{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:43:12Z","timestamp":1793644992078,"version":"4.5.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360644"],"award-info":[{"award-number":["82360644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860608"],"award-info":[{"award-number":["81860608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["YNWR-YLXZ-2018-026"],"award-info":[{"award-number":["YNWR-YLXZ-2018-026"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202301BD070001-176"],"award-info":[{"award-number":["202301BD070001-176"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202102AE090027"],"award-info":[{"award-number":["202102AE090027"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.phymed.2024.155852","type":"journal-article","created":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T01:33:59Z","timestamp":1720316039000},"page":"155852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Theabrownin from Pu-erh Tea Improves DSS-Induced Colitis via Restoring Gut Homeostasis and Inhibiting TLR2&amp;4 Signaling Pathway"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-3157","authenticated-orcid":false,"given":"Lei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.phymed.2024.155852_bib0001","doi-asserted-by":"crossref","first-page":"6331","DOI":"10.1039\/C9FO01537J","article-title":"Dietary cranberry suppressed colonic inflammation and alleviated gut microbiota dysbiosis in dextran sodium sulfate-treated mice","volume":"10","author":"Cai","year":"2019","journal-title":"Food. Funct"},{"key":"10.1016\/j.phymed.2024.155852_bib0002","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1479-5876-8-112","article-title":"The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker","volume":"8","author":"Cammarota","year":"2010","journal-title":"J. Transl. Med"},{"issue":"10","key":"10.1016\/j.phymed.2024.155852_bib0003","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","article-title":"Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms","volume":"19","author":"Cani","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol"},{"key":"10.1016\/j.phymed.2024.155852_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.684486","article-title":"Natural anti-inflammatory compounds as drug candidates for inflammatory bowel disease","volume":"12","author":"Duan","year":"2021","journal-title":"Front. Pharmacol"},{"issue":"1","key":"10.1016\/j.phymed.2024.155852_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1826746","article-title":"B. adolescentis ameliorates chronic colitis by regulating Treg\/Th2 response and gut microbiota remodeling","volume":"13","author":"Fan","year":"2021","journal-title":"Gut. Microbes"},{"issue":"10","key":"10.1016\/j.phymed.2024.155852_bib0006","doi-asserted-by":"crossref","first-page":"6416","DOI":"10.4049\/jimmunol.174.10.6416","article-title":"A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease","volume":"174","author":"Fort","year":"2005","journal-title":"J. Immunol"},{"key":"10.1016\/j.phymed.2024.155852_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.664003","article-title":"Theabrownin induces cell apoptosis and cell cycle arrest of oligodendroglioma and astrocytoma in different pathways","volume":"12","author":"Fu","year":"2021","journal-title":"Front. Pharmacol"},{"issue":"1","key":"10.1016\/j.phymed.2024.155852_bib0008","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1080\/21655979.2021.1975017","article-title":"High-altitude hypoxia exacerbates dextran sulfate sodium (DSS)-induced colitis by upregulating Th1 and Th17 lymphocytes","volume":"12","author":"Gamah","year":"2021","journal-title":"Bioengineered"},{"issue":"3","key":"10.1016\/j.phymed.2024.155852_bib0009","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/ibd\/izx029","article-title":"A cross-talk between microbiota-derived short-chain fatty acids and the host mucosal immune system regulates intestinal homeostasis and inflammatory bowel disease","volume":"24","author":"Gon\u00e7alves","year":"2018","journal-title":"Inflamm. Bowel. Dis"},{"issue":"2","key":"10.1016\/j.phymed.2024.155852_bib0012","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.gtc.2021.12.008","article-title":"Diet in the pathogenesis and management of crohn's disease","volume":"51","author":"Gu","year":"2022","journal-title":"Gastroenterol. Clin. North. Am"},{"issue":"3","key":"10.1016\/j.phymed.2024.155852_bib0013","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/j.2040-4603.2012.tb00450.x","article-title":"Claudins and other tight junction proteins","volume":"2","author":"G\u00fcnzel","year":"2012","journal-title":"Compr. Physiol"},{"issue":"Pt B","key":"10.1016\/j.phymed.2024.155852_bib0014","article-title":"Pu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions","volume":"162","author":"Hou","year":"2022","journal-title":"Food. Res. Int"},{"issue":"1","key":"10.1016\/j.phymed.2024.155852_bib0015","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1038\/s41467-019-12896-x","article-title":"Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism","volume":"10","author":"Huang","year":"2019","journal-title":"Nat. Commun"},{"issue":"33","key":"10.1016\/j.phymed.2024.155852_bib0016","doi-asserted-by":"crossref","first-page":"9168","DOI":"10.1021\/acs.jafc.8b05581","article-title":"Dietary intake of whole strawberry inhibited colonic inflammation in dextran-sulfate-sodium-treated Mice via restoring immune homeostasis and alleviating gut microbiota dysbiosis","volume":"67","author":"Han","year":"2019","journal-title":"J. Agric. Food. Chem"},{"issue":"7785","key":"10.1016\/j.phymed.2024.155852_bib0017","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-019-1785-z","article-title":"Bile acid metabolites control TH17 and Treg cell differentiation","volume":"576","author":"Hang","year":"2019","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.phymed.2024.155852_bib0018","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/19490976.2019.1589281","article-title":"Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota","volume":"10","author":"Jang","year":"2019","journal-title":"Gut. microbes"},{"issue":"32","key":"10.1016\/j.phymed.2024.155852_bib0019","doi-asserted-by":"crossref","first-page":"9313","DOI":"10.1021\/acs.jafc.1c03850","article-title":"Immune-enhancing effects of a novel glucan from purple sweet potato Ipomoea batatas (L.) Lam on RAW264.7 macrophage cells via TLR2- and TLR4-mediated pathways","volume":"69","author":"Ji","year":"2021","journal-title":"J. Agric. Food. Chem"},{"issue":"11","key":"10.1016\/j.phymed.2024.155852_bib0020","doi-asserted-by":"crossref","first-page":"e1213","DOI":"10.1002\/cti2.1213","article-title":"Porphyromonas gingivalis and Lactobacillus rhamnosus GG regulate the Th17\/Treg balance in colitis via TLR4 and TLR2","volume":"9","author":"Jia","year":"2020","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.phymed.2024.155852_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/836485","article-title":"The effects of TLR activation on T-cell development and differentiation","volume":"2012","author":"Jin","year":"2012","journal-title":"Clin. Dev. Immunol"},{"issue":"2","key":"10.1016\/j.phymed.2024.155852_bib0022","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1053\/j.gastro.2020.09.056","article-title":"Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues","volume":"160","author":"Lee","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2024.155852_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2022.104941","article-title":"Theabrownin modulates the gut microbiome and serum metabolome in aging mice induced by d-galactose","volume":"89","author":"Lei","year":"2022","journal-title":"J. Funct. Foods"},{"issue":"4","key":"10.1016\/j.phymed.2024.155852_bib0024","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s10787-022-01007-w","article-title":"Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice","volume":"30","author":"Li","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.phymed.2024.155852_bib0025","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.fm.2018.07.001","article-title":"Revealing the influence of microbiota on the quality of Pu-erh tea during fermentation process by shotgun metagenomic and metabolomic analysis","volume":"76","author":"Li","year":"2018","journal-title":"Food Microbiol"},{"key":"10.1016\/j.phymed.2024.155852_bib0026","article-title":"Platelet membrane fragment self-assembled oral hydrogel microspheres for restoring intestinal microvascular injury","volume":"33","author":"Liu","year":"2023","journal-title":"Adv. Funct. Mater"},{"issue":"11","key":"10.1016\/j.phymed.2024.155852_bib0027","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/jsfa.7556","article-title":"Serum metabolomics analysis of rat after intragastric infusion of Pu-erh theabrownin","volume":"96","author":"Liu","year":"2016","journal-title":"J. Sci. Food. Agric"},{"issue":"12","key":"10.1016\/j.phymed.2024.155852_bib0028","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.7150\/thno.43716","article-title":"Parthenolide ameliorates colon inflammation through regulating Treg\/Th17 balance in a gut microbiota-dependent manner","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.phymed.2024.155852_bib0030","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/app7020166","article-title":"Microbial succession and the dynamics of chemical compounds during the solid-state fermentation of Pu-erh tea","volume":"7","author":"Ma","year":"2017","journal-title":"Appl. Sci"},{"issue":"7","key":"10.1016\/j.phymed.2024.155852_bib0031","doi-asserted-by":"crossref","first-page":"e69936","DOI":"10.1371\/journal.pone.0069936","article-title":"New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation","volume":"8","author":"Morgan","year":"2013","journal-title":"PLoS. One"},{"key":"10.1016\/j.phymed.2024.155852_bib0032","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1093\/nar\/20.22.6115","article-title":"A simple and efficient protocol for isolation of high molecular weight DNA from filamentous fungi, fruit bodies, and infected plant tissues","volume":"20","author":"M\u00f6ller","year":"1992","journal-title":"Nucl. Acids. Res"},{"issue":"10114","key":"10.1016\/j.phymed.2024.155852_bib0033","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.phymed.2024.155852_bib0034","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/jpp\/rgac101","article-title":"Sophorolipids produced by Yarrowia lipolytica grown on Moringa oleifera oil cake protect against acetic acid-induced colitis in rats: impact on TLR-4\/p-JNK\/NF\u03baB-p65 pathway","volume":"75","author":"Nooman","year":"2023","journal-title":"J. Pharm. Pharmacol"},{"key":"10.1016\/j.phymed.2024.155852_bib0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ijbiomac.2012.12.021","article-title":"Influence of different fermentation raw materials on pyrolyzates of Pu-erh tea theabrownin by curie-point pyrolysis-gas chromatography-mass spectroscopy","volume":"54","author":"Peng","year":"2013","journal-title":"Int. J. Biol. Macromol"},{"key":"10.1016\/j.phymed.2024.155852_bib0036","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.freeradbiomed.2019.04.005","article-title":"Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in mice","volume":"136","author":"Peng","year":"2019","journal-title":"Free Radic. Biol. Med"},{"issue":"12","key":"10.1016\/j.phymed.2024.155852_bib0037","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.3390\/nu14122469","article-title":"Nutrition and supplementation in ulcerative colitis","volume":"14","author":"Radziszewska","year":"2022","journal-title":"Nutrients"},{"issue":"14","key":"10.1016\/j.phymed.2024.155852_bib0038","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.3390\/ijms22147618","article-title":"Innate Lymphoid cells in intestinal homeostasis and inflammatory bowel disease","volume":"22","author":"Saez","year":"2021","journal-title":"Int. J. Mol. Sci"},{"issue":"12","key":"10.1016\/j.phymed.2024.155852_bib0039","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/apt.14688","article-title":"Systematic review: safety of mesalazine in ulcerative colitis","volume":"47","author":"Sehgal","year":"2018","journal-title":"Aliment. Pharmacol. Ther"},{"issue":"10","key":"10.1016\/j.phymed.2024.155852_bib0040","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/ibd.20951","article-title":"Role of TNF receptors, TNFR1 and TNFR2, in dextran sodium sulfate-induced colitis","volume":"15","author":"Stillie","year":"2009","journal-title":"Inflamm. Bowel. Dis"},{"issue":"8","key":"10.1016\/j.phymed.2024.155852_bib0041","article-title":"Lyciumruthenicum anthocyanins attenuate high-fat diet-induced colonic barrier dysfunction and inflammation in mice by modulating the gut microbiota","volume":"65","author":"Tian","year":"2021","journal-title":"Mol. Nutr. Food. Res"},{"key":"10.1016\/j.phymed.2024.155852_bib0042","article-title":"Theabrownin and Poria cocos Polysaccharide improve lipid metabolism via modulation of bile acid and fatty acid metabolism","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol"},{"key":"10.1016\/j.phymed.2024.155852_bib0043","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.lwt.2018.01.021","article-title":"Physicochemical properties and biological activities of a high-theabrownins instant Pu-erh tea produced using Aspergillus tubingensis","volume":"90","author":"Wang","year":"2018","journal-title":"LWT-Food Sci. Technol"},{"issue":"13","key":"10.1016\/j.phymed.2024.155852_bib0044","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1002\/jsfa.4480","article-title":"Effects of enzymatic action on the formation of theabrownin during solid state fermentation of Pu-erh tea","volume":"91","author":"Wang","year":"2011","journal-title":"J. Sci. Food. Agric"},{"key":"10.1016\/j.phymed.2024.155852_bib0046","doi-asserted-by":"crossref","first-page":"11900","DOI":"10.1021\/acs.jafc.1c04626","article-title":"Theabrownin from Fu Brick Tea exhibits the thermogenic function of adipocytes in high-fat-diet-induced obesity","volume":"69","author":"Wang","year":"2021","journal-title":"J. Agric. Food. Chem"},{"key":"10.1016\/j.phymed.2024.155852_bib0047","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bcp.2017.03.012","article-title":"Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols","volume":"139","author":"Williamson","year":"2017","journal-title":"Biochem. Pharmacol"},{"key":"10.1016\/j.phymed.2024.155852_bib0048","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc"},{"issue":"7855","key":"10.1016\/j.phymed.2024.155852_bib0049","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/s41586-021-03283-y","article-title":"MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche","volume":"592","author":"Wu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2024.155852_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154460","article-title":"Qingchang Wenzhong decoction reduce ulcerative colitis in mice by inhibiting Th17 lymphocyte differentiation","volume":"107","author":"Xia","year":"2022","journal-title":"Phytomedicine"},{"issue":"38","key":"10.1016\/j.phymed.2024.155852_bib0051","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.2174\/0929867324666171009100900","article-title":"Potential of plant-sourced phenols for inflammatory bowel disease","volume":"25","author":"Xiao","year":"2018","journal-title":"Curr. Med. Chem"},{"key":"10.1016\/j.phymed.2024.155852_bib0052","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/biom10020204","article-title":"Structural characteristics and hypolipidemic activity of theabrownins from dark tea fermented by single species eurotiumcristatum PW-1","volume":"10","author":"Xiao","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2024.155852_bib0053","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.biopha.2018.11.087","article-title":"Effect of compound sophorae decoction on dextran sodium sulfate (DSS)-induced colitis in mice by regulating Th17\/Treg cell balance","volume":"109","author":"Xu","year":"2019","journal-title":"Biomed. Pharmacother"},{"key":"10.1016\/j.phymed.2024.155852_bib0054","first-page":"1850","article-title":"Study on the UV-quantitative analysis of theabrownins in Pu-erh tea","volume":"33","author":"Yang","year":"2013","journal-title":"Spectrosc. Spectral. Anal."},{"key":"10.1016\/j.phymed.2024.155852_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103751","article-title":"MUC2 and related bacterial factors: therapeutic targets for ulcerative colitis","volume":"74","author":"Yao","year":"2021","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.phymed.2024.155852_bib62","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.bbrc.2020.10.002","article-title":"ACE2 contributes to the maintenance of mouse epithelial barrier function","volume":"533","author":"Yu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2024.155852_bib0056","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1039\/D1FO03374C","article-title":"Theabrownin-targeted regulation of intestinal microorganisms to improve glucose and lipid metabolism in Goto-Kakizaki rats","volume":"13","author":"Yue","year":"2022","journal-title":"Food Funct"},{"key":"10.1016\/j.phymed.2024.155852_bib0057","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1039\/C9FO01334B","article-title":"Effects of theabrownin on serum metabolite and gut microbiome in rats with high-sugar diet","volume":"10","author":"Yue","year":"2019","journal-title":"Food Funct"},{"issue":"7","key":"10.1016\/j.phymed.2024.155852_bib0058","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3390\/foods12071468","article-title":"Theabrownin isolated from pu-erh tea enhances the innate immune and anti-inflammatory effects of RAW264.7 macrophages via the TLR2&4-mediated signaling pathway","volume":"12","author":"Zhao","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2024.155852_bib0059","doi-asserted-by":"crossref","first-page":"10117","DOI":"10.1038\/srep10117","article-title":"An integrated metagenomics\/metaproteomics investigation of the microbial communities and enzymes in solid-state fermentation of Pu-erh tea","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci. Rep."},{"issue":"45","key":"10.1016\/j.phymed.2024.155852_bib0060","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202004529","article-title":"Prebiotics-encapsulated probiotic spores regulate gut microbiota and suppress colon cancer","volume":"32","author":"Zheng","year":"2020","journal-title":"Adv. Mater"},{"key":"10.1016\/j.phymed.2024.155852_bib0061","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.939377","article-title":"Nuciferine regulates immune function and gut microbiota in DSS-induced ulcerative colitis","volume":"9","author":"Zhu","year":"2022","journal-title":"Front. Vet. Sci"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711324005105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:17:39Z","timestamp":1778559459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711324005105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":58,"alternative-id":["S0944711324005105"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155852","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Theabrownin from Pu-erh Tea Improves DSS-Induced Colitis via Restoring Gut Homeostasis and Inhibiting TLR2&4 Signaling Pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2024.155852","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155852"}}