume":"13","author":"Dinallo","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.phymed.2024.155741_bib0006","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/abbi.1996.0470","article-title":"Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK","volume":"334","author":"El Benna","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2024.155741_bib0007","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3390\/cells9040915","article-title":"Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses","volume":"9","author":"Fousert","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2024.155741_bib0008","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nchembio.496","article-title":"Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation","volume":"7","author":"Hakkim","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phymed.2024.155741_bib0009","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tim.2020.02.018","article-title":"Sutterella species, IgA-degrading bacteria in ulcerative colitis","volume":"28","author":"Kaakoush","year":"2020","journal-title":"Trends. Microbiol."},{"key":"10.1016\/j.phymed.2024.155741_bib0010","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/ibd.21177","article-title":"Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate","volume":"16","author":"Lewis","year":"2010","journal-title":"Inflamm. Bowel. Dis."},{"key":"10.1016\/j.phymed.2024.155741_bib0011","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1968257","article-title":"Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease","volume":"13","author":"Li","year":"2021","journal-title":"Gut. Microbes"},{"key":"10.1016\/j.phymed.2024.155741_bib0012","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature24467","article-title":"Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence","volume":"551","author":"Li","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155741_bib0013","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40168-022-01296-x","article-title":"TLR4 regulates RORgammat(+) regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila","volume":"10","author":"Liu","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.phymed.2024.155741_bib0014","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1186\/s12951-022-01670-9","article-title":"Pitfalls in methods to study colocalization of nanoparticles in mouse macrophage lysosomes","volume":"20","author":"Moreno-Echeverri","year":"2022","journal-title":"J. Nanobiotechnology."},{"key":"10.1016\/j.phymed.2024.155741_bib0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2478\/intox-2014-0028","article-title":"Arbutin and decrease of potentially toxic substances generated in human blood neutrophils","volume":"7","author":"Pecivova","year":"2014","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.phymed.2024.155741_bib0016","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1053\/j.gastro.2020.03.064","article-title":"Wheat consumption aggravates colitis in mice via amylase trypsin inhibitor-mediated dysbiosis","volume":"159","author":"Pickert","year":"2020","journal-title":"Gastroenterology"},{"issue":"15","key":"10.1016\/j.phymed.2024.155741_bib30","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood-2012-03-416156","article-title":"Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity","volume":"120","author":"Sangaletti","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.phymed.2024.155741_bib0017","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1021\/acs.jafc.9b07151","article-title":"Engineering yarrowia lipolytica for enhanced production of arbutin","volume":"68","author":"Shang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2024.155741_bib0018","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.smim.2018.02.008","article-title":"The intestinal complement system in inflammatory bowel disease: shaping intestinal barrier function","volume":"37","author":"Sina","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.phymed.2024.155741_bib0019","doi-asserted-by":"crossref","first-page":"eabd1453","DOI":"10.1126\/sciadv.abd1453","article-title":"Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution","volume":"7","author":"Trilleaud","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2024.155741_bib0020","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1038\/s41467-018-06125-0","article-title":"NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease","volume":"9","author":"Tye","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2024.155741_bib0021","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3748\/wjg.v20.i1.6","article-title":"Immunopathology of inflammatory bowel disease","volume":"20","author":"Wallace","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2024.155741_bib0022","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41571-023-00766-x","article-title":"Gut microbiota in colorectal cancer development and therapy","volume":"20","author":"Wong","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phymed.2024.155741_bib0023","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s40168-021-01115-9","article-title":"Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis","volume":"9","author":"Wu","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.phymed.2024.155741_bib0024","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2024.155741_bib0025","article-title":"Recent progress on feasible strategies for arbutin production","volume":"10","author":"Xu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.phymed.2024.155741_bib0026","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002875","article-title":"Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis","volume":"9","author":"Yang","year":"2021","journal-title":"J. ImmunOther. Cancer"},{"key":"10.1016\/j.phymed.2024.155741_bib0027","doi-asserted-by":"crossref","first-page":"14810","DOI":"10.1096\/fj.202001502R","article-title":"Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development","volume":"34","author":"Yashiro","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2024.155741_bib0028","article-title":"Neutrophil extracellular traps caused by gut leakage trigger the autoimmune response in nonobese diabetic mice","volume":"12","author":"You","year":"2021","journal-title":"Front. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.phymed.2024.155741_bib31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000442934","article-title":"ASCA, ANCA, ALCA and Many More: Are They Useful in the Diagnosis of Inflammatory Bowel Disease?","volume":"34","author":"Zhou","year":"2016","journal-title":"Dig Dis"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324004008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324004008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T01:22:20Z","timestamp":1717464140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324004008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":31,"alternative-id":["S0944711324004008"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155741","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arbutin alleviates intestinal colitis by regulating neutrophil extracellular traps formation and microbiota composition","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155741"}}