{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:54:39Z","timestamp":1776858879526,"version":"3.51.2"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.phymed.2024.155748","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T16:54:41Z","timestamp":1715964881000},"page":"155748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Nardosinone relieves metabolic-associated fatty liver disease and promotes energy metabolism through targeting CYP2D6"],"prefix":"10.1016","volume":"130","author":[{"given":"Zeqiang","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanjie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zupeng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songtao","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiale","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155748_bib0001","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1136\/bjsports-2020-103720","article-title":"Fat but powerful' paradox: association of muscle power and adiposity markers with all-cause mortality in older adults from the EXERNET multicentre study","volume":"55","author":"Alcazar","year":"2021","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.phymed.2024.155748_bib0002","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2337\/diabetes.55.02.06.db05-0963","article-title":"Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages","volume":"55","author":"Aouadi","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2024.155748_bib0003","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/hep.28709","article-title":"Bile acids and nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives","volume":"65","author":"Arab","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2024.155748_bib0004","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.molmet.2016.06.003","article-title":"Non-alcoholic fatty liver and the gut microbiota","volume":"5","author":"Bashiardes","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phymed.2024.155748_bib0005","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1586\/17474124.2015.1057122","article-title":"Is intestinal inflammation linking dysbiosis to gut barrier dysfunction during liver disease?","volume":"9","author":"Brandl","year":"2015","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2024.155748_bib0006","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/cvr\/cvq239","article-title":"Mitochondria in the diabetic heart","volume":"88","author":"Bugger","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phymed.2024.155748_bib0007","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2024.155748_bib0008","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.celrep.2017.10.056","article-title":"Dietary uncoupling of gut microbiota and energy harvesting from obesity and glucose tolerance in mice","volume":"21","author":"Dalby","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2024.155748_bib0009","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-2002-30106","article-title":"Drugs and steatohepatitis","volume":"22","author":"Farrell","year":"2002","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.phymed.2024.155748_bib0010","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/jcb.25064","article-title":"Adiponectin prevents reduction of lipid-induced mitochondrial biogenesis via AMPK\/ACC2 pathway in chicken adipocyte","volume":"116","author":"Gan","year":"2015","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2024.155748_bib0011","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.7150\/ijbs.74348","article-title":"Small intestine-specific knockout of CIDEC improves obesity and hepatic steatosis by inhibiting synthesis of phosphatidic acid","volume":"18","author":"Huang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2024.155748_bib0012","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/ijo.2008.102","article-title":"Global burden of obesity in 2005 and projections to 2030","volume":"32","author":"Kelly","year":"2008","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.phymed.2024.155748_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113601","article-title":"Antidepressant activities and regulative effects on serotonin transporter of Nardostachys jatamansi DC","volume":"268","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155748_bib0014","doi-asserted-by":"crossref","first-page":"e91260","DOI":"10.1371\/journal.pone.0091260","article-title":"Nardosinone improves the proliferation, migration and selective differentiation of mouse embryonic neural stem cells","volume":"9","author":"Li","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phymed.2024.155748_bib0015","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.lfs.2016.04.010","article-title":"Monoterpene limonene induces brown fat-like phenotype in 3T3-L1 white adipocytes","volume":"153","author":"Lone","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2024.155748_bib0016","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3390\/nu9101124","article-title":"Gut microbiota and nonalcoholic fatty liver disease: insights on mechanisms and therapy","volume":"9","author":"Ma","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.155748_bib0017","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.2174\/0929867330666221107095646","article-title":"The roles of natural alkaloids and polyphenols in lipid metabolism: therapeutic implications and potential targets in metabolic diseases","volume":"30","author":"Ma","year":"2023","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phymed.2024.155748_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.742672","article-title":"Integrative ATAC-seq and RNA-seq analysis of the longissimus muscle of luchuan and duroc pigs","volume":"8","author":"Miao","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2024.155748_bib0019","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1053\/j.gastro.2008.10.080","article-title":"Microbes in gastrointestinal health and disease","volume":"136","author":"Neish","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2024.155748_bib0020","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3389\/fphar.2017.00626","article-title":"Nardosinone suppresses RANKL-induced osteoclastogenesis and attenuates lipopolysaccharide-induced alveolar bone resorption","volume":"8","author":"Niu","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155748_bib0021","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41419-020-03122-4","article-title":"High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction","volume":"11","author":"Sun","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2024.155748_bib0022","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.3390\/nu12103197","article-title":"A high-fat diet increases gut microbiota biodiversity and energy expenditure due to nutrient difference","volume":"12","author":"Wang","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2024.155748_bib0023","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1111\/bph.15767","article-title":"Ruthenium 360 and mitoxantrone inhibit mitochondrial calcium uniporter channel to prevent liver steatosis induced by high-fat diet","volume":"179","author":"Zhang","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155748_bib0024","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chom.2017.11.003","article-title":"Fiber-mediated nourishment of gut microbiota protects against diet-induced obesity by restoring IL-22-mediated colonic health","volume":"23","author":"Zou","year":"2018","journal-title":"Cell Host Microbe"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324004070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324004070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T01:22:33Z","timestamp":1717464153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324004070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":24,"alternative-id":["S0944711324004070"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155748","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nardosinone relieves metabolic-associated fatty liver disease and promotes energy metabolism through targeting CYP2D6","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155748"}}