{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:58:06Z","timestamp":1784919486753,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Jilin Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["YDZJ202301ZYTS209"],"award-info":[{"award-number":["YDZJ202301ZYTS209"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360400"],"award-info":[{"award-number":["82360400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960375"],"award-info":[{"award-number":["81960375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.phymed.2024.155765","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T17:42:30Z","timestamp":1716486150000},"page":"155765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["A novel mechanism of resveratrol alleviates Toxoplasma gondii infection-induced pulmonary inflammation via inhibiting inflammasome activation"],"prefix":"10.1016","volume":"131","author":[{"given":"Yu Nan","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Mei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang Nan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Yu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing He","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Wen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Zhu","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-5918","authenticated-orcid":false,"given":"Lian Xun","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2024.155765_bib0001","article-title":"A rare case of pulmonary toxoplasmosis in a patient with undifferentiated inflammatory arthritis on chronic methotrexate and corticosteroid therapy","volume":"2017","author":"Abdulkareem","year":"2017","journal-title":"BMJ. Case. Rep."},{"key":"10.1016\/j.phymed.2024.155765_bib0002","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/eji.1830111013","article-title":"F4\/80, a monoclonal antibody directed specifically against the mouse macrophage","volume":"11","author":"Austyn","year":"1981","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phymed.2024.155765_bib0003","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1021\/jf0112973","article-title":"Plant foods and herbal sources of resveratrol","volume":"50","author":"Burns","year":"2002","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.phymed.2024.155765_bib0004","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5858\/arpa.2015-0519-RA","article-title":"Acute lung injury: a clinical and molecular review","volume":"140","author":"Butt","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.phymed.2024.155765_bib0005","first-page":"704","article-title":"Pulmonary toxoplasmosis","volume":"133","author":"Catterall","year":"1986","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.phymed.2024.155765_bib0006","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ajpath.2013.09.007","article-title":"New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease","volume":"18","author":"De Nardo","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2024.155765_bib0007","doi-asserted-by":"crossref","first-page":"e00057","DOI":"10.1128\/CMR.00057-17","article-title":"Treatment of toxoplasmosis: historical perspective, animal models, and current clinical practice","volume":"31","author":"Dunay","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.phymed.2024.155765_bib0008","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.4049\/jimmunol.1002720","article-title":"Differential expression of NLRP3 among hematopoietic cells","volume":"186","author":"Guarda","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2024.155765_bib0009","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00436-023-07833-3","article-title":"Protective effect of luteoloside against Toxoplasma gondii-induced liver injury through inhibiting TLR4\/NF-\u03baB and P2X7R\/NLRP3 and enhancing Nrf2\/HO-1 signaling pathway","volume":"122","author":"Han","year":"2023","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.phymed.2024.155765_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154143","article-title":"Hydnocarpin D attenuates lipopolysaccharide-induced acute lung injury via MAPK\/NF-\u03baB and Keap1\/Nrf2\/HO-1 pathway","volume":"101","author":"Hong","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155765_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120782","article-title":"Deciphering the role of damage-associated molecular patterns and inflammatory responses in acute lung injury","volume":"305","author":"Hsieh","year":"2022","journal-title":"Life Sci"},{"key":"10.1016\/j.phymed.2024.155765_bib0012","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.phymed.2024.155765_bib0013","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1084\/jem.20171419","article-title":"Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders","volume":"214","author":"Jiang","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phymed.2024.155765_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109176","article-title":"Protective effect of ginsenoside Rh2 against Toxoplasma gondii infection-induced neuronal injury through binding TgCDPK1 and NLRP3 to inhibit microglial NLRP3 inflammasome signaling pathway","volume":"112","author":"Jin","year":"2022","journal-title":"Int. immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155765_bib0015","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/fsn3.855","article-title":"Resveratrol: a miraculous natural compound for diseases treatment","volume":"6","author":"Koushki","year":"2018","journal-title":"Food. Sci. Nutr."},{"key":"10.1016\/j.phymed.2024.155765_bib0016","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1165\/rcmb.2015-0231TR","article-title":"Regulation and function of the nucleotide binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 inflammasome in lung disease","volume":"54","author":"Lee","year":"2016","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.phymed.2024.155765_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154522","article-title":"Resveratrol inhibits Toxoplasma gondii-induced lung injury, inflammatory cascade and evidences of its mechanism of action","volume":"108","author":"Lu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2024.155765_bib0018","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.4049\/jimmunol.167.8.4574","article-title":"Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines","volume":"167","author":"Mordue","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2024.155765_bib0019","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/clinids\/14.4.863","article-title":"Pulmonary toxoplasmosis: a review","volume":"14","author":"Pomeroy","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.phymed.2024.155765_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2023.08.016","article-title":"Toxoplasma gondii induces pyroptosis in human placental trophoblast and amniotic cells by inducing ROS production and activation of cathepsin B and NLRP1\/NLRP3\/NLRC4\/AIM2 inflammasome","author":"Quan","year":"2023","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2024.155765_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2021.106202","article-title":"Toxoplasma gondii activates NLRP12 inflammasome pathway in the BALB\/c murine model","volume":"225","author":"Rajabi","year":"2022","journal-title":"Acta Trop"},{"key":"10.1016\/j.phymed.2024.155765_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110031","article-title":"Coixol ameliorates Toxoplasma gondii infection-induced lung injury by interfering with T. gondii HSP70\/TLR4\/NF-\u03baB signaling pathway","volume":"118","author":"Shen","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155765_bib0023","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2024.155765_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107621","article-title":"Suppression of NLRP3 inflammasome by Platycodin D via the TLR4\/MyD88\/NF-\u03baB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats","volume":"96","author":"Wu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155765_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112433","article-title":"PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice","volume":"221","author":"Xiong","year":"2021","journal-title":"Environ. Saf."},{"key":"10.1016\/j.phymed.2024.155765_bib0026","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1111\/bph.15261","article-title":"Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1\/TLR4\/NF-\u03baB and TNF-\u03b1\/TNFR1\/NF-\u03baB pathways","volume":"177","author":"Xu","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2024.155765_bib0027","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2019.08.054","article-title":"PKR suppress NLRP3-pyroptosis pathway in lipopolysaccharide-induced acute lung injury model of mice","volume":"519","author":"Zeng","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2024.155765_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107529","article-title":"Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation","volume":"95","author":"Zhang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2024.155765_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116615","article-title":"Shiwei Qingwen decoction regulates TLR4\/NF-\u03baB signaling pathway and NLRP3 inflammasome to reduce inflammatory response in lipopolysaccharide-induced acute lung injury","volume":"313","author":"Zhang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2024.155765_bib0030","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/infdis\/jiac422","article-title":"TgMIF promotes hepatocyte pyroptosis and recruitment of proinflammatory macrophages during severe liver injury in acute toxoplasmosis","volume":"227","author":"Zhou","year":"2023","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.phymed.2024.155765_bib0031","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.lfs.2019.03.017","article-title":"Isorhynchophylline exerts anti-inflammatory and anti-oxidative activities in LPS-stimulated murine alveolar macrophages","volume":"223","author":"Zhou","year":"2019","journal-title":"Life Sci"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324004240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324004240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T18:33:54Z","timestamp":1718994834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324004240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":31,"alternative-id":["S0944711324004240"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155765","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel mechanism of resveratrol alleviates Toxoplasma gondii infection-induced pulmonary inflammation via inhibiting inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155765","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155765"}}